JPH0549648B1 - - Google Patents
Info
- Publication number
- JPH0549648B1 JPH0549648B1 JP57503581A JP50358182A JPH0549648B1 JP H0549648 B1 JPH0549648 B1 JP H0549648B1 JP 57503581 A JP57503581 A JP 57503581A JP 50358182 A JP50358182 A JP 50358182A JP H0549648 B1 JPH0549648 B1 JP H0549648B1
- Authority
- JP
- Japan
- Prior art keywords
- cells
- lattice
- wound
- collagen
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/915—Method or apparatus for preparing biological material
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/315,234 US4418691A (en) | 1981-10-26 | 1981-10-26 | Method of promoting the regeneration of tissue at a wound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0549648B1 true JPH0549648B1 (enExample) | 1993-07-26 |
Family
ID=23223486
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57503581A Pending JPS58501772A (ja) | 1981-10-26 | 1982-10-26 | 遠心による繊維格子中への細胞の接種方法 |
| JP57503581A Pending JPH0549648B1 (enExample) | 1981-10-26 | 1982-10-26 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57503581A Pending JPS58501772A (ja) | 1981-10-26 | 1982-10-26 | 遠心による繊維格子中への細胞の接種方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4418691A (enExample) |
| EP (1) | EP0091953B1 (enExample) |
| JP (2) | JPS58501772A (enExample) |
| DE (1) | DE3268184D1 (enExample) |
| WO (1) | WO1983001385A1 (enExample) |
Families Citing this family (147)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458678A (en) * | 1981-10-26 | 1984-07-10 | Massachusetts Institute Of Technology | Cell-seeding procedures involving fibrous lattices |
| US4787900A (en) * | 1982-04-19 | 1988-11-29 | Massachusetts Institute Of Technology | Process for forming multilayer bioreplaceable blood vessel prosthesis |
| IL69719A0 (en) * | 1983-09-14 | 1983-12-30 | Yeda Res & Dev | Synthetic peptides with egf like activity |
| US4745098A (en) * | 1984-02-24 | 1988-05-17 | The Regents Of The University Of California | Compositions and method for improving wound healing |
| US4808570A (en) * | 1984-02-24 | 1989-02-28 | University Of California | Compositions and method for improving wound healing |
| US4837285A (en) * | 1984-03-27 | 1989-06-06 | Medimatrix | Collagen matrix beads for soft tissue repair |
| CA1295796C (en) * | 1984-03-27 | 1992-02-18 | Conrad Whyne | Biodegradable matrix and methods for producing same |
| GB8604360D0 (en) * | 1986-02-21 | 1986-03-26 | Univ Dundee | Stimulation of hair growth |
| US4760131A (en) * | 1986-04-23 | 1988-07-26 | Collagen Corporation | Wound-healing composition |
| US5273900A (en) * | 1987-04-28 | 1993-12-28 | The Regents Of The University Of California | Method and apparatus for preparing composite skin replacement |
| US4880429A (en) * | 1987-07-20 | 1989-11-14 | Stone Kevin R | Prosthetic meniscus |
| US5306311A (en) * | 1987-07-20 | 1994-04-26 | Regen Corporation | Prosthetic articular cartilage |
| US5116374A (en) * | 1989-03-02 | 1992-05-26 | Regen Corporation | Prosthetic meniscus |
| US5735902A (en) * | 1987-07-20 | 1998-04-07 | Regen Biologics, Inc. | Hand implant device |
| US5158574A (en) * | 1987-07-20 | 1992-10-27 | Regen Corporation | Prosthetic meniscus |
| US5108438A (en) * | 1989-03-02 | 1992-04-28 | Regen Corporation | Prosthetic intervertebral disc |
| US5263984A (en) * | 1987-07-20 | 1993-11-23 | Regen Biologics, Inc. | Prosthetic ligaments |
| US5007934A (en) * | 1987-07-20 | 1991-04-16 | Regen Corporation | Prosthetic meniscus |
| US5258043A (en) * | 1987-07-20 | 1993-11-02 | Regen Corporation | Method for making a prosthetic intervertebral disc |
| US5681353A (en) * | 1987-07-20 | 1997-10-28 | Regen Biologics, Inc. | Meniscal augmentation device |
| US4947840A (en) * | 1987-08-21 | 1990-08-14 | Massachusetts Institute Of Technology | Biodegradable templates for the regeneration of tissues |
| US5472702A (en) * | 1987-08-26 | 1995-12-05 | United States Surgical Corporation | Sterilization of growth factors |
| US5222978A (en) | 1987-08-26 | 1993-06-29 | United States Surgical Corporation | Packaged synthetic absorbable surgical elements |
| US5366081A (en) | 1987-08-26 | 1994-11-22 | United States Surgical Corporation | Packaged synthetic absorbable surgical elements |
| US5015584A (en) * | 1987-10-14 | 1991-05-14 | Board Of Regents, The University Of Texas System | Epidermal graft system |
| US5108428A (en) * | 1988-03-02 | 1992-04-28 | Minnesota Mining And Manufacturing Company | Corneal implants and manufacture and use thereof |
| US4925677A (en) * | 1988-08-31 | 1990-05-15 | Theratech, Inc. | Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents |
| CH676195A5 (enExample) * | 1988-10-07 | 1990-12-28 | Sulzer Ag | |
| US5008116A (en) * | 1988-11-14 | 1991-04-16 | Frederick Cahn | Immunostimulatory microsphere |
| US5693625A (en) * | 1989-03-09 | 1997-12-02 | Therapeutiques Substitutives | Method of regenerating cells and tissues using functionalized dextrans |
| US5376118A (en) * | 1989-05-10 | 1994-12-27 | United States Surgical Corporation | Support material for cell impregnation |
| US5359831A (en) | 1989-08-01 | 1994-11-01 | United States Surgical Corporation | Molded suture retainer |
| US5246104A (en) * | 1989-08-01 | 1993-09-21 | United States Surgical Corporation | Molded suture retainer |
| SG49267A1 (en) | 1989-08-14 | 1998-05-18 | Photogenesis Inc | Surgical instrument and cell isolation and transplantation |
| AU653499B2 (en) * | 1989-08-14 | 1994-10-06 | Photogenesis, Incorporated | Surgical instrument and cell isolation and transplantation |
| US6514238B1 (en) * | 1989-08-14 | 2003-02-04 | Photogenesis, Inc. | Method for preparation and transplantation of volute grafts and surgical instrument therefor |
| US5817075A (en) * | 1989-08-14 | 1998-10-06 | Photogenesis, Inc. | Method for preparation and transplantation of planar implants and surgical instrument therefor |
| BR9106354A (pt) * | 1990-04-24 | 1993-04-27 | Mark Eisenberg | Equivalente de pele viva composta,seu processo de preparacao; kit de teste,seu processo de preparacao,e processo de testar efeito de substancia sobre a pele |
| US5645591A (en) | 1990-05-29 | 1997-07-08 | Stryker Corporation | Synthetic bone matrix |
| CA2086014A1 (en) * | 1990-07-03 | 1992-01-04 | CHARLES D. kELMAN | Collagen-based viscoelastic solution for visco-surgery |
| US8067149B2 (en) * | 1990-09-12 | 2011-11-29 | Lifecell Corporation | Acellular dermal matrix and method of use thereof for grafting |
| US5206023A (en) * | 1991-01-31 | 1993-04-27 | Robert F. Shaw | Method and compositions for the treatment and repair of defects or lesions in cartilage |
| CA2059245C (en) * | 1991-02-08 | 2004-07-06 | Michael P. Chesterfield | Method and apparatus for calendering and coating/filling sutures |
| US5270300A (en) * | 1991-09-06 | 1993-12-14 | Robert Francis Shaw | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone |
| US6045791A (en) * | 1992-03-06 | 2000-04-04 | Photogenesis, Inc. | Retinal pigment epithelium transplantation |
| US5868728A (en) * | 1995-02-28 | 1999-02-09 | Photogenesis, Inc. | Medical linear actuator for surgical delivery, manipulation, and extraction |
| US5904716A (en) * | 1995-04-26 | 1999-05-18 | Gendler; El | Method for reconstituting cartilage tissue using demineralized bone and product thereof |
| US20040002772A1 (en) * | 1995-04-28 | 2004-01-01 | Organogenesis, Inc. | Tissue equivalents with perforations for improved integration to host tissues and methods for producing perforated tissue equivalents |
| US5780100A (en) * | 1995-05-18 | 1998-07-14 | Powderject Vaccines, Inc. | Method and apparatus for preparing sample cartridges for particle acceleration device |
| US5766584A (en) * | 1995-06-02 | 1998-06-16 | Massachusetts Institute Of Technology | Inhibition of vascular smooth muscle cell proliferation with implanted matrix containing vascular endothelial cells |
| US6146847A (en) * | 1996-11-01 | 2000-11-14 | Genespan Corporation | Stabilized transient gene expression |
| US5925053A (en) | 1997-09-02 | 1999-07-20 | Children's Medical Center Corporation | Multi-lumen polymeric guidance channel, method for promoting nerve regeneration, and method of manufacturing a multi-lumen nerve guidance channel |
| US6933326B1 (en) | 1998-06-19 | 2005-08-23 | Lifecell Coporation | Particulate acellular tissue matrix |
| US7662409B2 (en) | 1998-09-25 | 2010-02-16 | Gel-Del Technologies, Inc. | Protein matrix materials, devices and methods of making and using thereof |
| US7374777B2 (en) * | 1999-04-14 | 2008-05-20 | Collagen Matrix, Inc. | Oriented biopolymeric membrane for meningeal tissue repair |
| US8366787B2 (en) * | 2000-08-04 | 2013-02-05 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
| US6638312B2 (en) | 2000-08-04 | 2003-10-28 | Depuy Orthopaedics, Inc. | Reinforced small intestinal submucosa (SIS) |
| AU2001288458A1 (en) * | 2000-08-28 | 2002-03-13 | Collagenesis, Inc. | Methods for processing animal tissues |
| AUPR298901A0 (en) * | 2001-02-07 | 2001-03-08 | McComb Foundation, Inc., The | Cell suspension preparation technique and device |
| US7163563B2 (en) | 2001-07-16 | 2007-01-16 | Depuy Products, Inc. | Unitary surgical device and method |
| US8025896B2 (en) | 2001-07-16 | 2011-09-27 | Depuy Products, Inc. | Porous extracellular matrix scaffold and method |
| US7201917B2 (en) | 2001-07-16 | 2007-04-10 | Depuy Products, Inc. | Porous delivery scaffold and method |
| EP1416874A4 (en) | 2001-07-16 | 2007-04-18 | Depuy Products Inc | BIOLOGICAL / SYNTHETIC POROUS EXTRACELLULAR HYBRID MATRIX SCUFF |
| JP4197160B2 (ja) * | 2001-07-16 | 2008-12-17 | デピュイ・プロダクツ・インコーポレイテッド | 軟骨修復および再生用の支持骨格材料および方法 |
| US7819918B2 (en) * | 2001-07-16 | 2010-10-26 | Depuy Products, Inc. | Implantable tissue repair device |
| US8337537B2 (en) | 2001-07-16 | 2012-12-25 | Depuy Products, Inc. | Device from naturally occurring biologically derived materials |
| AU2002354911B2 (en) | 2001-07-16 | 2007-08-30 | Depuy Products, Inc. | Meniscus regeneration device and method |
| US20030104386A1 (en) * | 2001-08-31 | 2003-06-05 | The Regents Of The University Of California | Methods for the specific detection of redox-active tags and the use thereof for capillary gel electrophoresis and DNA sequencing |
| WO2006075986A1 (en) * | 2005-01-10 | 2006-07-20 | Macropore Biosurgery, Inc. | Devices and methods for monitoring, managing, and servicing medical devices |
| US9597395B2 (en) * | 2001-12-07 | 2017-03-21 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
| US7595043B2 (en) * | 2001-12-07 | 2009-09-29 | Cytori Therapeutics, Inc. | Method for processing and using adipose-derived stem cells |
| US7771716B2 (en) | 2001-12-07 | 2010-08-10 | Cytori Therapeutics, Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
| US7651684B2 (en) * | 2001-12-07 | 2010-01-26 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in augmenting autologous fat transfer |
| US8404229B2 (en) * | 2001-12-07 | 2013-03-26 | Cytori Therapeutics, Inc. | Methods of using adipose derived stem cells to treat acute tubular necrosis |
| US8105580B2 (en) | 2001-12-07 | 2012-01-31 | Cytori Therapeutics, Inc. | Methods of using adipose derived stem cells to promote wound healing |
| US20050095228A1 (en) | 2001-12-07 | 2005-05-05 | Fraser John K. | Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders |
| CN1630526B (zh) * | 2001-12-07 | 2010-05-05 | 马克罗珀尔生物外科公司 | 用加工的脂肪抽吸细胞来治疗患者的系统和方法 |
| US7585670B2 (en) | 2001-12-07 | 2009-09-08 | Cytori Therapeutics, Inc. | Automated methods for isolating and using clinically safe adipose derived regenerative cells |
| US8394371B2 (en) | 2002-02-11 | 2013-03-12 | Neocutis Sa | Compositions for the treatment of skin conditions, disorders or diseases and methods of making and using the same |
| US7189245B2 (en) * | 2002-02-14 | 2007-03-13 | Photogenesis, Inc. | Subretinal implantation device and surgical cannulas for use therewith |
| EP1528894B1 (en) | 2002-04-29 | 2015-06-03 | Gel-Del Technologies, Inc. | Biomatrix structural containment and fixation systems |
| US20040054414A1 (en) * | 2002-09-18 | 2004-03-18 | Trieu Hai H. | Collagen-based materials and methods for augmenting intervertebral discs |
| US7309359B2 (en) * | 2003-08-21 | 2007-12-18 | Warsaw Orthopedic, Inc. | Allogenic/xenogenic implants and methods for augmenting or repairing intervertebral discs |
| JP2005538810A (ja) * | 2002-09-18 | 2005-12-22 | エスディージーアイ・ホールディングス・インコーポレーテッド | 天然組織デバイスおよび移植方法 |
| US7744651B2 (en) | 2002-09-18 | 2010-06-29 | Warsaw Orthopedic, Inc | Compositions and methods for treating intervertebral discs with collagen-based materials |
| GB0224986D0 (en) | 2002-10-28 | 2002-12-04 | Smith & Nephew | Apparatus |
| CN100394989C (zh) | 2002-11-15 | 2008-06-18 | 华沙整形外科股份有限公司 | 包含微粒状基于胶原材料的组合物的制药应用和包含所述组合物的滑膜关节 |
| US8465537B2 (en) * | 2003-06-17 | 2013-06-18 | Gel-Del Technologies, Inc. | Encapsulated or coated stent systems |
| US8153591B2 (en) | 2003-08-26 | 2012-04-10 | Gel-Del Technologies, Inc. | Protein biomaterials and biocoacervates and methods of making and using thereof |
| US20050055085A1 (en) * | 2003-09-04 | 2005-03-10 | Rivron Nicolas C. | Implantable medical devices having recesses |
| GB0325126D0 (en) | 2003-10-28 | 2003-12-03 | Smith & Nephew | Apparatus with heat |
| GB0325130D0 (en) | 2003-10-28 | 2003-12-03 | Smith & Nephew | Apparatus with scaffold |
| US7909805B2 (en) | 2004-04-05 | 2011-03-22 | Bluesky Medical Group Incorporated | Flexible reduced pressure treatment appliance |
| US8062272B2 (en) | 2004-05-21 | 2011-11-22 | Bluesky Medical Group Incorporated | Flexible reduced pressure treatment appliance |
| US10058642B2 (en) | 2004-04-05 | 2018-08-28 | Bluesky Medical Group Incorporated | Reduced pressure treatment system |
| US7569233B2 (en) | 2004-05-04 | 2009-08-04 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
| WO2005115259A2 (en) * | 2004-05-24 | 2005-12-08 | Biomedical Strategies | Wound closure system and methods |
| US20060058238A1 (en) * | 2004-09-15 | 2006-03-16 | Lee Laurent-Applegate | Fetal skin cell protein compositions for the treatment of skin conditions, disorders or diseases and methods of making and using the same |
| AU2005286755A1 (en) * | 2004-09-21 | 2006-03-30 | Massachusetts Institute Of Technology | Gradient scaffolding and methods of producing the same |
| JP2006101986A (ja) * | 2004-10-01 | 2006-04-20 | Olympus Corp | 球状セラミックス粒子の製造方法、細胞の播種方法および生体組織補填体の製造方法 |
| US7513866B2 (en) | 2004-10-29 | 2009-04-07 | Depuy Products, Inc. | Intestine processing device and associated method |
| CN102772824A (zh) * | 2004-12-08 | 2012-11-14 | 渗透治疗有限公司 | 增强血管通路的方法和组合物 |
| US7354627B2 (en) | 2004-12-22 | 2008-04-08 | Depuy Products, Inc. | Method for organizing the assembly of collagen fibers and compositions formed therefrom |
| US7759120B2 (en) * | 2005-03-02 | 2010-07-20 | Kps Bay Medical, Inc. | Seeding implantable medical devices with cells |
| US20060199265A1 (en) * | 2005-03-02 | 2006-09-07 | Wolf Michael F | Seeding implantable medical devices with cells |
| CA2605080A1 (en) | 2005-04-21 | 2006-11-02 | Massachusetts Institute Of Technology | Materials and methods for altering an immune response to exogenous and endogenous immunogens, including syngeneic and non-syngeneic cells, tissues or organs |
| CN101878757A (zh) * | 2005-06-21 | 2010-11-10 | 渗透治疗有限公司 | 用于增强血管通路的方法和组合物 |
| US7595062B2 (en) | 2005-07-28 | 2009-09-29 | Depuy Products, Inc. | Joint resurfacing orthopaedic implant and associated method |
| US20070100323A1 (en) * | 2005-10-31 | 2007-05-03 | Ludwig Florian N | Facilitation of endothelialization by in situ surface modification |
| US20070112360A1 (en) * | 2005-11-15 | 2007-05-17 | Patrick De Deyne | Bioprosthetic device |
| US20100204783A1 (en) * | 2005-12-06 | 2010-08-12 | Helen Marie Nugent | Methods and compositions for enhancing vascular access |
| US8338402B2 (en) * | 2006-05-12 | 2012-12-25 | Smith & Nephew Plc | Scaffold |
| US8118779B2 (en) | 2006-06-30 | 2012-02-21 | Warsaw Orthopedic, Inc. | Collagen delivery device |
| US8399619B2 (en) | 2006-06-30 | 2013-03-19 | Warsaw Orthopedic, Inc. | Injectable collagen material |
| EP2081528B1 (en) * | 2006-09-26 | 2018-11-14 | T.J. Smith & Nephew, Limited | Lattice dressing |
| US9820888B2 (en) | 2006-09-26 | 2017-11-21 | Smith & Nephew, Inc. | Wound dressing |
| SG176460A1 (en) * | 2006-11-07 | 2011-12-29 | Pervasis Therapeutics Inc | Materials and methods for treating and managing angiogenesis-mediated diseases |
| US7871440B2 (en) | 2006-12-11 | 2011-01-18 | Depuy Products, Inc. | Unitary surgical device and method |
| ATE545441T1 (de) * | 2007-06-13 | 2012-03-15 | Pervasis Therapeutics Inc | Verfahren und vorrichtungen zur minimal invasiven abgabe von zellhaltigen fliessfähigen zusammensetzungen |
| US8282963B2 (en) * | 2007-10-15 | 2012-10-09 | The Regents Of The University Of Colorado, A Body Corporate | Methods for extracting platelets and compositions obtained therefrom |
| EP2237770A4 (en) | 2007-12-26 | 2011-11-09 | Gel Del Technologies Inc | BIOCOMPATIBLE PROTEIN PARTICLES, PARTICLE DEVICES AND METHODS THEREOF |
| US20090192554A1 (en) | 2008-01-29 | 2009-07-30 | Confluent Surgical, Inc. | Bioabsorbable block copolymer |
| WO2010021993A1 (en) | 2008-08-19 | 2010-02-25 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease |
| US10016534B2 (en) | 2008-11-17 | 2018-07-10 | Gel-Del Technologies, Inc. | Protein biomaterial and biocoacervate vessel graft systems and methods of making and using thereof |
| US7982087B2 (en) * | 2009-01-09 | 2011-07-19 | Smith & Nephew, Inc. | Wound dressing |
| GB0902368D0 (en) | 2009-02-13 | 2009-04-01 | Smith & Nephew | Wound packing |
| JP5917392B2 (ja) | 2009-05-01 | 2016-05-11 | ビミニ テクノロジーズ リミテッド ライアビリティ カンパニー | 組織及び細胞富化グラフトを最適化するシステム、方法及び組成物 |
| TWI401098B (zh) * | 2010-09-09 | 2013-07-11 | Univ China Medical | 傷口敷料 |
| US9677042B2 (en) | 2010-10-08 | 2017-06-13 | Terumo Bct, Inc. | Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
| AU2013205148B2 (en) | 2013-03-14 | 2014-10-30 | AVITA Medical Americas, LLC | Systems and methods for tissue processing and preparation of cell suspension therefrom |
| US9617506B2 (en) | 2013-11-16 | 2017-04-11 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
| WO2015148704A1 (en) | 2014-03-25 | 2015-10-01 | Terumo Bct, Inc. | Passive replacement of media |
| JP6830059B2 (ja) | 2014-09-26 | 2021-02-17 | テルモ ビーシーティー、インコーポレーテッド | スケジュール化された細胞フィーディング |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| EP3464565A4 (en) | 2016-05-25 | 2020-01-01 | Terumo BCT, Inc. | CELL EXPANSION |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| EP4162886B1 (en) * | 2016-10-28 | 2025-01-29 | The General Hospital Corporation | Methods for assembling tissue grafts |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| JP7393945B2 (ja) | 2017-03-31 | 2023-12-07 | テルモ ビーシーティー、インコーポレーテッド | 細胞増殖 |
| CN108379661B (zh) * | 2018-05-25 | 2024-01-23 | 中国人民解放军总医院 | 利用离心种植构建组织工程膀胱的方法 |
| JP2022059393A (ja) * | 2020-10-01 | 2022-04-13 | 国立大学法人横浜国立大学 | 組織体の製造方法及び組織体を用いた疾患の治療方法 |
| WO2022204315A1 (en) | 2021-03-23 | 2022-09-29 | Terumo Bct, Inc. | Cell capture and expansion |
| US12152699B2 (en) | 2022-02-28 | 2024-11-26 | Terumo Bct, Inc. | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
| CN120603927A (zh) | 2022-12-27 | 2025-09-05 | 埃维塔医疗美国有限责任公司 | 自动制备再生表皮悬浮液的系统及其相关使用方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55501130A (enExample) * | 1978-12-26 | 1980-12-18 | ||
| JPS58501817A (ja) * | 1981-10-26 | 1983-10-27 | マサチユ−セツツ・インステチユ−ト・オブ・テクノロジ− | 細胞を接種した繊維格子 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3955012A (en) * | 1970-08-06 | 1976-05-04 | Zaidan Hojin, Seisan Kaihatsu Kagaku Kenkyusho | Method for manufacturing medical articles composed of silicone rubber coated with collagen |
| US3826678A (en) * | 1972-06-06 | 1974-07-30 | Atomic Energy Commission | Method for preparation of biocompatible and biofunctional materials and product thereof |
| US4280954A (en) * | 1975-07-15 | 1981-07-28 | Massachusetts Institute Of Technology | Crosslinked collagen-mucopolysaccharide composite materials |
| US4352883A (en) * | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
| FR2461002A1 (fr) * | 1979-07-13 | 1981-01-30 | Inst Nat Sante Rech Med | Procede pour stimuler la croissance des cellules d'epiderme humain et produits faisant application dudit procede |
| US4326532A (en) * | 1980-10-06 | 1982-04-27 | Minnesota Mining And Manufacturing Company | Antithrombogenic articles |
-
1981
- 1981-10-26 US US06/315,234 patent/US4418691A/en not_active Expired - Lifetime
-
1982
- 1982-10-26 JP JP57503581A patent/JPS58501772A/ja active Pending
- 1982-10-26 DE DE8282903565T patent/DE3268184D1/de not_active Expired
- 1982-10-26 WO PCT/US1982/001514 patent/WO1983001385A1/en not_active Ceased
- 1982-10-26 JP JP57503581A patent/JPH0549648B1/ja active Pending
- 1982-10-26 EP EP82903565A patent/EP0091953B1/en not_active Expired
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55501130A (enExample) * | 1978-12-26 | 1980-12-18 | ||
| JPS58501817A (ja) * | 1981-10-26 | 1983-10-27 | マサチユ−セツツ・インステチユ−ト・オブ・テクノロジ− | 細胞を接種した繊維格子 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1983001385A1 (en) | 1983-04-28 |
| EP0091953B1 (en) | 1985-12-27 |
| EP0091953A1 (en) | 1983-10-26 |
| US4418691A (en) | 1983-12-06 |
| DE3268184D1 (en) | 1986-02-06 |
| JPS58501772A (ja) | 1983-10-20 |
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