JPH06261934A - Compound for forming stopping for vital body structure - Google Patents
Compound for forming stopping for vital body structureInfo
- Publication number
- JPH06261934A JPH06261934A JP5090370A JP9037093A JPH06261934A JP H06261934 A JPH06261934 A JP H06261934A JP 5090370 A JP5090370 A JP 5090370A JP 9037093 A JP9037093 A JP 9037093A JP H06261934 A JPH06261934 A JP H06261934A
- Authority
- JP
- Japan
- Prior art keywords
- body structure
- vital body
- chitosan
- polypeptide
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は生体組織補填再生組成物
に関するもので、特に蛋白質再生材料としてポリペプチ
ドを含有させたクリーム状キトサンを用いることによっ
て人工的に生体組織を再生させるための組成物とその利
用に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a regenerating composition for supplementing biological tissue, and more particularly to a composition for artificially regenerating biological tissue by using a creamy chitosan containing a polypeptide as a protein regenerating material. And its use.
【０００２】[0002]
【従来の技術】最近の医療分野においてドラッグデリバ
リーシステム（Ｄ．Ｄ．Ｓ．）が急速な進歩をとげてい
ることは周知の通りであるが、そのための薬物投与手段
に関しては何等の改善もみられていない実情にある。こ
のため本発明者は既に特願平４−２４２５０９号として
美容成分や薬物成分等の人体投与を目的とする有効成分
を経皮的に人体に透過、吸収させるための手段を提案し
たところである。2. Description of the Related Art It is well known that drug delivery systems (D.D.S.) are making rapid progress in the medical field in recent years, but any improvement in the means of drug administration has been observed. Not in reality. Therefore, the present inventor has already proposed, as Japanese Patent Application No. 4-242509, means for transdermally permeating and absorbing an active ingredient such as a cosmetic ingredient or a drug ingredient for the purpose of human administration.
【０００３】一般に人体の角質層は皮膚が乾燥している
場合は、約１５μの厚さであるが、十分に含水した状態
では３倍以上に膨潤する。水和した角質は約７５％の水
分、２０％の蛋白質、５％の脂肪が含まれている。これ
らの構成成分のうち脂質は外からの異物侵入に対して防
壁として水分含量との関係で特に重要な働きをしている
と云われる。物質の経皮吸収に対して角質層の水分含量
による拡散抵抗の変動があって、角質壁が主たる防壁の
役目を果たしているものと考えられている。Generally, the stratum corneum of the human body has a thickness of about 15 μ when the skin is dry, but it swells more than 3 times when fully hydrated. Hydrated keratin contains about 75% water, 20% protein, 5% fat. Among these constituents, lipids are said to play a particularly important role in relation to the water content as a barrier against the invasion of foreign substances from the outside. It is considered that there is a change in the diffusion resistance due to the moisture content of the stratum corneum with respect to the transdermal absorption of substances, and the stratum corneum plays the main role of a barrier.
【０００４】従って本発明者は角質層の抵抗を少なくす
るために角質水分を６０％まで上げて、真皮水分７０
％、角質水分６０％、薬剤層水分５０％の連続的傾斜水
分量とすることによって浸透圧作用を利用して有効成分
を皮膚に吸収され方法について研究を続けてきたが、従
来のゼラチン、グリセリン、アクリル酸ソーダ主体のも
のでは有効成分層の水分量をこのレベルまで上げること
は困難であった。Therefore, the present inventor increased the keratin water content to 60% in order to reduce the resistance of the horny layer, and the dermal water content 70
%, Keratin water content 60%, and drug layer water content 50%, a continuous gradient water content was used to study the method in which the active ingredient is absorbed into the skin by utilizing the osmotic effect. However, it was difficult to raise the water content of the active ingredient layer to this level when using mainly sodium acrylate.
【０００５】[0005]
【発明が解決しようとする課題】本発明者は特願平４−
２４２５０９号の発明をさらに一歩進めて薬用成分、美
容成分を含む組成物を生体組織と一体化し得る人工的な
生体組織として形成することによって、化粧品は当然の
ことながら医療用品においても単なるＤ．Ｄ．Ｓ．用の
塗布剤だけでなく、例えば医療手術等によって切除、欠
損した生体組織の補填、再生、復元等をも含む生体再生
組織用組成物として提供するものであって、それによっ
て新規のＤ．Ｄ．Ｓ．ともいうべきシステムを構築しよ
うとするものである。DISCLOSURE OF THE INVENTION The inventor of the present invention has filed a patent application 4-
By taking the invention of No. 242509 one step further and forming a composition containing a medicinal component and a cosmetic component as an artificial biological tissue that can be integrated with the biological tissue, cosmetics are naturally mere D.I. D. S. The present invention provides a composition for bioregenerated tissue, which includes not only a coating agent for medical use but also excision by medical surgery or the like, filling of defective biological tissue, regeneration, restoration, and the like. D. S. It aims to build a system that should be called.
【０００６】[0006]
【課題を解決するための手段】本発明はペースト状のポ
リペプチド含有媒質にキトサンを含有させ、さらにそれ
にアスコルビン酸等の機能成分を添加することによって
人工的に角質層組織を形成同化させ、それによって著し
い浸透力、吸収力を改善をはかると共に人工的に人体組
織と同質の人工生体組織の形成をはかるものである。本
発明で使用される有効成分としては医薬品成分の他、ア
スコルビン酸、クエン酸、酒石酸、及びこの脂肪酸エス
テル、ビタミンＥ、コラーゲン、ポリペプチド、朝鮮人
参エキス、アロエエキス、アシタバエキス等、各種の天
然または合成成分がある。According to the present invention, chitosan is contained in a pasty polypeptide-containing medium, and a functional component such as ascorbic acid is further added to artificially form and assimilate the stratum corneum tissue. It is intended to improve the remarkably penetrating power and absorbing power and artificially form an artificial living tissue of the same quality as a human body tissue. As the active ingredient used in the present invention, in addition to pharmaceutical ingredients, various natural substances such as ascorbic acid, citric acid, tartaric acid, and fatty acid esters thereof, vitamin E, collagen, polypeptide, ginseng extract, aloe extract, acitaba extract, etc. Or there is a synthetic component.
【０００７】キチン質は周知のように、菌、植物、動物
の分野に広く存在するもので、菌や植物ではカビ、酵
母、キノコ等の細胞壁に、また動物では原生動物から広
く分布し、特にカニ、エビのクチクラの含有成分として
有名である。キトサンはこれを濃アルカリ溶液中で加熱
し脱蛋白化することによって得られる天然高分子の多糖
類であり、Ｃ３とＣ６位に２個の水酸基とＣ２位に反応
性に富んだアミノ基を含むためにこれらを化学修飾する
ことによってエチレングリコールキチンやグリコールキ
トサン等、植物細胞活性化化合物として知られる多彩な
キトサン誘導体化合物が得られることが知られている。
キトサンは従来から医療分野では人工皮膚や手術縫合用
糸に又、食品分野では植物繊維健康食品及び食品保存安
定剤として広く利用されており、また本発明で使用され
る、コラーゲンは人体の総蛋白質重量の１／３を占め人
体にとっては必要不可欠なものである。As is well known, chitin is widely present in the fields of fungi, plants and animals. In fungi and plants, it is widely distributed in the cell walls of fungi, yeasts, mushrooms, etc., and in animals, it is widely distributed from protozoa, especially It is famous as a cuticle of crab and shrimp. Chitosan is a natural polymer polysaccharide obtained by heating and deproteinizing this in a concentrated alkaline solution. It has two hydroxyl groups at the C 3 and C 6 positions and a highly reactive amino acid at the C 2 position. It is known that a variety of chitosan derivative compounds known as plant cell activating compounds, such as ethylene glycol chitin and glycol chitosan, can be obtained by chemically modifying these to have a group.
Chitosan has hitherto been widely used in the medical field for artificial skin and surgical suture thread, and in the food field for plant fiber health foods and food storage stabilizers. Collagen used in the present invention is the total protein of the human body. It accounts for 1/3 of the weight and is essential for the human body.
【０００８】[0008]
【実施例】以下に本発明の実施例を示すが、これらの実
施例において各成分量は特に断りのない限り重量部また
は重量％であり、またこれらの実施例は本発明を何等限
定するものではなく、単に本発明の理解を助けるための
ものに過ぎないことは当然理解されなければならないと
ころである。EXAMPLES Examples of the present invention will be shown below. In these examples, the amount of each component is parts by weight or% by weight unless otherwise specified, and these examples do not limit the present invention in any way. It should of course be understood that it is merely intended to aid in understanding the invention.
【０００９】実施例１ ゼラチン１５部、グリセリン３０部、カルボキシメチル
セルロース５部、ミネラルウオーター５０部よりなるペ
ースト状組成物（ハップ剤）９９．８％に、比較用とし
てアスコルビン酸脂肪酸エステル（日光ケミカル アス
コルビン酸ジパルミテート）０．２％のみのもの（Ａ）
と、本発明のアスコルビン酸ジパルミテート０．２％、
キトサン溶液１０％、コラーゲン（成和化成）１０％、
セラミックパウダー（日硝ラジエコーク）１％、パップ
剤７８．８％のもの（Ｂ）とを用いて各種の比較試験を
行った。使用したキトサン溶液の組成はキトサン（君津
化学）３％、Ｌ−アスコルビン酸（武田薬品工業）３
％、水９４％のものであり、またマスク１枚当りのパッ
プ剤塗布量はそれぞれ３０ｇであり、毎晩１回洗顔後３
０分パックを施した。Example 1 99.8% of a paste-like composition (Hap agent) consisting of 15 parts of gelatin, 30 parts of glycerin, 5 parts of carboxymethyl cellulose and 50 parts of mineral water was added to ascorbic acid fatty acid ester (Nikko Chemical Ascorbin) for comparison. Acid dipalmitate) 0.2% only (A)
And 0.2% of ascorbic acid dipalmitate of the present invention,
Chitosan solution 10%, collagen (Sowa Kasei) 10%,
Various comparative tests were carried out using 1% of ceramic powder (Nisso Radio Co., Ltd.) and 78.8% of poultice (B). The composition of the chitosan solution used was 3% chitosan (Kimitsu Chemical), 3 L-ascorbic acid (Takeda Pharmaceutical Co., Ltd.)
%, Water 94%, and the amount of poultice applied per mask is 30 g each, and 3 times after washing the face once every night.
A 0 minute pack was applied.
【００１０】[0010]
【表１】 [Table 1]
【００１１】表１の本発明組成物について韓国ソウル大
学、米国ＭＩＮＩＮＡＴＵＲＡＬＩＮＣ．、及び西独Ｈ
＆ＭＣＯ．の各研究所で得られた試験結果を示す。この
結果からも知られるように、本発明によって得られた組
成物は著しく優れた美容効果、薬用効果が得られる。The compositions of the present invention shown in Table 1 are described in MININATURAL INC., Seoul University, Korea. , And West Germany H
& MCO. The test results obtained at each of the laboratories are shown below. As is known from this result, the composition obtained according to the present invention has remarkably excellent cosmetic and medicinal effects.
【００１２】[0012]
【発明の効果】本発明の生体組織再生用組成物はその優
れた吸収力、浸透力によって、各種の含有有効成分を容
易に皮膚に吸収、浸透させて著しい吸収効果を示すばか
りでなく、本来の生体組織と一体化された人工的な生体
組織を形成再生させるものであって、手術、事故等によ
って切除された生体組織部分の一部を再生させるための
人工生体組織としても利用できる。INDUSTRIAL APPLICABILITY The composition for regenerating biological tissue of the present invention not only exhibits a remarkable absorption effect by easily absorbing and permeating various active ingredients contained in the skin due to its excellent absorption power and penetration power, The present invention forms and regenerates an artificial body tissue integrated with the body tissue, and can also be used as an artificial body tissue for regenerating a part of the body tissue portion excised by surgery, accident, or the like.
フロントページの続き (51)Int.Cl.5 識別記号 庁内整理番号 ＦＩ 技術表示箇所 Ａ６１Ｋ 9/00 Ｖ 7329−4Ｃ 31/375 ＡＤＫ 7431−4Ｃ 31/725 ＡＧＺ 8314−4Ｃ 37/02 ＡＤＡ 8314−4Ｃ //(Ａ６１Ｋ 37/02 31:725） 8314−4Ｃ (Ａ６１Ｋ 37/02 31:725 8314−4Ｃ 31:375） 7431−4Ｃ Continuation of the front page (51) Int.Cl. 5 Identification code Reference number within the agency FI Technical display location A61K 9/00 V 7329-4C 31/375 ADK 7431-4C 31/725 AGZ 8314-4C 37/02 ADA 8314- 4C // (A61K 37/02 31: 725) 8314-4C (A61K 37/02 31: 725 8314-4C 31: 375) 7431-4C
Claims (2)
ことを特徴とする生体組織補填形成組成物。1. A composition for forming a body tissue filling, which comprises a polypeptide together with chitosan.
請求項１の組成物。2. The composition according to claim 1, which contains a functional component such as ascorbic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5090370A JPH06261934A (en) | 1993-03-12 | 1993-03-12 | Compound for forming stopping for vital body structure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5090370A JPH06261934A (en) | 1993-03-12 | 1993-03-12 | Compound for forming stopping for vital body structure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH06261934A true JPH06261934A (en) | 1994-09-20 |
Family
ID=13996678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5090370A Pending JPH06261934A (en) | 1993-03-12 | 1993-03-12 | Compound for forming stopping for vital body structure |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH06261934A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999021566A1 (en) * | 1997-10-24 | 1999-05-06 | Rexall Sundown, Inc. | Dietary composition with lipid binding properties for weight management and serum lipid reduction |
-
1993
- 1993-03-12 JP JP5090370A patent/JPH06261934A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999021566A1 (en) * | 1997-10-24 | 1999-05-06 | Rexall Sundown, Inc. | Dietary composition with lipid binding properties for weight management and serum lipid reduction |
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