JPH05252896A - Formulated liquid nutritive food for patient with nephropathy - Google Patents

Abstract

PURPOSE:To provide the subject food containing nutrients casting no burden on the kidney, thus effective for diet of patients with nephropathy and other sickly persons declined in renal their function, containing ingredients prepared by treating e.g. lactobacillus-fermented milk through centrifugation and/or filtration, etc., to remove whey therefrom. CONSTITUTION:(A) Ingredients prepared by removing whey from lactobacillus- fermented milk through its centrifugation and/or filtration, (B) the ingredients A incorporated with a polysaccharide, (C) an ingredient prepared by homogenizing the ingredients B, or (D) a treated product thereof, is formulated with honey, corn oil, sucrose, and dextrin, etc., and, in addition, with vitamins and minerals, thus obtaining the objective nutritive food having the following characteristics: 1-12g of the ingredients A, B, C or D, per 100kcal of the energy of the final composition; 2-20g of honey; 0.2-1.5g of proteins; 5-30mg of phosphorus; 5-40mg of sodium; 5-50mg of potassium; 0.01-0.2g of lactose; pH: 3.5-4.5; and energy, 1.3-1.8kcal per ml.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition containing a component obtained by removing whey from fermented milk. The composition according to the present invention can supply necessary nutrients to a patient with reduced renal function without burdening the kidney, and thus is used in a pharmaceutical type as well as a beverage, a food, a nutritional food, and a function. It can be used not only in patients with kidney disease but also in sick people with impaired renal function, people after illness, and elderly healthy people, as well as sex foods, foods for specified health uses, drinks, etc. It is a thing.

[0002]

2. Description of the Related Art Foods and drinks for patients with kidney disease are composed of food components which are reduced in proteins and minerals which impose stress on the kidneys from a medical point of view. However, since protein and minerals are essential components for the living body, the minimum required amount must be taken. Moreover, dietary components for kidney disease patients are absorbed in a composition that does not have excess or deficiency of each component of vitamins and minerals including three major nutrients of protein, fat and carbohydrate while securing energy to maintain the living body. Since it has to be composed of easy-to-use high-quality ingredients, it is very difficult to compose an ideal food and drink for kidney disease patients with general foods. In addition, there is no liquid food and drink for kidney disease patients, which does not need to be prepared each time when ingested and can be taken as it is. Of course, no drug for that purpose is known at this time.

[0003]

SUMMARY OF THE INVENTION In view of the above situation, the present invention is an ideal composition composed of nutrients that does not impose an excessive burden on the kidney, and is not limited to patients with kidney disease but also kidneys. It was made for the purpose of developing an excellent composition that can be widely used for weak people, sick people with deteriorated renal function, and elderly healthy people.

[0004]

[Means for Solving the Problems] To achieve the above object, as a result of various studies, fermented milk with high nutritional value, which has no limiting amino acids and an amino acid score of 100, is used as a protein source, and its intake is restricted. It was discovered for the first time that fermented milk with reduced minerals can be obtained by removing whey minerals as whey. In view of the importance of limiting proteins and minerals in foods and drinks for kidney disease patients, the above-mentioned whey-removed fermented milk was first noted.

[0005] Here, from the viewpoint that a renal disease patient must take essential nutrients while securing energy while limiting protein and minerals, the composition ratio of the composition is generally the energy of food and drink. 100k
Represented by content per cal.

[0006] As a result of further study from various directions,
We obtained the finding that the components obtained by removing whey from fermented milk are extremely effective as a protein source for food and drink for patients with kidney disease, and as a result of further research based on this new finding, the present invention finally came to completion. The present invention is based on a basic technical idea of a composition containing whey-removed fermented milk. Hereinafter, the present invention will be described in detail.

[0007] In the composition according to the present invention, one of the important characteristics is that a component obtained by removing whey from fermented milk is used as the protein. Among these components, especially whey is removed from fermented milk. Energy of composition is 100k
It was found that 1 to 12 g per cal and a protein content of 0.2 to 1.5 g per 100 kcal energy of the composition were effective. Moreover, by removing the whey from the fermented milk, lactose is simultaneously added to the energy of the composition.
It was found to be reduced to 0.01 to 0.2 g per 00 kcal, and it was confirmed that it is also effective for lactose intolerant kidney disease patients.

Further, the composition according to the present invention is used not only as a pharmaceutical type but also as a food and drink type. In the latter case, not only nutrition and calorie aspects but also ease of eating and drinking, that is, a requirement regarding palatability is also required. Further required. Therefore, as a result of earnestly studying this point, it was found that the use of sugar is preferable. As sugars, natural and artificial sugars can be widely used alone or in combination, but a composition that does not cause discomfort to patients by adding honey as one of the three major nutrients and a highly nutritious carbohydrate It was confirmed that the honey content of the composition was 2 to 20 g per 100 kcal of energy of the composition, and it was effective.

Furthermore, it was confirmed that it is preferable to add lipids, vitamins, and minerals in order to enhance the effectiveness as a composition for patients with kidney disease. At that time, phosphorus is one of the minerals, and the energy of the composition is 100 kcal.
It was found that 5 to 30 mg per 100 mg of energy of the composition, 5 to 40 mg per 100 kcal of energy of the composition, and 5 to 50 mg of potassium per 100 kcal of energy of the composition are effective. Further, since the fermented milk and honey are acidic, the pH of the composition is 3.5 to 4.
It was found that 5 is extremely effective. further,
From the viewpoint that drinking water may be limited for kidney disease patients, the concentration of general enteral nutritional supplements (1.0k / ml)
It was found that it is effective to have a higher concentration than that of cal), that is, 1.3 to 1.8 kcal per 1 ml of the composition. We also succeeded in determining the optimum compounding amount of these and finally completed the invention of this product.

As used in the present invention, the components obtained by removing whey from fermented milk means the components obtained by removing whey from a fermented milk prepared according to a conventional method by a known method such as filtration or centrifugation. Any of the above can be used, for example, those manufactured as follows.

After sterilizing milk materials such as raw milk, skim milk and reduced skim milk, a lactic acid bacterium starter is added to ferment it.
After stirring and cooling, it is sterilized, and whey is removed by a known solid-liquid separation means such as concentration by centrifugation, filtration and the like, and the obtained product is the whey-removed fermented milk component.

In the present invention, this component can be used as it is without any special treatment, and a component to which a polysaccharide is further added, a component obtained by further homogenizing the same, and concentrated (diluted), dried etc. Treated products obtained by various treatments can also be used. As the polysaccharide, natural gums are widely used, and examples thereof include the following: xanthan gum, guar gum, locust bean gum, tragacanth gum, tamarind gum, carrageenan, furceleran, gum arabic, gellan gum and the like, or Two or more. The amount used is not particularly limited, but is 0.05 to 10
%, Preferably about 0.1 to 5%.

The composition according to the present invention comprises, as an active ingredient, a component obtained by removing whey from fermented milk and, if necessary, a sweetener such as honey and used as a food or drink or a medicine. .. When these active ingredients are used as foods or drinks, the active ingredients can be used as they are, or can be used in combination with other foods or food ingredients in accordance with a conventional method. The properties of the composition may be solid (powder, granules, etc.), paste, liquid or suspension, but in the case of a composition for patients with kidney disease,
In order to facilitate ingestion, it is preferable to use liquid or other liquid food form. For the preparation or composition in that case, the conventionally known techniques for enteral nutrition for kidney disease patients can be used as they are.

When the composition is used as a medicine, it can be prepared into tablets, granules, powders, capsules, powders, liquids, drinks, suppositories, etc. according to a conventional method and is orally administered. Or enterally.

The active ingredient according to the present invention has no or very low toxicity due to its natural origin and is extremely safe (LD ₅₀ > 65 g / kg orally: rat). Also,
The dose, when used as a medicine, may be determined by referring to conventionally known enteral nutrition according to the symptoms of the patient, and when used as a preventive, health, or food / drink product, it has a special There is no particular limitation, and it may be the same as for ordinary food and drink.

[0016]

[Function] By reducing the proteins and minerals involved in renal solute loading, the burden on the kidney can be reduced, and moreover, essential nutrients can be taken in just enough amount while ensuring energy.

Various solutes that must be excreted in urine are collectively called renal solute loading. Except in rare cases
It is mainly nitrogen-containing substances that contribute to renal solute loading. Sugar, the main constituent of food-derived solutes, is usually metabolized to carbon dioxide and water and therefore does not contribute to renal solute loading. The renal solute load is represented by the amount of solute (mainly protein, sodium, potassium, chlorine) excreted in 1 liter.

The renal solute load of 1 mEq of these electrolytes is about 1.
mOsm / l, 1 g of protein is 5.7 m for adults
Eq, 4.0 mEq for children.

The production examples and examples of the present invention will be described in detail below.

[0020]

[Production Example 1] 5 t of skim milk was heat-sterilized and then used as a starter for Lactobacillus bulgaricu
s, Streptococcus thermophi
Lus was added according to a conventional method, and after fermentation at about 40 ° C., the mixture was stirred and cooled (pH 4.0 ± 0.1) and sterilized by heating.

Then, after concentration by centrifugation to remove whey,
Ingredient 992 obtained by removing whey from fermented milk by adding 0.2% locust bean gum, homogenizing and cooling.
kg was obtained and this was filled in a container.

[0022]

Example 1 About 66.7 ml (100 × 100/15
0: Energy (100 kcal): Fermented milk except for whey 10 g (obtained in Production Example 1) 10 g (protein 1.3 g), honey 5 g, corn oil 3 g, sucrose 1 g, and dextrin 11 g were added. In addition, vitamins and minerals should be in the ratios shown in Tables 1 and 2 below (components / composition (content) and renal solute load per 100 kcal of liquid diet for kidney disease patients according to Example 1 of the present invention). In addition, a product according to the present invention was manufactured.

[0023]

[Table 1]

[0024]

[Table 2]

As is clear from the above results, the renal solute load of this product was 141.4 mOsm / l, and the renal solute load of general enteral nutrients (Tables 5 and 6 below) was about 300 m.
It became less than half of Osm / l. Moreover, although the concentration of this product is 1.5 times that of a general enteral nutritional product, a product having extremely high efficacy as a composition for renal disease patients with reduced renal solute load was completed.

[0026]

Example 2 About 76.9 ml (100 × 100/13
0: 4.5 g (protein 0.6 g) obtained by removing whey from fermented milk per energy 100 kcal) (obtained in Production Example 1), honey 8 g, corn oil 2.5 g, coconut oil 0.7 g, sucrose 1 g and dextrin 9 g were added, and vitamins and minerals were added as shown in Table 3 below.
Table 4 (liquid food 10 for patients with kidney disease according to Example 2 of the present invention)
The product according to the present invention was produced in addition to the ratios shown in the components / composition (content) and renal solute load per 0 kcal.

[0027]

[Table 3]

[0028]

[Table 4]

As is clear from the above results, the renal solute load of this product was 64.1 mOsm / l, and the renal solute load of general enteral nutrients (Tables 5 and 6 below) was about 300 mOsm.
It became 1/4 or less of / l. Moreover, although the concentration of this product is 1.3 times that of general enteral nutritional supplements, a product with extremely high efficacy as a liquid diet for renal disease patients with reduced renal solute loading was completed.

[0030]

[Table 5]

[0031]

[Table 6]

[0032]

Industrial Applicability According to the present invention, it has become possible to safely and effectively treat and maintain a renal disease for which long-term dietary treatment has been difficult, without any side effects. Of course, the composition according to the present invention is also useful as a food / drink product for sick people with impaired renal function, and is extremely effective even if taken for health by elderly healthy people with impaired renal function. is there.

Front page continuation (72) Inventor Yu Kuwata 1-21-3 Sakaemachi, Higashimurayama, Tokyo Meiji Dairy Industry Co., Ltd. (72) Ryoro Yamamoto 1-21-3 Sakaemachi, Higashimurayama, Tokyo Meiji Milk Industry Central Research Institute Co., Ltd.

Claims (12)

[Claims] 1. A composition comprising fermented milk excluding whey. 2. The content of fermented milk excluding whey is 1 to 12 g per 100 kcal energy of the composition, and the honey content is 2 per 100 kcal energy of the composition.
The composition of claim 1, wherein the composition is ˜20 g. 3. The protein content of a component obtained by removing whey from fermented milk is 0.1 per 100 kcal of energy of the composition.
The composition according to claim 1, which is 2 to 1.5 g. 4. The energy of phosphorus is 100 kca of the composition.
It is 5 to 30 mg per liter.
The composition according to. 5. Sodium is the energy of composition 100.
The composition according to claim 1, which is 5 to 40 mg per kcal. 6. Potassium is the energy of the composition 100 k
The composition according to claim 1, which is 5 to 50 mg per cal. 7. Lactose is the energy of a composition of 100 kca.
The composition according to claim 1, which is 0.01 to 0.2 g per liter. 8. The composition according to claim 1, having a pH of 3.5 to 4.5. 9. Energy is 1.3 per ml of the composition.
The composition of claim 1, wherein the composition is ˜1.8 kcal. 10. The composition according to any one of claims 1 to 9, wherein the composition is an orally administered drug type and / or food and drink type composition. 11. A component obtained by removing whey from fermented milk is a component obtained by centrifuging and / or filtering lactic acid bacterium fermented milk to remove whey, a component to which a polysaccharide is added, or a homogenized mixture thereof. The composition according to any one of claims 1 to 10, which is selected from the group consisting of treated components or treated products of these components. 12. A fluid composition for a renal disease patient, which comprises the composition according to any one of claims 1 to 11.