JPH06228130A - 結晶ｒｓ−チオクト酸およびエナンチオマー純粋結晶ｒ−又はｓ−チオクト酸、およびその製法 - Google Patents

結晶ｒｓ−チオクト酸およびエナンチオマー純粋結晶ｒ−又はｓ−チオクト酸、およびその製法

Info

Publication number
JPH06228130A
JPH06228130A JP5263454A JP26345493A JPH06228130A JP H06228130 A JPH06228130 A JP H06228130A JP 5263454 A JP5263454 A JP 5263454A JP 26345493 A JP26345493 A JP 26345493A JP H06228130 A JPH06228130 A JP H06228130A
Authority
JP
Japan
Prior art keywords
acid
thioctic acid
crystalline
thioctic
enantiomerically pure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5263454A
Other languages
English (en)
Japanese (ja)
Inventor
Thomas Beisswenger
バイスヴェンガー トーマス
Horst Bethge
ベトゲ ホルスト
Joachim Goede
ゲーデ ヨアヒム
Frank Dr Huebner
ヒュプナー フランク
Klaus Dr Huthmacher
フートマッハー クラウス
Herbert Klenk
クレンク ヘルベルト
Roland Moeller
メラー ローラント
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asta Medica GmbH
Original Assignee
Asta Medica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6471240&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPH06228130(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Asta Medica GmbH filed Critical Asta Medica GmbH
Publication of JPH06228130A publication Critical patent/JPH06228130A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Saccharide Compounds (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
JP5263454A 1992-10-23 1993-10-21 結晶ｒｓ−チオクト酸およびエナンチオマー純粋結晶ｒ−又はｓ−チオクト酸、およびその製法 Pending JPH06228130A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4235912.0 1992-10-23
DE4235912A DE4235912C2 (de) 1992-10-23 1992-10-23 Verfahren zur Herstellung kristalliner Thioctsäure und deren Verwendung

Publications (1)

Publication Number Publication Date
JPH06228130A true JPH06228130A (ja) 1994-08-16

Family

ID=6471240

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5263454A Pending JPH06228130A (ja) 1992-10-23 1993-10-21 結晶ｒｓ−チオクト酸およびエナンチオマー純粋結晶ｒ−又はｓ−チオクト酸、およびその製法

Country Status (11)

Country Link
US (1) US5455264A (enExample)
EP (1) EP0593896B2 (enExample)
JP (1) JPH06228130A (enExample)
AT (1) ATE157093T1 (enExample)
CA (1) CA2109050C (enExample)
DE (2) DE4235912C2 (enExample)
DK (1) DK0593896T4 (enExample)
ES (1) ES2106236T5 (enExample)
GR (1) GR3024746T3 (enExample)
IN (1) IN176618B (enExample)
MX (1) MX9306571A (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100913684B1 (ko) * 2001-07-31 2009-08-24 에보니크 데구사 게엠베하 Ｒ-티옥트산의 트로메타몰 염의 신규한 결정체, 이의 제조방법 및 이를 포함하는 약제

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19510130C1 (de) * 1995-03-21 1996-11-21 Asta Medica Ag Verfahren zur Herstellung rieselfähiger R,S-Thioctsäure, R,S-Thioctsäure sowie deren Verwendung
DE19705555A1 (de) * 1997-02-13 1998-08-20 Ulrich Dr Posanski Pharmazeutische Präparate der Thioctsäure zur oralen Anwendung
DE19726519A1 (de) * 1997-06-23 1998-12-24 Asta Medica Ag Verfahren zur Herstellung trockener Thioctsäure
DE19810336A1 (de) * 1998-03-11 1999-09-23 Asta Medica Ag Alpha-Liponsäure mit neuartiger Modifikation
US20050085498A1 (en) * 1998-05-28 2005-04-21 Byrd Edward A. Oral formulation of lipid soluble thiamine, lipoic acid, creatine derivative, and L-arginine alpha-ketoglutarate
US6905707B2 (en) * 1998-05-28 2005-06-14 Medical Research Institute Controlled release arginine alpha ketoglutarate
US20040259895A1 (en) * 1998-05-28 2004-12-23 Medical Research Institute Oral formulation of lipid soluble thiamine and lipoic acid
US6197340B1 (en) * 1998-05-28 2001-03-06 Medical Research Institute Controlled release lipoic acid
US6191162B1 (en) 1998-05-28 2001-02-20 Medical Research Institute Method of reducing serum glucose levels
DE19834608A1 (de) * 1998-07-31 2000-02-03 Basf Ag Kristallmodifikation der Liponsäure
DE10223882A1 (de) * 2002-05-29 2003-12-18 Degussa Fliessfähige, pulverförmige Liponsäure(-Derivate) enthaltende Zusammensetzung
US20090176864A1 (en) * 2004-11-24 2009-07-09 Hill's Pet Nutrition, Inc. Methods For Improving Hepatic and Immune Function In An Animal
ES2550952T3 (es) * 2004-11-24 2015-11-13 Hill's Pet Nutrition, Inc. Composición para su uso en la mejora del aclaramiento hepático de sustancias xenobióticas en un animal
AU2005322887B2 (en) * 2004-12-30 2010-03-11 Hill's Pet Nutrition, Inc. Methods for enhancing the quality of life of a senior animal
US8252742B2 (en) 2004-12-30 2012-08-28 Hill's Pet Nutrition, Inc. Methods for enhancing the quality of life of a senior animal
BRPI0916476A2 (pt) * 2008-12-01 2016-02-16 Invasc Therapeutics Inc composição, método de tratamento para um distúrbio relacionado ao sistema renina-angiotensina-aldosterona, método para reduzir a resistência à insulina, método para tratar um distúrbio relacionado à síndrome metabólica
US7928067B2 (en) 2009-05-14 2011-04-19 Ischemix Llc Compositions and methods for treating ischemia and ischemia-reperfusion injury
ITMI20111286A1 (it) 2011-07-11 2013-01-12 Laboratorio Chimico Int Spa Nuova forma cristallina
EP3615023B1 (en) 2017-04-25 2023-06-21 Ischemix LLC Lipoyl-glu-ala for the treatment of neurodegenerative damage caused by traumatic brain injury
CN107652264A (zh) * 2017-09-25 2018-02-02 苏州华诺医药有限公司 硫辛酸杂质a的制备方法
CN108484570B (zh) * 2018-05-15 2021-05-04 苏州富士莱医药股份有限公司 一种制备硫辛酸颗粒的方法及设备

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3049549A (en) * 1954-03-22 1962-08-14 Research Corp Lipoic acid and derivatives
US2933430A (en) * 1959-01-22 1960-04-19 Du Pont Lipoic acid compositions
DE3629116A1 (de) * 1986-08-27 1988-03-10 Asta Pharma Ag Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer
PT95826B (pt) * 1989-11-09 1997-11-28 Asta Medica Ag Processo para a preparacao de composicoes farmaceuticas contendo como ingrediente activo acido r-alfa-liponico ou acido s-alfa-liponico
DE4137773A1 (de) * 1991-11-16 1993-05-19 Degussa Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100913684B1 (ko) * 2001-07-31 2009-08-24 에보니크 데구사 게엠베하 Ｒ-티옥트산의 트로메타몰 염의 신규한 결정체, 이의 제조방법 및 이를 포함하는 약제

Also Published As

Publication number Publication date
GR3024746T3 (en) 1997-12-31
EP0593896B1 (de) 1997-08-20
IN176618B (enExample) 1996-08-10
DK0593896T4 (da) 2005-06-20
DK0593896T3 (da) 1998-03-02
DE4235912C2 (de) 2002-12-05
EP0593896A1 (de) 1994-04-27
CA2109050A1 (en) 1994-04-24
MX9306571A (es) 1994-05-31
DE59307160D1 (de) 1997-09-25
ES2106236T5 (es) 2005-09-16
EP0593896B2 (de) 2005-03-02
CA2109050C (en) 2002-04-23
ATE157093T1 (de) 1997-09-15
ES2106236T3 (es) 1997-11-01
DE4235912A1 (de) 1994-04-28
US5455264A (en) 1995-10-03

Similar Documents

Publication Publication Date Title
US5455264A (en) RS-thioctic acid with novel morphology
CA1306755C (en) Gabapentin monohydrate and a process for producing the same
JP2002518399A (ja) 多形クロピドグレル硫酸水素塩フォーム
US5206262A (en) Soluble salts of ibuprofen and naproxen with N-(2-hydroxyethyl) pyrrolidine and pharmaceutic compositions containing said salts
KR101929960B1 (ko) 에르타페넴 나트륨의 결정형 및 이의 제조 방법
JPS61100521A (ja) 水性医薬組成物
AU642309B2 (en) Complexes containing S(+) phenyl alkane acids and amino sugars
US2461949A (en) Method of obtaining a crystalline sodium penicillin
KR20170084107A (ko) 레바프라잔 염산염 다형체 및 그의 제조 방법
EP3115356A1 (en) Polymorphs of bromfenac sodium and methods for preparing bromfenec sodium ploymorphs
AU2003206755B2 (en) Solid salts benzazepine compounds and their use in the preparation of pharmaceuticals compounds
NO140497B (no) Fremgangsmaate for fremstilling av alfa-isomeren 2-klor-9-(3`-(n`-hydroksyetyl-piperazino-n)-propyliden)-tiaxanten, alifatiske karboksylsyreestere med 1-16 karbonatomer av denne og syreaddisjonssalter av disse forbindelser
CN1043043C (zh) 晶状头孢烯酸加成盐及其制备方法
US5994393A (en) Alpha-lipoic acid with novel modification
JP3167327B2 (ja) 結晶性イブプロフェンの流れ特性を改良する方法
US3665020A (en) Process for the preparation of crystalline vitamin d3
US2734014A (en) Glucoside colchicoside and a method of
US5254728A (en) Complexes containing S(+)-phenyl alkanoic acids and α-hydroxyalkanoic
US3360549A (en) Ornithine aspartate and a process for its preparation
FR2472557A1 (fr) Procede de resolution de l'acide d,1-2-(6-methoxy-2-naphtyl)-propionique et son application a un melange de sels des formes d et l de cet acide avec une n-alkyl-d-glucamine
US2720481A (en) Bisulfite addition products of aldehyde derivatives of cortisone and hydrocortisone
US4248785A (en) Preparation of germaazaspirodiones and germaazaspiranes
EP0018813B1 (en) Crystalline germaazaspirodiones,their preparation and their use in the preparation of germaazaspiranes
US3888916A (en) Amantadine salt of 16,16-dimethyl-pge' 2
US2554690A (en) Zinc-penicillin and preparation thereof