JPH07196520A - Modified chitosan composition - Google Patents

Abstract

PURPOSE:To obtain an artificial skin composition designed so as to be absorbed and permeated into the skin and further integrated with an essential biological tissue. CONSTITUTION:This composition is capable of regenerating a biological tissue lost by an accident such as a burn or a decubitus or operation, etc., by comprising a polypeptide in chitosan. Furthermore, the composition is not only directly applicable as an excellent cosmetic to a human body but also capable of providing a textile material having unconventional compatibility with the human body by use thereof in a textile raw material for clothes such as a diaper, underwear or a shirt. This composition is obtained by blending a creamy composition containing the polypeptide and chitosan with a required medicinal ingredient and collagen, urea, etc., are especially used as the polypeptide.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a modified chitosan composition, and in particular, by using modified chitosan containing a polypeptide as a protein regenerating material, it is effective as a cosmetic, medicinal, medical material and functional fiber material. The present invention relates to a novel composition and its use.

[0002]

2. Description of the Related Art It is well known that drug delivery systems (D.D.S.) have made rapid progress in the medical field in recent years, but some improvements have been seen in drug administration means therefor. Not in reality. Moreover, when the dermis layer is damaged due to severe burns or skin diseases, it is necessary to greatly cut out and transplant the skin of the other part of the patient for the regeneration. Moreover, since the dermis layer is below the dermis layer covering the human body, and blood vessels, nerves, lymph vessels, etc. are concentrated, transplantation itself is difficult in the case of whole body burns, and even when transplanted, the skin must be deeply cut off. It was a heavy burden for the patient, who had to be scarred.

Therefore, the present inventor proposes means for transdermally permeating and absorbing an active ingredient such as a cosmetic ingredient or a drug ingredient for the purpose of human administration. Generally, the horny layer of the human body is about 15μ when the skin is dry.
However, it swells three times or more when it is sufficiently hydrated. Hydrated keratin contains about 75% water, 20% protein, 5% fat. Among these constituents, lipids are said to play a particularly important role in relation to the water content as a barrier against the invasion of foreign substances from the outside. It is considered that there is a change in the diffusion resistance due to the moisture content of the stratum corneum with respect to the transdermal absorption of substances, and the stratum corneum plays the main role of a barrier.

Therefore, the present inventor increased the keratin water content to 60% in order to reduce the resistance of the horny layer, and the dermal water content 70
%, Keratin water content 60%, and drug layer water content 50%, a continuous gradient water content was used to study the method in which the active ingredient is absorbed into the skin by utilizing the osmotic effect. However, it was difficult to raise the water content of the active ingredient layer to this level when using mainly sodium acrylate.

[0005]

DISCLOSURE OF THE INVENTION The present inventor
By forming a composition containing a cosmetic component as an artificial living tissue that can be integrated with living tissue, cosmetics are naturally used in medical products as well. D. S. Not only the adhesive for use, but also excised by medical surgery,
The present invention provides a composition for biologically regenerated tissue, which also includes filling, regeneration, restoration, etc. of a defective biological tissue. D. S. It aims to build a system that should be called.

[0006]

According to the present invention, a pasty polypeptide-containing medium is allowed to contain chitosan, and a functional component such as ascorbic acid is further added thereto to artificially form and assimilate a dermal layer tissue. It is intended to improve the remarkably penetrating power and absorbing power and artificially form an artificial living tissue of the same quality as a human body tissue. As the active ingredient used in the present invention, in addition to pharmaceutical ingredients, various natural substances such as ascorbic acid, citric acid, tartaric acid, and fatty acid esters thereof, vitamin E, collagen, polypeptide, ginseng extract, aloe extract, acitaba extract, etc. Or there is a synthetic component.

As is well known, chitin is widely present in the fields of fungi, plants and animals. In fungi and plants, it is widely distributed in the cell walls of fungi, yeasts, mushrooms, etc., and in animals, it is widely distributed from protozoa, especially It is famous as a cuticle of crab and shrimp. Chitosan is a natural polymer polysaccharide obtained by heating and deproteinizing this in a concentrated alkaline solution. It has two hydroxyl groups at the C ₃ and C ₆ positions and a highly reactive amino acid at the C ₂ position. It is known that a variety of chitosan derivative compounds known as plant cell activating compounds, such as ethylene glycol chitin and glycol chitosan, can be obtained by chemically modifying these to have a group.

Chitosan has hitherto been widely used in the medical field as artificial skin and surgical suture thread, and in the food field as a vegetable fiber health food and a food storage stabilizer, and the collagen used in the present invention is used in humans. 1 / total protein weight
It occupies 3 and is indispensable for the human body. The present invention has found that by using chitosan together with collagen, excellent performance that cannot be obtained by chitosan alone for beauty, medicinal, and medical purposes can be obtained, but as a result of further research, the present invention It has been found that the composition of (1) can be applied not only directly to the human body but also to textile products to obtain an excellent product which has never been obtained. That is, as a result of continuing research on compatibility with various germicidal deodorants for textile products, based on chitosan and collagen (polypeptide), reactive silicone resin or ethylene vinyl acetate (EVA)
It was found that the addition of the above does not impair the texture to the textile product, but rather the dyeing and dyeing properties are significantly improved, and by combining it with various bactericides and deodorants, excellent texture, washing durability, Water absorption,
It has succeeded in obtaining a fiber material having bactericidal properties and dyeing properties. In the present invention, not only collagen but also various protein materials can be used instead.

[0009]

EXAMPLES The following examples of the present invention will be shown. In these examples, the amounts of the respective components are parts by weight or wt% unless otherwise specified, and these examples do not limit the present invention in any way. It should, of course, be understood that it is merely intended to aid in understanding the invention.

Example 1 99.8% of a paste composition (happening agent) consisting of 15 parts of gelatin, 30 parts of glycerin, 5 parts of carboxymethylcellulose and 50 parts of mineral water was added to ascorbic acid fatty acid ester (Nikko Chemical Ascorbin) for comparison. Acid dipalmitate) 0.2% only (A)
And 0.2% of ascorbic acid dipalmitate of the present invention,
Chitosan solution 10%, collagen (Sowa Kasei) 10%,
Various comparative tests were carried out using 1% of ceramic powder (Nisso Radio Co., Ltd.) and 78.8% of HAP agent (B). The composition of the chitosan solution used was 3% chitosan (Kimitsu Chemical), 3 L-ascorbic acid (Takeda Pharmaceutical Co., Ltd.)
%, Water 94%, and the amount of poultice applied per mask is 30 g each, and 3 times after washing the face once every night.
A 0 minute pack was applied.

[0011]

[Table 1]

For the compositions of the present invention shown in Table 1, MININATURAL INC., Seoul University, Korea. , And West Germany H
& MCO. The test results obtained at each of the laboratories are shown below. As is known from this result, the composition obtained according to the present invention has remarkably excellent cosmetic and medicinal effects.

Example 2 Torre Silicon Amino Silicon SM-8709 5
0%, Kimitsu chemical chitosan (LLWP acetic acid) and 35% by Kyowa Kasei Promois W-52, 10% by Daiichi Seika Kogyo Daimeshu 5002, 5% by bactericide CAP (20 times), and a texture is used. A fiber product excellent in both sterilizing and deodorizing power and fastness in dyeing and dyeing was obtained.

Example 3 Water-soluble urethane resin (Bayer BAYPRET US
V) 50%, 1% chitosan solution (Kimitsu Kagaku LLWP lactic acid) 20%, collagen (SEIWA KASEI Promoise W-32)
10%, antibacterial agent (Calfa chemical CAP EX-
80) 10%, deodorant (Dainichi Seika Kogyo Dime Shoe 50
02) Washing durability, antibacterial property, deodorant antifouling property, and hydrophilic property are obtained by reacting an aqueous treatment solution containing 10% with water to a factor of 10 and polymerizing it by acting on the hydrophilically treated polyester fiber material. A remarkably excellent polyester fiber could be obtained.

Example 4 100% polyester cashmere skin was mixed with chitosan / collagen mixed liquid 7, crosslinking agent 0.5, auxiliary agent 0.2, water 9
Immerse in the treatment liquid of 2.3 for 20 seconds and squeeze at 60% for 12
It was dried at 0 ° C. for 3 minutes and then cured at 160 ° C. for 3 minutes.

Example 5 As a printing ink, a composition comprising EVA 50%, water 3%, deodorant 5%, antibacterial agent 2%, ceramic fine particles 9%, chitosan / collagen mixture 30% and thickener 1% was prepared. However, by using this as an ink for transfer paper, which has a concentration of 80% by adding 20% of EVA, it is possible to obtain a transfer print with an excellent texture in a process significantly simplified as compared with the conventional method and without unevenness. I was able to.

[0017]

The modified chitosan composition of the present invention has excellent absorption capacity. Due to the osmotic force, various active ingredients contained are easily absorbed and penetrated into the skin to show a remarkable absorption effect, and also absorbed into the original living tissue to form an artificial living tissue integrated with it. It is regenerated and can also be used as an artificial biological tissue for regenerating a part of a biological tissue portion lost due to an accident such as a burn or a bedsore or an operation. In addition, the composition of the present invention can utilize a protein instead of a polypeptide, such as underwear, a diaper,
It can be used as a raw material for various kinds of clothing such as shirts and Y-shirts. Especially, by using silk protein instead of polypeptide, silk appearance, cotton hygroscopicity, polyester toughness It is possible to obtain a fiber material having excellent performance not found in the above.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Office reference number FI Technical display location A61K 31/375 38/00 A61L 27/00 U C08B 37/08 A 7433-4C

Claims (5)

[Claims] 1. A modified chitosan composition comprising a polypeptide together with chitosan. 2. The composition of claim 1 containing ascorbic acid. 3. The composition of claim 1 containing urethane. 4. The composition of claim 1 containing aminosilicon. 5. The composition of claim 1 containing ethylene vinyl acetate.