CN111135283A - Traditional Chinese medicine composition containing ants, preparation method and application thereof, and ant moxibustion patch - Google Patents
Traditional Chinese medicine composition containing ants, preparation method and application thereof, and ant moxibustion patch Download PDFInfo
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- CN111135283A CN111135283A CN202010061939.4A CN202010061939A CN111135283A CN 111135283 A CN111135283 A CN 111135283A CN 202010061939 A CN202010061939 A CN 202010061939A CN 111135283 A CN111135283 A CN 111135283A
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Abstract
The invention discloses a traditional Chinese medicine composition containing ants, a preparation method and application thereof and an ant moxibustion patch. The composition is prepared by crushing and sieving polyrhachis vicina Roger, dried ginger and mint, and mixing the crushed and sieved materials in a proportion of 4-5: 3-4: 2-3, can be used for preparing a medicine or a health-care product for treating or relieving arthralgia, has a simple formula, can effectively resist inflammation and pain, eliminate swelling and improve pain threshold, is suitable for treating or relieving arthralgia, and has the advantages of obvious effect, quick response and short treatment period. The ant moxibustion plaster of the ant-containing traditional Chinese medicine composition combines an ant therapy with a hot compress therapy, reduces the toxicity of oral administration on liver and kidney, breaks through the traditional moxibustion method, controls the amount of oxygen entering a heating bag through the air permeability of a breathable film, enables the temperature to be controllable, has long heating time and realizes high-efficiency moxibustion.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition containing ants, a preparation method and application thereof, and an ant moxibustion patch.
Background
The ant therapy originates from the ancient period of blood drinking by rufa, and ancestors find that pangolin and koala are healthy and strong after eating ants, and then practical ants are started. China is the origin of ant edible and medicinal purposes, Zhou Li, Tian Gong (national treasures, internal rules) is the earliest literature on ant therapy in China, " is for feeding Tian Zi for the back of the year", Ben Cao gang mu (compendium of materia Medica) is carried out: "Yili is the biggest, can act as an equivalent body iron, and can benefit strength and luster when eaten by people. The ant therapy is characterized in that ants are used for treatment, health care and health preservation of people, the characteristics of balanced nutrition, organism balance, simultaneous treatment of different diseases and dual purposes of medicine and food of the ants (polyrhachis vicina), the ant therapy integrates the functions of nourishing and nutrition, strengthening spleen and tonifying kidney, clearing and activating the channels and collaterals, tonifying qi and activating blood, regulating immunity in two directions, resisting virus, resisting inflammation and easing pain, calming and the like, and the ants are used for preventing and treating rheumatism, rheumatoid, hepatitis B, cough, diabetes and other deficiency and impairment difficult miscellaneous diseases.
Joint pain is particularly common in life, especially in the elderly, and is a long-term affliction. In modern society, many people are left to care their bodies because of long-term work and use of computers, which causes serious damage to the bodies, and causes the current pain incidence of cervical spondylosis, scapulohumeral periarthritis, lumbar spondylosis, knee joint pain, rheumatoid arthritis and the like to rise year by year. At present, related external medicines for relieving pain exist, but the medicines are used more, the formula is complex, the treatment period is long, and the curative effect is not obvious.
The most commonly used moxibustion is the traditional moxibustion, which is a treatment method for preventing and treating diseases by stimulating acupuncture points or specific parts on the body surface with moxa heat generated by moxa-moxibustion materials made of folium artemisiae argyi and regulating the physiological function of human body disorder by exciting the activity of meridian qi. While the moxibustion method is difficult for individual operation, uncontrollable temperature, easy scald, difficult control of acupuncture points and the like, the new type of thermal moxibustion plaster has the problems of poor using effect, poor product air permeability, short using time, uncontrollable heating temperature and the like.
Disclosure of Invention
The invention aims to provide the ant-containing traditional Chinese medicine composition which has the advantages of anti-inflammatory, analgesia, swelling elimination, pain threshold improvement, simple formula, obvious effect, quick response and short treatment period.
The invention also aims to provide a preparation method of the ant-containing traditional Chinese medicine composition.
The invention also aims to provide the application of the traditional Chinese medicine composition in preparing medicines or health-care products with the functions of resisting inflammation, easing pain and eliminating swelling, in particular to the application in medicines or health-care products for treating or relieving joint pain.
The invention also aims to provide the ant moxibustion patch containing the traditional Chinese medicine composition and mainly having good physiotherapy effect on arthralgia.
The purpose of the invention is realized by the following modes:
a traditional Chinese medicine composition containing ants comprises the following components of polyrhachis vicina Roger, dried ginger and mint, wherein the weight ratio of the polyrhachis vicina Roger to the dried ginger to the mint is 4-5: 3-4: 2-3 by mass ratio.
The composition preferably comprises polyrhachis vicina roger, dried ginger and mint in a ratio of 5: 3: 2 in mass ratio.
The composition and pharmaceutically acceptable auxiliary agents are prepared into an external preparation, and the preparation can be a patch, and is preferably an ant moxibustion patch.
The preparation method of the ant-containing Chinese medicinal composition comprises pulverizing polyrhachis vicina Roger, Zingiberis rhizoma and herba Menthae, sieving, mixing at a certain proportion, and preferably sieving with 100 mesh sieve.
The ant-containing traditional Chinese medicine composition can be used for preparing medicines or health products with anti-inflammatory and analgesic effects or swelling eliminating effects, and preferably the traditional Chinese medicine composition is used for preparing medicines or health products for treating or relieving joint pain.
Square solution: the ant used in the invention is polyrhachis vicina Roger, which is only approved by the ministry of health of China to be used as both medicine and food, has salty and sour taste and neutral nature, enters liver and kidney channels, can tonify liver and kidney, benefit essence, nourish blood, fill bones, remove stasis, dredge collaterals, dispel wind, dispel cold and remove dampness, and is a monarch drug. The dried ginger powder is pungent and warm in nature, has the effects of warming middle-jiao to dispel cold, restoring yang and dredging collaterals, can guide blood into blood system and qi into qi system, can remove aversion to nourishment new, and has the effect of promoting the growth of yin and yang. Meanwhile, the mint is pungent in flavor and cool in nature, has the effects of dispelling wind and heat, clearing head and eyes, relieving sore throat, promoting eruption, soothing liver and promoting qi circulation, and can also reduce swelling and relieve pain. According to the traditional Chinese medicine composition, the polyrhachis vicina Roger is used as a monarch drug, the dried ginger and the mint are used as ministerial and adjuvant drugs in a compatible manner, so that the effects of removing blood stasis, dredging collaterals, dispelling wind, cold and dampness, dispelling wind and heat, promoting blood circulation and relieving pain are achieved, and the effects of resisting inflammation and easing pain, eliminating swelling and relieving arthralgia are better due to the synergistic effect of the medicinal materials.
The ant moxibustion plaster comprises a non-woven fabric layer, an ant medicine core layer, a heating cladding layer and an adhesive layer which are sequentially adhered and fixed, medical pressure-sensitive hot melt adhesive is used for adhering and fixing all the layers, the effective raw material of the ant medicine core layer is the traditional Chinese medicine composition, the heating cladding layer comprises an upper breathable film and a lower breathable film, the upper breathable film is in contact with the lower surface of the ant medicine core layer, the lower breathable film is adhered to the upper surface of the adhesive layer, and a heating body is filled between the upper breathable film and the lower breathable film.
The ant medicine core layer is prepared by mixing a traditional Chinese medicine composition containing ants and a medical pressure-sensitive hot melt adhesive according to the proportion of 1: 4, and preparing the pasty flux-cored wafer after uniformly mixing, wherein the diameter of the flux-cored wafer is 3-4 cm, and the thickness of the flux-cored wafer is 1 mm. The ointment medicine core has small volume, thin thickness and good experience feeling, the medicine powder of ants, dried gingers and mint is subjected to superfine grinding, the granularity is finer, and the medicine powder is uniformly mixed with the medical pressure-sensitive hot melt adhesive to prepare the ointment medicine core, so that the medicine is uniformly dispersed, the action points are concentrated, and the dispersion force of the medicine gas is enhanced along with the heating power.
The diameters of the micropores of the upper and lower breathable films of the heating layer are 5-10 μm, and the air permeability is 5-10 cm3/m2d.MP. The heating body is preferably tourmaline mineral powder, carbon powder and iron powder. The double-deck ventilated membrane of package generates heat, and the control gets into package oxygen volume that generates heat, realizes that the temperature is controllable, and the time of generating heat is long through the air permeability of accessible ventilated membrane.
A heat insulation film can be arranged between the ant medicine core layer and the heating cladding layer, so that rapid heating or over-high temperature at the medicine core part is avoided, and uniform and stable temperature rise of a program is realized. The heat insulation film is made of peritoneum cloth, and the shape and the size of the heat insulation film are consistent with those of the ant medicine core layer.
The adhesive layer is the adhesive base cloth which comprises the physiotherapy portion in contact with the heating covering layer and the side wing portions on two sides of the physiotherapy portion, the release paper is adhered to the surfaces of the side wing portions, the physiotherapy portion can be covered by the side wing portions when the physiotherapy portion is folded, space is saved, and fixation is facilitated when the physiotherapy portion is used.
Above-mentioned ant moxibustion subsides mixes powder and hot melt adhesive, laminates with the package upper portion that generates heat, and is fixed, pastes again in the painful department of patient, and self-heating package heats powder, promotes the medicine diffusion, and the medicine passes through the skin and penetrates into painful position, has played the effect of local medicine, has reduced the damage that the toxicity that the oral administration was used and is caused the liver and kidney. The acupuncture points are preferably selected according to the arthralgia part, and ant essential oil can be matched and used as an essential oil inlet at the medicine core part, so that the joint pain physiotherapy effect is better. The ant moxibustion plaster can be used as a temperature control plaster by matching with self-adhesive paper, can prevent the ant moxibustion plaster from contacting with air, and can be regulated and controlled by the temperature control plaster if the temperature does not need to be raised too fast or too high.
Compared with the prior art, the invention has the beneficial effects that:
(1) the ant-containing traditional Chinese medicine composition disclosed by the invention is few in used medicinal materials, simple in formula, capable of effectively resisting inflammation, easing pain, eliminating swelling and improving pain threshold, suitable for treating or relieving arthralgia, remarkable in effect, capable of quickly taking effect and short in treatment period.
(2) The ant moxibustion plaster of the ant-containing traditional Chinese medicine composition combines an ant therapy with a hot compress therapy, reduces the toxicity of oral administration on liver and kidney, breaks through the traditional moxibustion method, controls the amount of oxygen entering a heating bag through the air permeability of a breathable film, enables the temperature to be controllable, has long heating time and realizes high-efficiency moxibustion.
Drawings
Fig. 1 is a structural schematic diagram of an ant moxibustion patch of the ant-containing traditional Chinese medicine composition of the invention.
In the figure: 1-non-woven fabric layer, 2-ant medicine core layer, 3-heating cladding layer, 31-upper breathable film, 32-lower breathable film, 4-adhesive layer, 41-physiotherapy portion, 42-side wing portion, 5-release paper and 6-heat-insulating film.
Detailed Description
Preferred embodiments of the present invention will be described in more detail with reference to specific examples.
Example 1
Weighing 10g of polyrhachis vicina Roger, 6g of dried ginger and 4g of mint, respectively crushing, sieving with a 100-mesh sieve, and uniformly mixing.
Example 2
Weighing 9g of polyrhachis vicina Roger, 7g of dried ginger and 6g of mint, respectively crushing, sieving with a 100-mesh sieve, and uniformly mixing.
Comparative example 1
Weighing 20g of polyrhachis vicina Roger, pulverizing, and sieving with 100 mesh sieve.
Comparative example 2
Weighing 12.5g of polyrhachis vicina Roger and 7.5g of dried ginger, respectively crushing, sieving with a 100-mesh sieve, and uniformly mixing.
Comparative example 3
Weighing 14.25g of polyrhachis vicina Roger and 5.7g of mint, respectively crushing, sieving with a 100-mesh sieve, and uniformly mixing.
Example 3
An ant moxibustion plaster of an ant-containing traditional Chinese medicine composition comprises a non-woven fabric layer 1, an ant medicine core layer 2, a heating cladding layer 3 and an adhesive layer 4 which are sequentially adhered and fixed by using medical pressure-sensitive hot melt adhesive, wherein the ant medicine core layer 2 is formed by adhering the ant-containing traditional Chinese medicine composition prepared in the embodiment 1 of the invention and the medical pressure-sensitive hot melt adhesive according to the proportion of 1: 4 mass ratio ofThe paste drug core wafer is prepared after uniform combination, the diameter of the drug core wafer is 4cm, the thickness of the drug core wafer is 1mm, the heating cladding layer 3 comprises an upper breathable film 31 and a lower breathable film 32, heating elements tourmaline mineral powder, carbon powder and iron powder are filled in the middle of the heating cladding layer, the upper breathable film 31 is in contact with the lower surface of the ant drug core layer 2, the lower breathable film 32 is pasted on the upper surface of the pasting layer 4, the diameter of micropores of the breathable films is controlled to be 5-10 um, and the air permeability is 5-10 cm3/m2d.MP. A round peritoneum cloth heat insulation film 6 with the same size as the medicine core wafer is arranged between the ant medicine core layer 2 and the heating cladding layer 3. The sticking layer 4 is a base cloth with glue, the base cloth with glue comprises a physiotherapy part 41 in contact with the heating cladding layer 3 and side wing parts 42 on two sides of the physiotherapy part 41, release paper 5 is stuck to the surfaces of the side wing parts 42, and the specification of the finished product ant moxibustion stick is 230mm x 80 mm.
Tearing the release paper at the side wing part, aligning the medicated core with pain point or related acupuncture points (cervical vertebra acupoint, shoulder and shoulder acupoint, waist and waist Yangguan acupoint, Mingmen acupoint, leg blood and sea acupoint, Zusanli, YANGLINGQUAN acupoint, WEIZONGQUAN acupoint, and foot Yongquan acupoint), and sticking on skin, wherein the heat generated by the heating bag makes the medicinal molecules reach the surface of skin to achieve moxibustion effect. Multiple tests prove that the heating duration time of the product is not less than 8 hours, the constant temperature time is not less than 4 hours, the temperature is 40-55 ℃, and the temperature rise time is less than 10 minutes. The product integrates the ant therapy and the hot compress therapy deeply, the ant moxibustion is introduced on the basis of the traditional moxibustion method, the operation is simple and safe, the temperature is comfortable and lasting, the pertinence is strong, the effect is obvious, the product is suitable for the auxiliary physiotherapy of uncomfortable symptoms of the shoulder, the neck, the waist, the abdomen and other parts, and the using effect of the product in matching with ant essential oil for the patient with severe symptoms is better.
The present invention is further explained below by the examples of efficacy test and clinical test:
test example 1
1. Experimental materials:
1.1 drugs and reagents the composition of example 1 of the present invention (hereinafter referred to as patch 1 group); example 2 composition (hereinafter referred to as dusting powder 2 group); comparative example 1 composition (hereinafter referred to as ant powder group); comparative example 2 composition (hereinafter referred to as ant + dried ginger powder group); comparative example 3 composition (hereinafter referred to as ant + mint powder group); 1% of nataline latex (Ciba-Geigy, Switzerland); carrageenan (Sigma).
The patch powder 1, the patch powder 2, the ant powder, the ant + dried ginger powder and the ant + mint powder are uniformly stirred by normal saline to be pasty for later use.
1.2 animal SD rat with weight of 180-250 g; kunming mice weighing 18-25 g are all male mice.
2. The experimental method comprises the following steps:
2.1 analgesic test
2.1.1 twisting method 70 mice were randomly divided into 7 groups of 10 mice each, namely, saline control group, sitalin group, patch powder 1 group, patch powder 2 group, ant powder group, ant + dried ginger powder group, ant + mint powder group. The hair of the abdomen is shaved by a shaver, the physiological saline group and the retinene group are respectively smeared on the abdomen by 0.25 g/mouse, and the other 5 groups, namely the plaster powder 1 group, the plaster powder 2 group, the ant powder group, the ant + dried ginger powder group and the ant + mint powder composition are respectively smeared on the abdomen of the mouse by 0.25 g/mouse according to the crude drug amount. After 30min, each group was injected intraperitoneally with 0.6% acetic acid (0.2ml/20g), and the number of writhing animals and the number of writhing times within 30min were observed (see table 1).
2.1.2 the hot plate method is to place the mice in an iron leather cylinder with the thickness of 10cm multiplied by 20cm multiplied by 15cm in a thermostatic water bath box with the temperature of 55.0 +/-0.5 ℃, record the time(s) from the mice to be put into the hot plate until the mice lick feet as the pain threshold value of the mice by using a stopwatch, screen 70 mice with the pain threshold value of 20-30 s, randomly divide the mice into 7 groups, and each group comprises 10 mice, namely a physiological saline water control group, a sitalin group, a powder pasting 1 group, a powder pasting 2 group, a ant powder group, an ant + dried ginger powder group and an ant + mint powder group. After applying the drugs (0.25 g/mouse based on crude drug) on the mouse feet for 5min, the mice were put on a hot plate, the time of licking the feet was recorded, and the pain threshold before and after administration was recorded (see table 2).
2.2 anti-inflammatory experiments
2.2.1 rat foot sole swelling experiment the anti-inflammatory effect of the drug was evaluated by a plethysmography, capillary amplification measurement foot sole volume method. 70 rats were randomly divided into 7 groups of 10 rats each, and the normal paw volumes were measured. Marking a mark at the left hind ankle joint of each mouse, injecting 0.1ml of 1 percent of carrageen into the plantar tendon membrane to cause inflammation, respectively smearing normal saline, nataline emulsion (0.25 g/mouse), patch powder 1, patch powder 2, ant powder, ant + dried ginger powder and ant + mint powder (0.25 g/mouse in terms of crude drug amount) after 30min, respectively measuring the volume of the left hind ankle joint of each mouse after 1, 2, 3, 4, 5 and 6h of inflammation, and calculating the swelling degree according to the following formula (see table 3).
Swelling degree (%) (volume of postinflammatory metatarsal-volume of proinflammatory metatarsal)/volume of proinflammatory metatarsal × 100%
2.2.2 mouse auricular swelling experiments 70 mice were taken and randomly divided into 7 groups of 10 mice each. Under ether anesthesia, the mixture is coated on the front and back surfaces of the left ear of a mouse by dimethylbenzene to cause inflammation, each mouse is 0.02ml, physiological saline, a hibirine emulsion (0.25 g/mouse), patch powder 1, patch powder 2, ant powder, ant + dried ginger powder, ant + mint powder (0.25 g/mouse according to crude drug content) are respectively coated on the same part 30min after the inflammation is caused, the mouse is killed after 4h, the two ears are cut off, a hole puncher with the diameter of 9mm is used for punching the round ear piece, a torsion balance is used for weighing, and the swelling rate of the ears of each group of mice is calculated according to the following formula (see table 4).
The swelling ratio (%) - (left ear weight-right ear weight)/right ear weight × 100%
3, experimental results:
3.1 analgesic test
3.1.1 results of the writhing method analgesia test in mice are shown in Table 1.
Table 1 effect of ant compositions on writhing response in mice by acetic acid (n-10,
)
p <0.05 compared to saline group; p <0.01 compared to saline group.
As can be seen from table 1, compared with the saline solution group, each ant composition group had relatively less writhing response to mice, had significant analgesic effect on mice writhing experiment caused by acetic acid, and the effect of the patch powder 1 group was significantly stronger than that of the other composition groups, which had significant difference.
3.1.2 the results of the hot plate analgesia experiments in mice are shown in Table 2.
Table 2 effect of ant compositions on pain-causing effects of mouse hot plate method (n-10,
)
p <0.05 compared to saline group; p <0.01 compared to saline group.
As can be seen from Table 2, the ant composition can prolong the time of the mouse licking the foot, can obviously improve the pain threshold of the mouse, and compared with other compositions, the patch powder 1 has obvious curative effect and obvious difference on the pain caused by the mouse hot plate method.
3.2 anti-inflammatory experiments
3.2.1 the results of the rat plantar swelling experiments are shown in Table 3.
Table 3 effect of ant composition on the degree of swelling of the plantar foot of normal rats (n-10,
)％
p <0.05 compared to saline group; p <0.01 compared to saline group.
As can be seen from table 3, the ant composition had a significant inhibitory effect on carrageenan-induced plantar swelling in rats compared to the saline group; compared with other compositions, the plaster 1 has remarkable inhibiting effect.
3.2.2 mouse auricle swelling test results are shown in Table 4.
Table 4 effect of ant compositions on inflammatory swelling of mouse auricles (n-10,
)％
p <0.05 compared to saline group; p <0.01 compared to saline group.
The results in table 4 show that each ant composition attenuates xylene-induced inflammatory swelling of mouse pinna; but the inhibition effect of the plaster 1 on the auricle inflammatory swelling of mice is obviously stronger than that of other compositions.
From the experimental results, the composition can obviously reduce the frequency of mouse writhing reaction caused by acetic acid, obviously improve the pain threshold of mice by a hot plate method, and inhibit rat plantar swelling caused by carrageenan and mouse auricle swelling caused by xylene, and the four finger label powder 1 is obviously superior to other compositions, has stronger anti-inflammatory and analgesic effects and better curative effect.
Test example 2
In order to verify the physiotherapy effect of the ant moxibustion patch on arthralgia, the applicant carries out clinical observation by adopting the ant moxibustion patch prepared in the embodiment 3 of the invention, and the conditions are as follows:
clinical data
1. General data
150 patients were selected, 80 men, 70 women, 20 years of least age, 75 years of maximum age, 2 weeks of least course, and 12 months of maximum length.
2. Inclusion criteria
All cases were patients who met the following diagnostic criteria, and were convenient to follow-up and to use the ant moxibustion patch on time. Diagnostic criteria: a. the patient has a history of acute or chronic injury, and is aged by a single posture for a long time; b. the injury part is heavy in pain, tenderness and unobvious in red and swollen, and the symptoms are aggravated when the injury part meets weather change; c. the movement of the joint or the adjacent joints is limited, the tendons are restricted and the movement is not smooth. Rejection standard: a. pregnant or breast-bearing women; b. those with allergic constitution; c. those with ulcerated skin or bleeding; d. patients with serious primary diseases such as heart, brain, liver, kidney and hemopoietic system and mental disease are combined.
3. Method of treatment
Grouping: the experimental group, the positive control group and the blank control group are all 50 cases, and a random grouping method is adopted.
The method comprises the following steps: the experimental group takes the ant moxibustion plaster of the invention and pastes the ant moxibustion plaster on pain spots or related acupuncture points. The plaster is used every other day for 4 hours every time, three times is a using period, and after one period is finished, the plaster is used after two days and is used for 8 periods. The positive control group takes the musk bone strengthening paste sold by the drugstore, and the treatment method is the same as that of the experimental group. The blank control group adopts matrix without pharmacological action for external application, and the application method is the same as that of the experimental group. Other drugs of the same type or consistent function are discontinued during the treatment period. If adverse reaction occurs, the medicine is immediately stopped, and the condition is recorded and timely treated.
4. Observation of therapeutic effects
Index quantification is carried out according to 'traditional Chinese medicine disease diagnosis curative effect standard':
4.1 grading of pain
(6 points) pain affects motor function; (4 min) inactivity also pain; (2 min) pain is caused when the patient is in a certain position; (0) has no pain.
4.2 functional Classification of joints
Stage I: freely move (0 min); and II, stage: activity is moderately limited, not flexible but capable of engaging in normal activities (1 point); grade III: the activity is obviously limited, affecting the daily life (2 points).
4.3 pain threshold measurement
The area (cm) is calculated by examining from the unintentional region to the normal region with appropriate stimulation intensity2)。
4.4 evaluation criteria for comprehensive therapeutic Effect
And (3) curing: the clinical symptoms disappear, the movement is free, no obvious discomfort feeling is caused when the patient encounters a sudden change climate, and the curative effect integral is 0; the effect is shown: the chief symptoms disappear, the joint function returns to normal, the life and work can be normal, and the curative effect integral is reduced 2/3; the improvement is as follows: the principal symptoms basically disappear, the joint function is obviously improved, the pain threshold area is reduced 1/2, the physical strength can be lightened, and the curative effect integral is reduced 1/3; and (4) invalidation: compared with the treatment before, the improvement is not obvious, and the integral of the curative effect is reduced to be less than 1/3.
5. Treatment results and analysis
5.1 analysis of the functional symptom integrals and the change in pain threshold area of painful joints is shown in Table 5
Table 5 score of painful joint functional syndromes and change in pain threshold area (n-50,
)
note: p <0.05, P <0.01, compared to blank; compared with the positive group, # P <0.05, # P <0.01
It can be seen from table 5 that the differences between the experimental group and the blank control group and the positive control group have statistical significance, and the pain symptoms, the joint functions and the pain threshold area of the experimental group are all significantly improved.
5.2 evaluation results of comprehensive therapeutic effects are shown in Table 6
Table 6 evaluation of comprehensive therapeutic effect (n-50, case (%))
As can be seen from Table 6, the total effective rates of the blank control group, the positive control group and the experimental group are 40%, 64% and 90%, respectively, and the experimental group, the blank group and the positive group have statistical significance, and p is less than 0.01, so that the curative effect of the composition is obviously better than that of the positive group.
Claims (10)
1. A ant-containing traditional Chinese medicine composition is characterized by comprising the following components in percentage by weight of 4-5: 3-4: 2-3 by mass ratio.
2. The ant-containing traditional Chinese medicine composition as claimed in claim 1, wherein the composition is prepared from polyrhachis vicina Roger, dried ginger and mint in a weight ratio of 5: 3: 2 in mass ratio.
3. The ant-containing traditional Chinese medicine composition as claimed in claim 1 or 2, wherein the composition is formulated with pharmaceutically acceptable adjuvants into an external preparation.
4. The ant-containing traditional Chinese medicine composition according to claim 3, wherein the external preparation is a patch.
5. A preparation method of ant-containing traditional Chinese medicine composition as claimed in claim 1 or 2, characterized in that polyrhachis vicina roger, rhizoma zingiberis and herba menthae are pulverized, sieved and mixed uniformly in proportion.
6. Use of the ant-containing traditional Chinese medicine composition of claim 1 or 2 for preparing a medicine or health product having anti-inflammatory analgesic or swelling eliminating effects.
7. Use of the ant-containing traditional Chinese medicine composition of claim 1 or 2 in the preparation of a medicament or health product for treating or relieving joint pain.
8. An ant moxibustion plaster of ant-containing traditional Chinese medicine composition is characterized by comprising a non-woven fabric layer, an ant medicine core layer, a heating cladding layer and an adhesive layer which are sequentially adhered and fixed, wherein the effective raw material of the ant medicine core layer is the ant-containing traditional Chinese medicine composition as claimed in claim 1 or 2, the heating cladding layer comprises an upper breathable film which is in contact with the lower surface of the ant medicine core layer and a lower breathable film which is adhered to the upper surface of the adhesive layer, and a heating element is filled between the upper breathable film and the lower breathable film.
9. The ant moxibustion patch as claimed in claim 8, wherein the ant drug core layer is prepared from a traditional Chinese medicine composition containing ants and a medical pressure-sensitive hot melt adhesive in a proportion of 1: 4, and preparing the pasty flux-cored wafer after uniformly mixing, wherein the diameter of the flux-cored wafer is 3-4 cm, and the thickness of the flux-cored wafer is 1 mm.
10. The ant moxibustion patch according to claim 8, characterized in that the diameters of the micropores of the upper and lower air-permeable films of the heat-generating covering layer are 5 to 10 μm.
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| CN108992240A (en) * | 2018-08-07 | 2018-12-14 | 河北厚德汉方医疗器械股份有限公司 | A kind of two-sided hot moxibustion patch of breathing freely |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108992240A (en) * | 2018-08-07 | 2018-12-14 | 河北厚德汉方医疗器械股份有限公司 | A kind of two-sided hot moxibustion patch of breathing freely |
Non-Patent Citations (3)
| Title |
|---|
| 周德生等: "《实用临床中西药合用解读》", 31 December 2016, 山西科学技术出版社 * |
| 国家食品药品监督管理总局执业药师资格认证中心组织: "《中药学专业知识.2》", 31 January 2017, 中国医药科技出版社 * |
| 朱静波等: "《怎样办好一个蚂蚁、土元、蜈蚣养殖场》", 31 July 2004, 中国农业出版社 * |
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Application publication date: 20200512 |