JP3107254B2 - Fair skin - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a fair-skin cosmetic, and more particularly to sandalwood (Santalum alb).
um L.) and an aqueous extract of roots.

[0002]

2. Description of the Related Art Kojic acid, ascorbic acid, arbutin and the like are known as substances having a fair skin effect.
Among them, arbutin and the like are known as plant-derived products. Sandalwood heartwood has been used as incense wood for a long time, and its essential oil component is also used in cosmetics as a fragrance. Further, it has been reported that cosmetics containing the essential oil component in sandalwood also have a sedative and hypnotic effect (Japanese Patent Application Laid-Open No. 63-199292).

[0003]

The conventional application of sandalwood to cosmetics focuses on its aroma, that is, essential oil components (fragrance components), for example, Santalol, Santanalene, Sante
ne, Santalal, Santenone, Santalic acid, Citronellol, T
A formulation containing erpineol, Carvone, or the like (a viscous liquid obtained by steam distillation or an organic solvent extract such as alcohol) was prescribed. The present inventor has been conducting research on the effective use of components other than the essential oil component contained in the sandalwood, and this time, the water extract of sandalwood, which has not been conventionally used in cosmetics, has a whitening effect. Have been obtained, and based on this finding, the present invention has been completed.

The sandalwood extract in the present invention is an aqueous extract of sandalwood (extracted at room temperature) and contains almost no aromatic components. The periphery (sapwood) of the timber is white and has relatively few essential oil components, while the heartwood portion is pale yellow or yellowish brown and contains a large amount of aromatic components (essential oil) along with roots. And the fragrance was significantly different depending on the location of the wood, for example, the quality of the wood was superior to that of "sandalwood" in the sapwood. However, the sandalwood water extract according to the present invention is an extract from the whole tree including sandalwood lumber, roots and leaves, and is not particularly limited in the extraction location. That is, it is irrelevant to the location of the aromatic component.

[0005]

According to the inventor's knowledge, Santalum alb, whose Japanese name is sandalwood, is referred to as sandalwood.
A uniform whitening effect was found in the water extract (normal temperature extraction) of the whole tree (including roots and leaves) of um L. This water extract contains almost no essential oil as an aroma component (attached to a gas chromatography chart) and is 0.01 to 10.0% by weight, preferably 0.1 to 5.0% by weight, based on the cosmetic. Excellent whitening effect can be obtained with 0% by weight.

[0006] Also, what is generally called sandalwood in the Japanese name is usually sandalwood in East India (Santalwood).
um album L), but there are many varieties of sandalwood, for example, Australian sandalwood is distributed under the name of sandalwood like East Indian sandalwood, but its plant origin is completely different And the scientific name is Eucarya spicata or Santalum spicatu
It is called m. In addition, there are Santalum lanceolatum and Eremophila mitchelli in Australia; Osyris lenuifalia in East Africa;

Among the various types of sandalwood, sandalwood having a fair-skinning effect according to the present invention is:
Although not particularly limited, preferably in sandalwood (Santalum album L.) from East India,
A better fairing effect can be obtained. Also, the extraction temperature is not particularly limited, and similar whitening effect can be obtained in cold water extraction, normal temperature extraction, weak temperature extraction, and warm extraction. However, in cold water extraction,
In the case of a decrease in yield, a slight temperature, and a warm extraction, the necessity of a heating device arises, and in consideration of economy, normal temperature extraction without special temperature control can be said to be sufficient.

[0008] As a practical use, cosmetics may be prepared by combining the above-mentioned water extracts of sandalwood alone or in combination of two or more kinds, but conventionally known whitening agents, for example, kojic acid , Ascorbic acid, hydroquinone, liquiritin and derivatives thereof, or plants containing them, such as, for example, extracts of ouarushi (arbutin) and liquorice (liquiritin), thereby synergizing the effects of the conventional whitening agent. Can be increased.

When two or more water extracts of sandalwood are combined and used as a cosmetic to prepare a cosmetic,
As in the case of ntalum alubum L. alone, a good whitening effect can be obtained with a combination of 0.01 to 10.0% by weight, preferably 0.1 to 5.0% by weight, based on the total amount of the cosmetic. Obtainable.

The compounding amount when combined with a conventionally known whitening agent is as follows. A conventionally known whitening agent, for example, kojic acid, ascorbic acid, hydroquinone, liquiritin or a derivative thereof is incorporated, alone or in combination, in an amount of 0.01 to 10.0% by weight, and a sandalwood aqueous extract is added thereto. A total amount of 0.1 to 10 times is used alone or in combination.

A conventionally known whitening agent, for example, an extract of a plant containing kojic acid, ascorbic acid, hydroquinone, liquiritin and a derivative thereof is incorporated, alone or in combination, in an amount of 0.05 to 20%. The sandalwood water extract is incorporated alone or in combination in a total amount of 0.1 to 10 times.

FIG. 1 shows the water extract of sandalwood of the present invention (5).
FIG. 2 is a gas chromatographic chart of sandalwood oil manufactured by Nagaoka Perfume Co., Ltd.
FIG. 3 is a chart obtained by gas chromatography of sandalwood oil manufactured by Tokiwa Kampo Pharmaceutical Co., Ltd. As shown in FIG. 1, the sandalwood aqueous extract according to the present invention does not contain an aromatic (essential oil) component.

[0013] Further, an extract of an organic solvent (ethanol, acetone, hexane, etc.) containing a large amount of essential oil components and a steam distillate do not have an effective fair-whitening effect, and water which has not been used because it does not contain an aromatic component conventionally. A fair skin effect is recognized only in the extract. In other words, the present invention can re-use (extract with water) the extraction residue of sandalwood material that has been conventionally subjected to steam distillation or organic solvent extraction for the purpose of aroma components, and can be said to be a revolutionary invention in terms of effective use of resources. Things.

<Production Example> (Manufacture of Sandalwood; Santalum album L. Aqueous Extract) 500 g of dried material of wood, roots and leaves of sandalwood (Santalum album L.), and 3 liters of water were added thereto at room temperature. For several days. At this time, occasional stirring was performed. After the extract was filtered, 6.3 g of a pale yellow water extract was obtained by drying under reduced pressure or freeze-drying.

(Sandalwood; Santalum album L. Production of ethanol, acetone and hexane extracts) Dried material of sandalwood (Santalum album L.), roots and leaves 50
0 g was sliced, added with 3 liters of ethanol, and immersed at room temperature for several days. At this time, occasional stirring was performed. After the extract was filtered, 5.4 g of a pale yellow ethanol extract was obtained by drying under reduced pressure or freeze-drying. Similarly, extraction was performed with acetone and hexane to obtain 4.7 g of an acetone extract and 4.4 g of a hexane extract.

(Production of water extract of Santalum lanceolatum) 500 g of dried material of sandalwood (Santalum lanceolatum) wood, roots and leaves were immersed in 3 liters of water and immersed at room temperature for several days. At this time, occasional stirring was performed. After the extract was filtered, 5.7 g of a pale yellow water extract was obtained by drying under reduced pressure or freeze-drying.

(Production of Licorice Ethanol Extract) Licorice
After drying the root and stron of Glycyrrhiza glabra L.
Three liters of ethanol was added to 500 g of the shredded pieces and immersed at room temperature for several days. At this time, occasional stirring was performed. The extract was filtered to obtain an ethanol extract. The residue was extracted and filtered three times in total with 2 liters of ethanol each time, and the combined filtrate was evaporated under reduced pressure to remove the solvent.
1 g of an ethanol extract was obtained.

(Production of liquiritin) 20 g of liquorice ethanol extract was dissolved and suspended in 1 liter of n-butanol, and 1 liter of water was added thereto for distribution. The solvent was distilled off from the n-butanol layer under reduced pressure to obtain a crude liquiritin extract. The obtained crude liquiritin extract was separated with Sephadex LH-20 (Pharmacia).
And water-methanol solvent) to obtain 732 mg of liquiritin.

(Production of a methanol extract of Pleurotus terrestris) After drying the leaves of the bearberry, Arctostaphylos uva-ursi (LINNE) SPRENG., 500 g of the leaves were soaked with 3 liters of methanol. It was immersed at room temperature all day and night, stirred several times, and filtered to obtain a methanol extract. The residue was combined with 2 liters of methanol, extracted and filtered three times in the same manner, and the combined filtrate was evaporated under reduced pressure to obtain 97 g of a methanol extract.

(Production of arbutin) A suspension of 10 g of the arginine methanol extract dissolved in 30 g of methanol was purified by column chromatography using Sephadex LH-20 (Pharmacia, water-methanol solvent). 91 g of arbutin were obtained.

[0021]

【Example】

 <Whitening test method using mouse melanoma B16 cells>
Sandalwood water extract is added to MEM (Eagle's Minimum Essential
Medium) to the final concentration shown in Tables 1 and 2.
Prepare and dissolve as described above, and filter with a 0.4 μm pore size sterilization filter.
Filtered. Two plastic dishes (Falcon, inside
Each of the sandalwood water extract is dissolved in 9 cm in diameter), filtered,
8 ml of sterilized MEM, 1 ml of FBS (fetal bovine serum) and
1 × 10 suspended in 1 ml of MEM^Five Add cells / ml of B16 cells
And 5% CO _Two, And 95% air conditions at 37 ° C. Start culture
After 3 days, the medium was exchanged and cultured for a total of 5 days. Petri dish
Collect the cells grown at the bottom of the
e (PBS), centrifuge at 2000rpm for 3 minutes,
The degree of blackening of the obtained cell pellet was visually evaluated.

The criteria are as follows. -: About the same as that in which the melanin production inhibitor was not added (untreated group). +: Shows a slightly lower degree of blackening than the non-added group. ++: The degree of blackening is clearly lower than in the non-added group. +++: Indicates a slight degree of blackening. ++++: White to gray, not recognized as black. ++++++: White

<Test Results> The results are shown in Tables 1 to 3.

[Table 1]

[0024]

[Table 2]

[0025]

[Table 3]

<Formulation Examples> Formulation examples of the fair-skin cosmetic of the present invention are shown below. In the formulation examples, “appropriate amount” means that the entire formulation is 10
It means the ratio to become 0% by weight. (1) <Liquid agent> (% by weight) Sandalwood Santalum album Water extract 10.00 Glycerin 5.00 Sorbitol 4.00 Polyoxyl stearate 40 1.55 Ethanol 10.00 Purified water Appropriate amount Is dissolved to prepare a liquid preparation.

(2) <Emulsion> 1,3-butylene glycol 4.00 Sandalwood Santalum lanceolatum water extract 5.00 Purified water q.s. Ethanol 5.00 Polyethylene glycol 6.00 Purified water 20.00 A and B are heated, and A is added to B to prepare an emulsion.

(3) <Ointment> A. Polysorbate 5.00 Ethanol 5.00 B. White petrolatum qs Tallow 20.00 cetanol 2.00 glyceryl monostearate 5.00 Sandalwood Santalum album Aqueous extract 0.01 A is stirred and mixed. B is heated and mixed and dissolved, and A is mixed at the time of cooling to prepare an ointment.

(4) <Emulsion> A. White petrolatum 2.50 silicoso oil 0.50 stearyl alcohol 2.20 sucrose fatty acid ester 5.00 octyldothecanol 2.20 squalane 6.30 jojoba oil 0.20 polyoxyl stearate 40 2.50 B. Purified water Appropriate amount Sandalwood Santalum album Water extract 0.10 Dipropylene glycol 3.00 Propylene glycol alginate 0.30 Xanthan gum 0.05 Heat A and B to dissolve. Add A to B to make an emulsion.

(5) <Cream> A. Purified water q.s. sandalwood Santalum album water extract 1.00 1,3-butylene glycol 3.00 sorbitol 7.00 dl-PCA sodium (50%) 3.00 Polysorbate 60 2.50 Glyceride monostearate 1.50 Cetanol 3.00 Vaseline 5.00 Octyldotesyl myristate 5.00 Octimedotecanol 6.00 Squalane 15.00 A and B are dissolved by heating, and B is dissolved in A. To make a cream.

(6) <Packing Agent> Carboxyvinyl polymer 1.40 dipropylene glycol 10.00 glycerin 3.00 diisopropanolamine 0.15 B. Triacetin 30.00 Xanthan gum 2.00 C.I. Purified water qs Sandalwood Santalum lanceolatum water extract 2.00 A is mixed and dissolved to form a gel. Next, B and C are sequentially added to A to prepare a bag agent.

(7) <Solution> Sandalwood Santalum album water extract 1.00 Sandalwood Santalum lanceolatum water extract 1.00 glycerin 5.00 sorbitol 4.00 polyoxyl stearate 40 1.55 ethanol 10.00 purified water qs Each component is mixed and dissolved to prepare a liquid preparation.

(8) <Emulsion> A. 1,3-butylene glycol 4.00 Sandalwood Santalum album 0.25 Sandalwood Santalum lanceolatum water extract 0.25 Arbutin 0.50 Purified water q.s. Ethanol 5.00 Polyethylene glycol 6.00 Purified water 20.00 A. B is heated and A is added to B to form an emulsion.

(9) <Emulsion> A. White petrolatum 2.50 Silicon oil 0.50 Stearyl alcohol 2.20 Sucrose fatty acid ester 5.00 Octyldodecanol 2.20 Squalane 6.30 Jojoba oil 0.20 Polyoxyl stearate 40 2.50 Uwaurushi methanol extract 0. 50 B. Purified water Appropriate amount Sandalwood Santalum lanceolatum Water extract 0.10 Dipropylene glycol 3.00 Propylene glycol alginate 0.30 Xanthan gum 0.05 Heat A and B to dissolve. Add A to B to make an emulsion.

(10) <Cream> A. Purified water qs Sandalwood Santalum lanceolatum water extract 0.75 1,3-butylene glycol 3.00 liquorice ethanol extract 0.25 uwaurushimethanol extract 0.25 sorbitol 7.00 dl-PCA sodium (50%) 3. 00 B. Polysorbate 60 2.50 Glyceride monostearate 1.50 Cetanol 3.00 Vaseline 5.00 Octyldodecyl myristate 5.00 Octimedodecanol 6.00 Squalane 15.00 A and B are dissolved by heating, and B is dissolved in A. In addition, emulsify to make a cream.

(11) <Cream> A. Purified water qs Sandalwood Santalum album water extract 1.00 1,3-butylene glycol 3.00 liquiritin 0.50 sorbitol 7.00 dl-PCA sodium (50%) 3.00 Polysorbate 60 2.50 Glyceride monostearate 1.50 Cetanol 3.00 Vaseline 5.00 Octyldodecyl myristate 5.00 Octimedodecanol 6.00 Squalane 15.00 A and B are dissolved by heating, and B is dissolved in A. In addition, emulsify to make a cream.

[0037]

According to the present invention, there is provided a safe cosmetic containing an aqueous extract of sandalwood as an active ingredient, and when the cosmetic is applied to the skin, an excellent fair skin effect can be exhibited.

[Brief description of the drawings]

1 is a water extract of sandalwood of the present invention (50-fold dilution,
3 is a chart by gas chromatography of (ethanol).

FIG. 2 is a chart obtained by gas chromatography of sandalwood oil manufactured by Nagaoka Inc.

FIG. 3 is a chart of sandalwood oil manufactured by Tokiwa Kampo Pharmaceutical Co., Ltd., obtained by gas chromatography.

Continuation of the front page (56) References JP-A-59-48412 (JP, A) JP-A-61-207316 (JP, A) JP-A-61-210007 (JP, A) JP-A-3-174497 (JP) JP-A-3-275613 (JP, A) JP-A-5-140181 (JP, A) JP-A-5-310562 (JP, A) JP-A-6-48934 (JP, A) 6-48935 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61K 7/48 A61K 7/00 A61K 35/78

Claims (3)

(57) [Claims] 1. A fair skin cosmetic comprising an aqueous extract of sandalwood (Santalum album L.). 2. The fair skin cosmetic according to claim 1, further comprising at least one fair skin agent. 3. The method of claim 1, wherein the whitening agent is kojic acid, ascorbic acid,
3. The fair-skin cosmetic according to claim 2, which is at least one selected from the group consisting of hydroquinone, liquiritin, and derivatives thereof.