JPH05507438A - ＬＤＬ又は／及びｖＬＤＬを選択的に除去するための吸着物質 - Google Patents

ＬＤＬ又は／及びｖＬＤＬを選択的に除去するための吸着物質

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JPH05507438A
JPH05507438A JP91509899A JP50989991A JPH05507438A JP H05507438 A JPH05507438 A JP H05507438A JP 91509899 A JP91509899 A JP 91509899A JP 50989991 A JP50989991 A JP 50989991A JP H05507438 A JPH05507438 A JP H05507438A
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adsorbent material
ldl
vldl
group
adsorbent
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ラウ，アンドレアス
ジヒラー，ヴァルトラウト
ヘンケ，グードルーン
フェラー，ヴォルフガング
モルシュ，ゲロルト
コッホ，ズーザン
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ベー　ブラウン　メルズンゲン　アクチエンゲゼルシヤフト
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    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
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    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
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    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • External Artificial Organs (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Separation Of Gases By Adsorption (AREA)

Abstract

(57)【要約】本公報は電子出願前の出願データであるため要約のデータは記録されません。

Description

【発明の詳細な説明】 表面上に存在するンラノール基を介して共有結合した配位子（これは４〜１２個 のＣ−原子を有するアルキル基を含有する末端位のα、β−ジオール基を有する 少なくとも１個のエーテル基を有しかつ遊離のシラノール基はもはや存在しない ）を有する、固体担体物質としての多孔性ガラス体より成る、水性液体、特に血 液、血漿又は血清からのＬｐ（ａ）−リポタンパク質、ＬＤＬ−又は／及びｖＬ ＤＬ−コレステリンを選択的に除去するための吸着物質。
国際調査報告 国際調査報告

Claims (22)

    【特許請求の範囲】
  1. １．配位子としてのその表面上に存在するシラノール基を介して共有結合した有 機官能性基を有する固体の担体物質としての多孔性のガラス体より成る、水性液 体、特に血液、血漿又は血清からＬｐ（ａ）−リボタンパク質、ＬＤＬ−又は／ 及びｖＬＤＬ−コレステリンを選択的に除去するための吸着物質において、配位 子として、４〜１２個のＣ−原子を有するアルキル基を含有する末端位のα，β −ジオール基を有する少なくとも１個のエーテル基を有し、かつ遊離のシラノー ル基は存在していないことを特徴とする、ＬＤＬ又は／及びｖＬＤＬを選択的に 除去するための吸着物質。
  2. ２．配位子は、一般式： ▲数式、化学式、表等があります▼（Ｉ）［式中ｘ及びｙは１〜５の整数を表わ し、Ｒ１はＨ又はＯＨを表わしかつＲ２は、Ｒ１がＯＨである場合に、−ＣＨ２ ＯＨを表わす］に相応する、請求項１に記載の吸着物質。
  3. ３．配位子として１−アミノエチル−３−オキシプロピル−基を含有する、請求 項１又は２に記載の吸着物質。
  4. ４．他の配位子として、一般式： −（ＣＨ２）ｘ−Ｏ−（ＣＨ２）ｙ−ＣＨ２−ＯＨ（ＩＩ）［式中ｘ及びｙは１ 〜５の整数を表わす］の基を含有する、前記請求項のいずれかに記載の吸着物質 。
  5. ５．式ＩＩの配位子として、１値又は数個の１−ヒドロキシエチル−３−オキシ ブチル−基を含有する、請求項４に記載の吸着物質。
  6. ６．配位子として、１個又は数個の１−ヒドロキシプロピル−３−オキシプロピ ル−基を含有する、請求項４に記載の吸着物質。
  7. ７．他の配位子として、一般式： −（ＣＨ２）ｘ−Ｏ−（ＣＨ２）ｙ−ＣＲ１Ｒ２Ｒ３（ＩＩＩ）［式中Ｒ１はメ トキシ基を表わしかつＲ２及びＲ３はＨ又はメトキシ基を表わしかつｘ及びｙは １〜５の整数を表わす］の基を含有する、前記請求項のいずれかに記載の吸着物 質。
  8. ８．一般式ＩＩＩの配位子として、１個又は数個の１，１−ジメトキシエチル− ３−オキシプロピル−基を含有する、請求項７に記載の吸着物質。
  9. ９．式Ｉ、ＩＩ及びＩＩＩの配位子は、量比約１．３：１：０．８で担体物質に シラノール基を介して結合して存在している、前記請求項のいずれかに記載の吸 着物質。
  10. １０．式Ｉ及びＩＩの配位子は、量比１：１、１：２、１：３及び１：４並びに ２：１、３：１及び４：１で担体物質にシラノール基を介して結合して存在して いる、前記請求項のいずれかに記載の吸着物質。
  11. １１．表面積３０〜３００ｍ２／ｇを有する、前記請求項のいずれかに記載の吸 着物質。
  12. １２．配位子での担体物質の付加度は、２〜２０μμｍｏｌ／ｍ２である、前記 請求項のいずれかに記載の吸着物質。
  13. １３．ガラスビーズは、粒径６０〜５００μｍ及び孔径５０〜３５０ｎｍを有す る、前記請求項のいずれかに記載の吸着物質。
  14. １４．液体を請求項１〜１２のいずれかに記載の吸着物質に通すことを特徴とす る水性液体から、特に血液、血漿又は血清からＬＤＬ−又は／及びｖＬＤＬ−コ レステリン又は／及びＬｐ（ａ）−リボタンパク質を除去する方法。
  15. １５．請求項１〜１２のいずれかに記載の吸着物質を用いて、ＬＤＬ−及びｖＬ ＤＬ−コレステリン及びＬｐ（ａ）−リボタンパク質をクロマトグラフィーによ り分離し、かつ吸着物質からの溶離後にその濃度を自体公知の方法により測定す ることを特徴とする、水性液体、特に血液、血漿又は血清中のＬＤＬ−又は／及 びｖＬＤＬ−コレステリン又は／及びＬｐ（ａ）−リボタンパク質の濃度を測定 する方法。
  16. １６．溶離を、高分子の食塩溶液、グリセリン−水−混合物又は尿素溶液で実施 する、請求項１５に記載の方法。
  17. １７．水性液体、特に血液、血漿又は血清からＬＤＬ−又は／及びｖＬＤＬ−コ レステリン又は／及びＬｐ（ａ）−リボタンパク質を体外除去するために、請求 項１〜１２のいずれかに記載の吸着物質で充填されていて、かつその前面の末端 に、中央の供給−もしくは排出管を各々有する蓋が備えられている、円筒状の容 器から成ることを特徴とする、水性液体からＬＤＬ−又は／及びｖＬＤＬ−コレ ステリン又は／及びＬｐ（ａ）−リポプロティンを除去する装置。
  18. １８．容器は、直径３〜２０ｃｍ、殊に５〜１０ｃｍ及び長さ１〜４０ｃｍ、殊 に１０〜２０ｃｍを存する、請求項１７に記載の装置。
  19. １９．容器は、ガラス又はプラスチックから成る、請求項１７又は１８に記載の 装置。
  20. ２０．容器は、供給側の蓋に目幅１０〜３００μｍ、殊に２０〜１００μｍを有 する篩を有する、請求項１７、１８又は１９の１項に記載の装置。
  21. ２１．容器は、閉鎖循環で構成されていて、その中で液体はポンプにより還流さ れる、請求項１７から２０までのいずれか１項に記載の装置。
  22. ２２．吸着物質で充填され、かつ供給−もしくは排出管を有する蓋を備えたもう １つの円筒状の容器が循環中に存在する、請求項１７から２１までのいずれか１ 項に記載の装置。
JP50989991A 1990-06-12 1991-06-11 Ｌｐ（ａ）−リポタンパク質、ＬＤＬ−コレステリン及びｖＬＤＬ−コレステリンから選択された物質１種以上を選択的に除去するための物質、除去する方法、濃度を測定する方法及び体外除去する装置 Expired - Fee Related JP3378579B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4018778A DE4018778A1 (de) 1990-06-12 1990-06-12 Adsorptionsmaterial zur selektiven entfernung von ldl- oder/und vldl
DE4018778,0 1990-06-12
PCT/EP1991/001086 WO1991019565A1 (de) 1990-06-12 1991-06-11 ADSORPTIONSMATERIAL ZUR SELEKTIVEN ENTFERNUNG VON LDL ODER/UND vLDL

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JPH05507438A true JPH05507438A (ja) 1993-10-28
JP3378579B2 JP3378579B2 (ja) 2003-02-17

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JP50989991A Expired - Fee Related JP3378579B2 (ja) 1990-06-12 1991-06-11 Ｌｐ（ａ）−リポタンパク質、ＬＤＬ−コレステリン及びｖＬＤＬ−コレステリンから選択された物質１種以上を選択的に除去するための物質、除去する方法、濃度を測定する方法及び体外除去する装置

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Country Link
US (1) US5401415A (ja)
EP (1) EP0533727B1 (ja)
JP (1) JP3378579B2 (ja)
AT (1) ATE100354T1 (ja)
DE (2) DE4018778A1 (ja)
DK (1) DK0533727T3 (ja)
ES (1) ES2062795T3 (ja)
HK (1) HK1002495A1 (ja)
WO (1) WO1991019565A1 (ja)

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DE4300412A1 (de) * 1993-01-09 1994-07-14 Behringwerke Ag Hydrophobe Adsorbentien und ihre Verwendung zur Absorption von Lipoproteinen
AUPN030794A0 (en) * 1994-12-22 1995-01-27 Aruba International Pty Ltd Discontinuous plasma or serum delipidation
US5772874A (en) * 1995-11-02 1998-06-30 Cohesive Technologies, Inc. High performance liquid chromatography method and apparatus
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EP0533727B1 (de) 1994-01-19
JP3378579B2 (ja) 2003-02-17
DE4018778A1 (de) 1991-12-19
ATE100354T1 (de) 1994-02-15
EP0533727A1 (de) 1993-03-31
DE59100913D1 (de) 1994-03-03
US5401415A (en) 1995-03-28

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