JPH0576940B2 - - Google Patents

Info

Publication number
JPH0576940B2
JPH0576940B2 JP60501000A JP50100085A JPH0576940B2 JP H0576940 B2 JPH0576940 B2 JP H0576940B2 JP 60501000 A JP60501000 A JP 60501000A JP 50100085 A JP50100085 A JP 50100085A JP H0576940 B2 JPH0576940 B2 JP H0576940B2
Authority
JP
Japan
Prior art keywords
vitamin
mmol
ethyl acetate
compounds
nmr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP60501000A
Other languages
English (en)
Japanese (ja)
Other versions
JPS61502257A (ja
Inventor
Hekutaa Efu Deruuka
Nobuo Ikegawa
Yoko Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of JPS61502257A publication Critical patent/JPS61502257A/ja
Publication of JPH0576940B2 publication Critical patent/JPH0576940B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP60501000A 1984-05-31 1985-02-28 １，２４―ジヒドロキシ―△２２―ビタミンｄ３化合物 Granted JPS61502257A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/615,974 US4588528A (en) 1984-05-31 1984-05-31 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same
US615974 2003-07-09

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP5064683A Division JPH0662664B2 (ja) 1984-05-31 1993-03-01 Δ２２−コレスタ−５，７，２２−トリエン−１α，３β，２４−トリオール化合物

Publications (2)

Publication Number Publication Date
JPS61502257A JPS61502257A (ja) 1986-10-09
JPH0576940B2 true JPH0576940B2 (en, 2012) 1993-10-25

Family

ID=24467528

Family Applications (2)

Application Number Title Priority Date Filing Date
JP60501000A Granted JPS61502257A (ja) 1984-05-31 1985-02-28 １，２４―ジヒドロキシ―△２２―ビタミンｄ３化合物
JP5064683A Expired - Lifetime JPH0662664B2 (ja) 1984-05-31 1993-03-01 Δ２２−コレスタ−５，７，２２−トリエン−１α，３β，２４−トリオール化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP5064683A Expired - Lifetime JPH0662664B2 (ja) 1984-05-31 1993-03-01 Δ２２−コレスタ−５，７，２２−トリエン−１α，３β，２４−トリオール化合物

Country Status (9)

Country Link
US (1) US4588528A (en, 2012)
JP (2) JPS61502257A (en, 2012)
AU (1) AU4063985A (en, 2012)
BE (1) BE902528A (en, 2012)
DE (2) DE3590232T (en, 2012)
FR (1) FR2565227B1 (en, 2012)
GB (1) GB2159520B (en, 2012)
IE (1) IE58286B1 (en, 2012)
WO (1) WO1985005622A1 (en, 2012)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5120722A (en) * 1984-02-08 1992-06-09 Hoffmann-La Roche Inc. Trihydroxy-cholecacliferol and trihydroxy-ergocalciferol for treating leukemia
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
CA2058637A1 (en) * 1990-02-06 1991-08-07 Gunter Neef Side-chain homologous vitamin d derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
ES2200238T3 (es) * 1991-01-08 2004-03-01 Bone Care International, Inc. Procedimiento para la preparacion de la 1-alpha-24-dihidroxi vitamina d2.
US5786348A (en) * 1991-01-08 1998-07-28 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxy vitamin D2
KR960013798B1 (ko) * 1992-04-24 1996-10-10 재단법인 한국전자통신연구소 평면 도파로형 공간 스위치
AU666529B2 (en) * 1992-04-24 1996-02-15 Wisconsin Alumni Research Foundation Method of treating osteoporosis with 1 alpha, 24 (R)-dihydroxy-22 (E)-dehydro-vitamin D3
US5247104A (en) * 1992-11-04 1993-09-21 Wisconsin Alumni Research Foundation Preparation of 1α, 24-dihydroxyvitamin D analogs
TW267161B (en, 2012) * 1992-11-20 1996-01-01 Hoffmann La Roche
US5422127A (en) * 1992-12-21 1995-06-06 Bristol-Myers Squibb Company Nutritional compositions containing vitamin D esters
US5716946A (en) * 1996-02-13 1998-02-10 Wisconsin Alumni Research Foundation Multiple sclerosis treatment
US6136799A (en) * 1998-04-08 2000-10-24 Abbott Laboratories Cosolvent formulations
US6479474B2 (en) 1999-07-08 2002-11-12 Wisconsin Alumni Research Foundation Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
CA2981549A1 (en) * 2009-01-27 2010-08-05 Berg Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
BR112012003372A2 (pt) 2009-08-14 2019-09-24 Berg Biosystems Llc vitamina d3 e análogos da mesma para o tratamento de alopecia.
AU2014274099A1 (en) 2013-05-29 2015-12-24 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin D
AU2016293240B2 (en) * 2015-07-12 2021-02-04 INNOVAL Technology Switzerland AG Cholecalciferol sulfate salts and their use for the treatment of vitamin D deficiency

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3786062A (en) * 1973-02-16 1974-01-15 Wisconsin Alumni Res Found 22-dehydro-25-hydroxycholecalciferol and process for preparing same
US4202829A (en) * 1978-01-05 1980-05-13 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4267117A (en) * 1978-06-19 1981-05-12 The Upjohn Company Compounds and process
US4206131A (en) * 1978-06-19 1980-06-03 The Upjohn Company Compounds and process
US4225596A (en) * 1978-10-13 1980-09-30 Wisconsin Alumni Research Foundation Method for treating calcium imbalance and improving calcium absorption in mammals
US4265822A (en) * 1979-09-10 1981-05-05 Wisconsin Alumni Research Foundation Process for preparing 1-hydroxylated vitamin D compounds from 5,6-trans-vitamin D compounds
US4313942A (en) * 1979-10-09 1982-02-02 Wisconsin Alumni Research Foundation Activated vitamin D rodenticides
US4448721A (en) * 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same

Also Published As

Publication number Publication date
GB2159520B (en) 1987-12-16
JPS61502257A (ja) 1986-10-09
GB2159520A (en) 1985-12-04
DE3590232T (de) 1986-06-26
FR2565227B1 (fr) 1987-01-16
AU4063985A (en) 1985-12-31
JPH0692989A (ja) 1994-04-05
GB8513721D0 (en) 1985-07-03
JPH0662664B2 (ja) 1994-08-17
IE851284L (en) 1985-11-30
US4588528A (en) 1986-05-13
IE58286B1 (en) 1993-08-25
WO1985005622A1 (en) 1985-12-19
DE3590232C2 (de) 1992-09-17
BE902528A (fr) 1985-09-16
FR2565227A1 (fr) 1985-12-06

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