JPH05279240A - Cosmetic - Google Patents

Abstract

PURPOSE:To obtain a stable cosmetic having excellent improving effects on skin roughening by blending EPA and/or DHA or fats and oils containing them therein. CONSTITUTION:The objective cosmetic is obtained by blending eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) or fats and oils containing them and one or two or more compounds selected from hyaluronic acid or its salt, collagen and elastin.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to cosmetics, and more particularly to cosmetics having an excellent effect of improving rough skin.

[0002]

2. Description of the Related Art Allantoin, aloe extract, ginseng extract, placenta extract, bovine blood deproteinate, fermented metabolites, etc. are known as medicinal ingredients conventionally used for improving rough skin. .. However, cosmetics containing these medicinal components cannot obtain sufficient effects, and development of cosmetics having more excellent action has been desired.

On the other hand, anti-inflammatory action and anti-allergic action ("Oil Chemistry", 37, p9, (1988), "Oil Chemistry", 40,
As a compound having p203, (1991)) or the like, an oil and fat containing eicosapentaenoic acid (hereinafter abbreviated as “EPA”) and docosahexaenoic acid (hereinafter abbreviated as “DHA”) has attracted attention. It has long been known that EPA and DHA are contained in fish oil in a large amount and have pharmacological effects such as thrombus prevention activity and arteriosclerosis prevention activity. Further, in recent years, it has been found that local administration has a vasomotor and vasodilatory effect (Japanese Patent Application Laid-Open No. HEI-2).
-48528).

[0004]

DISCLOSURE OF THE INVENTION The present inventors have found that EPA
Attention was paid to the above-mentioned action of DHA and DHA, and an attempt was made to mix it with a cosmetic, particularly a cosmetic having an effect of improving skin roughness. However, when EPA, DHA or fats and oils containing them are blended alone, the effect of improving skin roughness cannot be said to be sufficient, and due to the influence of other bases, these inherent effects are fully exerted. The reality is that it cannot be done.

Further, for the purpose of obtaining a higher effect, EPA
And / or DHA or fats and oils containing this has a limited effect when mixed at a high concentration, and conversely,
There is also a problem that due to the generation of unique colors and odors possessed by these compounds themselves, there is a limitation in terms of product amount and formulation.

[0006]

In view of the above-mentioned circumstances, the inventors of the present invention have conducted diligent research so as to sufficiently bring out the action of EPA and / or DHA or fats and oils containing the same. As a result, they have found that by combining these with a specific compound, an excellent effect of improving rough skin can be stably and synergistically achieved, and the present invention has been completed.

That is, the present invention relates to EPA and / or D
It is intended to provide a cosmetic containing HA or an oil or fat containing the same and one or more compounds selected from hyaluronic acid or a salt thereof, collagen and elastin.

As described above, EPA and / or DHA are unsaturated fatty acids contained in a large amount in fish oils such as sardine oil, saury oil, herring oil, mackerel oil and cod oil. For example, sardine oil contains about 16% EPA, about 8.4% DHA, and saury oil contains about 4.9% EPA and about 1 DHA.
0.5%, mackerel oil about EPA 8.1%, DHA about 1
0.6%, cod oil EPA about 13.3%, DHA about 1
3.7% each is included.

The EPA and / or DHA or fats and oils containing the same used in the present invention may be obtained by separating and purifying fish oil by a conventional method, but EPA obtained by simply extracting fish oil. Oils and fats containing DHA and / or DHA may be used. The method for extracting fish oil is not particularly limited, and a known method such as a critical gas extraction method, a molecular distillation method, a liquid chromatography method, or the like can be adopted as a method for extracting fats and oils.

The fats and oils containing EPA and / or DHA may be blended as they are with the cosmetic composition of the present invention, or may be refined by steam distillation, activated carbon treatment, acid clay treatment or the like.

The content of EPA and / or DHA in the cosmetic composition of the present invention is 0.0001 to 10% by weight (hereinafter simply referred to as "%"), and more preferably 0.01 to 10.
5%. When using a low-purity oil or fat of EPA and / or DHA, the content of EPA and / or DHA may be within the above range.

The content of EPA and / or DHA is 0.
If it is less than 0001%, a sufficient effect may not be obtained, and even if it exceeds 10%, no further increase in the effect is observed. Instead, depending on the coloring, the generation of odor, and the dosage form. Problems such as precipitation may occur on the product side.

On the other hand, hyaluronic acid or a salt thereof, collagen and elastin, which are other essential components in the present invention, are all components of the skin and are components that have been conventionally blended in cosmetics.

The origin of each of these components is not particularly limited, and may be animal-derived, microbial-derived, or synthetic. In addition, there are no particular restrictions on the extraction method and purification method in the case of natural origin.

In the present invention, examples of hyaluronic acid or a salt thereof used include umbilical cord, chicken gooseberry, animal skin, ocular glass band, and a molecular weight of 10 obtained by subjecting a culture of a microorganism to an extraction treatment. 1 million to 3 million and their sodium, potassium, basic amino acid salts, etc., and examples of collagen include subjecting skin tissue of cattle or pigs to extraction treatment or hydrolyzing it. Soluble collagen obtained by the method described above or a product obtained by further subjecting this to a treatment such as succinylation.
Furthermore, as an example of elastin, a molecular weight of 10,000 to 5 obtained by hydrolyzing elastin purified from bovine nuchal ligament
Examples include, 000,000 of soluble elastin and the like.

The content of these compounds in the cosmetic of the present invention is generally 0.0001 to 5%, preferably 0.001.
~ 3%. The content of these compounds is 0.0001%
If it is less than the above range, a sufficient effect may not be obtained, and even if it exceeds 5%, the effect is almost constant and the increase is not observed.

According to a conventional method, the cosmetic composition of the present invention usually contains EPA and / or DHA as essential components or oils or fats containing them and hyaluronic acid or a salt thereof, and one or more kinds of collagen and elastin. It can be prepared by blending with various types of bases known as cosmetics.

The form of the cosmetic is not particularly limited, and it may be a cosmetic such as emulsion, cream, lotion, pack, dispersion, and cleaning agent. The base of the cosmetic is Bases depending on the form of these cosmetics, for example,
Purified water, lower alcohols, polyhydric alcohols, oils and fats, surfactants, various cosmetic ingredients, ultraviolet absorbers, thickeners, pigments, preservatives, fragrances and the like can be used.

[0019]

EXAMPLES Next, the present invention will be described in more detail by way of examples, which should not be construed as limiting the invention thereto.

Examples 1 to 2 Emulsion: An emulsion was prepared by the composition shown in Table 1 and the following production method, and its rough skin improving action was examined by the following method. The results are shown in Table 2.

(Composition) Table 1 ───────────────────────────────────── Actual Example Comparison Example component (%) ─────────────────────── 1 2 1 2 3 4 ──────────────── ───────────────────── (1) Squalane 5.0 5.0 5.0 5.0 5.0 5.0 5.0 (2) Vaseline 2.0 2.0 2.0 2.0 2.0 2.0 (3) Beeswax 0.5 0.5 0.5 0.5 0.5 0.5 0.5 (4) Sorbitan sesqui 0.8 0.8 0.8. 8 0.8 0.8 0.8 Oleic acid ester (5) Polyoxyethylene oleyl ether 1.2 1.2 1.2 1.2 1.2 1.2 1.2 (20 EO) (6) 1, 3-butylene 5.0 5.0 5.0 5.0 5.0 5.0 glycol ^{(7) EPA * 0.1 0.1 0.1} - - - (8) hyaluronic acid ^** 0. 1 - - 0.01 - - (9) collagen ^*** - 0.01 - - 0.01 - (10) Ethyl alcohol 5.0 5.0 5.0 5.0 5.0 5.0 (11 ) Preservatives 0.2 0.2 0.2 0.2 0.2 0.2 (12) Fragrances 0.1 0.1 0.1 0.1 0.1 0.1 0.1 (13) Xanthan gum 20 0.0 20.0 20.0 20.0 20.0 20.0 (2% aqueous solution) (14) Purified water Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount ─────────── ────────────────────────── * Kurita Water Industries Co., Ltd. ** Bio-hyaluronic acid solution [Nikko Chemicals Co., Ltd.]
Made] *** Atelocollagen SS [made by Koken Co., Ltd.]

(Production Method) A. Components (6), (8) to (10) and (14) are heated and mixed at 70 ° C.
Keep on. B. Components (1) to (5), (7), (11) and (12) are heated and mixed,
Keep at 70 ° C. C. The above B was added to the above A and mixed, and the component (13) was added to uniformly emulsify, and the mixture was cooled to 30 ° C. to obtain an emulsion.

(Test method) Female 3 to 30 years old 3
A panel of 0 persons was used to observe the skin condition on the day before skiing with a microscope camera, and the score was calculated according to the following criteria. The skin condition score was also obtained one day after returning from skiing. After that, the test emulsion was applied twice after washing the face twice in the morning and at night every day for 7 days.
Then, after 3, 5 and 7 days of skiing, the skin condition score was obtained in the same manner as above.

Skin condition score: [score] [condition] 1 The skin groove of the skin is unclear and peeling of the keratin is observed. 2 The skin groove on the skin is slightly blurred or unidirectional. 3 Skin folds are visible, but shallow or unidirectional. 4 Skin crevices are observed or are slightly mesh-like. 5 Skin crevices are clearly visible or have a clean mesh.

(Results) Table 2 ──────────────────────────────────── Test milk emulsion The day before 1 day 3 days 5 days 7 days ─────────────────────────────────── Example 1 3.32 1 .94 2.50 3.01 3.90 2 3.30 1.80 2.42 2.94 3.70 Comparative Example 1 3.50 1.95 2.20 2.60 3.05 2 3.29 1.94 2.12 2.30 2.50 3 3.42 2.02 2.16 2.30 2.47 4 3.25 1.95 2.08 2.15 2.30 ────── ─────────────────────────────

As is clear from the results in Table 2, Example 1 in which EPA and hyaluronic acid were combined and Example 2 in which EPA and collagen were combined did not include Comparative Products 1 to 3 in which each of them was blended alone, and those Compared with the comparative product 4, it showed a remarkable rough skin improving effect.

Example 3 to 4 cream: A cream was prepared by the composition shown in Table 3 and the following production method, and its skin-beautifying effect was examined. The results are shown in Table 4.

[0028] * Made by Serdary Research Lab. Inc. ** Hyaluronic acid Q-3-AQ [made by QP Corporation] *** Error Shan [made by Sansho Pharmaceutical Co., Ltd.]

(Production Method) A. Components (1) to (7), (8), (11) and (12) are mixed and heated to 70 ° C. B. Mix components (9), (10) and (13) and heat to 70
Keep at ℃. C. B was added to A, mixed and cooled to obtain a cream.

(Test method) Female 1 aged 26 to 52
A panel of 5 people was applied twice daily in the morning and at night twice on the face for 12 weeks, and then an appropriate amount of the test cream was applied to the face.
The skin beautifying effect of the application was evaluated according to the following criteria.

Skin beautifying effect: [Evaluation] [Content] Effectiveness The dullness of the skin became inconspicuous. Somewhat effective The dullness of the skin has become less noticeable. No effect No change from before use.

[0032] As is clear from the results in Table 4, the creams of Examples 3 and 4 were effective in preventing and improving the occurrence of "dullness" on the skin, and the skin-beautifying effect was recognized.

Example 5 Cosmetic water: <Formulation> (%) (1) Glycerin 5.0 (2) 1,3-butylene glycol 6.5 (3) Polyoxyethylene sorbitan 1.2 Monolauric acid ester ( 20E.O.) (4) Ethyl alcohol 8.0 (5) EPA ^* 1.0 (6) Collagen ^** 0.5 (7) Preservative A suitable amount (8) Perfume suitable amount (9) Refining Water balance * Kurita Water Industries Co., Ltd. ** Atelocollagen SS [Koken Co., Ltd.]

(Production Method) A. Components (3), (4), (5), (7) and (8) are mixed and dissolved. B. Components (1), (2), (6) and (9) are mixed and dissolved. C. The above A and B were mixed to make uniform, and lotion was obtained.

Example 6 Pack: <Prescription> (%) (1) Polyvinyl alcohol 20.0 (2) Ethyl alcohol 20.0 (3) Glycerin 5.0 (4) Kaolin 6.0 (5) Sardine extract oil and fat 0.05 (6) Hyaluronic acid ^* 0.01 (7) Preservative 0.2 (8) Fragrance 0.05 (9) Refined water balance * Bio hyaluronic acid liquid [Nikko Chemicals Co., Ltd. ) Made]

(Production Method) A. Components (1), (3), (4), (6) and (9) are mixed, heated to 70 ° C. and stirred. B. Mix components (2), (5), (7) and (8). C. The above B was added to the above A, mixed and cooled to obtain a pack.

Example 7 Cleaning agent: <Prescription> (%) (1) Stearic acid 10.0 (2) Palmitic acid 8.0 (3) Myristic acid 12.0 (4) Lauric acid 4.0 ( 5) Oleyl alcohol 1.5 (6) Purified lanolin 1.0 (7) Perfume 0.1 (8) Preservative 0.2 (9) Glycerin 18.0 (10) Potassium hydroxide 6.0 (11) ) Oil and fat extracted from saury 0.5 (12) hyaluronic acid ^* 0.05 (13) purified water residual amount * bio-hyaluronic acid solution [manufactured by Nikko Chemicals Co., Ltd.]

(Production Method) A. Components (9), (10) and (13) were mixed to obtain 70
Heat to ℃. B. Components (1) to (6), (8) and (11) are mixed and heated to 70 ° C. C. The above B was added to the above A, the temperature was kept at 70 ° C. for a while, and after the saponification reaction was completed, the mixture was cooled to 50 ° C., (7) and (12).
Was added and cooled to obtain a cleaning agent.

[0039]

According to the present invention, EPA and / or DH
By mixing A or oils and fats containing this, a cosmetic having a stable and excellent effect of improving rough skin can be obtained.

Claims (1)

[Claims] 1. A cosmetic comprising eicosapentaenoic acid and / or docosahexaenoic acid or an oil or fat containing the same, and one or more compounds selected from hyaluronic acid or a salt thereof, collagen and elastin.