JPH06157337A - Hair tonic for oral administration - Google Patents

Abstract

PURPOSE:To provide a hair tonic utilizing silk, giving excellent hair tonic activity. CONSTITUTION:The hair tonic formulated with silk hydrolyzate. For the silk, it is preferable that waste silk be used, such as waste yarns or pieces of cloth representing the source of offensive odor in their incineration after discharged from weaving mills. The waste silk is scoured with an alkali and then hydrolyzed with an acid, alkali or enzyme. The resultant hydrolyzate liquor, a gelled product thereof or powder thereof is either directly or, if desired, together with an additive suitable for oral administration, made into a food or medicine in the form of powder, paste, tablets, granules, capsules or liquid.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a hair nourishing agent for oral administration using silk.

[0002]

2. Description of the Related Art Recently, silk fibroin or its acylated product, No. 4 has been used for improving hair and for nourishing and growing hair.
Cosmetics and external medicines using quaternary ammonium derivatives and silk peptides have been proposed.

For example, in Japanese Patent Laid-Open No. 58-72513,
Hair cosmetics containing a colloidal solution of silk fibroin in a dipping aqueous solution of an electrolyte as a hair protection additive are disclosed. Further, JP-A-60-243099 discloses that a quaternary trimethylammonium-derived silk polypeptide having a side chain of amino acids constituting a polypeptide derived from silk protein does not damage hair.
It is disclosed that a high degree of flexibility can be imparted. Further, JP-A-64-61412 discloses a cosmetic composition containing a fibroin peptide ester having a side chain of an amino acid constituting a fibroin peptide derived from silk. Further, JP-A-4-74111 discloses a hair restorer and a hair nourishing cosmetic comprising N-methyl-L-serine, which is a derivative of serine, which is contained in a relatively large amount in the silk components. However, these were all external products.

On the other hand, the use of silk for foods is being developed. For example, Japanese Unexamined Patent Publication No. 1-256350 discloses use in gelled foods such as pudding and jelly, and Japanese Unexamined Patent Publication Nos. 1-256351 and 1-256352 describe hangover-preventing gelled foods using silk fibroin Is disclosed. However, it is completely unknown about the hair nourishing effect by it.

[0005]

The present inventors have surprisingly found that an oral hair administration of a silk component can provide an excellent hair nourishing effect while intensively studying the use of silk. The present invention has been completed.

[0006]

The present invention provides an orally administered hair nourishing agent containing a silk hydrolyzate.

The hydrolyzate of waste silk used in the hair-growing agent for oral administration of the present invention is, for example, alkali-refined silk, acid-hydrolyzed, then neutralized, desalted and, if necessary, concentrated. And dried and powdered. Alternatively, it can be obtained by alkali scouring, alkali hydrolysis, dialysis, gelation, drying if necessary, and powdering. Further, it is obtained by decomposing a concentrated liquid of waste silk with an enzyme, if necessary, drying and pulverizing.

As the silk used in the present invention, various forms such as silkworm cocoons, silk threads, cloths, cotton-like spun before spinning, and roving-like ones can be used, but there is a problem due to a bad odor during incineration. It is preferable to use waste thread from a weaving factory and the like, and waste silk such as a piece of cloth. Decorative threads and various kinds of dust are attached to these waste threads and pieces of cloth, as well as lubricants, surfactants, and fine metals due to contact with machines. Therefore, first, visible decoration threads, dust, etc. are removed from the waste silk, and then cut into an appropriate length, preferably 4 to 5 cm, and alkali scouring.

Alkali scouring can be carried out according to a known method, for example, 0.5 times to 1 times 80 times the amount of the sample.
% Sodium carbonate solution for 30 minutes at boiling temperature. By the complete removal of the sericin, the contamination due to the lubricant used in the weaving process and other causes is almost eliminated.

As mentioned above, the hydrolysis can utilize acid hydrolysis, alkali hydrolysis or enzymatic hydrolysis, which can be carried out according to known methods. For example, acid hydrolysis is 80 times the amount of alkali-refined silk,
Inorganic acids such as hydrochloric acid, sulfuric acid, phosphoric acid, nitric acid and hydrobromic acid having a concentration of 5 to 85%, or organic acids such as acetic acid and formic acid,
Acid hydrolysis can be performed by preferably using 2N hydrochloric acid and treating at 100 ° C. for 48 hours.

Neutralization and desalting after hydrolysis can be carried out according to known methods, for example, treatment with 2N sodium hydroxide, washing with water, filtration and dehydration. Drying can be performed by adding dextrin and spray-drying, or by freeze-drying. Furthermore, if desired, color and odor can be removed by ion exchange resin treatment or activated carbon treatment.

Alkaline hydrolysis can be carried out by scouring alkalin silk, putting it in boiling water, washing and drying, and then dissolving it in boiling calcium chloride solution.
The alkaline hydrolyzate may be dialyzed, gelled, freeze-dried, and ground in a mortar or the like to produce silk powder. As a solution for dissolving alkali-refined silk, lithium bromide, potassium thiocyanide, copper ethylenediamine, etc. can be used in addition to the boiling calcium chloride solution, and a boiling 50% calcium chloride solution is preferable. For dialysis, put it in a dialysis membrane and put it in running water.
It can be done by exposure for ~ 3 days, and conventional dialysis machines can also be used. Gelation is performed with acid or alcohol. The gelation time can be shortened by lowering the pH with citric acid to the isoelectric point of silk (about pH 3.8).

[0013] Enzymatic hydrolysis is carried out using a regenerated silk solution, for example, 6
After hydrolyzing with an enzyme such as Samoases at 0 ° C for 1 hour, the enzyme is inactivated by boiling and freeze-drying to obtain a brown powdery water-soluble silk powder.

The hair nourishing agent for oral administration of the present invention is a purified hydrolyzate solution, the above-mentioned gel-like material or powder as it is, or, if desired, with other additives suitable for oral administration, by a conventional method. It can be in the form of food or medicine such as paste, tablets, granules, capsules and liquids.

The hair nourishing agent for oral administration of the present invention contains 1 amino acid or oligopeptide in silk hydrolyzate per adult.
An excellent hair nourishing effect is exhibited by continuing oral administration by dividing 5 to 15 g per day into 1 to 3 times a day. The silk itself has already been used for food, and its toxicity does not cause any particular problem.

[0016]

EXAMPLES The present invention will be described in more detail with reference to the following examples. Example 1 Alkali Scouring Debris, decorative threads, colored threads, etc. were removed from litter of crepe and cut to a length of 5 cm, and then at 100 ° C. for 30 minutes at a bath ratio of 1: 1.
It was immersed in a sodium carbonate solution of 00 (concentration: 1%), washed twice with hot water at 80 ° C., thoroughly washed with water and dried. Hydrolysis and pulverization The obtained sample was heated at 100 ° C. for 48 hours in a nitrogen stream at 80 ° C.
It was hydrolyzed with a double amount of 2N hydrochloric acid. Next, sodium hydroxide was added to neutralize, desalted, concentrated and freeze-dried to obtain a powdery powder. As a result of amino acid analysis using a trace amount sample of the powder, the powder showed 65% amino acid.
And 35% oligopeptide.

Administration test: An aqueous solution prepared by dissolving 5 g of the obtained powder in 100 ml of water was used, and three test subjects (A: 51-year-old male, B: 49-year-old male) having sesame salty hair with white hair mixed therein. , C: 5
(Five-year-old woman) was orally administered three times a day for 30 days after each meal. On the 25th day after the start of administration, any of the subjects began to grow black hair that was dispersed in the white hair and was visible to the naked eye, and about 0.2 cm on the 25th day after the start of administration.
Became. In particular, the subject A grew like a bundle of black hair.

[0018]

INDUSTRIAL APPLICABILITY According to the present invention, an orally administered hair nourishing agent exhibiting an excellent hair nourishing effect can be obtained.

Claims (1)

[Claims] 1. An orally administered hair nourishing agent containing a silk hydrolyzate.