JPH06500636A - 化学、生化学および生物学的な測定試料の特異物質を選択的に検出する光学的な方法 - Google Patents
化学、生化学および生物学的な測定試料の特異物質を選択的に検出する光学的な方法Info
- Publication number
- JPH06500636A JPH06500636A JP4511206A JP51120692A JPH06500636A JP H06500636 A JPH06500636 A JP H06500636A JP 4511206 A JP4511206 A JP 4511206A JP 51120692 A JP51120692 A JP 51120692A JP H06500636 A JPH06500636 A JP H06500636A
- Authority
- JP
- Japan
- Prior art keywords
- sensitive
- waveguide
- diffraction grating
- chemical
- grating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 239000000126 substance Substances 0.000 title claims description 44
- 238000005259 measurement Methods 0.000 title claims description 27
- 238000000034 method Methods 0.000 title claims description 22
- 230000005672 electromagnetic field Effects 0.000 claims description 38
- 230000008878 coupling Effects 0.000 claims description 17
- 238000010168 coupling process Methods 0.000 claims description 17
- 238000005859 coupling reaction Methods 0.000 claims description 17
- 230000008859 change Effects 0.000 claims description 8
- 230000005284 excitation Effects 0.000 claims description 7
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 238000001514 detection method Methods 0.000 claims description 3
- 239000000758 substrate Substances 0.000 claims description 3
- 238000005286 illumination Methods 0.000 claims description 2
- 239000004020 conductor Substances 0.000 claims 1
- 230000000644 propagated effect Effects 0.000 claims 1
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- 238000011896 sensitive detection Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 description 6
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
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- 239000004793 Polystyrene Substances 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000003416 augmentation Effects 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
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- 230000003197 catalytic effect Effects 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
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- 239000010453 quartz Substances 0.000 description 1
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- 239000000377 silicon dioxide Substances 0.000 description 1
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- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
- G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
- G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0385—Diffusing membrane; Semipermeable membrane
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1954/91A CH681920A5 (cg-RX-API-DMAC7.html) | 1991-07-02 | 1991-07-02 | |
| CH1954/91-1 | 1991-07-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH06500636A true JPH06500636A (ja) | 1994-01-20 |
Family
ID=4222477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4511206A Pending JPH06500636A (ja) | 1991-07-02 | 1992-06-19 | 化学、生化学および生物学的な測定試料の特異物質を選択的に検出する光学的な方法 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0551456A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPH06500636A (cg-RX-API-DMAC7.html) |
| CH (1) | CH681920A5 (cg-RX-API-DMAC7.html) |
| WO (1) | WO1993001487A1 (cg-RX-API-DMAC7.html) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012058218A (ja) * | 2010-09-13 | 2012-03-22 | Shimadzu Corp | 導波モード共鳴格子を用いた屈折率測定装置及び屈折率測定方法 |
| JP2016524163A (ja) * | 2013-07-12 | 2016-08-12 | エフ．ホフマン−ラ ロッシュ アーゲー | 結合親和性の検出に用いる装置 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0617273B1 (de) * | 1993-03-26 | 2002-10-16 | F. Hoffmann-La Roche Ag | Optisches Verfahren und Vorrichtung zur Analyse von Substanzen an Sensoroberflächen |
| GB9314991D0 (en) * | 1993-07-20 | 1993-09-01 | Sandoz Ltd | Mechanical device |
| WO1995014225A1 (de) * | 1993-11-15 | 1995-05-26 | Carl Zeiss Jena Gmbh | Anordnung zur analyse von substanzen an der oberfläche eines optischen sensors |
| DE4345225A1 (de) * | 1993-11-15 | 1995-05-18 | Hoffmann La Roche | Anordnung zur Analyse von Substanzen an der Oberfläche eines optischen Sensors |
| DE4424628B4 (de) * | 1994-07-13 | 2005-11-17 | Lau, Matthias, Dipl.-Ing. | Verfahren und Anordnung zur Brechzahlmessung verschiedener Medien |
| GB9602542D0 (en) * | 1996-02-08 | 1996-04-10 | Fisons Plc | Analytical device |
| JP3872817B2 (ja) | 1996-03-30 | 2007-01-24 | ノバルティス アクチエンゲゼルシャフト | 集積化された光学的ルミネセンスセンサ |
| DE19615366B4 (de) * | 1996-04-19 | 2006-02-09 | Carl Zeiss Jena Gmbh | Verfahren und Einrichtung zum Nachweis physikalischer, chemischer, biologischer oder biochemischer Reaktionen und Wechselwirkungen |
| US6277330B1 (en) | 1996-09-30 | 2001-08-21 | Aventis Research & Technologies Gmbh & Co K.G. | Optical sensor for detecting chemical substances dissolved or dispersed in water |
| US8111401B2 (en) * | 1999-11-05 | 2012-02-07 | Robert Magnusson | Guided-mode resonance sensors employing angular, spectral, modal, and polarization diversity for high-precision sensing in compact formats |
| US7046357B2 (en) | 2003-01-30 | 2006-05-16 | Ciphergen Biosystems, Inc. | Apparatus for microfluidic processing and reading of biochip arrays |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3680999D1 (de) * | 1985-05-29 | 1991-09-26 | Artificial Sensing Instr Asi A | Optischer sensor zum selektiven nachweis von substanzen und zum nachweis von brechzahlaenderungen in messubstanzen. |
| DE3723159A1 (de) * | 1986-07-17 | 1988-01-21 | Prosumus Ag | Chemosensor sowie mit diesem durchfuehrbare verfahren |
| US5082629A (en) * | 1989-12-29 | 1992-01-21 | The Board Of The University Of Washington | Thin-film spectroscopic sensor |
| EP0455067B1 (de) * | 1990-05-03 | 2003-02-26 | F. Hoffmann-La Roche Ag | Mikrooptischer Sensor |
| DE4033912C2 (de) * | 1990-10-25 | 1995-05-24 | Fraunhofer Ges Forschung | Optischer Sensor |
-
1991
- 1991-07-02 CH CH1954/91A patent/CH681920A5/de not_active IP Right Cessation
-
1992
- 1992-06-19 WO PCT/CH1992/000117 patent/WO1993001487A1/de not_active Ceased
- 1992-06-19 JP JP4511206A patent/JPH06500636A/ja active Pending
- 1992-06-19 EP EP92912252A patent/EP0551456A1/de not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012058218A (ja) * | 2010-09-13 | 2012-03-22 | Shimadzu Corp | 導波モード共鳴格子を用いた屈折率測定装置及び屈折率測定方法 |
| JP2016524163A (ja) * | 2013-07-12 | 2016-08-12 | エフ．ホフマン−ラ ロッシュ アーゲー | 結合親和性の検出に用いる装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0551456A1 (de) | 1993-07-21 |
| WO1993001487A1 (de) | 1993-01-21 |
| CH681920A5 (cg-RX-API-DMAC7.html) | 1993-06-15 |
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