JPH0575066B2 - - Google Patents
Info
- Publication number
- JPH0575066B2 JPH0575066B2 JP6269485A JP6269485A JPH0575066B2 JP H0575066 B2 JPH0575066 B2 JP H0575066B2 JP 6269485 A JP6269485 A JP 6269485A JP 6269485 A JP6269485 A JP 6269485A JP H0575066 B2 JPH0575066 B2 JP H0575066B2
- Authority
- JP
- Japan
- Prior art keywords
- histamine
- solution
- orthophthalaldehyde
- separation column
- buffer solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims description 86
- 229960001340 histamine Drugs 0.000 claims description 43
- 238000006243 chemical reaction Methods 0.000 claims description 38
- ZWLUXSQADUDCSB-UHFFFAOYSA-N phthalaldehyde Chemical compound O=CC1=CC=CC=C1C=O ZWLUXSQADUDCSB-UHFFFAOYSA-N 0.000 claims description 30
- 239000000243 solution Substances 0.000 claims description 21
- 238000000926 separation method Methods 0.000 claims description 19
- 238000004458 analytical method Methods 0.000 claims description 16
- 239000007853 buffer solution Substances 0.000 claims description 16
- 239000003480 eluent Substances 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 14
- 238000004811 liquid chromatography Methods 0.000 claims description 9
- 238000002835 absorbance Methods 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 4
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 4
- 238000005277 cation exchange chromatography Methods 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 238000011144 upstream manufacturing Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 description 13
- 150000001875 compounds Chemical class 0.000 description 11
- 125000003277 amino group Chemical group 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 239000000872 buffer Substances 0.000 description 6
- 239000007850 fluorescent dye Substances 0.000 description 6
- 150000001413 amino acids Chemical group 0.000 description 5
- 125000003396 thiol group Chemical group [H]S* 0.000 description 5
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethyl mercaptane Natural products CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 4
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 3
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 125000002883 imidazolyl group Chemical group 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 239000001632 sodium acetate Substances 0.000 description 3
- 235000017281 sodium acetate Nutrition 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000031700 light absorption Effects 0.000 description 2
- 238000004452 microanalysis Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 101100493714 Caenorhabditis elegans bath-47 gene Proteins 0.000 description 1
- 238000011481 absorbance measurement Methods 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000001917 fluorescence detection Methods 0.000 description 1
- 229960004931 histamine dihydrochloride Drugs 0.000 description 1
- PPZMYIBUHIPZOS-UHFFFAOYSA-N histamine dihydrochloride Chemical compound Cl.Cl.NCCC1=CN=CN1 PPZMYIBUHIPZOS-UHFFFAOYSA-N 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- WLGDAKIJYPIYLR-UHFFFAOYSA-N octane-1-sulfonic acid Chemical compound CCCCCCCCS(O)(=O)=O WLGDAKIJYPIYLR-UHFFFAOYSA-N 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
Landscapes
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6269485A JPS61219864A (ja) | 1985-03-27 | 1985-03-27 | ヒスタミンの分析方法及び装置 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6269485A JPS61219864A (ja) | 1985-03-27 | 1985-03-27 | ヒスタミンの分析方法及び装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61219864A JPS61219864A (ja) | 1986-09-30 |
| JPH0575066B2 true JPH0575066B2 (enrdf_load_stackoverflow) | 1993-10-19 |
Family
ID=13207656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6269485A Granted JPS61219864A (ja) | 1985-03-27 | 1985-03-27 | ヒスタミンの分析方法及び装置 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61219864A (enrdf_load_stackoverflow) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0625737B2 (ja) * | 1989-12-27 | 1994-04-06 | 株式会社島津製作所 | 亜硫酸化合物の分析方法 |
| WO2000018892A1 (fr) * | 1998-09-25 | 2000-04-06 | Kikkoman Corporation | Histamine deshydrogenase, procede de production, procede de decelement quantitatif de l'histamine et reactif de decelement quantitatif |
| JP4300360B2 (ja) * | 2004-05-20 | 2009-07-22 | 財団法人名古屋産業科学研究所 | ヒスタミン検出方法およびヒスタミン検出キット |
-
1985
- 1985-03-27 JP JP6269485A patent/JPS61219864A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61219864A (ja) | 1986-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EXPY | Cancellation because of completion of term |