JP2019014694A - Diet patch using thermoplastic elastomer gel composition containing capsaicin - Google Patents

Abstract

To provide diet patches using a thermoplastic elastomer gel composition containing capsaicin in which a capsaicin component added to the thermoplastic elastomer gel constituting a skin adhesion layer attached to a specific part of the body induces fat decomposition along with heat generation and assists the dieting of the attachment site.SOLUTION: A diet patch using a thermoplastic elastomer gel composition containing capsaicin is used by adhering to the skin and comprises a skin adhesion layer formed by adding capsaicin to a thermoplastic elastomer gel, a support layer impregnated with the skin adhesion layer, and a release liner attached to one side of the skin adhesion layer. The skin adhesion layer comprises 3 to 20 parts by weight of SEBS or SEEPS, 42 to 53 parts by weight of a tackifier, 42 to 53 parts by weight of a mineral oil, and 0.001 to 0.025 parts by weight of capsaicin, and the capsaicin component contained in the thermoplastic elastomer gel induces fat decomposition with heat generation to aid in the dieting of the adhesive site.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a diet patch, and more specifically, a capsaicin component added to a thermoplastic elastomer gel constituting a skin adhesion layer attached to a specific part of the body induces lipolysis along with heat generation and adheres. The present invention relates to a diet patch using a thermoplastic elastomer gel composition containing capsaicin, which assists in the diet of the site.

  Chili peppers are well known to activate metabolism, promote blood circulation and lipolysis, and are often used as diet foods. The fact that the efficacy of such peppers is mainly due to the action of the capsaicin component is also widely known. On the other hand, capsaicin has a characteristic of giving a burning sensation to relieve pain. Therefore, the range of use of capsaicin has expanded to pain relief agents, passes, sports creams, etc. Research has been published one after another, not only to give sensations, but also to actually generate heat accompanied by lipolysis.

  When capsaicin is eaten or applied to the skin, it stimulates the receptor TRPV1 (Transient Receptor Potential Vanilloid 1) distributed on the tongue and skin to induce heat generation, and in this process brown fat and beige fat And will burn. When capsaicin stimulates TRPV1, this signal is transmitted through the sympathetic nerve and stimulates β-adrenergic receptor, which activates UCP1 (uncoupled protein 1) of brown and beige adipose tissue to induce heat generation. To do. That is, only thermal energy is generated without generating kinetic energy, and lipolysis and combustion are performed in this process.

  In recent years, lipolytic injection treatment for dieting has been widely performed while the obese population has rapidly increased while the food culture has become westernized due to the improvement of living standards through economic development. The method of injecting aminophylline or isoproterenol for the purpose of reducing subcutaneous fat was originally used as an asthma drug and stimulated β-adrenergic receptors at the local site where these components were injected to induce lipolysis This is a lipolytic injection treatment for dieting purposes. However, there is a problem in that it may cause phlegm during the injection process, hypersensitivity reactions such as itchiness, hot air, and seizures may occur, and side effects may occur, and it is expensive.

  Currently, various anti-obesity drugs are on the market. Patent Documents 1 and 2 listed below describe apples, yogurt, strawberries, malt, germinated brown rice, soybeans, natto as applications for suppressing and preventing obesity. Diet alternative diet foods that use these are proposed. On the other hand, diet is of great interest to many people, especially women, and is sold in various forms such as oral drugs, beverages, foods and creams. Capsaicin and caffeine are well known as lipolytic substances, but absorption via the oral route is caused by the active ingredient being degraded or metabolized in the liver and gastrointestinal tract, or inactivated by excessive intake. There is a problem that products that are applied like creams and gels are less effective.

Recently, patch products that apply directly to the skin are growing rapidly. As such a patch product, the following patent document 3 discloses a technique such as “a diet patch using a skin temperature-sensitive hydrogel and a manufacturing method thereof”. It is a patch produced by adhering a nonwoven fabric to the side surface with an adhesive and applying hydrogel to the other side surface of the nonwoven fabric.

Korean Published Patent No. 10-2002-0020305 Korean Published Patent No. 10-2005-0081984 Korean Patent Registration No. 10-1417952

Problems to be Solved by the Invention

  However, the conventional techniques have the following problems.

  First, since the hydrogel is a product containing a large amount of water using purified water, the function is lost due to evaporation of water in the air after opening. Therefore, since it is effective only within a short period of time, not only will it not be possible to elute the active ingredient continuously over a certain period of time, but in order to prevent moisture evaporation, it must be sealed and packaged one by one. In order to prevent moisture from escaping from the non-woven fabric portion on the opposite side, the polyurethane is applied or the film is adhered, which is an uneconomical structure with an unnecessary configuration.

  Secondly, the diet patch disclosed in Patent Document 3 contains a plurality of components that are not directly related to the active ingredient such as an absorption accelerator so that the active ingredient is absorbed within a short time. Must be contained. In other words, this diet patch has to add a component such as sodium hydroxide for sol solification, i.e. liquefaction, butylene glycol and There is a problem that components such as ethylenediaminetetraacetic acid must be added.

  Thirdly, since hydrogel absorbs a lot of water, it becomes difficult to work when the water evaporates, so it is suitable for cosmetic mask packs and cosmetics used within a short time, There is a problem that it is not suitable for a diet patch that must be worn for several hours or more, or must be in close contact with a skin area where there is much movement.

  Fourthly, since the hydrogel has weak adhesive strength, there is a problem that the patch will peel off if you exercise with a patch or if the movement increases, so there are many adhesive components to increase the adhesive strength. When it is added, not only does the patch not peel off easily when it is peeled off from the skin, but there is also a problem that the skin is troubled at the part where the patch is applied.

  Therefore, the present invention uses a thermoplastic elastomer (TPE) to maintain a gel state at room temperature and adhere to the skin, and reacts to the skin temperature for a certain time (8 hours or more). The capsaicin component mixed in the thermoplastic elastomer gel not only induces lipolysis with heat generation, but also helps the diet at the adhesive site. It is an object of the present invention to provide a diet patch using a thermoplastic elastomer gel composition containing capsaicin which does not occur.

In order to solve the above-described problems, a diet patch using the thermoplastic elastomer gel composition containing capsaicin of the present invention includes a skin adhesion layer formed by adding capsaicin to a thermoplastic elastomer gel, and the skin adhesion. A support layer impregnated with a layer, and a release paper attached to one side of the skin adhesion layer, wherein the skin adhesion layer is SEBS (StyreneEthyleneButyleneStyrene) or SEEPS (StyreneEthyne).
len Propyrene Style) 3 to 20 parts by weight, 42 to 53 parts by weight of a tackifier, 42 to 53 parts by weight of mineral oil, and 0.001 to 0.025 parts by weight of capsaicin It is characterized by being composed of.

  Desirably, the thickness of the skin adhesion layer is 20 μm to 400 μm, the support layer is a nonwoven fabric or polyester, and a thermoplastic elastomer gel is impregnated into the support layer and bonded.

  Desirably, the mineral oil is liquid paraffin having a kinematic viscosity of 60 cSt or more, and the tackifier is a C5 or C9 hydrocarbon resin.

  In the diet patch of the present invention, the capsaicin component added to the thermoplastic elastomer gel stimulates the TRPV1 receptor in the skin tissue and activates the β-adrenergic receptor to promote heat generation and lipolysis, and has a special exercise Even if you don't do it, it will function as a health patch that increases body temperature and helps metabolism, blood circulation, and physiological activity. In particular, when it is applied to the lower abdomen, additional effects such as improvement of large intestine activity and relaxation of menstrual irregularities can be obtained by raising the body temperature of the lower abdomen.

  In addition, since the mineral oil contained in the TPE gel does not evaporate at room temperature in the diet patch of the present invention, after opening the patch, the active ingredient of the functional substance remains as it is even after the passage of time. The gel has a moist feel and is comfortable and comfortable.It not only has a strong adhesive force, but also is easy to peel off so that it does not hurt. It can also be used, and it is easy to correct and fix the attachment position without causing skin problems.

  Further, the diet patch of the present invention eliminates the low efficiency and side effects of the method of oral absorption of diet drugs and the method of applying to the skin, and enables local lipolysis. In addition, the temperature of the skin is raised by the heat generation effect while adhering, and the TPE gel is in close contact with the skin, so that the moisture permeation of the skin is strengthened to improve the skin permeation of active substances such as capsaicin. There is no need to add auxiliary components such as absorption promoters, emulsifiers, skin soothing agents, fluidization promoters, and it is not very irritating to the skin.

It is sectional drawing of the diet patch which concerns on this invention. It is the photograph which image | photographed the temperature distribution of the skin before attaching the patch of this invention with the thermal image. It is the photograph which image | photographed the temperature distribution of the skin 2 hours after attaching the patch of this invention with the thermal image. It is the photograph which image | photographed the temperature distribution of the skin 4 hours after attaching the patch of this invention with the thermal image.

  The greatest technical feature of the diet patch of the present invention is that the capsaicin component contained in the skin adhesion layer induces lipolysis along with heat generation to help diet the adhesive site, and the patch adheres to the skin. Not only does the active ingredient elute quickly depending on the body temperature and the effect lasts for a long time (8 hours or more), but it does not fall off even if you exercise with a patch because of its strong adhesiveness, and it will not cause skin problems It is in the point that it did.

Although described as “diet patch” in this specification, the thermoplastic elastomer gel used in the patch of the present invention is used by adhering to the skin such as diapers, sanitary napkins, incontinence dispensers as well as diet patches. It can be applied as it is to various types of products and various uses. Although the “diet patch” is described in the title and claims of the invention, it will be made clear in advance that even if the thermoplastic elastomer gel of the present invention is used for other purposes, it is included in all rights.

  The diet patch 10 of the present invention is used by directly attaching to or peeling off from the skin, and includes a skin adhesion layer 11 containing a thermoplastic elastomer (TPE) gel and capsaicin, A support layer 12 impregnated with a skin adhesion layer on one side and a release paper 13 adhered to one side of the skin adhesion layer 11 and peeled off when used.

  The skin adhesion layer 11 is composed of 3 parts by weight to 20 parts by weight of SEBS (Styrene Ethylene Butylene Styrene) or SEEPS (Styrene Ethylene Proline Styrene), 42 parts by weight of mineral oil, and 42 parts by weight to 53 parts by weight of mineral oil. A composition comprising 0.001 part by weight to 0.025 part by weight of capsaicin in a TPE gel containing A composition containing such a TPE gel is attached to the skin of a human body and quickly absorbed by the skin, and plays a role of allowing the components to elute continuously over a certain period of time. In order to exert an effect of temporarily desensitizing nerves when capsaicin acts on TRPV1, a pain management drug sold as an over-the-counter drug (OTC) in the United States is Contains 0.025% or more capsaicin. Therefore, in the present invention, it is desirable that the content of capsaicin used to avoid desensitization of TRVP1 is less than 0.025%.

  The TPE gel used in the present invention comprises a base polymer, which is a block polymer, a tackifier, and a plasticizing oil, and is composed of mineral oil. The TPE gel of the present invention has a glass transition temperature (−72 ° C.) similar to that of natural rubber, is a soft gel physical property at room temperature, and exhibits a characteristic of starting to liquefy at a high heat of 100 ° C. or higher. Therefore, it is always moist and comfortable when used at room temperature.

  Styrenic SEBS or SEEPS is used as the block polymer for the base polymer. SEBS and SEEPS are block polymers that are often used as raw materials for pharmaceuticals and cosmetics because they are safe for the human body and excellent in mechanical properties. However, in detail, cosmetics such as medical patches, lip gloss, and baby diapers Typical examples of use are personal hygiene products. In particular, SEBS and SEEPS are more excellent in cohesive strength than other styrene block polymers, and are therefore suitable for patches in which the residue should not remain on the skin when peeled off.

  The tackifier is used from C5 or C9 hydrocarbon resin having excellent compatibility with the styrene block polymer, but preferably hydrogen is added to ensure excellent adhesive strength. Hydrocarbon resin, more preferably one approved for use in food wraps and food labels by the US FDA, or listed on INCI (International Nomenclature of Cosmetic Ingredients). Among those having a CAS number, a hydrocarbon resin to which hydrogen is added is used.

The mineral oil as the plasticizing oil uses high-purity liquid paraffin purified for cosmetics and food additives, but preferably has a kinematic viscosity of 60 cSt or more than the low-viscosity oil used in general cosmetics. It is recommended to use the oil. This is because, while general cosmetics place importance on the comfort, washing and moisturizing effect, the TPE gel used in the patch of the present invention is more important for the softening effect on the skin, and the physical properties of the TPE gel suitable for the present invention It is for granting. Since the mineral oil does not evaporate at room temperature, the active ingredient remains as it is even after the production time has elapsed or without sealing, and the moist feel of the gel can be maintained.

  The dosage form formulated in this manner has pressure sensitive adhesive (PSA) properties due to the structure of both end-block and rubber-block in the polystyrene, which SEBS or SEEPS has. Has a glass transition temperature similar to that of natural rubber at -72 ° C and maintains a soft and soft gel form at room temperature. When applied to the skin, it reacts quickly with the temperature of the skin and is effective like capsaicin. Provide ingredients.

  TPE gels thus formulated contain no water and are more soluble in fat-soluble capsaicin and capable of transmitting to the skin than water soluble acrylic, hydrogel and emulsion dosage forms. Because it is excellent, it enables continuous elution (over 8 hours) of capsaicin components even at a composition ratio that does not irritate the skin, and there are no side effects such as skin troubles and discomfort due to excessive content of the components. Allows feeling and lipolysis.

  Capsaicin is a causative substance of the pungent taste contained in chili pepper, promotes energy metabolism in the human body, stimulates fat tissue and promotes heat generation, burns fat tissue and reduces body fat and cholesterol The composition ratio of capsaicin is important so that the skin does not feel irritation, and if it exceeds a certain composition ratio, the user feels irritation of the skin and immediately removes the patch. This is because the use itself is interrupted. Therefore, the content of capsaicin in the patch according to the present invention is 0.001 to 0.025 parts by weight, but considering the absorption sensitivity of capsaicin varies depending on the part of the human body, the content of capsaicin is It is desirable to apply differently depending on the site, but the abdomen and the cellulite-rich site contain 0.003 to 0.008 parts by weight, and forearms, calves, thighs, buttocks, etc. More preferably, 0.001 to 0.003 parts by weight is applied.

  The diet patch according to the present invention is designed to be used for 8 hours per day for a rest period of 16 hours for skin breathing. It is possible to adjust the content of capsaicin and the thickness of the skin adhesion layer 11 so that capsaicin is continuously eluted for 8 hours or more while reducing irritation. The thickness of the TPE gel of the skin adhesion layer 11 is desirably 20 μm to 400 μm.

  When the TPE gel is attached to the skin, it has an effect of increasing the temperature and humidity of the skin by being blocked from the surrounding air. While wearing the diet patch of the present invention, the temperature of the skin is increased by the heat generation effect. Since the TPE gel attached to the nonwoven fabric is in close contact with the skin, it is shielded from the surrounding air to protect the skin temperature, strengthen the skin's moisture retention, and effective substances such as capsaicin are directly applied to the skin. The absorbed condition is further improved and diffused without a separate absorption enhancer and fluidization enhancer to effectively absorb capsaicin into the skin.

  When adding lipolytic substances other than capsaicin to the TPE gel, fat-soluble components such as conjugated linoleic acid (conjugated linoleic acid) and coconut oil are mainly used, but water-soluble like caffeine Substances can also be used.

In the present invention, the skin adhesion layer 11 is provided on one side of the support layer (back layer, 12).
The TPE gel and the support layer 12 must be well bonded so that the TPE gel does not remain on the skin when the patch is peeled from the skin. As a method for such bonding, the TPE gel liquefied at a high temperature of 100 ° C. or higher must diffuse and penetrate into the support layer 12 to be impregnated by 0.01 mm or more. When bonded in this manner, when the TPE gel is peeled from the skin, the TPE gel does not stick to the skin withstand the peel strength. Further, the material of the support layer 12 may be a non-woven fabric or a polyester fabric, and any device for preventing the skin adhesion layer 11 from evaporating or slipping off is not required.

  When the patch of the present invention is a patch to be attached to the lower abdomen, it is desirable to form a hole 14 in a certain portion of the patch 10 so that the patch 10 does not seal the navel, and the hole 14 is positioned according to the body shape. Two can be formed to allow adjustment (see FIG. 1).

  A TPE gel was prepared by mixing 10 parts by weight of SEBS, 45 parts by weight of a tackifier and 45 parts by weight of mineral oil, and then 0.003 parts by weight of capsaicin was added and mixed to form a skin adhesion layer to prepare a patch. . An experiment was conducted in which the patch was attached to the lower abdomen of the subject and the temperature of the skin was measured with a thermal image over time. After 2 hours (see FIG. 2), the patch was attached (see FIG. 2). 3) and after 4 hours (see FIG. 4), the skin temperature was found to increase by 2 ° C. each.

  The above description is illustrative of the present invention, and the embodiments described in the specification are not intended to limit the technical idea of the present invention, but to illustrate the present invention. Those who have ordinary knowledge in the technical field to which the present invention belongs can make various modifications and variations without departing from the technical idea of the present invention. Therefore, the scope of protection of the present invention should be construed by matters described in the claims, and technical matters within the scope equivalent thereto should be construed as being included in the scope of rights of the present invention.

10: Patch 11: Skin adhesion layer 12: Support layer 13: Release paper 14: Hole

Claims (5)

In diet patches that are used on the skin,
The diet patch is
A skin adhesion layer formed by adding capsaicin to a thermoplastic elastomer (TPE) gel;
A support layer impregnated with the skin adhesion layer;
Release paper attached to one side of the skin adhesion layer;
Consisting of
The skin adhesion layer is
3-20 parts by weight of SEBS (Styrene Ethylene Butyrene Styrene) or SEEPS (Styrene Ethylene Proline Styrene),
42 to 53 parts by weight of a tackifier,
42 to 53 parts by weight of mineral oil,
0.001 to 0.025 part by weight of capsaicin,
A diet patch using a thermoplastic elastomer gel composition containing capsaicin, characterized in that it comprises a composition.   The diet patch using the thermoplastic elastomer gel composition containing capsaicin according to claim 1, wherein the thickness of the skin adhesion layer is 20 to 400 µm.   2. The diet using a thermoplastic elastomer gel composition containing capsaicin according to claim 1, wherein the support layer is a nonwoven fabric or polyester, and a thermoplastic elastomer gel is impregnated and bonded to the support layer. patch.   The dietary patch using a thermoplastic elastomer gel composition containing capsaicin according to claim 1, wherein the mineral oil is liquid paraffin having a kinematic viscosity of 60 cSt or more. The patch for diet using a thermoplastic elastomer gel composition containing capsaicin according to claim 1, wherein the tackifier is a C5 or C9 hydrocarbon resin.