JPH0616542A - Medical adhesive tape or sheet - Google Patents

Abstract

PURPOSE:To obtain a medical tacky tape or sheet having low stimulation, capable of providing moisture permeability in applying without impairing tackiness of a rubber based tacky agent and nearly free from physical stimulation such as tearing of hair in releasing and release of skin keratin. CONSTITUTION:The medical tacky tape or sheet is provided with a tacky agent layer on one side of a support. This tacky agent layer consists of a rubber based tacky agent containing 5-25wt.% styrene based thermoplastic elastomer consisting of A-B-A type block copolymer and 75-95wt.% 10-30C paraffin based and/or naphthene based hydrocarbon and tackiness-providing resin and 2-30wt.% water soluble high polymer and 2-30wt.% fatty acid ester of a polyhydric alcohol blended in the tacky agent layer.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a medical adhesive tape or sheet in which an adhesive layer is provided on one surface of a support, and more specifically, it imparts moisture permeability during application without impairing the adhesiveness. The present invention also relates to a low-stimulation medical adhesive tape or sheet with little physical irritation such as hair rub during peeling and peeling of skin keratin.

[0002]

2. Description of the Related Art Generally, medical adhesive tapes or sheets for medical plasters, plasters, surgical dressings, etc. are prepared by blending a rubber elastic body such as natural rubber or polyisoprene rubber as an adhesive, a tackifying resin and a softening agent. The rubber-based pressure-sensitive adhesive is used. However, a medical adhesive tape or sheet having an adhesive layer mainly composed of such a rubber elastic body has excellent adhesiveness at the time of application, but at the time of peeling, it has a strong adhesive force to the stratum corneum of the skin. It peeled off and caused hair to be shaved, and due to lack of moisture permeability, it caused a rash on the skin and caused inflammation.

Therefore, as a method for reducing the irritation to the skin, a medical adhesive tape or sheet having the following constitution has been proposed.

For example, Japanese Patent Publication No. 54-44688 discloses a water-soluble polyol such as propylene glycol, butylene glycol, hexylene glycol, polyethylene glycol having a molecular weight of 1000 or less, glycerin and sorbitol, and high water-solubility or water-swellability. It has been proposed to blend a molecule with a rubber-based pressure-sensitive adhesive, and JP-A-1-29
No. 7069 discloses a water-absorbent polymer that absorbs 10 times or more weight of water and gels and swells (for example, a water-soluble polymer having a cross-linking bond introduced therein, specific examples: Sanyo Kasei Co., Ltd., Sunwet IM). -300, Sunwet IM-1000
It has been proposed to incorporate MPS) into a rubber adhesive.

[0005]

As described above, the medical adhesive tape or sheet using a rubber-based adhesive has problems such as rash and skin irritation due to stuffiness during application as described above. Further, when the water-soluble polyol is blended with the rubber-based pressure-sensitive adhesive as in the above proposal, the compatibility between the two is poor, and there is a drawback that the polyol bleeds from the rubber-based pressure-sensitive adhesive.
Furthermore, when a water-absorbent polymer is blended with a rubber-based adhesive, the water-absorbent polymer absorbs water and does not repel water during application, so there is a problem that water absorption swells, the volume expands, and the adhesiveness decreases during use. It was

An object of the present invention is to provide a moisture-permeable adhesive tape for medical use which is a hypoallergenic moisture-permeable adhesive which reduces irritation to the skin by imparting moisture permeability to the rubber-based adhesive without impairing the adhesiveness of the rubber-based adhesive. Is to provide a sheet.

[0007]

Means for Solving the Problems The inventors of the present invention have made earnest studies to overcome the above-mentioned problems in conventional medical adhesive tapes or sheets, and as a result, have found that a specific rubber-based adhesive contains a water-soluble polymer and a polyhydric polymer. By blending the required amount of fatty acid ester of alcohol with each other, the compatibility of these compounded substances with the adhesive is good, and the moisture-absorbing ability of the adhesive makes it possible to impart moisture permeability. As for the medical adhesive tape, a styrene-based thermoplastic elastomer is blended with a specific paraffin-based and / or naphthene-based hydrocarbon and a tackifying resin, so that there is almost no physical irritation such as peeling of the skin or exfoliation of the skin. Alternatively, the present invention has been completed based on the knowledge that a sheet can be obtained.

That is, the medical pressure-sensitive adhesive tape or sheet according to the present invention is a medical pressure-sensitive adhesive tape or sheet in which a pressure-sensitive adhesive layer is provided on one surface of a support, wherein the pressure-sensitive adhesive layer is an ABA type block. 5 to 25% by weight of a styrene thermoplastic elastomer made of a polymer, having 10 carbon atoms
Rubber adhesive containing 75 to 95% by weight of paraffinic and / or naphthenic hydrocarbon and tackifying resin, and water-soluble polymer 2 to 3 blended in the adhesive layer
0% by weight and fatty acid esters of polyhydric alcohols 2-3
It is composed of 0% by weight.

Hereinafter, each component of the pressure-sensitive adhesive tape or sheet for anti-inflammatory and analgesic medical treatment according to the present invention, the manufacturing method and the like will be described in detail.

A) A which is a constituent of a rubber-based pressure-sensitive adhesive
Examples of the styrene-based thermoplastic elastomer composed of the -BA type block copolymer include a styrene-isoprene-styrene block copolymer (solution viscosity: 300 to 2000c).
P (25 wt% toluene solution); styrene / rubber weight ratio: 14/86 to 21/79), styrene-butadiene-styrene block copolymer (solution viscosity: 220 to 40)
0 cP (25 wt% toluene solution); styrene / rubber weight ratio: 28/72 to 50/50), styrene-ethylene / butylene-styrene block copolymer (solution viscosity: 2
00 to 1500 cP (20 wt% toluene solution); styrene / rubber weight ratio: 13/87 to 30/70) and the like are used.

The proportion of the styrene thermoplastic elastomer in the rubber adhesive is 5 to 25% by weight. This ratio is 5
If it is less than 10% by weight, the cohesive force of the rubber-based pressure-sensitive adhesive is low, so that sufficient sticking properties cannot be obtained, and adhesive residue or the like occurs during peeling. Further, if the proportion of the styrene-based thermoplastic elastomer in the rubber-based adhesive is more than 25% by weight, the adhesive strength of the rubber-based adhesive becomes too strong, and repeated application cannot be performed, resulting in keratin peeling and hair peeling during peeling. Occurs and becomes more irritating.

Examples of the paraffinic hydrocarbon having 10 to 30 carbon atoms and / or naphthene hydrocarbon used in the present invention include light liquid paraffin, heavy liquid paraffin, hexamethyltetracosane, hexamethyltetracosahexane, α -Olefin oligomers are exemplified, and these are used alone or in combination of two or more.

Paraffin hydrocarbons and / or naphthene hydrocarbons having 31 or more carbon atoms are solid at room temperature and do not have sufficient softening properties when compounded with a tackifying resin or a styrene thermoplastic elastomer. A patch having good adhesive strength cannot be obtained. Those having 9 or less carbon atoms are not preferable because the softening property becomes high and the pressure-sensitive adhesive layer becomes too soft.

Examples of the tackifying resin used in the present invention include rosin resins (rosin, hydrogenated rosin, esters of these, etc.), polyterpene resins, coumarone-isoden resins, petroleum resins (aliphatic and alicyclic resins). Etc.), terpene-phenol resin, and other softening points of 50-
Examples are those at 130 ° C, and these are either alone or 2
Used in the above combination. In particular, alicyclic hydrocarbon resin of petroleum resin (softening point 65 to 130 ° C), glycerin ester of hydrogenated rosin (softening point 80 to 130 ° C),
Polyterpene resin (softening point 80 to 130 ° C.) and the like are preferable.

The blending ratio of the tackifying resin is appropriately determined so as not to cause tackiness at the time of sticking and hair peeling at the time of peeling. The above petroleum-based resin is prepared by cationically polymerizing diolefins and monoolefins contained in the C ₅ fraction and C ₉ fraction obtained during naphtha decomposition in the presence of a Friedel-Craft catalyst. Those produced and having a molecular weight of 500 to 2,000 are preferably used.

In a further preferred embodiment of the medical adhesive tape or sheet according to the present invention, the paraffin hydrocarbon and / or naphthene hydrocarbon and the tackifying resin are in a weight ratio of 2: 3 to 3: 2. Be compounded. The reason is that if the weight ratio of the paraffinic hydrocarbon and / or naphtheneic hydrocarbon to the tackifying resin is larger than 3: 2, the tackiness tends to be insufficient, or adhesive residue tends to occur after peeling. And conversely, the weight ratio is 2: 3.
If it is smaller than the above, peeling may occur during peeling,
This is because the stratum corneum of the skin peels off and skin irritation easily occurs.

The water-soluble polymer compounded in the adhesive layer includes methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, crystalline cellulose.
Water-soluble cellulose derivatives such as sodium carboxymethyl cellulose, starch, pregelatinized starch, dextrin, cyclodextrin, pullulan, hydroxypropyl starch, starch or derivatives thereof such as sodium carboxymethyl starch, polyvinylpyrrolidone, carboxyvinyl polymer, polyvinyl alcohol, etc. And water-soluble natural polymers such as gum arabic, sodium alginate, propylene glycol alginate, xanthan gum and gelatin.

The particle size of the water-soluble polymer is 500 μm or less in order to obtain a uniform dispersion at the time of compounding in the adhesive solution.
Further, it is preferably 200 μm or less.

The amount of the water-soluble polymer added is 2 in the adhesive layer.
~ 30% by weight. If this blending amount is less than 2%, the patch cannot have sufficient moisture permeability, and conversely, this blending amount is 30%.
If the content is more than weight%, problems such as difficulty in compounding into the pressure-sensitive adhesive and poor sticking property occur. The amount of the water-soluble polymer is preferably 4 to ensure proper moisture permeability and adhesiveness.
~ 25% by weight.

The fatty acid ester of polyhydric alcohol contained in the pressure-sensitive adhesive layer is compatible with the rubber-based pressure-sensitive adhesive, and specific examples thereof include sorbitan plate, sorbitan laurate, sorbitan palmitate, Sorbitan stearate, sorbitan fatty acid ester such as sorbitan oleate, glycerin caprate, glycerin myristate, glycerin stearate, glycerin monooleate, decaglycerin laurate, decaglycerin myrilate, decaglycerin stearate, decaglycerin oleate, Diglyceryl stearate, diglyceryl oleate, tetraglyceryl stearate, tetraglyceryl oleate, hexaglyceryl stearate, hexaglyceryl oleate, hexaglyceryl myristate Glycerin fatty acid ester such as hexaglyceryl laurate, propylene glycol fatty acid ester such as propylene glycol stearate, polyoxyethylene sorbitan fatty acid ester such as polyoxyethylene sorbitan stearate, polyoxyethylene glycerin fatty acid ester such as polyoxyethylene glyceryl oleate , Polyethylene glycol fatty acid esters such as polyethylene glycol stearate.

The content of the fatty acid ester of polyhydric alcohol is 2 to 30% by weight in the pressure-sensitive adhesive layer. If the blending amount is less than 2%, the patch cannot have sufficient moisture permeability, and conversely, if the blending amount exceeds 30% by weight, it may bleed from the pressure-sensitive adhesive layer or the sticking property may be poor. The problem arises. The amount of the fatty acid ester of the polyhydric alcohol is preferably 4 to 25% by weight in order to secure appropriate moisture permeability and adhesiveness. Thus, by including the water-soluble polymer and the fatty acid ester of polyhydric alcohol in the pressure-sensitive adhesive layer, sufficient moisture permeability can be obtained for the patch. The moisture vapor transmission rate is
60 g / m ² · 24 hr. If it is less than 60 g / m ² · 24 hr. The above is desirable.

B) The medical adhesive tape or sheet according to the present invention is used as a plaster, a drape for operation, a tape for taping, etc. without containing a drug, but in addition to this, it may contain a drug. May be.

As the drug, those which can penetrate the biological membrane by transdermal or transmucosal administration can be applied without particular limitation,
For example, antipyretic anti-inflammatory analgesics, steroidal anti-inflammatory agents, vasodilators, hypertensive / arrhythmic agents, antihypertensive agents, antitussive expectorants, antitumor agents, local anesthetics, hormones, asthma, antiallergic rhinitis agents, antihistamines , Anticoagulants, anticonvulsants, cerebral circulation / metabolic agents, antidepressants / anxiety agents, vitamin preparations, oral hypoglycemic agents, antiulcer agents, hypnotics, antibiotics,
Skin stimulants and the like are exemplified.

Antipyretic and anti-inflammatory analgesics include salicylic acid, methyl salicylate, glycol salicylate, glycyrrhetinic acid, glycyrrhizinic acid, indomethacin, ketoprofen, flurbiprofen and ampenac.

The antihistamines include diphenhydramine, diphenhydramine hydrochloride, chlorpheniramine maleate and the like.

Examples of the skin stimulants include menthol, peppermint oil, camphor, nonyl acid vanillyl amide, benzyl nicotinate, β-butoxyethyl nicotinate, capsicum (extract), capsaicin, sashishi (extract) and the like.

As the vasodilator, isosorbide dinitrate,
Examples include pentaerythritol tetranitrate and nifedipine.

Regarding the added amount of the drug, it is possible to mix the drug in a ratio of up to 30% by weight with respect to the entire pressure-sensitive adhesive layer. The reason is that if the amount of the drug compounded exceeds 30% by weight, the function of the above-mentioned pressure-sensitive adhesive is impaired, and it becomes impossible to satisfy the sufficient adhesiveness and the low irritation to the skin.

C) In the pressure-sensitive adhesive layer of the medical pressure-sensitive adhesive tape or sheet according to the present invention, a liquid polymer component is optionally incorporated. As the liquid polymer component, polyisobutylene, polybutene, liquid polyisoprene, or the like that is compatible with the styrene-based thermoplastic elastomer composed of an ABA type block copolymer is used.
From the viewpoint of stickability, polybutene is suitable as the liquid polymer component. The addition amount of the liquid polymer component is preferably 10% by weight or less in the rubber-based pressure-sensitive adhesive. The reason for this is that if the amount added exceeds 10% by weight, sufficient sticking properties and sufficient low irritation to the skin cannot be secured.

In the pressure-sensitive adhesive layer of the medical pressure-sensitive adhesive tape or sheet according to the present invention, an antioxidant, a filler, etc. may be contained in addition to the above-mentioned drug or liquid polymer component unless the effects of the present invention are impaired. , May be added appropriately.

D) Materials of the support used in the present invention include non-woven fabric, woven fabric, polyester, polyethylene,
Examples thereof include polyvinyl chloride, polyvinylidene chloride, ethylene-vinyl acetate copolymer, polyurethane, perforated aluminum foil and laminate films thereof. Among these, it is preferable that the material having low moisture permeability is subjected to physicochemical processing to impart moisture permeability. This treatment is to prevent skin irritation due to excessive stuffiness. Further, it is desirable that the support has a function of expanding and contracting in at least one direction, and a material having no such function is preferably subjected to appropriate expansion and contraction processing. This is because if the support has a stretching function, it can follow the stretching of the skin surface when the medical adhesive tape or sheet is attached to the body. The thickness of the support is preferably 5 to 2,000 μm.

E) Examples of the release paper described below used in the present invention include polyester, polypropylene, high-quality polyethylene-coated paper, polyethylene-coated glassine paper, and the like, the upper surface of which is treated with silicon. The thickness of the release paper is preferably 20 to 200 μm.

F) As a typical example of the method for producing the medical adhesive tape or sheet according to the present invention, a solvent method,
A hot melt method can be mentioned.

In the solvent method, a water-soluble polymer and a fatty acid ester of a polyhydric alcohol are added to a rubber-based pressure-sensitive adhesive, and if necessary, a drug component and / or a liquid polymer component and other additives are added, and these are added. Dissolve or disperse uniformly. Examples of the solvent used include those which are compatible with rubber adhesives, drugs and the like, for example, tetrahydrofuran, chloroform and methylene chloride. However, among the water-soluble polymers, polyvinylpyrrolidone is difficult to dissolve unless it is an alcohol solvent, so it is advisable to first dissolve it in methanol or the like and then mix it with other components. The solution or dispersion thus obtained is spread on a release paper (or support), dried to remove the solvent, and the support (or release paper) is laminated on the pressure-sensitive adhesive layer obtained.

When the hot melt method is applied,
A rubber-based pressure-sensitive adhesive, a water-soluble polymer, a fatty acid ester of a polyhydric alcohol, a liquid polymer component, if necessary, and other additives are mixed in predetermined amounts, and the mixture is heated at a temperature of 120 to 150 ° C. under nitrogen substitution. Mix and melt. After melting,
The temperature of the pressure-sensitive adhesive is lowered to 100 to 120 °, and further drug components added as necessary are added and uniformly mixed to obtain a solution in a molten state. Then, this solution is spread on a release paper (or support) using a hot melt coater, and the support (or release paper) is laminated on the obtained pressure-sensitive adhesive layer.

[0036]

EFFECTS OF THE INVENTION Since the present invention is constituted as described above, it imparts moisture permeability at the time of application without impairing the adhesiveness of the rubber-based pressure-sensitive adhesive, and further provides physical properties such as peeling of the hair and exfoliation of the skin exfoliation. It is possible to provide a low-stimulative medical adhesive tape or sheet with little physical irritation.

[0037]

EXAMPLES Examples of the present invention will be described below.

Examples 1 to 12 and Comparative Examples 1 to 10 Ingredients other than the drug were blended in the proportions shown in Tables 1 to 5, and the resulting blends were heated at a temperature of 120 to 160 ° C. under nitrogen substitution. Stir and melt. After melting, the temperature is 100-120
The temperature was lowered to ° C, the drug was added, and the solution was obtained by uniform mixing. In Example 1, since no drug was contained, a solution was obtained by melting the compound after heating and stirring.

Next, the solution in a molten state was spread on a release paper made of polyethylene-coated high-quality paper so that the thickness after cooling was about 200 μm using a hot melt coater,
Then, a polyurethane film having a thickness of 30 μm was laminated as a support on the pressure-sensitive adhesive layer. Thus, Examples 1 to 1
Twelve medical adhesive tapes were obtained.

In the same manner as above, the medical adhesive tapes of Comparative Examples 1 to 10 were prepared with the formulations shown in Tables 6 to 9.

[0041]

[Table 1]

[Table 2]

[Table 3]

[Table 4]

[Table 5]

[Table 6]

[Table 7]

[Table 8]

[Table 9] The details of the components used in Tables 1 to 9 are as follows.

SIS: Styrene-isoprene-styrene block copolymer Product name Califlex TR1107 (solution viscosity: about 1
600 cP (25 wt% toluene solution); styrene / rubber weight ratio: 14/86 (manufactured by Shell Chemical Co.)) Tackifying resin: alicyclic saturated hydrocarbon resin, trade name Alcon P-90 (softening point 90 ° C., Arakawa Chemical Co., Ltd. Industrial liquid) Heavy liquid paraffin (Nikko Pharmaceutical Co., Ltd.) Polybutene Product name Nisseki Polybutene (Average molecular weight of about 1350) (Nippon Petrochemical Co., Ltd.) Water-soluble polymer Polyvinylpyrrolidone Product name Kollidon K90 (BASF) Polyvinyl alcohol Product name P. V. AC-17 (manufactured by Shin-Etsu Chemical Co., Ltd.) Methyl Cellulose Product name Metroze SM-15 (manufactured by Shin-Etsu Chemical Co., Ltd.) Corn starch (manufactured by Wako Pure Chemical Industries, Ltd.) Fatty acid ester of polyhydric alcohol Glycerin monostearate Product name Glycerin monostearate MGS -B (Nikko Chemicals) sorbitan monostearate Product name sorbitan monostearate SS-10 (Nikko Chemicals product) Propylene glycol monostearate Product name Propylene glycol monostearate PM
SIC (manufactured by Nikko Chemicals) Polyoxyethylene sorbitan monostearate Product name POE (6) sorbitan monostearate TS
-106 (manufactured by Nikko Chemicals) Polyoxyethylene glycerin monostearate Product name POE (5) Sorbitan monostearate TM
GS-5 (manufactured by Nikko Chemicals) Polyethylene glycol monostearate (trade name) POE (2) monostearate YMS-2 (manufactured by Nikko Chemicals) Water-absorbent polymer (trade name) Sunwet IM-300 MPS (manufactured by Sanyo Kasei) (Crosslinked product of starch / acrylic acid salt graft copolymer) In Tables 1 to 9, SIS, heavy liquid paraffin, alicyclic saturated hydrocarbon resin, and polybutene are shown by weight% with respect to the total of these components. Further, the contents of the water-soluble polymer, the fatty acid ester of polyhydric alcohol, the water-absorbing polymer and the drug are shown in% by weight based on the whole pressure-sensitive adhesive layer.

Performance Test The performance tests of the medical adhesive tapes obtained in Examples and Comparative Examples were carried out by the following method.

<Adhesion Test> With respect to each medical adhesive tape (3 × 4 cm) of Examples and Comparative Examples, an adhesion test on human skin was conducted as follows. That is, a medical adhesive tape was attached to the upper arms of five (healthy, male) test subjects, and after 12 hours, the adhesiveness and the feeling of attachment were evaluated, and then the medical adhesive tape was peeled off, adhesive residue remained, and peeled off. Each medical adhesive tape was evaluated for pain and irritation.
The number of repetitions was once. The results of this sticking test are shown in Table 1.
0 to Table 14 show.

[0045]

[Table 10]

[Table 11]

[Table 12]

[Table 13]

[Table 14] 1) Sticking property: After sticking for 12 hours, the ratio of the area where the medical adhesive tape adhered to the area at the start of the test was observed.

Good: Residual adhesive area of the patch was 95% or more Normal: Residual adhesive area of the patch was 75% to less than 95% Poor: Residual adhesive area of the patch was less than 75% It was

2) Adhesive residue: It was evaluated whether the adhesive remained on the skin after peeling. -: The adhesive did not remain on the skin after peeling. +: The adhesive remained on the skin after peeling.

3) Pain during peeling: The pain during peeling was evaluated by a sensory test. −: No particular pain ±: Slight pain +: Very painful

4) Irritation: About 1 hour after peeling, the condition of the skin at the application site was visually evaluated. -: No change ±: Slight erythema is observed +: Erythema is observed.

5) Feeling of sticking: The feeling of sticking during the sticking test was evaluated by a sensory test. -: No stuffiness ±: Slight stuffiness +: Some stuffiness

<Moisture Permeability Test> The moisture permeability test is based on JIS Z.
0208 “moisture permeability test method for moisture-proof packaging material (cup method)”. That is, about 12 g of anhydrous calcium chloride is put in a cup, and the mouth of the cup is sealed with a medical adhesive tape. The test cup was placed in a thermo-hygrostat having a temperature of 40 ° C. and a relative humidity of 90% and allowed to stand for 24 hours. Then, the increase in mass of calcium chloride was measured to determine the water vapor transmission rate (g / m ² · 24 hours).

As is clear from Tables 10 to 14, it is recognized that the medical adhesive tapes of Examples are excellent in all test items.

On the other hand, in Comparative Example 4, since the amount of the water-soluble polymer added was 30% by weight or more, the pressure-sensitive adhesive surface during coating was uneven, the sticking property was poor, and adhesive residue was generated. It was

In Comparative Example 5, the addition amount of glycerin monostearate as fatty acid ester of polyhydric alcohol was 3
Since it was 0% by weight or more, glycerin monostearate bleeded from the pressure-sensitive adhesive layer, the sticking property was poor, and adhesive residue was generated.

In Comparative Example 7, the amount of SIS added is 25% by weight.
Since it exceeded the threshold, there was pain during peeling.

In Comparative Example 8, since the amount of SIS added was less than 5% by weight, the sticking property was poor and adhesive residue was generated.

Comparative Example 9 is an example of a medical adhesive tape described in JP-B-54-44688, in which glycerin bleeded from the adhesive layer and the sticking property was poor.

Comparative Example 10 is an example of the medical adhesive tape described in JP-A-1-297069, and the sticking property was poor.

Claims (2)

[Claims] 1. A medical pressure-sensitive adhesive tape or sheet having a pressure-sensitive adhesive layer provided on one surface of a support, wherein the pressure-sensitive adhesive layer comprises a styrenic thermoplastic elastomer composed of an ABA type block copolymer. ~ 25 wt%, carbon number 10
30 paraffinic and / or naphthenic hydrocarbons and a rubber-based adhesive containing 75 to 95% by weight of a tackifying resin, and a water-soluble polymer 2 to 30 blended in the adhesive layer
% By weight and fatty acid ester of polyhydric alcohol 2-30
Medical adhesive tape or sheet consisting of 10% by weight. 2. A weight ratio of the paraffin hydrocarbon and / or naphthene hydrocarbon to the tackifying resin is 2: 3.
The medical adhesive tape or sheet according to claim 1, wherein the adhesive tape or sheet is in the range of 3 to 3: 2.