KR100266799B1 - Nutritional formula for patients with renal disease and process for preparing the same - Google Patents

Abstract

The present invention relates to a nutritional composition for kidney disease patients. More specifically, the present invention is a liquid or liquid that can easily and safely provide sufficient nutrition to patients with non-dialysis nephropathy who have acute or chronic weakened filtration and excretion functions or dialysis nephropathy patients who require hemodialysis due to renal failure. It relates to a nutritional composition of and a method for producing the same. The foster composition of the present invention has a total calorific value of 200 kcal per 100 g, the caloric ratio of the three major nutrients (protein, fat, carbohydrate) is 4 to 14% by weight protein, 22.5 to 31.5% fat and 62 to 74% carbohydrate Vitamins and minerals are nutritionally balanced special nutrition products containing 5 to 15% by weight of the daily recommended amount of Korean adults, the ratio of polyunsaturated fatty acid (P / M) to monounsaturated fatty acid is less than 1, Contains no lactose Liquid nutritional composition for kidney disease patients of the present invention can be used as a new nutritional substance that can provide a sheep to the kidney disease patients more simply and effectively than the diet for kidney disease patients made in the existing hospital or home.

Description

Nutritional Formula for Patients with Renal Disease and Process for Preparing the Same

The present invention relates to a nutritional composition for kidney disease patients. More specifically, the present invention is a liquid or liquid that can easily and safely provide sufficient nutrition to patients with non-dialysis nephropathy who have acute or chronic weakened filtration and excretion functions or dialysis nephropathy patients who require hemodialysis due to renal failure. It relates to a nutritional composition of and a method for producing the same.

In our body, there is a pair of kidneys on either side of the spine below the diaphragm, wrapped in a fat envelope, between the peritoneum and the posterior wall. One adult weighs 130-170 grams, the size of an adult's fist. One kidney contains about 1 million units of nephron, the basic unit of market function. It consists of glomeruli, capillary masses, and elongated tubules connected to it.

The main function of the kidney is to excrete waste products from the metabolism of various foods in the body and foreign substances that enter the body through urine.In addition, it regulates body fluids, maintains blood pressure, regulates the number of red blood cells and synthesizes growth factors. It performs many functions.

Thus, the kidney plays a role in excretion, regulation and endocrine organs, so when the function of the kidney is reduced, the amount of waste products (urea, uric acid, creatinine, sulfate, and organic acid) in the blood increases, and the body's water and electrolyte excretion disorders Will lose balance. Symptoms of this disease include anorexia, fatigue, nausea and headache, chronic symptoms such as swelling, severe symptoms such as increased blood pressure, and when the disease worsens, the life of uremia.

Treatments for kidney disease include (1) maintenance or conservative treatment, (2) hemodialysis, (3) peritoneal dialysis, or (4) renal transplantation. There is a different standard of nutrition for each treatment.

In kidney disease, many metabolic disorders and weakness of the patient are likely to occur, so nutrition therapy is an important aspect in treating kidney disease. In particular, during kidney disease, metabolic abnormalities or metabolic abnormalities of nutrients are generated. For example, these abnormalities include protein metabolites such as urea, uric acid, and creatinine, and sodium (Na), potassium (K), and Kidney excretion, such as phosphorus (P) is reduced, and the intestinal absorption of minerals such as calcium (Ca), iron (Fe) is also reduced. In addition, kidney disease patients are often weak or malnourished, for the following reasons:

First, due to anorexia caused by chronic debilitating illness, uremia, and emotional depression, the intake of meals is insufficient, resulting in insufficient calories;

Second, severe catabolic illness is merged;

Third, there is a deficiency of protein in the body due to blood sampling and occult gastrointestinal bleeding;

Fourth, bioactive substances such as amino acids, proteins, glucose and water-soluble vitamins are lost.

Efforts to improve the metabolic disorders, weakness, and malnutrition of kidney diseases have been attempted systematically since the beginning of the 20th century. For example, high-protein protein foods and starch products are recommended for energy intake of kidney disease patients. Giovannetti (S) et al. Reported by Giovannetti, S. et al., Lancet, 1: 1000 (1964). On the other hand, Oldrizzi (L.) and others reported that nutrition management is the most important factor in the treatment of patients with acute and chronic renal failure, and may delay the exacerbation of kidney disease by limiting the amount and quality of the nitrogen source ingested. : L. Oldrizzi, et al., Nutritional in Clinical Practice, 9: 1 (1994)).

ㆍ Nutrition management for chronic renal failure

Dietary management of chronic kidney failure began with maintenance therapy (or palliative therapy) in the 1960s, and protein and phosphorus restriction are now the most common dietary management conditions. In addition, chronic renal failure due to metabolic abnormalities of lipids may progress to uremia, so proper amount and quality of fat supply is necessary. The general dietary management criteria for chronic renal failure proposed by Aldrich et al. Include: (1) High-protein proteins are recommended to limit the intake of nitrogen sources and to maintain nitrogen balance in the body; (2) protein intake that meets essential amino acid requirements is recommended; (3) sufficient energy supply to reduce body protein loss is recommended; (4) The diet should be tasty and economic.

ㆍ Nutrition management for acute renal failure

Nutritional management of acute renal failure requires dietary restrictions that are more stringent than nutritional management of chronic renal failure, including: (1) Since adequate energy intake plays a role in inhibiting urea synthesis and protein catabolism, It is the core of nutritional therapy for patients with acute renal failure, and energy supply of 1,500 ~ 2,700㎉ / day is recommended depending on the patient; (2) It is recommended to use a mixture of essential amino acid and non-essential amino acid, and 0.6g / day per kg of body weight is recommended if oral ingestion is possible. It is recommended that about 400 ㎉ (45 g) per day is recommended; (4) the required amount of water-soluble vitamins is increased;

Ultimately, nutritional management goals for kidney disease are:

First, to provide protein with high amino acid composition and high biovalence to prevent excessive accumulation of nitric acid products and to maintain a positive nitrogen balance;

Second, they consume enough calories to prevent loss of body protein;

Third, limit sodium intake to control blood pressure and prevent thirst and edema.

Fourth, limit water intake to prevent hyperkalemia and weight gain;

Fifth, limit the intake of phosphorus to prevent hyperphosphatemia and renal osteodystrophy.

Kidney patients can meet the above nutritional standards and nutritional therapies to improve or delay disease, maintain physical and psychological stability and maintain quality of life. However, like other diseases, kidney disease is impossible to eat a variety of foods, and digestive capacity is reduced, so as to be able to eat a balanced diet of necessary nutrients as much as possible daily, and at the same time the addition of nutrients according to kidney disease And proper selection of components. In this regard, dietary preparations in hospitals and homes for kidney disease have been used in patients with inadequate nutritional standards, which inevitably lead to nutritional imbalances, in particular the following problems:

First, it is susceptible to bacterial contamination in the manufacture of patient foods;

Second, there are differences in nutritional composition depending on the ingredients used;

Third, feeding through the tube is difficult due to incomplete liquefaction or insoluble components;

Fourth, extra space is required, and time and effort for preparation are high;

Fifth, it is difficult to supply accurate and uniform calories and nutrients;

Sixth, cost burden increases due to food and overhead costs;

Seventh, the sedimentation or emulsification is not made due to the out of stock deterioration of the oil component is difficult to feed.

As a result, due to the problems that the ingredients contained in the conventional ingredients do not meet the nutritional requirements of the kidney disease, and many problems of product stability, such as precipitation, coagulation and flotation, an appropriate nutritional composition for the kidney disease was not developed. Therefore, there is an urgent need to develop a nutritional composition that is improved in nutritional balance and product safety in order to effectively provide nutrition to kidney disease patients.

Therefore, the present inventors have solved these problems and improved the nutritional balance and stability of the product, and as a result of intensive research to develop a nutritional composition that can effectively provide nutrition for kidney disease patients whose nutrient intake is strictly restricted, Liquid nutrient composition containing appropriate fats, carbohydrates and vitamins and minerals effectively supply nutrients to the kidney disease to confirm that their various body index increases, and completed the present invention.

After all, it is an object of the present invention to provide a nutritional composition suitable for patients with kidney disease.

It is another object of the present invention to provide a method of preparing a nutritional composition for an electric kidney patient.

The main nutritional function of proteins is the synthesis of essential amino acids and body tissue proteins, and the required amount is 'the minimum level that balances the amount of nitrogen excretion and dietary nitrogen intake in the body while maintaining the energy balance when the physical activity is at an appropriate level'. Defined (WHO, 1985). When proteins are metabolized in the body, they produce a variety of nitric acid products (urea, creatinine, and uric acid), which are excreted through the kidneys, which can be a burden for kidney patients with reduced kidney function. It is becoming. Therefore, the present inventors expected to reduce the burden on the kidneys when the protein is broken down by using protein or hydrolysates, which are known to have high biological scores and protein scores. .

On the other hand, fat contains the highest calorie value (9㎉ / g) among the nutrients, and it supports the supply of essential fatty acids and digestion and absorption of fat-soluble vitamins in the body, functions as a body composition, biological organ protection and food flavor And the ability to increase taste. In the diet of the kidney disease, the protein is limited, so the fat and carbohydrates to supplement the necessary calories are high in their diet. However, in the case of kidney disease, hyperlipidemia is known to occur due to various causes, so it is very important to select a fat source in the diet. Accordingly, the present inventors have suggested that monounsaturated fatty acid (weakly referred to as 'M') and polyunsaturated fatty acid (polyunsaturated fatty acid) in order to lower the contents of low density lipoprotein cholesterol and total cholesterol and increase the relative content of high density lipoprotein cholesterol in hyperlipidemia patients. The use of sunflower oil, which is known to be rich in fatty acids (hereinafter referred to as 'P'), aims to reduce the side effects of high-fat diets. In addition, the use of heavy chain triglycerides (MCT oil), which is easy to digest and absorb, can be used in patients with poor fat absorption.

In addition, carbohydrates occupy an important position as a calorie source for kidney disease patients requiring low protein, high calorie diet. However, carbohydrates, when digested and absorbed, may be broken down into monosaccharides or disaccharides to increase sweetness, making it difficult to consume large quantities, or may cause rapid blood sugar rise, which may worsen symptoms such as diabetes. Therefore, the ingestion of a complex sugar that can be a source of energy while slowing the absorption of digestion is recommended, the present inventors used dextrin in the nutritional composition of the present invention in consideration of sweetness and digestion absorption rate.

The present inventors first divide the use of nutritional composition for patients with dialysis kidney disease and patients with dialysis kidney disease, and then, according to the selection principle as described above, contain protein, fat, and carbohydrate in appropriate composition and composition ratio, respectively, A nutrition composition containing inorganic matters was prepared. That is, the protein source comprises a separated milk protein or a separated milk protein hydrolyzate; Unsaturated fatty acids so that the ratio (P / M) of polyunsaturated fatty acids to monounsaturated fatty acids is 1 or less; A complex carbohydrate as a carbohydrate source; Kidney patients mixed and homogenized liquid nutritional composition containing vitamins and minerals according to the daily needs, and then subjected to high temperature sterilization, to prepare a nutritional composition for kidney disease patients. These nutrients are formulated to provide balanced nutrition when intake of 2,000 ㎉ calories, which is recommended for most kidney disease, and is characterized by limiting the amount of calories supplied by protein to a level suitable for kidney disease. have. In particular, in the case of the nutritional composition for dialysis kidney disease, it was prepared to have a higher protein content than non-dialysis patients in consideration of the loss of protein due to dialysis. In addition, fats and carbohydrates were selected as physiologically superior raw materials, to minimize various side effects as described above.

Hereinafter, a method of preparing the nutritional composition for a kidney disease patient of the present invention will be described in more detail.

Table 1 below shows the amounts of each nutrient substance for preparing a liquid nutritional composition for dialysis and dialysis kidney disease patients of the present invention.

ingredient Nutritional composition for non-dialysis kidney disease (wt%) Nutritional composition for dialysis kidney disease patients (wt%) protein 2 to 3 6 to 7 Fat 5 to 7 5 to 7 carbohydrate 31 to 37 31 to 37 Vitamin powder 0.0071 to 0.0212 0.0071 to 0.0212 Mineral powder 0.3877-1.163 0.3127 to 0.938 Emulsifier 0.3 to 0.5 0.3 to 0.5 Spices 0.2 to 0.4 0.2 to 0.4 Purified water Remainder Remainder

Liquid nutrient composition for patients with kidney disease of the present invention, as shown in Table 1, a casein separated milk protein (casein, casein sodium, casein potassium, casein calcium) or casein isolate milk protein hydrolyzate having a protein content of 90% or more as a protein source Animal proteins such as (3-5 amino acids) (dissolved in amino acids) are dissolved in water so as to contain 2 to 7% by weight, based on the characteristics of the product, and then polyunsaturated fatty acids (P) and monounsaturated fatty acids (M) as fat sources. 5 to 7% by weight of vegetable oils such as sunflower oil or heavy chain neutral fat having a ratio of 1 or less, and dextrin and white sugar having a dexrose equivalent (DE) value of 10 to 19 as a carbohydrate source (mixing ratio is weight ratio 24: 1 to 25: 1) to 31 to 37% by weight, the amount of vitamins and minerals required by Korean adults daily The mixture is mixed in a small amount, and dispersed in a glycerin fatty acid so as to contain 0.3 to 0.5% by weight of emulsifiers such as steter and 0.2 to 0.4% by weight of flavors such as yogurt, peanut, vanilla, milk, coffee, chestnut and the like. Subsequently, the mixture is homogenized under a pressure condition of 150 kg / cm 2 to 450 kg / cm 2, and filled at a filling temperature of 80 ° C. to 95 ° C., followed by high temperature sterilization at 121 ° C. to 140 ° C. for 30 seconds to 15 minutes.

The pure content of each nutrient contained in the liquid nutrient composition of the present invention prepared as described above and the recommended amount of Korean nutrition are shown in Table 2 below.

Nutritional Components in 100g of Nutritional Composition for Non-dialysis and Dialysis Kidney Diseases of the Present Invention (Based on Male 20-49 Years) Ingredient Name unit Nutritional composition for non-dialysis kidney disease Nutritional Composition for Dialysis Kidney Disease Patients Korean Adult Daily Nutrition Recommendations * Protein Fat Loss Carbohydrates Vitamin A Vitamin D ₃ Vitamin E Vitamin B ₁ Vitamin B ₂ Vitamin B ₆ Vitamin B ₁₂ Vitamin C Biotin nicotinic acid-amide folic acid glg ggμgmgmgmgmgmgμmgμgmgμg 2 ~ 35 ~ 731 ~ 3730 ~ 1100.25 ~ 0.750.5 ~ 1.50.05 ~ 0.20.08 ~ 0.250.25 ~ 0.750.1 ~ 0.15 ~ 155 ~ 150.8 ~ 2.625 ~ 75 6 ~ 75 ~ 731 ~ 3730 ~ 1100.25 ~ 0.750.5 ~ 1.50.05 ~ 0.20.08 ~ 0.250.25 ~ 0.750.1 ~ 0.35 ~ 155 ~ 150.8 ~ 2.625 ~ 75 75--7005101.31.51.5-55-17250

ingredient unit Nutritional composition for non-dialysis kidney disease Nutritional Composition for Dialysis Kidney Disease Patients Korean Adult Daily Nutrition Recommendations * Calcium Pantothenate Calcium Phosphate Magnesium Iron Soft Iron Nitrate Mgmgmgmgmgmgmgmg㎉ 0.25 ~ 0.7560 ~ 20020 ~ 5510 ~ 300.7 ~ 2.30.6 ~ 2.040 ~ 12040 ~ 120200 0.25 ~ 0.7560 ~ 20020 ~ 5510 ~ 300.7 ~ 2.30.6 ~ 2.040 ~ 12040 ~ 120200 -700700-1512--2,500

* Reference: Sixth Amendment (1995), The Korean Nutrition Society

On the other hand, the nutritional composition of the present invention prepared as described above, has the physical properties as shown in Table 3 below, even if stored for 1 year at room temperature of 15 to 25 ℃ did not occur fat separation and protein precipitation.

Physical Properties of Nutritional Compositions of the Invention Properties Nutritional composition for non-dialysis kidney disease Nutritional Composition for Dialysis Kidney Disease Patients The hydrogen ion concentration (pH) Viscosity (cps) weight osmolality (mOsm / ㎏ and H ₂ O) credit quality load (mOsm / L) 6.5 to 70.50 to 601.15 to 1.25890 ± 10220 to 230 6.5 to 7.0 120 to 1301.15 to 1.25950 ± 10400 to 410

Hereinafter, the present invention will be described in detail with reference to Examples. These examples are only for illustrating the present invention in more detail, and it will be apparent to those skilled in the art that the scope of the present invention is not limited to these examples according to the gist of the present invention.

Example 1;

2.2 g of the separated milk protein or separated milk protein hydrolyzate, 3.4 g of sunflower oil, 1.3 g of medium chain neutral fat, 0.3 g of glycerin fatty acid ester and 0.3877 g of the inorganic mixed powder of Table 4 were uniformly mixed and dispersed in 40.6052 g of purified water, and 150 kg / Homogenized at a high pressure of 2 cm 2 to 450 kg / cm 2. To this, 49.6 g of dextrin, 2.0 g of per white sugar, 0.0071 g of vitamin mixed powder of Table 5 and 0.2 g of incense were added to make the total weight 100 g, and then mixed again for 10 to 20 minutes. Subsequently, the mixture was filled at a temperature of 80 ° C. to 95 ° C., followed by high temperature sterilization at 121 ° C. to 140 ° C. for 30 seconds to 15 minutes, thereby preparing a liquid nutrition composition.

Composition of Mineral Mixed Powders * Mineral class content Mineral class content Ferrous sulfate 1.75 mg Potassium phosphate monobasic 15 mg Zinc oxide 0.85 mg Potassium citrate 90 mg Dicalcium phosphate 55 mg Magnesium chloride 24.8 mg Calcium Carbonate1 100 mg Sodium citrate 75 mg Magnesium carbonate 25.3 mg

* Content composition: 5% of Korean recommended amount

Composition of Vitamin Mixed Powders * Vitamin types content Vitamin types content Vitamin A Acetate 35 μg Vitamin B ₁₂ 0.1 μg Vitamin D ₃ 0.25 ㎍ Vitamin c 5 mg Vitamin E 0.5 mg Biotin 5 μg Vitamin B ₁ 0.07 mg Nicotinic acid amide 0.85 mg Vitamin B ₂ 0.08 mg Folic acid 25 μg Vitamin B ₆ 0.25 mg Calcium Pantothenate 0.25 mg

* Content composition: 5% of Korean recommended amount

Example 2 :

3.3g separated milk protein or separated milk protein hydrolyzate, 5.0g sunflower oil, 1.3g medium chain neutral fat, 0.4g glycerin fatty acid ester and 0.7753g of mineral mixed powder of Table 6 below were mixed and dispersed uniformly in 43.8106g of purified water, 150kg / Homogenized at a high pressure of 2 cm 2 to 450 kg / cm 2. To this, 43.6 g of dextrin, 1.5 g of white sugar, 0.0141 g of vitamin mixed powder and 0.3 g of fragrance of Table 7 were added to make the total weight 100 g, and then mixed again for 10 to 20 minutes. Subsequently, the mixture was filled at a temperature of 80 ° C. to 95 ° C., followed by high temperature sterilization at 121 ° C. to 140 ° C. for 30 seconds to 15 minutes, thereby preparing a liquid nutrition composition.

Composition of Mineral Mixed Powders * Mineral class content Mineral class content Ferrous sulfate 3.5 mg Potassium phosphate monobasic 30 mg Zinc oxide 1.7 mg Potassium citrate 180 mg Dicalcium Phosphate 110 mg Magnesium chloride 49.5 mg Calcium carbonate 200 mg Sodium citrate 150 mg Magnesium carbonate 50.6 mg

* Content Composition: 10% of the recommended amount of Koreans

Composition of Vitamin Mixed Powders * Vitamin types content Vitamin types content Vitamin A Acetate 70 μg Vitamin B12 0.2 μg Vitamin D3 0.5 μg Vitamin c 10 mg Vitamin E 1.0 mg Biotin 10 μg Vitamin B1 0.13 mg Nicotinic acid amide 1.7 mg Vitamin B2 0.15 mg Folic acid 50 μg Vitamin B6 0.5 mg Calcium Pantothenate 0.5 mg

* Content Composition: 10% of the recommended amount of Koreans

Example 3 :

2.7 g of isolated milk protein or hydrolyzed milk protein, 5.2 g of sunflower oil, 1.3 g of medium chain neutral fat, 0.5 g of glycerin fatty acid ester, and 1.163 g of the inorganic mixed powder of Table 8 were uniformly mixed and dispersed in 44.0158 g of purified water, and 150 kg. Homogenized at a high pressure of / cm 2 to 450kg / cm 2. 43.2 g of dextrin, 1.5 g per white, 0.0212 g of vitamin mixed powder of Table 9 and 0.4 g of fragrance were added thereto to make the total weight 100 g, and then mixed again for 10 to 20 minutes. Subsequently, the mixture was filled at a temperature of 80 ° C. to 90 ° C., and then sterilized at 121 ° C. to 140 ° C. for 30 seconds to 15 minutes to prepare a liquid nutrition composition.

Composition of Mineral Mixed Powders * Mineral class content Mineral class content Ferrous sulfate 5.25 mg Potassium phosphate monobasic 45 mg Zinc oxide 2.55 mg Potassium citrate 270 mg Dicalcium Phosphate 165 mg Magnesium chloride 74.3 mg Calcium carbonate 300 mg Sodium citrate 225 mg Magnesium carbonate 75.9 mg

* Content Composition: 15% of Korean recommended

Composition of Vitamin Mixed Powders * Vitamin types content Vitamin types content Vitamin A Acetate 105 ㎍ Vitamin B ₁₂ 0.3 μg Vitamin D ₃ 0.75 μg Vitamin c 15 mg Vitamin E 1.5 mg Biotin 15 μg Vitamin B ₁ 0.2 mg Nicotinic acid amide 2.55 mg Vitamin B ₂ 0.23 mg Folic acid 75 μg Vitamin B ₆ 0.75 mg Calcium Pantothenate 0.75 mg

* Content composition: 5% of Korean recommended amount

Example 4 :

7.1 g of separated milk protein or separated milk protein hydrolyzate, 3.4 g of sunflower oil, 1.3 g of medium chain neutral fat, 0.3 g of glycerin fatty acid ester, and 0.3127 g of inorganic mixed powder of Table 8 were uniformly mixed and dispersed in 41.9802 g of purified water, and 150 kg. Homogenized at a high pressure of / cm 2 to 450kg / cm 2. 43.9g of dextrin, 1.5g per white, 0.0071g of vitamin mixed powder of Table 5 and 0.2g of flavor were added to make the total weight 100g, and then mixed again for 10 to 20 minutes. Subsequently, the mixture was filled at a temperature of 80 ° C. to 95 ° C., followed by high temperature sterilization at 121 ° C. to 140 ° C. for 30 seconds to 15 minutes, thereby preparing a liquid nutrition composition.

Composition of Mineral Mixed Powders * Mineral class content Mineral class content Ferrous sulfate 1.75 mg Magnesium carbonate 25.3 mg Zinc oxide 0.85 mg Potassium phosphate monobasic 15 mg Dicalcium Phosphate 55 mg Potassium citrate 90 mg Calcium carbonate 100 mg Magnesium chloride 24.8 mg

* Content composition: 5% of Korean recommended amount

Example 5 :

6.5 g of the separated milk protein or the separated milk protein hydrolyzate, 5.0 g of sunflower oil, 1.3 g of medium chain neutral fat, 0.4 g of glycerin fatty acid ester, and 0.6253 g of the inorganic mixed powder of Table 11 were uniformly mixed and dispersed in 45.1106 g of purified water, and 150 kg. Homogenized at a high pressure of / cm 2 to 450kg / cm 2. 39.3 g of dextrin, 1.45 g of white sugar, 0.0141 g of vitamin mixed powder of Table 7 and 0.3 g of fragrance were added thereto to make the total weight 100 g, and then mixed again for 10 to 20 minutes. Subsequently, the mixture was filled at a temperature of 80 ° C. to 95 ° C., followed by high temperature sterilization at 121 ° C. to 140 ° C. for 30 seconds to 15 minutes, thereby preparing a liquid nutrition composition.

Composition of Mineral Mixed Powders * Mineral class content Mineral class content Ferrous sulfate 3.5 mg Magnesium carbonate 50.6 mg Zinc oxide 1.7 mg Potassium phosphate monobasic 30 mg Dicalcium Phosphate 110 mg Potassium citrate 180 mg Calcium carbonate 200 mg Magnesium chloride 49.5 mg

* Content Composition: 10% of the recommended amount of Koreans

Example 6 :

7.6 g of separated milk protein or separated milk protein hydrolyzate, 5.2 g of sunflower oil, 1.3 g of medium chain neutral fat, 0.5 g of glycerin fatty acid ester, and 0.938 g of the inorganic mixed powder of Table 12 were uniformly mixed and dispersed in 45.7408 g of purified water, and 150 kg. Homogenized at a high pressure of / cm 2 to 450kg / cm 2. 36.8 g of dextrin, 1.5 g of white spirit, 0.0212 g of vitamin mixed powder of Table 9 and 0.4 g of flavor were added thereto to make the total weight 100 g, and then mixed again for 10 to 20 minutes. Subsequently, the mixture was filled at a temperature of 80 ° C. to 95 ° C., followed by high temperature sterilization at 121 ° C. to 140 ° C. for 30 seconds to 15 minutes, thereby preparing a liquid nutrition composition.

Composition of Mineral Mixed Powders * Mineral class content Mineral class content Ferrous sulfate 5.25 mg Magnesium carbonate 75.6 mg Zinc oxide 2.55 mg Potassium phosphate monobasic 45 mg Dicalcium Phosphate 165 mg Potassium citrate 270 mg Calcium carbonate 300 mg Magnesium chloride 74.3 mg

* Content Composition: 15% of Korean recommended

Example 7 :

In order to clinically examine whether the nutritional effect of this nutrient composition can improve various nutritional status in patients with nephropathy, the subjects of 15 malnourished patients who had undergone peritoneal dialysis for 6 months or more were 400 to 1 day. Serum biochemical index, subjective, subjective global assessment (SGA), which is an indicator of nutritional status, was orally administered for 3 months orally with the liquid nutritional composition of the present invention supplying 800 kcal and 12-24 g of protein. Weak), and phylogenetic measurements were performed to determine the nutritional status before and after administration and to compare with 11 controls. As a result, it was confirmed that the human body measurements such as mean weight,% abnormal body weight (% IBW), body mass index (BMI), body fat fraction, total muscle mass and circumferential muscle circumference increased significantly in the nutrient-treated group after 3 months. In addition, the liquid nutritional composition of the present invention has been found to be suitable as a nutritional source for kidney disease (Table 13).

Clinical Effect of Nutritional Composition for Dialysis Renal Disease of the Present Invention Human survey Nutritional composition administration group Control Before drinking After drinking Before drinking After drinking Weight (kg) 52.4 ± 8.3 54.2 ± 8.8 56.7 ± 8.1 56.3 ± 8.5 Ideal weight% 87.7 ± 9.0 91.7 ± 9.3 97.5 ± 7.8 96.0 ± 7.8 Body mass index (㎏ / m2) 18.7 ± 1.8 19.5 ± 2.0 20.7 ± 1.6 20.3 ± 1.6 Body fat fraction (%) 13.2 ± 4.2 15.4 ± 3.9 12.6 ± 8.1 12.2 ± 7.4 Humerus Muscle Circumference (cm) 22.8 ± 2.1 23.7 ± 2.2 24.5 ± 2.6 24.4 ± 2.8 Total muscle mass (kg) 16.8 ± 3.7 18.2 ± 3.3 18.3 ± 3.9 17.4 ± 4.1

As described in detail above, the nutritional composition of the present invention has a total calories of 200㎉ per 100g, the caloric ratio of the three major nutrients (proteins, fats, carbohydrates) is 4 to 14% by weight protein, 22.5 to 31.5% by weight fat and Carbohydrate 62 to 74% by weight, vitamins and minerals are nutritional balance special nutrition products containing 5 to 15% by weight of the daily recommended amount of Korean adults, the ratio of polyunsaturated fatty acid to monounsaturated fatty acid (P / M) It is 1 or less and does not contain lactose. As a result of clinical studies in dialysis kidney patients, oral nutrition supplement for 3 months using the nutritional composition of the present invention had high compliance of patients and resulted in improvement of anthropometric nutritional status indicators. Therefore, the liquid nutritional composition for kidney disease patients of the present invention can be used as a new nutritional substance that can more easily and effectively provide nutrition to kidney disease patients, compared to the diet for kidney disease patients made in existing hospitals or homes.

Claims (8)

Liquid nutritional composition for patients with kidney disease containing the following ingredients: ingredient Nutritional composition for dialysis kidney disease patients (wt%) protein 6 to 7 Fat 5 to 7 carbohydrate 31 to 37 Vitamin powder 0.0071 to 0.0212 Mineral powder 0.3127 to 0.938 Emulsifier 0.3 to 0.5 Spices 0.2 to 0.4 Purified water Remainder In the above, The vitamin powder may contain 35 to 105 µg of vitamin A acetate; 0.25 to 0.75 μg of vitamin D ₃ ; Vitamin E 0.5-1.5 mg; Vitamin B ₁ 0.07 to 0.2 mg; 0.08 to 0.23 mg of vitamin B ₂ ; 0.25 to 0.75 mg of vitamin B ₆ ; 0.1 to 0.3 μg of vitamin B ₁₂ ; Vitamin C 5-15 mg; Biotin 5-15 μg; Nicotinic acid amide 0.85-2.55 mg; Folic acid 25-75 μg; Calcium 0.25 to 0.75 mg of pantothenate; And, Inorganic powder is 1.75-5.25 mg of ferrous sulfate; Zinc oxide 0.85-2.55 mg; 55 to 165 mg dicalcium phosphate; Calcium carbonate 100-300 mg; Magnesium carbonate 25.3-75.9 mg; 15 to 45 mg of monobasic calcium phosphate; Potassium citrate 90 to 270 mg; Magnesium chloride 24.8-74.3 mg; It contains 75 to 225 mg of sodium citrate. The method of claim 1, Protein source is characterized in that the separated protein or animal milk protein hydrolysate of animal protein Nutritional composition. The method of claim 2, The isolated milk protein is at least one substance selected from the group consisting of casein, sodium caseinate, potassium caseinate, calcium caseinate and casein hydrolysates. Nutritional composition. The method of claim 1, Fat source is a vegetable oil, characterized in that the ratio of polyunsaturated fatty acid and monounsaturated fatty acid is 1 or less Nutritional composition. The method of claim 4, wherein Vegetable oil is characterized in that the sunflower oil or medium-chain triglycerides Nutritional composition. The method of claim 1, Carbohydrate source is characterized in that the degree of glycolysis is between 10 and 19 Nutritional composition. The method of claim 6, Carbohydrate source is characterized in that the mixture of dextrin and white sugar in a weight ratio of 24: 1 to 25: 1 Nutritional composition. The liquid nutrient composition disclosed in claim 1 is mixed, homogenized under a pressure condition of 150 to 450 kg / cm 2, filled at a temperature of 80 to 95 ° C., and subjected to high temperature sterilization at 121 to 140 ° C. for 30 seconds to 15 minutes. Method of producing a nutritional composition for kidney disease patients comprising the process