KR20050119914A - High and multi functional oral care patch type composition - Google Patents

Abstract

The present invention can be easily attached to hard tissue teeth and soft tissue gums in the oral cavity, and is hardly attached by applying a patch-type formulation that can provide sufficient contact time. It is related to a high-performance complex patch-type oral composition that prevents tooth decay, relieves swelling, removes tartar, and softens gums.

Description

High and multi functional oral care patch type composition

The present invention relates to a high-function complex patch-type oral composition. Specifically, the present invention can be easily attached to the hard tissue teeth and soft tissue gums in the oral cavity, and only by attaching in a patch-type formulation that can provide sufficient contact time. Tooth hard tissue is to prevent tooth decay, to reduce the cavities and to remove calculus, soft tissue gums relates to a high-performance complex patch-type oral composition to relieve gum disease.

More specifically, the present invention provides an adhesive layer that can easily adhere to teeth and gums and deliver various active ingredients without having fluidity by using a hydrophilic polymer in an adhesive layer of a matrix type. Tooth, which is a hard tissue under the adhesion layer, prevents tooth decay, alleviates dental plaque, removes calculus, and the gum, which is a soft tissue, contains various drugs that alleviate gum disease, and adjusts tooth adhesion under the drug layer for a long time. It relates to a high-performance complex patch-type oral composition having a multi-layered multi-faceted structure having an adhesive layer to allow adhesion, and a support layer under which the moisture is less permeable.

The present invention seeks to develop a highly effective and stable tooth and gum attachment patch-type oral composition and provides a system for delivering various agonists in the drug layer to the tooth and gum surface based on sufficient tooth and gum adhesion.

Existing oral compositions (e.g. toothpaste-pasta, dentifrice-liquid, etc.) have a contact time or retention time, i.e., a time when the active ingredient stays in the teeth and gums. It is short in minutes, and because it is washed off when washed with water, there is a problem that can not fully exhibit the efficacy in a short time.

 Recently, new formulations have been introduced or patented to solve these problems. Korean Patent Application Nos. 10-2002-7001877 and 10-2002-0035728 describe only the limited efficacy effect of tooth whitening.

The present invention can be easily attached to the hard tissue teeth in the oral cavity and the soft tissue gums, and just by applying a patch-type formulation that can provide sufficient time to contact the hard tissue teeth to prevent tooth decay and alleviate the syringe. It is a high-performance complex patch-type oral composition that removes tartar and relieves gum disease on the gum, which is a soft tissue.It is a formulation using a hydrophilic polymer in an adhesive layer of a matrix type. Easily adheres to teeth and gums without medicating the active ingredients and does not have fluidity.As the polymer is hydrated by the water on the surface, strong adhesive force and various active ingredients begin to be released. It is to provide a high-performance complex patch-type oral composition excellent efficacy.

The present invention has an adhesive layer, a drug layer, an adhesive layer and a support layer in order from the top of the sheet-form adhesive agent, the drug layer comprises a caries prevention component, a symptom relief component, tartar prevention and removal component, gum disease relief component, And it provides a tooth and gum adhesive composition comprising a medicinal ingredient consisting of a sterilizing component.

The adhesion layer is essentially required for the polymer to be developed or strengthened while being hydrated by a small amount of water at the site where the drug agent is desired to act, and the release of the drug agent is started. In the present invention, it was found that the hydrophilic polymer has these properties, and a hydrophilic polymer was used as the adhesion layer of the patch in the form of a matrix.

In other words, by selecting and using a polymer that promotes adhesion to teeth and gums when it is hydrated, it is a patch-type formulation that has little or no adhesion before hydration and develops or rises upon hydration. It is not so excellent in maintaining the stability and efficacy of various drugs.

In the case of a sheet-type adhesive that is easily attached to the adhesive layer with saliva or moisture in terms of feeling, it is not hydrated when the adhesive is removed from a release liner on which the adhesive is attached, so that the adhesive force to the teeth and gums is reduced. When the tooth adhesion layer is low and touches the tooth with the oral saliva, it becomes hydrated and adheres naturally to the teeth and gums.

The process of delivering the active ingredient is to attach and elute the active ingredient contained in the drug layer to the teeth and gums after the adhesion layer is hydrated to deliver. A long time adhesion force is to maintain the adhesion by placing an adhesive layer under the drug layer, the drug layer is shielded between the other layers to provide a system that can be a little more stable because the active ingredient is not exposed to the external environment.

In addition, when the active ingredient starts to elute in water or saliva, the adhesive layer is then hydrated, giving the adhesive force necessary for long-term adhesion and having a function of adjusting the adhesion time, and by making the adhesion layer as thin as possible, the delay time of drug delivery Adhesion can be maintained by keeping the adhesive layer as low as possible (lag time).

In preparing the drug layer containing the active ingredient, an adhesive layer may be applied and fixed without fluidity to ensure uniformity of the content, and it may be possible to laminate the separately prepared layers, and may be detached. Even when the support layer can be induced to fall well from the tooth.

In addition, it is possible to improve the feeling of use by manufacturing a multi-layer in a system that allows the delivery of the active ingredient only to the teeth and gums by providing a support layer as a water-impermeable layer.

According to the present invention, there is provided a patch-type adhesive having a multi-layered structure containing various drug substances in the drug layer, applying the drug layer between the adhesive layer and the adhesive layer, and having a support layer under which the moisture is difficult to permeate. Efficacy effect can be controlled by the thickness of the drug layer or the concentration of the drug, and the support layer is a film former using a water-insoluble and water-impermeable polymer. When used as a sheet (sheet) attached to the tooth does not adhere to the gums or tongue, and serves to prevent the deformation or detachment of the patch form by saliva.

Using this multi-layered structure, it can be attached to teeth easily and for a long time, and it can be easily removed even when it is detached, and it can be excellent in maintaining efficacy and stability.

 The present invention can be easily attached to the hard tissue teeth in the oral cavity and the soft tissue gums, and just by applying a patch-type formulation that can provide sufficient time to contact the hard tissue teeth to prevent tooth decay and alleviate the syringe. It is a high-performance complex patch-type oral composition that removes tartar and softens gums. It is an adhesive layer that can be easily attached to teeth and gums, a drug layer containing various drugs under the adhesive layer, and under the drug layer. It relates to a high-performance complex patch-type oral composition of a multi-layered multi-faceted structure as shown in Figs. 1 and 2 having an adhesive layer that enables adhesion for a long time by adjusting the adhesive force, and a support layer that is hard to permeate moisture under the adhesive layer.

The tooth attachment layer can be in the form of a sheet-type non-flowable film. In the case of the sheet-type non-flowable film form, the tooth adhesion layer has no adhesion or is very weak on the skin, lips, and tooth surfaces where moisture or saliva is not present. However, in teeth with sufficient moisture or saliva, the adhesion is excellent, so that the tooth adhesion layer naturally adheres to the tooth surface and the adhesion force is excellent while the tooth adhesion layer remains in the teeth. The polymer used to solve this problem uses a polymer that generates adhesion when hydrated. In addition, since the drug layer containing the various active ingredients is formed between the tooth adhesion layer and the adhesive layer, the adhesive layer may provide a structure capable of controlling adhesion since the drug layer provides adhesion to the adhesive layer for a long time.

The polymer used is important for making such sheet-type non-flowable film-like dental adhesion layers and adhesive layers. In the present invention, the following polymer is used for the tooth adhesion layer. Polymers of carboxymethyl cellulose, carboxypropyl cellulose or salts thereof, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl ethyl cellulose, gum based Polymers of gelan gum, xanthan gum, guar gum, carrageenan gum, carayan gum, arabic gum, alginate gum ) Or salt derivatives thereof, and polyvinyl alcohol, poloxamer, polyvinylpyrrolidone, polyvinylpyrrolidone-vinylacetate copolymer, polyacrylic acid, carbopol, poly Quaternium-11, 39 (polyquaternium-11, 39), polyalkyl vinyl ether

Maleic acid copolymers (PVM / MA copolymer: Gantgrez AN 119, 139, S-97), and polyox;

The polymer is dissolved in an organic solvent such as purified water or ethanol, or a mixed solution of two or more to prepare a film. The thickness of the tooth attachment layer should be thick enough to allow attachment to the tooth and should not be so thick that it acts as a barrier to delivery of the active ingredient to the tooth and gum surfaces. Therefore, in order to minimize the lag time of drug delivery, the thickness may be said to be 100 μm or less, preferably 50 μm or less, and more preferably 10 μm or less. In addition, the film may be inferior in flexibility depending on the thickness, in order to improve this may be used by adding a plasticizer in some cases. Plasticizers include commonly used PEG (polyethyleneglycol), glycerin, polypropylene glycol, propylene glycol and the like.

The next feature relates to a drug layer containing the active ingredient. The active ingredients that can be used here are caries prevention ingredients such as sodium fluoride (NaF), sodium phosphate tribasic (SMFP), tin fluoride (SnF ₂ ), calcium glycophosphate (CGP), and xylitol. Potassium nitrate (KNO ₃ ), potassium phosphate (KH ₂ PO ₄ , K ₂ HPO ₄ ), hydroxyapatite

(hydroxyapatite), calcium triphosphate (tricalcium phosphate), etc.As the prevention and removal of tartar, sodium pyrophosphate (TSPP), potassium pyrophosphate (TKPP), acidic pyrophosphate (SAPP), sodium ultrametaphosphate, zeolite Tranexamic acid, aluminum chlorohydroxy allantoinate, ε-aminocaproic acid tocopherol acetate, vitamin E, hydrochloric acid, etc. Pyridoxine hydrochloride (vitamin B ₆ ), ursodesoxycholic acid, salt, bamboo salt, etc., and the active ingredients such as triclosan, gluconate gluconate and cetylpyridinium chloride as bactericidal ingredients 1 type, or 2 or more types of mixtures are used for each corresponding area | region. In addition, flavors and sweeteners may be additionally used to enhance the feeling.

In addition, since the drug layer may be easily broken according to the thickness, it may be completed by adding a plasticizer. That is, the thickness and the polymer to be added will vary, but generally used PEG (polyethyleneglycol), glycerin, polypropylene glycol, propylene glycol and the like can adjust the sufficient flexibility of the adhesive. According to the above aspect, since the thickness of the drug layer is too thick, the foreign matter is strong, it should be 10 μm or more at 500 μm or less, preferably 30 μm or more at 200 μm or less, more preferably 100 μm or more at 30 μm.

The next feature of the present invention is an adhesive layer. This adhesive layer hydrates the tooth adhesive layer and begins to elute the drug layer with various active ingredients, and then the adhesive layer is hydrated to give adhesion to the teeth, thereby supplying the adhesive force to the teeth for a long time to control the adhesion time of the attachment body. Have it. In other words, since the drug layer is disposed between the adhesive layer and the adhesive layer, it has an initial adhesive force and can maintain and control the adhesive force while minimizing the lag time required for delivery to the tooth and gum of the active ingredient. Since the adhesive layer also uses the kind of polymer used for the adhesion layer, it can impart adhesion. In addition, when the active ingredient is applied to the adhesive layer, it is fixed and applied without fluidity and ensures content uniformity. In the process, it is also possible to laminate the layers with the adhesive layer.

In addition, the adhesive layer allows the adhesive to be freely separated from the teeth and gums even when detached. In other words, if the adhesive is detached from the teeth and gums without proper adhesion between the drug layer and the support layer, the adhesive force may not be constant on the teeth and gums, so that a strong force may be pulled on a part of the support layer. When the adhesive layer is placed, there is adhesive force between both layers, so that the adhesive can be peeled off at once.

If the thickness of the adhesive layer is too thin, the fluidity of the active ingredient cannot be improved and the adhesion time can not be exhibited. In addition, if too thick to give a sense of foreign matter, it is applied in a layer of 200㎛ or less 10㎛ or more. Preferably, the fluidity improvement and the stability improvement can be expected when producing a layer of 100 µm or less and 10 µm or more, more preferably 80 µm or less and 10 µm or more. The polymer used for an adhesive layer is as follows, and the polymer used for the tooth adhesion layer in this invention is possible as it is. That is, cellulose methyl carboxymethyl cellulose, carboxypropyl cellulose or a salt thereof polymer, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl ethyl cellulose, gum-based polymer gellan gum ( gelan gum, xanthan gum, guar gum, carrageenan gum, Karayan gum, arabic gum, alginate gum or salt derivatives thereof, And gelatin, synthetic polymers such as polyvinyl alcohol, poloxamer, polyvinylpyrrolidone, polyvinylpyrrolidone-vinylacetate copolymer, polyacrylic acid, carbopol, polyquaternium-11, 39 (polyquaternium-11, 39), polyalkyl vinyl ether-maleic acid copolymer (PVM / MA copolymer: Gantgrez AN 119, 139, S-97), polyox, etc. do. It is also possible to use the plasticizers mentioned above when the polymer is less flexible.

Since the support layer of the present invention uses a polymer that does not dissolve in water or saliva, it retains its shape even when attached to teeth and gums, and elutes only in the tooth direction even when the active ingredient is eluted upon attachment to the teeth and gums. direction). This allows drug delivery in a selective direction. That is, it is preferable to be transparent or translucent so as not to be dissolved by moisture, hardly pass moisture, and have no visual rejection. In the present invention, the support layer has a thickness in the range of 10 to 500 µm, preferably 20 to 200 µm, more preferably 40 to 80 µm, in order to maintain its shape even when there are layers such as adhesion layers. And the polymer that can be used for the support layer is as follows when considering the above physical properties. Polyvinylacetate, ethylcellulose, polymethylmethacrylate, methacrylic acid copolymers, for example methacryloylethylbetaine / methacrylate copolymer (yukaformer), methacrylic copolymers, aminoalkylmethacrylates Coalesce (Eudragit E, RL), cellulose acetate phthalate, shellac, polyethylene, PVC, polyurethane alone or mixtures thereof. The support layer may also be used by adding various plasticizers for the same reason as the adhesion layer. In addition to the plasticizers mentioned above, it is possible to use more plasticizers, depending on the solvent used, as well as castor oils and hydrogenated castor oils.

The main feature of the present invention relates to the corresponding multi-face structure in addition to those described above. In the present invention, a tooth decay prevention component, a vaccine prevention component, tartar removal component, gum disease alleviation component and bactericidal component in the same shape as shown in FIG. New high-performance drug delivery systems can be completed that can provide a variety of efficacy effects.

Hereinafter, it will be described in more detail based on the specific examples of the present invention and a comparative example for comparison thereto. However, the following examples are only intended to help the understanding of the present invention, whereby the technical scope of the present invention is not limited.

Example 1

Tooth adhesion layer solution: 10% hydroxypropylcellulose (alcohol solution)

Drug layer: 50% of tooth decay prevention ingredients, 50% of mitigating ingredients

Adhesive layer solution: 3% of hydroxypropylmethylcellulose (purified water solution)

Support layer solution: 16% ethylcellulose, castor oil 8% (alcohol solution)

According to the above prescription, first, the support layer is dried to 100 μm, and then the adhesive layer is applied to the support layer to dry it, but is prepared to have a thickness of 30 μm upon drying. And again, the drug substance corresponding to each drug layer is sprayed onto each corresponding surface using a spray and pressed to fix it to an adhesive layer to be 100 μm. Finally, the adhesion layer is applied and dried to have a dry thickness of 10 μm. When applied in this way it is manufactured in the shape as shown in Figs.

Example 2

Tooth adhesion layer solution: 10% hydroxypropylcellulose (alcohol solution)

Drug layer: 30% of tooth decay prevention ingredients, 30% of symptom relief ingredients, 40% of gum disease relief ingredients

Adhesive layer solution: 3% of hydroxypropylmethylcellulose (purified water solution)

Support layer solution: 16% ethylcellulose, 8% castor oil (alcohol solution)

According to the above prescription, first, the support layer is dried to 100 μm, and then the adhesive layer is applied to the support layer to dry it, but is prepared to have a thickness of 30 μm upon drying. And again, the drug substance corresponding to each drug layer is sprayed onto each corresponding surface using a spray and pressed to fix it to an adhesive layer to be 100 μm. Finally, the adhesion layer is applied and dried to have a dry thickness of 10 μm. When applied in this way it is manufactured in the shape as shown in Figs.

Example 3

Tooth adhesion layer solution: 10% hydroxypropylcellulose (alcohol solution)

Drug layer: 25% of caries prevention ingredients, 25% of mitigating ingredients, 25% of alleviating gum disease, 25% of sterilizing ingredients

Adhesive layer solution: 3% of hydroxypropylmethylcellulose (purified water solution)

Support layer solution: 16% ethylcellulose, 8% castor oil (alcohol solution)

According to the above prescription, first, the support layer is dried to 100 μm, and then the adhesive layer is applied to the support layer to dry it, but is prepared to have a thickness of 30 μm upon drying. And again, the drug substance corresponding to each drug layer is sprayed onto each corresponding surface using a spray and pressed to fix it to an adhesive layer to be 100 μm. Finally, the adhesion layer is applied and dried to have a dry thickness of 10 μm. When applied in this way it is produced in the shape as shown in Figs.

Example 4

Tooth adhesion layer solution: 10% hydroxypropylcellulose (alcohol solution)

Drug layer: 20% caries prevention ingredient, 20% astringent mitigation ingredient, 20% tartar prevention and removal ingredient, 20% gum disease relief ingredient, 20% sterilization ingredient

Adhesive layer solution: 3% of hydroxypropylmethylcellulose (purified water solution)

Support layer solution: 16% ethylcellulose, 8% castor oil (alcohol solution)

According to the above prescription, first, the support layer is dried to 100 μm, and then the adhesive layer is applied to the support layer to dry it, but is prepared to have a thickness of 30 μm upon drying. And again, the drug substance corresponding to each drug layer is sprayed onto each corresponding surface using a spray and pressed to fix it to an adhesive layer to be 100 μm. Finally, the adhesion layer is applied and dried to have a dry thickness of 10 μm. When applied in this way it is produced in the shape as shown in Figs.

Example 5

Tooth adhesion layer solution: 10% hydroxypropylcellulose (alcohol solution)

Drug layer: 10% of caries prevention ingredients, 30% of mitigating vaccines, 10% of prevention and removal of tartar, 40% of gum disease relief ingredients, 10% of sterilizing ingredients

Adhesive layer solution: 3% of hydroxypropylmethylcellulose (purified water solution)

Support layer solution: 16% ethylcellulose, 8% castor oil (alcohol solution)

According to the above prescription, first, the support layer is dried to 100 μm, and then the adhesive layer is applied to the support layer to dry it, but is prepared to have a thickness of 30 μm upon drying. And again, the drug substance corresponding to each drug layer is sprayed onto each corresponding surface using a spray and pressed to fix it to an adhesive layer to be 100 μm. Finally, the adhesion layer is applied and dried to have a dry thickness of 10 μm. When applied in this way it is manufactured in the shape as shown in Figs.

Comparative Example 1

Tooth adhesion layer solution: 10% hydroxypropylcellulose (alcohol solution)

Adhesive layer solution: 3% of hydroxypropylmethylcellulose (purified water solution)

Support layer solution: 16% ethylcellulose, 8% castor oil (alcohol solution)

According to the above prescription, first, the support layer is dried to 100 μm, and then the adhesive layer is applied to the support layer to dry it, but is prepared to have a thickness of 30 μm upon drying. Finally, the adhesion layer is applied and dried to have a dry thickness of 10 μm. When applied in this way it is manufactured in the shape as shown in Figs.

Experimental Example 1 . Clinical hypersensitivity relief effect

In order to evaluate the effect of hypersensitivity hypersensitivity to the highly functional complex patch-type oral composition having a multi-layered multi-faceted structure of the present invention, the effect of perceptual hypersensitivity was evaluated by direct human use for 4 weeks.

Selecting people with hypersensitivity hypersensitivity to select teeth with hypersensitivity and to have a cold wind before these experiments to evaluate the degree of hypersensitivity based on the criteria as shown in Table 1 below. The groups were divided so that the number of teeth and the degree of hypersensitivity were similar. The number of teeth with hypersensitivity in each group is 40. For each of these groups, the composition of the present invention was divided and used to evaluate the degree of hypersensitivity in the same manner at 2 and 4 weeks. As a result of the measurement, t ?? Test was used to compare the difference with the comparative example. The results are shown in Table 2 below.

Table 1. Evaluation criteria for hypersensitivity

Symptom score Not cold at all One It's a bit cold, but you don't feel it 2 I feel a bit chilly and unconscious 3 It is very cold and tolerable. 4 I can not stand very cold 5

Table 2. Evaluation Results for Perceptual Sensitization

division Hypersensitivity Remarks Early 2 weeks 4 Weeks Example 1 3.24 ± 1.02 2.48 ± 0.98 1.62 ± 0.92 P <0.05 Example 2 3.29 ± 0.92 2.68 ± 0.89 2.05 ± 0.82 P <0.05 Example 3 3.17 ± 0.79 2.76 ± 0.82 2.30 ± 0.88 P <0.05 Example 4 3.25 ± 0.72 3.04 ± 0.78 2.78 ± 0.92 P <0.05 Example 5 3.31 ± 0.88 2.72 ± 0.82 2.18 ± 0.72 P <0.05 Comparative Example 1 3.20 ± 1.08 3.21 ± 1.02 3.30 ± 0.97 P> 0.05

From the results of Table 2, it can be seen that in clinical evaluation, Examples 1, 2, 3, 4, 5 according to the present invention all have an effect of relieving hypersensitivity better than the comparative example.

Experimental Example 2 . Clinical gum inflammation relief effect

In order to evaluate the definite effect of gum inflammation on the multifunctional multi-faceted multi-faceted oral composition of the present invention, 20 to 40 years old men and women with oral inflammation were selected and divided into six groups. According to the gingival index scores of Loe and Silness, primary oral examination was performed on the transverse and papillary gingival of the upper and lower anterior labrum, and then divided into Examples and Comparative Examples. The composition of the present invention divided into six groups were divided and used so that the oral examination was performed in the same manner as the primary oral examination at the stage of 4 weeks. T-Test was used to compare the results with the comparative example. The results are shown in Table 3 below.

Table 3. Evaluation Results for Gum Inflammation Relief

division Gum inflammation relief Remarks Early 2 weeks 4 Weeks Example 1 8.61 ± 1.05 8.44 ± 0.91 8.52 ± 1.02 P> 0.05 Example 2 8.76 ± 0.97 6.05 ± 0.82 2.95 ± 0.89 P <0.05 Example 3 8.52 ± 0.72 7.26 ± 0.85 4.82 ± 0.97 P <0.05 Example 4 8.47 ± 0.79 7.07 ± 0.92 5.27 ± 1.05 P <0.05 Example 5 8.92 ± 0.81 5.68 ± 0.79 2.48 ± 0.85 P <0.05 Comparative Example 1 8.75 ± 1.02 8.62 ± 1.07 8.85 ± 1.12 P> 0.05

From the results of Table 3, it can be seen that most of Examples 2, 3, 4, and 5 according to the present invention when clinically evaluated have a better efficacy of reducing gum inflammation than the comparative example.

Experimental Example 3 . Clinical tartar removal effect

In order to evaluate the definite tartar removal effect on the high-performance complex patch-type oral composition having a multi-layered multi-faceted structure of the present invention, 180 males and females of 20 to 40 years old with oral inflammation were selected and divided into six groups. It was used for 1 week as a simple fluoride toothpaste, and after the oral examination was divided into Examples and Comparative Examples used group so that the test results are not different. And the calculus index at this time was recorded and it was set as the initial index value. The composition of the present invention divided into six groups were divided and used so that the oral examination was performed in the same manner as the primary oral examination at the stage of 4 weeks. T-Test was used to compare the results with the comparative example. The results are shown in Table 4 below.

Percent tartar reduction (%) = (initial calculus index-terminal calculus index) / terminal calculus index × 100

Table 4. Evaluation results for tartar removal effect

division Example 1 Example 2 Example 3 Example 4 Example 5 Comparative Example 1 Tartar reduction rate (%) 5.4 7.1 9.5 48.2 31.5 6.9

From the results of Table 4, it can be seen that in the clinical evaluation in Examples 4, 5 according to the present invention has a better efficacy of calculus removal than the comparative example.

The present invention can be easily attached to the hard tissue teeth in the oral cavity and the soft tissue gums, and just by applying a patch-type formulation that can provide sufficient time to contact the hard tissue teeth to prevent tooth decay and alleviate the syringe. It removes calculus and alleviates gum disease on gums that are soft tissues.Adhesion layer that can be easily attached to teeth and gums, a drug layer containing various medicinal agents under the adhesion layer, and control adhesion under the drug layer for a long time Multi-layered multi-faceted multi-faceted multi-faceted oral composition with an adhesive layer that enables adhesion and a support layer that is hard to permeate moisture.As a result, it provides a convenient high-functional product that gives various efficacy effects at the same time and shows efficacy effects in a short time. can do.

1 is a cross-sectional view showing the side structure between the layer and the surface of the sheet formulation adhesive composition according to the present invention.

Figure 2 is a cross-sectional view showing a planar structure between the layer and the surface of the sheet formulation adhesive composition according to the present invention.

Claims (7)

It has an adhesion layer, a drug layer, an adhesive layer and a support layer in order from the top of the sheet-form adhesive agent, the drug layer comprises a caries prevention component, a symptom relief component, tartar prevention and removal component, gum disease relief component, and bactericidal component Tooth and gum adhesive composition comprising a medicinal ingredient consisting of. The tooth and gum adhesive composition according to claim 1, wherein the medicinal components are each formed on a sheet by applying a predetermined amount to each predetermined surface. The method of claim 1 wherein the caries prevention component is sodium fluoride (NaF), tribasic sodium fluoride (SMFP), tin fluoride (SnF ₂ ), calcium glycophosphate (CGP), and xylitol, and the mitigating component of the aniline is potassium nitrate (KNO ₃ ), potassium phosphate (KH ₂ PO ₄ , K ₂ HPO ₄ ), hydroxyapatite, and calcium triphosphate. Stone preventive and removal components include sodium pyrophosphate (TSPP), potassium pyrophosphate (TKPP), and acid fatigue It is selected from the group consisting of sodium sulphate (SAPP), sodium ultrametaphosphate, and zeolite, and the gum disease alleviating agent is tranexamic acid, allantoin chlorohydroxyaluminum, -amino capronic acid, tocopherol acetate (tocopherol acetate, vitamin E), pyridoxine hydrochloride (vitamin B ₆ ), urodexoxycholine acid, salt and bamboo salt, and the bactericidal components are triclosan, gluconate hexahexidine, and cetylpyridinium chloride. Tooth and gum adhesive composition, characterized in that selected from the group consisting of. The thickness of the adhesive layer is 10㎛ ~ 100㎛, the polymer used is a cellulose-based polymer of carboxymethyl cellulose, carboxypropyl cellulose or a salt thereof, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxy Hydroxypropylmethylcellulose, hydroxypropylethylcellulose, gum-based polymers such as gellan gum, xanthan gum, guar gum, carrageenan gum, karan gum, gum arabic, alginate gum or its derivatives, and gelatin, synthetic polymers Vinyl alcohol, poloxamer, polyvinylpyrrolidone, polyvinylpyrrolidone-vinylacetate copolymer, polyacrylic acid, carbopol, polyquaternium-11, 39, polyalkylvinylether-maleic acid copolymer (PVM / MA copolymer : Gantgrez AN 119, 139, S-97), and a tooth and gum portion characterized in that one or two or more selected from polyox. Complex composition. The thickness of the drug layer is 30㎛ ~ 200㎛, the polymer used is a cellulose-based polymer of carboxymethyl cellulose, carboxypropyl cellulose or a salt thereof, hydroxyethyl cellulose, hydroxypropyl cellulose, Hydroxypropylmethylcellulose, hydroxypropylethylcellulose, gum-based polymers such as gellan gum, xanthan gum, guar gum, carrageenan gum, karan gum, gum arabic, alginate or its derivatives, and gelatin, synthetic polymers Vinyl alcohol, poloxamer, polyvinylpyrrolidone, polyvinylpyrrolidone-vinylacetate copolymer, polyacrylic acid, carbopol, polyquaternium-11, 39, polyalkylvinylether-maleic acid copolymer (PVM / MA copolymer : Gantgrez AN 119, 139, S-97), and a tooth and gum attachment characterized in that it is selected from the group consisting of polyox. Composition. The thickness of the support layer is 20-200 μm, and the polymer used may be polyvinylacetate, ethyl cellulose, polymethyl methacrylate, methacrylic acid copolymer, for example methacryloylethylbetaine. Select and use methacrylate copolymer (yukaformer), methacryl copolymer, aminoalkyl methacrylate copolymer (Eudragit E, RL), cellulose acetate phthalate, shellac, polyethylene, PVC, polyurethane alone or mixtures thereof Tooth and gum adhesive composition, characterized in that. The tooth and gum adhesive composition of claim 1, further comprising a flavoring and sweetening agent.