JPH05252896A - Formulated liquid nutritive food for patient with nephropathy - Google Patents
Formulated liquid nutritive food for patient with nephropathyInfo
- Publication number
- JPH05252896A JPH05252896A JP4086105A JP8610592A JPH05252896A JP H05252896 A JPH05252896 A JP H05252896A JP 4086105 A JP4086105 A JP 4086105A JP 8610592 A JP8610592 A JP 8610592A JP H05252896 A JPH05252896 A JP H05252896A
- Authority
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- composition
- energy
- per
- fermented milk
- whey
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Dairy Products (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Jellies, Jams, And Syrups (AREA)
Abstract
Description
【0001】[0001]
【産業上の利用分野】本発明は、発酵乳より乳清を除い
た成分を含有する組成物に関するものである。本発明に
係る組成物は、腎機能が低下した患者に対して必要な栄
養素を腎臓に負担をかけることなく供給することができ
るので、医薬タイプで使用するほか、飲料、食品、栄養
食品、機能性食品、特定保健用食品、ドリンク剤等飲食
品タイプで使用し、腎臓病患者のみならず、腎機能の低
下した病弱者、病後の人、また、高齢の健常人に対して
も広く使用できるものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition containing a component obtained by removing whey from fermented milk. The composition according to the present invention can supply necessary nutrients to a patient with reduced renal function without burdening the kidney, and thus is used in a pharmaceutical type as well as a beverage, a food, a nutritional food, and a function. It can be used not only in patients with kidney disease but also in sick people with impaired renal function, people after illness, and elderly healthy people, as well as sex foods, foods for specified health uses, drinks, etc. It is a thing.
【0002】[0002]
【従来の技術】腎臓病患者用の飲食品は、医学的見地よ
り腎臓に負担をかけるたんぱく質およびミネラルが低減
された食品成分によって構成される。しかし、たんぱく
質およびミネラルとも生体にとって必須成分であるため
最低必要量は摂取しなければならない。しかも、腎臓病
患者用の食餌成分は、生体維持のためエネルギーを確保
しながらたんぱく質、脂肪、炭水化物の三大栄養素を始
めとするビタミンおよびミネラルの各成分が過不足のな
い組成で、しかも吸収され易い良質の成分で構成されな
ければならないため、一般の食品で理想的な腎臓病患者
用の飲食品を構成することは非常に難しい。また、摂取
時にその都度調製する必要がなくそのままの状態で飲用
できる液状の腎臓病患者用の飲食品がないのが現状であ
る。もとより、そのための医薬品も現時点では知られて
いない。2. Description of the Related Art Foods and drinks for patients with kidney disease are composed of food components which are reduced in proteins and minerals which impose stress on the kidneys from a medical point of view. However, since protein and minerals are essential components for the living body, the minimum required amount must be taken. Moreover, dietary components for kidney disease patients are absorbed in a composition that does not have excess or deficiency of each component of vitamins and minerals including three major nutrients of protein, fat and carbohydrate while securing energy to maintain the living body. Since it has to be composed of easy-to-use high-quality ingredients, it is very difficult to compose an ideal food and drink for kidney disease patients with general foods. In addition, there is no liquid food and drink for kidney disease patients, which does not need to be prepared each time when ingested and can be taken as it is. Of course, no drug for that purpose is known at this time.
【0003】[0003]
【発明が解決しようとする課題】本発明は、このような
現状に鑑みて、腎臓に過剰の負担をかけない栄養素で構
成された理想的な組成物、しかも腎臓病患者のみなら
ず、腎臓の弱い人、腎機能の低下した病弱者、及び高齢
の健常人に対しても広く使用することのできるすぐれた
組成物を開発する目的でなされたものである。SUMMARY OF THE INVENTION In view of the above situation, the present invention is an ideal composition composed of nutrients that does not impose an excessive burden on the kidney, and is not limited to patients with kidney disease but also kidneys. It was made for the purpose of developing an excellent composition that can be widely used for weak people, sick people with deteriorated renal function, and elderly healthy people.
【0004】[0004]
【課題を解決するための手段】上記目的を達成するため
各方面から検討した結果、たんぱく質源として制限アミ
ノ酸がなくアミノ酸スコアが100である栄養価の高い
発酵乳を使用し、しかも摂取が制限されるミネラル類は
乳清として除去することにより低減させた発酵乳が得ら
れることをはじめて発見した。そして、腎臓病患者用の
飲食品はたんぱく質及びミネラルが制限されることが重
要であることに鑑み、上記した乳清除去発酵乳にはじめ
て注目した。[Means for Solving the Problems] To achieve the above object, as a result of various studies, fermented milk with high nutritional value, which has no limiting amino acids and an amino acid score of 100, is used as a protein source, and its intake is restricted. It was discovered for the first time that fermented milk with reduced minerals can be obtained by removing whey minerals as whey. In view of the importance of limiting proteins and minerals in foods and drinks for kidney disease patients, the above-mentioned whey-removed fermented milk was first noted.
【0005】ここで腎臓病患者は、たんぱく質およびミ
ネラルを制限する中でエネルギーを確保しながら必須栄
養成分を摂取しなければならないとの観点より、その組
成物の配合割合は、一般に飲食品のエネルギー100k
calあたり含量によって表される。[0005] Here, from the viewpoint that a renal disease patient must take essential nutrients while securing energy while limiting protein and minerals, the composition ratio of the composition is generally the energy of food and drink. 100k
Represented by content per cal.
【0006】そして各方面から更に検討を行った結果、
発酵乳より乳清を除いた成分が腎臓病患者用飲食品のた
んぱく質源として極めて有効であるとの知見を得、この
新知見を基礎として更に研究を重ねた結果、遂に本発明
の完成に至ったものであって、本発明は、乳清除去発酵
乳を含有する組成物を基本的技術思想としてなるもので
ある。以下、本発明について詳述する。[0006] As a result of further study from various directions,
We obtained the finding that the components obtained by removing whey from fermented milk are extremely effective as a protein source for food and drink for patients with kidney disease, and as a result of further research based on this new finding, the present invention finally came to completion. The present invention is based on a basic technical idea of a composition containing whey-removed fermented milk. Hereinafter, the present invention will be described in detail.
【0007】本発明に係る組成物において、たんぱく質
としては発酵乳より乳清を除いた成分を使用する点が重
要な特徴のひとつであるが、該成分の内、特に発酵乳よ
り乳清を除いた成分含量が組成物のエネルギー100k
calあたり1〜12g、たんぱく質含量が組成物のエ
ネルギー100kcalあたり0.2〜1.5g配合す
ると有効であることをつきとめた。しかも発酵乳より乳
清を除くことにより同時に乳糖を組成物のエネルギー1
00kcalあたり0.01〜0.2gに低減されるこ
とが判明し、乳糖不耐症の腎臓病患者にも有効であるこ
とが確認された。[0007] In the composition according to the present invention, one of the important characteristics is that a component obtained by removing whey from fermented milk is used as the protein. Among these components, especially whey is removed from fermented milk. Energy of composition is 100k
It was found that 1 to 12 g per cal and a protein content of 0.2 to 1.5 g per 100 kcal energy of the composition were effective. Moreover, by removing the whey from the fermented milk, lactose is simultaneously added to the energy of the composition.
It was found to be reduced to 0.01 to 0.2 g per 00 kcal, and it was confirmed that it is also effective for lactose intolerant kidney disease patients.
【0008】また、本発明に係る組成物は医薬品タイプ
のほか飲食品タイプとしても使用するものであるが、後
者の場合は栄養、カロリー面のみでなく飲食しやすいこ
と、つまり嗜好性に関する要件も更に必要となる。そこ
でこの点について鋭意検討の結果、糖分の使用が好適で
ある点もつきとめた。糖分としては、天然及び人工の糖
分が広く単用ないし複数併用することができるが、特に
三大栄養素の一つであり栄養価の高い炭水化物として蜂
蜜を加えることにより患者に不快感を与えない組成物を
構成できることを確認し、その蜂蜜含量が組成物のエネ
ルギー100kcalあたり2〜20g配合すると有効
であることをつきとめた。Further, the composition according to the present invention is used not only as a pharmaceutical type but also as a food and drink type. In the latter case, not only nutrition and calorie aspects but also ease of eating and drinking, that is, a requirement regarding palatability is also required. Further required. Therefore, as a result of earnestly studying this point, it was found that the use of sugar is preferable. As sugars, natural and artificial sugars can be widely used alone or in combination, but a composition that does not cause discomfort to patients by adding honey as one of the three major nutrients and a highly nutritious carbohydrate It was confirmed that the honey content of the composition was 2 to 20 g per 100 kcal of energy of the composition, and it was effective.
【0009】そして、更に、腎臓病患者用の組成物とし
ての有効性を高めるため脂質、ビタミン類、およびミネ
ラル類を配合するのが良いことを確認した。その際、ミ
ネラルのうちりんは組成物のエネルギー100kcal
あたり5〜30mg、ナトリウムは組成物のエネルギー
100kcalあたり5〜40mgおよびカリウムは組
成物のエネルギー100kcalあたり5〜50mg含
有すると有効であることをつきとめた。また、発酵乳お
よび蜂蜜が酸性であることから均質化された液状の腎臓
病患者用流動食を得るため組成物のpHが3.5〜4.
5であると極めて有効であるとの知見を得た。さらに、
腎臓病患者は飲用水をも制限されることがあるとの観点
より、一般の経腸栄養剤の濃度(1mlあたり1.0k
cal)より高い濃度、すなわち組成物1mlあたり
1.3〜1.8kcalにすることが有効であることを
つきとめた。そしてそ(れら)の最適配合量の決定にも
成功し、遂に本品発明の完成に至ったのである。Furthermore, it was confirmed that it is preferable to add lipids, vitamins, and minerals in order to enhance the effectiveness as a composition for patients with kidney disease. At that time, phosphorus is one of the minerals, and the energy of the composition is 100 kcal.
It was found that 5 to 30 mg per 100 mg of energy of the composition, 5 to 40 mg per 100 kcal of energy of the composition, and 5 to 50 mg of potassium per 100 kcal of energy of the composition are effective. Further, since the fermented milk and honey are acidic, the pH of the composition is 3.5 to 4.
It was found that 5 is extremely effective. further,
From the viewpoint that drinking water may be limited for kidney disease patients, the concentration of general enteral nutritional supplements (1.0k / ml)
It was found that it is effective to have a higher concentration than that of cal), that is, 1.3 to 1.8 kcal per 1 ml of the composition. We also succeeded in determining the optimum compounding amount of these and finally completed the invention of this product.
【0010】本発明において使用するところの、発酵乳
より乳清を除いた成分とは、常法にしたがって調製した
発酵乳から濾過、遠心分離等既知の方法によって乳清を
除去した後の成分をすべて指すものであって、例えば次
のようにして製造したものが使用可能である。As used in the present invention, the components obtained by removing whey from fermented milk means the components obtained by removing whey from a fermented milk prepared according to a conventional method by a known method such as filtration or centrifugation. Any of the above can be used, for example, those manufactured as follows.
【0011】生乳、脱脂乳、還元した脱脂乳等乳原料を
殺菌した後、乳酸菌スターターを添加して発酵せしめ、
攪拌冷却した後殺菌し、遠沈濃縮、濾過その他既知の固
液分離手段により乳清を除去し、得られたものが乳清除
去発酵乳成分である。After sterilizing milk materials such as raw milk, skim milk and reduced skim milk, a lactic acid bacterium starter is added to ferment it.
After stirring and cooling, it is sterilized, and whey is removed by a known solid-liquid separation means such as concentration by centrifugation, filtration and the like, and the obtained product is the whey-removed fermented milk component.
【0012】本発明においてはこの成分を格別の処理を
行うことなくそのまま使用できるほか、更に多糖類を添
加した成分、それを更に均質化した成分、そしてこれ
(ら)を濃縮、希釈、乾燥等各種処理して得られる処理
物も使用可能である。なお多糖類としては、天然ガム類
が広く用いられ、次のようなものが例示される:キサン
タンガム、グアーガム、ローカストビーンガム、トラガ
ントガム、タマリンドガム、カラギーナン、ファーセレ
ラン、アラビアガム、ジェランガム等の1種又は2種以
上。その使用量は、特に限定しないが、0.05〜10
%、好適には0.1〜5%程度である。In the present invention, this component can be used as it is without any special treatment, and a component to which a polysaccharide is further added, a component obtained by further homogenizing the same, and concentrated (diluted), dried etc. Treated products obtained by various treatments can also be used. As the polysaccharide, natural gums are widely used, and examples thereof include the following: xanthan gum, guar gum, locust bean gum, tragacanth gum, tamarind gum, carrageenan, furceleran, gum arabic, gellan gum and the like, or Two or more. The amount used is not particularly limited, but is 0.05 to 10
%, Preferably about 0.1 to 5%.
【0013】本発明に係る組成物は、発酵乳から乳清を
除いた成分及び、必要あれば、蜂蜜等の甘味料を有効成
分としてなるものであって、飲食品又は医薬として用い
るものである。こ(れら)の有効成分を飲食品として使
用する場合には、有効成分をそのまま、使用したり、他
の食品ないし食品成分と併用したりして適宜常法にした
がって使用できる。本組成物の性状としては、固体状
(粉末、顆粒状その他)、ペースト状、液状ないし懸濁
状のいずれでも良いが、腎臓病患者用組成物の場合は、
摂取を容易ならしめるため、液状その他流動食の形状と
するのが好適である。その場合の製剤ないし組成として
は、従来既知の腎臓病患者用の経腸栄養剤における技術
がそのまま使用可能である。The composition according to the present invention comprises, as an active ingredient, a component obtained by removing whey from fermented milk and, if necessary, a sweetener such as honey and used as a food or drink or a medicine. .. When these active ingredients are used as foods or drinks, the active ingredients can be used as they are, or can be used in combination with other foods or food ingredients in accordance with a conventional method. The properties of the composition may be solid (powder, granules, etc.), paste, liquid or suspension, but in the case of a composition for patients with kidney disease,
In order to facilitate ingestion, it is preferable to use liquid or other liquid food form. For the preparation or composition in that case, the conventionally known techniques for enteral nutrition for kidney disease patients can be used as they are.
【0014】また医薬として本組成物を使用する場合に
は、常法にしたがい、錠剤、顆粒剤、粉末剤、カプセル
剤、散剤、液剤、ドリンク剤、坐剤等とすることがで
き、経口投与ないし経腸投与することができる。When the composition is used as a medicine, it can be prepared into tablets, granules, powders, capsules, powders, liquids, drinks, suppositories, etc. according to a conventional method and is orally administered. Or enterally.
【0015】本発明に係る有効成分は、天然起源である
ために毒性が全くないか又は極めて低く、きわめて安全
である(LD50>65g/kg経口:ラット)。また、
その投与量も、医薬として用いる場合は、患者の症状に
応じて従来既知の経腸栄養を参考にして定めればよい
し、予防用、保健用、ないし飲食品として用いる場合に
は、格別の制限は特になく、通常の飲食品と同様にすれ
ばよい。The active ingredient according to the present invention has no or very low toxicity due to its natural origin and is extremely safe (LD 50 > 65 g / kg orally: rat). Also,
The dose, when used as a medicine, may be determined by referring to conventionally known enteral nutrition according to the symptoms of the patient, and when used as a preventive, health, or food / drink product, it has a special There is no particular limitation, and it may be the same as for ordinary food and drink.
【0016】[0016]
【作用】腎溶質負荷に関与するたんぱく質およびミネラ
ルを低減させることにより腎臓への負担を軽減させ、し
かもエネルギーを確保しながら必須栄養成分を過不足な
く摂取できる。[Function] By reducing the proteins and minerals involved in renal solute loading, the burden on the kidney can be reduced, and moreover, essential nutrients can be taken in just enough amount while ensuring energy.
【0017】尿中に排泄されなければならない各種溶質
をまとめて腎溶質負荷と呼ぶ。ごくまれな場合を除き、
腎溶質負荷に寄与しているのは主として、窒素を含有す
る物質である。食物に由来する溶質の主構成要素である
糖は、通常は二酸化炭素及び水に代謝されるので、腎溶
質負荷に寄与しない。腎溶質負荷は、1リットル中に排
泄される溶質(主に蛋白質、ナトリウム、カリウム、塩
素)量で表わす。Various solutes that must be excreted in urine are collectively called renal solute loading. Except in rare cases
It is mainly nitrogen-containing substances that contribute to renal solute loading. Sugar, the main constituent of food-derived solutes, is usually metabolized to carbon dioxide and water and therefore does not contribute to renal solute loading. The renal solute load is represented by the amount of solute (mainly protein, sodium, potassium, chlorine) excreted in 1 liter.
【0018】これら電解質1mEqの腎溶質負荷は約1
mOsm/lであり、蛋白質1gは成人の場合5.7m
Eq、小児の場合4.0mEqである。The renal solute load of 1 mEq of these electrolytes is about 1.
mOsm / l, 1 g of protein is 5.7 m for adults
Eq, 4.0 mEq for children.
【0019】以下に、本発明の製造例及び実施例につい
て詳述する。The production examples and examples of the present invention will be described in detail below.
【0020】[0020]
【製造例1】脱脂乳5tを加熱殺菌した後、スターター
としてLactobacillusbulgaricu
s、Streptococcus thermophi
lusを常法にしたがって添加、約40℃で発酵後、攪
拌、冷却し(pH4.0±0.1)、これを加熱殺菌し
た。[Production Example 1] 5 t of skim milk was heat-sterilized and then used as a starter for Lactobacillus bulgaricu
s, Streptococcus thermophi
Lus was added according to a conventional method, and after fermentation at about 40 ° C., the mixture was stirred and cooled (pH 4.0 ± 0.1) and sterilized by heating.
【0021】次いで遠沈濃縮してホエーを除去した後、
ローカストビーンガム 0.2%を加え、ホモゲナイズ
した後、冷却して、発酵乳より乳清を除いた成分992
kgを得、これを容器に充填した。Then, after concentration by centrifugation to remove whey,
Ingredient 992 obtained by removing whey from fermented milk by adding 0.2% locust bean gum, homogenizing and cooling.
kg was obtained and this was filled in a container.
【0022】[0022]
【実施例1】約66.7ml(100×100/15
0:エネルギー100kcal)あたり発酵乳より乳清
を除いた成分(製造例1で得たもの)10g(たんぱく
質1.3g)、蜂蜜5g、コーン油3g、蔗糖1g、及
びデキストリン11gの割合で配合し、更にビタミン類
とミネラル類を下記表1、表2(本発明実施例1に係る
腎臓病患者用の流動食100kcal当りの成分・組成
(含有量)及び腎溶質負荷)に示す割合になるように加
え、本発明に係る製品を製造した。Example 1 About 66.7 ml (100 × 100/15
0: Energy (100 kcal): Fermented milk except for whey 10 g (obtained in Production Example 1) 10 g (protein 1.3 g), honey 5 g, corn oil 3 g, sucrose 1 g, and dextrin 11 g were added. In addition, vitamins and minerals should be in the ratios shown in Tables 1 and 2 below (components / composition (content) and renal solute load per 100 kcal of liquid diet for kidney disease patients according to Example 1 of the present invention). In addition, a product according to the present invention was manufactured.
【0023】[0023]
【表1】 [Table 1]
【0024】[0024]
【表2】 [Table 2]
【0025】上記結果から明らかなように、本製品の腎
溶質負荷は141.4mOsm/lとなり、一般の経腸
栄養剤(後記する表5、表6)の腎溶質負荷約300m
Osm/lの半分以下となった。しかも本製品の濃度は
一般の経腸栄養剤の1.5倍にもかかわらず腎溶質負荷
を低減させた腎臓病患者用の組成物として極めて有効性
の高い製品が完成した。As is clear from the above results, the renal solute load of this product was 141.4 mOsm / l, and the renal solute load of general enteral nutrients (Tables 5 and 6 below) was about 300 m.
It became less than half of Osm / l. Moreover, although the concentration of this product is 1.5 times that of a general enteral nutritional product, a product having extremely high efficacy as a composition for renal disease patients with reduced renal solute load was completed.
【0026】[0026]
【実施例2】約76.9ml(100×100/13
0:エネルギー100kcal)あたり発酵乳より乳清
を除いた成分(製造例1で得たもの)4.5g(たんぱ
く質0.6g)、蜂蜜8g、コーン油2.5g、ココナ
ッツ油0.7g、蔗糖1g、及びデキストリン9gの割
合で配合し、更にビタミン類とミネラル類を下記表3、
表4(本発明実施例2に係る腎臓病患者用の流動食10
0kcal当りの成分・組成(含有量)及び腎溶質負
荷)に示す割合になるように加え、本発明に係る製品を
製造した。Example 2 About 76.9 ml (100 × 100/13
0: 4.5 g (protein 0.6 g) obtained by removing whey from fermented milk per energy 100 kcal) (obtained in Production Example 1), honey 8 g, corn oil 2.5 g, coconut oil 0.7 g, sucrose 1 g and dextrin 9 g were added, and vitamins and minerals were added as shown in Table 3 below.
Table 4 (liquid food 10 for patients with kidney disease according to Example 2 of the present invention)
The product according to the present invention was produced in addition to the ratios shown in the components / composition (content) and renal solute load per 0 kcal.
【0027】[0027]
【表3】 [Table 3]
【0028】[0028]
【表4】 [Table 4]
【0029】上記結果から明らかなように、本製品の腎
溶質負荷は64.1mOsm/lとなり、一般の経腸栄
養剤(下記表5、表6)の腎溶質負荷約300mOsm
/lの1/4以下となった。しかも本製品の濃度は一般
の経腸栄養剤の1.3倍にもかかわらず腎溶質負荷を低
減させた腎臓病患者用の流動食として極めて有効性の高
い製品が完成した。As is clear from the above results, the renal solute load of this product was 64.1 mOsm / l, and the renal solute load of general enteral nutrients (Tables 5 and 6 below) was about 300 mOsm.
It became 1/4 or less of / l. Moreover, although the concentration of this product is 1.3 times that of general enteral nutritional supplements, a product with extremely high efficacy as a liquid diet for renal disease patients with reduced renal solute loading was completed.
【0030】[0030]
【表5】 [Table 5]
【0031】[0031]
【表6】 [Table 6]
【0032】[0032]
【発明の効果】本発明によって、長期食餌治療が困難と
されていた腎疾患の治療、維持に副作用もなく安全且つ
有効に治療、維持することが可能となったのである。も
ちろん本発明に係る組成物は、腎機能の低下した病弱者
用の飲食品としても有用であるし、また、腎機能が低下
した高齢の健常者が保健のために摂取しても極めて有効
である。Industrial Applicability According to the present invention, it has become possible to safely and effectively treat and maintain a renal disease for which long-term dietary treatment has been difficult, without any side effects. Of course, the composition according to the present invention is also useful as a food / drink product for sick people with impaired renal function, and is extremely effective even if taken for health by elderly healthy people with impaired renal function. is there.
フロントページの続き (72)発明者 桑 田 有 東京都東村山市栄町1−21−3 明治乳業 株式会社中央研究所内 (72)発明者 山 本 良 郎 東京都東村山市栄町1−21−3 明治乳業 株式会社中央研究所内Front page continuation (72) Inventor Yu Kuwata 1-21-3 Sakaemachi, Higashimurayama, Tokyo Meiji Dairy Industry Co., Ltd. (72) Ryoro Yamamoto 1-21-3 Sakaemachi, Higashimurayama, Tokyo Meiji Milk Industry Central Research Institute Co., Ltd.
Claims (12)
なることを特徴とする組成物。1. A composition comprising fermented milk excluding whey.
物のエネルギー100kcalあたり1〜12gおよび
蜂蜜含量が組成物のエネルギー100kcalあたり2
〜20gであることを特徴とする請求項1に記載の組成
物。2. The content of fermented milk excluding whey is 1 to 12 g per 100 kcal energy of the composition, and the honey content is 2 per 100 kcal energy of the composition.
The composition of claim 1, wherein the composition is ˜20 g.
質含量が組成物のエネルギー100kcalあたり0.
2〜1.5gであることを特徴とする請求項1に記載の
組成物。3. The protein content of a component obtained by removing whey from fermented milk is 0.1 per 100 kcal of energy of the composition.
The composition according to claim 1, which is 2 to 1.5 g.
lあたり5〜30mgであることを特徴とする請求項1
に記載の組成物。4. The energy of phosphorus is 100 kca of the composition.
It is 5 to 30 mg per liter.
The composition according to.
kcalあたり5〜40mgであることを特徴とする請
求項1に記載の組成物。5. Sodium is the energy of composition 100.
The composition according to claim 1, which is 5 to 40 mg per kcal.
calあたり5〜50mgであることを特徴とする請求
項1に記載の組成物。6. Potassium is the energy of the composition 100 k
The composition according to claim 1, which is 5 to 50 mg per cal.
lあたり0.01〜0.2gであることを特徴とする請
求項1に記載の組成物。7. Lactose is the energy of a composition of 100 kca.
The composition according to claim 1, which is 0.01 to 0.2 g per liter.
とする請求項1に記載の組成物。8. The composition according to claim 1, having a pH of 3.5 to 4.5.
〜1.8kcalであることを特徴とする請求項1に記
載の組成物。9. Energy is 1.3 per ml of the composition.
The composition of claim 1, wherein the composition is ˜1.8 kcal.
/又は飲食品タイプの組成物であることを特徴とする請
求項1〜請求項9のいずれか1項に記載の組成物。10. The composition according to any one of claims 1 to 9, wherein the composition is an orally administered drug type and / or food and drink type composition.
菌発酵乳を遠心分離及び/又は濾過して乳清を除去した
成分、あるいはこれに多糖類を添加した成分、あるいは
これを更に均質化した成分、あるいはこ(れら)の成分
の処理物からなる群から選ばれたものであることを特徴
とする請求項1〜請求項10のいずれか1項に記載の組
成物。11. A component obtained by removing whey from fermented milk is a component obtained by centrifuging and / or filtering lactic acid bacterium fermented milk to remove whey, a component to which a polysaccharide is added, or a homogenized mixture thereof. The composition according to any one of claims 1 to 10, which is selected from the group consisting of treated components or treated products of these components.
に記載の組成物を含有してなることを特徴とする腎臓病
患者用の流動性組成物。12. A fluid composition for a renal disease patient, which comprises the composition according to any one of claims 1 to 11.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP08610592A JP3179555B2 (en) | 1992-03-10 | 1992-03-10 | Liquid prepared nutritional food for kidney disease patients |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP08610592A JP3179555B2 (en) | 1992-03-10 | 1992-03-10 | Liquid prepared nutritional food for kidney disease patients |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH05252896A true JPH05252896A (en) | 1993-10-05 |
JP3179555B2 JP3179555B2 (en) | 2001-06-25 |
Family
ID=13877429
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP08610592A Expired - Lifetime JP3179555B2 (en) | 1992-03-10 | 1992-03-10 | Liquid prepared nutritional food for kidney disease patients |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP3179555B2 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005094850A1 (en) * | 2004-03-31 | 2005-10-13 | Meiji Dairies Corporation | Antibacterial composition |
JP2007507526A (en) * | 2003-09-30 | 2007-03-29 | キボー バイオテック、インク | Compositions and methods for increasing kidney function |
JP2009011229A (en) * | 2007-07-04 | 2009-01-22 | Sanei Gen Ffi Inc | Gelling agent for acid thick liquid food, and acid gel-like thick liquid food prepared by using the same |
JP2017169491A (en) * | 2016-03-24 | 2017-09-28 | 森永乳業株式会社 | Method for producing liquid fermented milk |
-
1992
- 1992-03-10 JP JP08610592A patent/JP3179555B2/en not_active Expired - Lifetime
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007507526A (en) * | 2003-09-30 | 2007-03-29 | キボー バイオテック、インク | Compositions and methods for increasing kidney function |
JP2013209396A (en) * | 2003-09-30 | 2013-10-10 | Kibow Biotech Inc | Composition and method for augmenting kidney function |
WO2005094850A1 (en) * | 2004-03-31 | 2005-10-13 | Meiji Dairies Corporation | Antibacterial composition |
JPWO2005094850A1 (en) * | 2004-03-31 | 2008-02-14 | 明治乳業株式会社 | Antibacterial composition |
JP2009011229A (en) * | 2007-07-04 | 2009-01-22 | Sanei Gen Ffi Inc | Gelling agent for acid thick liquid food, and acid gel-like thick liquid food prepared by using the same |
JP2017169491A (en) * | 2016-03-24 | 2017-09-28 | 森永乳業株式会社 | Method for producing liquid fermented milk |
Also Published As
Publication number | Publication date |
---|---|
JP3179555B2 (en) | 2001-06-25 |
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