JPH0648931A - Whitening cosmetic - Google Patents

Abstract

PURPOSE:To provide the cosmetic containing ingredients contained in Santalum album L. except its essential oil and giving an excellent whitening effect. CONSTITUTION:The whitening cosmetic contains the water extract of Santalum album L. and, if necessary, further at least one selected from a group consisting of kojic acid, ascorbic acid, hydroquinone, liquiritin, and their derivatives. An extract produced by extracting the whole body of the Santalum album L. including its stem, roots and leave at the ordinary temperature can preferably be used as the water extract of the Santalum album L. as the active ingredient.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic composition, and more particularly to sandalwood (Santalum alb).
um L.) and a white skin cosmetic containing a root water extract.

[0002]

2. Description of the Related Art Kojic acid, ascorbic acid, arbutin and the like are known as substances having a whitening effect,
Among them, arbutin and the like are known as plant-derived products. Sandalwood heartwood has been used as a fragrance tree since ancient times, and its essential oil component is also used as a fragrance in cosmetics. Further, it has been reported that the cosmetics containing the essential oil component in sandalwood have sedative and hypnotic effects (Japanese Patent Laid-Open No. 63-199292).

[0003]

The conventional application of sandalwood to cosmetics focuses on its fragrance, that is, essential oil components (aroma components), for example, Santalol, Santalene, Sante.
ne, Santalal, Santenone, Santalic acid, Citronellol, T
It was a formulation that contained erpineol, Carvone, etc. (a viscous liquid obtained by steam distillation or an organic solvent extract such as alcohol). The present inventor has continued research on the effective use of components other than the essential oil component contained in sandalwood, and this time, the water extract of sandalwood that has never been used for cosmetics has a whitening effect. The present invention has been completed based on this finding.

The sandalwood extract in the present invention is a water extract of sandalwood (normal temperature extraction) and contains almost no aroma component. In addition, the peripheral part (sapwood) of the wood is white and the essential oil component is relatively small, but the heartwood part is light yellow, yellowish brown and contains a large amount of aromatic component (essential oil) along with the root. The quality of sapwood was superior to that of "sandalwood", and the fragrance of the wood had a significant difference. However, the sandalwood water extract according to the present invention is an extract from a whole tree including sandalwood wood, roots, and leaves, and its extraction site is not particularly limited. In other words, it is irrelevant to the localized location of the aroma component.

[0005]

According to the knowledge of the present inventor, a Santalum alb whose Japanese name is called sandalwood (sandalwood)
A uniform whitening effect was found in the water extract (normal temperature extraction) of the whole tree (including roots and leaves) of um L. This water extract contains almost no essential oil as an aromatic component (attached with a gas chromatography chart), and is 0.01 to 10.0% by weight, preferably 0.1 to 5. An excellent whitening effect is obtained with 0% by weight.

The sandalwood, which is commonly called Japanese sandalwood, is usually sandalwood (Santalwood) from East India.
um album L), but there are many varieties of sandalwood, for example, Australian sandalwood is distributed under the name of sandalwood like East India sandalwood, but its plant origin is completely different. And the scientific name is Eucarya spicata or Santalum spicatu
It is called m. In addition to this, there is Santalum lanceolatum, Eremophila mitchelli in Australia, Osyris lenuifalia in East Africa, and in Japan, there is also called Munin Sandalwood in the Ogasawara Islands.

Among various types of sandalwood as described above, the sandalwood having a whitening effect according to the present invention is
Although not particularly limited, it is preferable to use sandalwood (Santalum album L.) from East India,
It is possible to obtain a better whitening effect. The extraction temperature is also not particularly limited, and the same whitening effect can be obtained in cold water extraction, normal temperature extraction, low temperature extraction, and warm extraction. However, in cold water extraction,
In the case of yield reduction, slight temperature, and extraction with heating, the need for a heating device arises, and in view of economy, it can be said that normal temperature extraction without special temperature control is sufficient.

As a practical use, a plurality of the above-mentioned water extracts of sandalwood may be used alone or in combination of two or more kinds to prepare a cosmetic, but conventionally known whitening agents such as kojic acid. , Ascorbic acid, hydroquinone, liquiritin and their derivatives, or plants containing them, such as the extract of porcupine (arbutin), licorice (liquiritin), etc. Can be increased.

When a mixture of two or more types of sandalwood water extract is used as a cosmetic, the amount of the above-mentioned Sa is
ntalum alubum L. Similar to the single blend, 0.01 to 10.0% by weight, preferably 0.1 to 5.0% by weight, of the cosmetics in total of two or more types provides excellent whitening effect. Obtainable.

The compounding amount in the case of combining with a conventionally known whitening agent is as follows. A conventionally known whitening agent, for example, kojic acid, ascorbic acid, hydroquinone, liquiritin or a derivative thereof, alone or in combination, is added in an amount of 0.01 to 10.0% by weight, to which a sandalwood extract is added. A single or a combination thereof is added in a total amount of 0.1 to 10 times.

0.05 to 20% by weight of conventionally known whitening agents such as kojic acid, ascorbic acid, hydroquinone, liquiritin and their derivatives-containing plants and the like, alone or in combination, are compounded. The sandalwood water extract is added alone or in combination in a total amount of 0.1 to 10 times.

FIG. 1 shows the water extract (5) of sandalwood of the present invention.
FIG. 2 is a chart by gas chromatography of (0-fold dilution, ethanol), and FIG. 2 is a chart by gas chromatography of sandalwood oil manufactured by Nagaoka Koryo Co., Ltd.
FIG. 3 is a chart obtained by gas chromatography of sandalwood oil manufactured by Tokiwa Kampo Pharmaceutical Co., Ltd. As shown in FIG. 1, the sandalwood water extract according to the present invention does not contain an aromatic (essential oil) component.

In addition, an organic solvent (ethanol, acetone, hexane, etc.) extract containing a large amount of essential oil components and a steam distillate have no effective whitening effect, and water that has not been used since it does not contain an aromatic component. Only the extract has a whitening effect. That is, the present invention can be reused (water extraction) with the extraction residue of sandalwood wood that has been conventionally subjected to steam distillation or organic solvent extraction for the purpose of aromatic components, and can be said to be an epoch-making invention in terms of effective use of resources. It is a thing.

<Production Example> (Manufacture of sandalwood; Santalum album L. water extract) 500 g of dried sandalwood (Santalum album L.) material, roots and leaves are cut into small pieces, and 3 liters of water are added at room temperature. It was immersed for several days in. At this time, occasional stirring was performed. The extract was filtered and then dried under reduced pressure or freeze-dried to obtain 6.3 g of a pale yellow water extract.

Sandalwood; Santalum album L. Manufacture of ethanol, acetone and hexane extracts Sandalwood (Santalum album L.) lumber, root and leaf dry matter 50
0 g was cut into small pieces, 3 liters of ethanol were added, and the pieces were immersed at room temperature for several days. At this time, occasional stirring was performed. The extract was filtered and then dried under reduced pressure or lyophilized to obtain 5.4 g of a pale yellow ethanol extract. Similarly, extraction with acetone and hexane was performed to obtain 4.7 g of an acetone extract and 4.4 g of a hexane extract.

(Production of water extract of Santalum lanceolatum) 500 g of dried sandalwood (Santalum lanceolatum) material, roots and leaves were cut into small pieces, and 3 liters of water was added and the pieces were immersed at room temperature for several days. At this time, occasional stirring was performed. The extract was filtered and then dried under reduced pressure or lyophilized to obtain 5.7 g of a pale yellow water extract.

(Production of licorice ethanol extract) Licorice
After drying the roots of Glycyrrhiza glabra L. and Stron,
3 liters of ethanol was added to 500 g of finely chopped pieces, and the pieces were immersed at room temperature for several days. At this time, occasional stirring was performed. The extract was filtered to obtain an ethanol extract. The residue was extracted with 2 liters of ethanol, respectively, and extracted three times in the same manner. The filtrates were combined and the solvent was distilled off under reduced pressure.
1 g of ethanol extract was obtained.

(Production of liquiritin) 20 g of licorice ethanol extract was dissolved and suspended in 1 liter of n-butanol, and 1 liter of water was added for distribution. The solvent of the n-butanol layer was distilled off under reduced pressure to obtain a crude liquiritin extract. The obtained crude liquiritin extract was treated with Sephadex LH-20 (Pharmacia
Manufactured by column chromatography with water-methanol system solvent) to obtain 732 mg of liquiritin.

(Production of a methanol extract of Arctostaphyllum) After the leaves of Bearberry Arctostaphylos uva-ursi (LINNE) SPRENG. Were dried, 500 g of finely chopped one was dipped in 3 liters of methanol. It was immersed at room temperature for a whole day and night, stirred several times and then filtered to obtain a methanol extract. The residues were combined with 2 liters of methanol and extracted and filtered in the same manner three times, and the combined filtrates were evaporated under reduced pressure to obtain 97 g of a methanol extract.

(Manufacture of arbutin) 10 g of the lacquer methanol extract was dissolved and suspended in 30 g of methanol, and purification was repeated by column chromatography with Sephadex LH-20 (Pharmacia, water-methanol system solvent). 91 g of arbutin was obtained.

[0021]

【Example】

 <Whitening test method using mouse melanoma B16 cells>
Sandalwood water extract was added to MEM (Eagle's Minimum Essential
Medium), the final concentration will be the concentration shown in Table 1 and Table 2.
Prepared, dissolved, and filtered with a 0.4 μm pore size sterilization filter.
Filtered. Two plastic petri dishes (made by Falcon, inside
(9cm diameter) Dissolve sandalwood water extract in each, filter,
8 ml of sterilized MEM, 1 ml of FBS (fetal bovine serum) and
1 x 10 suspended in 1 ml of MEM^Five Cells / ml B16 cells added
And 5% CO ₂The cells were cultured at 37 ° C under 95% air. Start culture
The medium was replaced 3 days later, and the cells were cultured for 5 days in total. Petri dish
Collect the proliferated cells at the bottom of the
Suspend in e (PBS), centrifuge at 2000 rpm for 3 minutes,
The degree of blackening of the obtained cell pellet was visually evaluated.

The criteria for judgment are as follows. -: About the same level as that in which the melanin production inhibitor was not added (no addition group). +: Shows a slightly lower degree of blackening than the non-addition group. ++: The degree of blackening is clearly smaller than that in the non-addition group. +++: Shows a slight degree of blackening. ++++: White or gray, not black. ++++++: White

<Test Results> The results are shown in Tables 1 to 3.

[Table 1]

[0024]

[Table 2]

[0025]

[Table 3]

<Prescription Example> The following is a prescription example of the whitening cosmetic composition of the present invention. In the prescription example, "appropriate amount" means 10 for the whole prescription.
It means a ratio of 0% by weight. (1) <Liquid formulation> (% by weight) Sandalwood Santalum album Water extract 10.00 Glycerin 5.00 Sorbitol 4.00 Polyoxyl stearate 40 1.55 Ethanol 10.00 Purified water Appropriate amount Is dissolved to produce a liquid agent.

(2) <Emulsion> A. 1,3-butylene glycol 4.00 sandalwood Santalum lanceolatum water extract 5.00 purified water proper amount B. Ethanol 5.00 Polyethylene glycol 6.00 Purified water 20.00 A, B are heated and A is added to B to prepare an emulsion.

(3) <Ointment> A. Polysorbate 5.00 Ethanol 5.00 B.I. White petrolatum Appropriate amount Beef tallow 20.00 Cetanol 2.00 Glycerin monostearate 5.00 Sandalwood Santalum album Water extract 0.01 A is mixed with stirring. B is heated and mixed to dissolve, and A is mixed when cooled to prepare an ointment.

(4) <Emulsion> A. White petrolatum 2.50 Silicoso oil 0.50 Stearyl alcohol 2.20 Sucrose fatty acid ester 5.00 Octyldotecanol 2.20 Squalane 6.30 Jojoba oil 0.20 Polyoxyl stearate 40 2.50 B. Purified water Proper amount Sandalum Santalum album Water extract 0.10 Dipropylene glycol 3.00 Propylene glycol alginate 0.30 Xanthan gum 0.05 Heat A and B to dissolve. A is added to B to produce an emulsion.

(5) <Cream> A. Purified water Qualified Sandalwood Santalum album Water extract 1.00 1,3-Butylene glycol 3.00 Sorbitol 7.00 dl-PCA sodium (50%) 3.00 B. Polysorbate 60 2.50 Monostearic acid glyceride 1.50 Cetanol 3.00 Vaseline 5.00 Octyldotecyl myristate 5.00 Octimedotecanol 6.00 Squalane 15.00 A and B are dissolved by heating and B is A In addition to emulsifying cream.

(6) <Packing agent> A. Carboxyvinyl polymer 1.40 Dipropylene glycol 10.00 Glycerin 3.00 Diisopropanolamine 0.15 B.I. Triacetin 30.00 Xanthan gum 2.00 C.I. Purified water An appropriate amount of sandalwood Santalum lanceolatum water extract 2.00 A is mixed and dissolved to prepare a gel. Then, B and C are sequentially added to A to prepare a backing agent.

(7) <Liquid formulation> Sandalwood Santalum album Water extract 1.00 Sandalwood Santalum lanceolatum Water extract 1.00 Glycerin 5.00 Sorbitol 4.00 Polyoxyl stearate 40 1.55 Ethanol 10.00 Purified water Appropriate amount Each component is mixed and these are melt | dissolved and a liquid agent is manufactured.

(8) <Emulsion> A. 1,3-butylene glycol 4.00 sandalwood Santalum album 0.25 sandalwood Santalum lanceolatum water extract 0.25 arbutin 0.50 purified water suitable amount B. Ethanol 5.00 Polyethylene glycol 6.00 Purified water 20.00 A. Heat B and add A to B to make an emulsion.

(9) <Emulsion> A. White petrolatum 2.50 Silicone oil 0.50 Stearyl alcohol 2.20 Sucrose fatty acid ester 5.00 Octyldodecanol 2.20 Squalane 6.30 Jojoba oil 0.20 Polyoxyl stearate 40 2.50 Stirring methanol extract 0. 50 B. Purified water Appropriate amount Sandalum Santalum lanceolatum Water extract 0.10 Dipropylene glycol 3.00 Propylene glycol alginate 0.30 Xanthan gum 0.05 A and B are dissolved by heating. A is added to B to produce an emulsion.

(10) <Cream> A. Purified water Appropriate amount Sandalwood Santalum lanceolatum Water extract 0.75 1,3-Butylene glycol 3.00 Licorice ethanol extract 0.25 Olivier methanol extract 0.25 Sorbitol 7.00 dl-PCA sodium (50%) 3. 00 B. Polysorbate 60 2.50 Monostearic acid glyceride 1.50 Cetanol 3.00 Vaseline 5.00 Octyldodecyl myristate 5.00 Octimedodecanol 6.00 Squalane 15.00 A and B are dissolved by heating and B is added to A. In addition, an emulsifying cream is produced.

(11) <Cream> A. Purified water Appropriate amount Sandalwood Santalum album Water extract 1.00 1,3-Butylene glycol 3.00 Liquiritin 0.50 Sorbitol 7.00 dl-PCA sodium (50%) 3.00 B. Polysorbate 60 2.50 Monostearic acid glyceride 1.50 Cetanol 3.00 Vaseline 5.00 Octyldodecyl myristate 5.00 Octimedodecanol 6.00 Squalane 15.00 A and B are dissolved by heating and B is added to A. In addition, an emulsifying cream is produced.

[0037]

EFFECTS OF THE INVENTION According to the present invention, there is provided a safe cosmetic composition containing an aqueous extract of sandalwood as an active ingredient, and when this cosmetic composition is applied to the skin, an excellent whitening effect can be exhibited.

[Brief description of drawings]

FIG. 1: Water extract of sandalwood of the present invention (50-fold dilution,
It is a chart by gas chromatography of (ethanol).

FIG. 2 is a gas chromatography chart of sandalwood oil manufactured by Nagaoka Fragrance Co., Ltd.

FIG. 3 is a gas chromatography chart of sandalwood oil manufactured by Tokiwa Kampo Pharmaceutical Co., Ltd.

Claims (3)

[Claims] 1. A fair-white cosmetics comprising a water extract of sandalwood (Santalum album L.). 2. The whitening cosmetic composition according to claim 1, further comprising at least one kind of whitening agent. 3. A whitening agent is kojic acid, ascorbic acid,
The whitening cosmetic composition according to claim 2, which is at least one selected from the group consisting of hydroquinone, liquiritin, and derivatives thereof.