JP3285959B2 - Liquid preparation nutritional food for long-term medical care patients - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition containing components obtained by removing whey from fermented milk. The composition according to the present invention uses a milk protein having good digestibility and absorbability as a protein source, strengthens dietary fiber which is said to be scarce in modern humans, and is said to have an important balance of dietary fat. Therefore, ω-3 series polyunsaturated fatty acids are also fortified and used in medicine type, and used in food and drink types such as beverages, foods, nutritional foods, functional foods, foods for specified health uses, and drinks. However, it can be widely used for long-term care patients, post-sick people, and elderly healthy people.

[0002]

BACKGROUND OF THE INVENTION Normal nutritional compositions are generally neutral foods. However, in a liquid composition using an acidic material such as fermented milk, the protein source, fermented milk, is inherently poorly soluble and is difficult to be made into a high protein. In addition, it is difficult to obtain a balanced and complete diet for a long-term use of a nutritional composition using a material having these limited components, compositions, and properties.

[0003]

SUMMARY OF THE INVENTION In view of such circumstances, the present invention is an ideal composition for long-term use, which is closer to a general diet, and is not only for long-term patients,
The purpose of the present invention is to develop an excellent composition that can be widely used for post-sick people, the sick, and elderly healthy people.

[0004]

As a result of various studies to achieve the above object, it has been found that fermented milk with high nutritive value, which has a small number of restricted amino acids and an amino acid score of 100, is used as a protein source, and is used in the fermented milk. It has been found that by removing a large amount of lactose and potassium as whey, fermented milk with reduced lactose and potassium can be obtained. In view of the fact that lactose is restricted to lactose intolerant patients and the need to limit potassium to prevent hyperkalemia in long-term use of fermented milk products, focus on the whey-removed fermented milk described above did.

[0005] As a result of further study from various fields,
It was found that the components excluding whey from fermented milk were extremely effective as a protein source in foods and drinks for long-term medical care patients, and as a result of further research based on this new finding, they finally completed the present invention. The present invention is based on a composition containing whey-removed fermented milk as a basic technical idea. Hereinafter, the present invention will be described in detail.

[0006] Here, from the viewpoint that long-term care patients must ingest essential nutrients while securing energy, the composition ratio of the composition is generally represented by the content per 100 kcal of energy of food or drink.

[0007] One of the important features of the composition according to the present invention is that a component obtained by removing whey from fermented milk is used as a protein. Energy of the composition is 10
30-35 g per 0 kcal, protein content 4.0-4.5 g per 100 kcal energy of the composition
I found that it was effective when blended. Moreover, it has been found that lactose can be reduced to 0.6 to 0.9 g per 100 kcal energy of the composition by removing whey from the fermented milk, and it has been confirmed that it is effective to some extent in lactose intolerant patients. Was.

The composition according to the present invention is used not only as a pharmaceutical type but also as a food and drink type.
In the case of the latter, not only nutritional and calorie aspects, but also easy to drink, that is, requirements for palatability are further required. Therefore, as a result of intensive studies on this point, it was also found that the use of carbohydrate is preferable. As a carbohydrate, it is one of the three major ingredients, and it is effective to use mainly honey as a carbohydrate with high nutritional value.
It has been found that blending 5 to 10 g per 00 kcal is effective.

[0009] Then, it was confirmed that dietary fiber should be blended in order to enhance the effectiveness as a composition for long-term care patients. Its dietary fiber content is 100 k of energy of the composition
It has been found that containing 1.4 to 2.0 g per cal is effective. In addition, the term "dietary fiber" refers to all components that are hardly hydrolyzed by a dilute acid and components that are hardly digested even when eaten, and water-soluble dietary fiber in addition to cellulose and hemicellulose can be used as appropriate. Examples of these include: pectin, guar
Gum or its enzymatic degradation product, glucomannan, seaweed, cellulose, hemicellulose, lignin, wheat bran, o-
Tomir, alfalfa, okara, and others.

[0010] Further, it has been confirmed that it is better to mix lipids, vitamins and minerals in order to enhance the efficacy as a composition for long-term care patients. At that time, since the balance of ω-6 / ω-3 of the polyunsaturated fatty acid series is considered to be important as the lipid, the ω-3 series polyunsaturated fatty acid can be used in an amount of 70 to 100 kcal per 100 kcal of the composition.
100 mg, of the minerals, sodium is 20-80 mg per 100 kcal of the energy of the composition and potassium is 4 per 100 kcal of the energy of the composition.
It was found that containing 5 to 160 mg was effective. In addition, since the fermented milk and honey are acidic, a pH of the composition is set to 3.
It was found that a value of 5 to 4.5 is extremely effective.
They also succeeded in determining the optimal blending amount, and finally completed the product of the present invention. The ω-3 series polyunsaturated fatty acids include α-linolenic acid (C ₁₈ : ₃ ), eicosapentaenoic acid (EPA,
C ₂₀ : ₅ ), docosahexaenoic acid (DHA, C ₂₂ : ₆ ),
And the like, but the content thereof or the reinforced fats and oils thereof can also be appropriately used.

The component used in the present invention, from which the whey is removed from the fermented milk, is the component obtained by removing the whey from the fermented milk prepared according to a conventional method by a known method such as filtration and centrifugation. It is possible to use all of them, for example, those manufactured as follows.

Raw materials such as raw milk, skim milk, and reduced skim milk are sterilized, fermented by adding a lactic acid bacterium starter, sterilized after cooling with stirring, and concentrated by centrifugation, filtration, and other known solid-liquid separation means. And the resulting product is a whey-removed fermented milk component. As the lactic acid bacterium starter, a commonly used starter is appropriately used, and non-limiting examples thereof include the following, which are used alone or in combination of two or more: Lactobacillus bulgaricu
s IFO 3533, L.P. casei ATCC 7
469; Streptococcus thermop
hilus IFO 3535, Str. lactis
IFO 12546, Str. cremoris A
TCC 9625 and others.

In the present invention, this component can be used as it is without special treatment, a component further added with a polysaccharide, a component obtained by further homogenizing the component, and various components such as concentration, dilution, drying, etc. A processed product obtained by processing can also be used. Natural gums are widely used as polysaccharides, and the following are exemplified. : One or more of xanthan gum, guar gum, locust bean gum, tragacanth gum, tamarind gum, carrageenan, furceleran, arabic gum, juran gum and the like. The amount used is not particularly limited, but is 0.05 to 1%.
A flowable composition can be produced by using 0%, preferably about 0.1 to 5%.

The composition according to the present invention comprises a fermented milk excluding whey and a saccharide such as honey as an active ingredient, and is used as a food or drink or a medicine. When these active ingredients are used as foods and drinks, the active ingredients can be used as they are, or used in combination with other foods or food ingredients, and used in accordance with a conventional method. The composition may be in the form of a solid (powder, granule, or the like), paste, liquid or suspension, but is preferably in the form of a liquid or other liquid food to facilitate ingestion. It is. In such a case, as a preparation or composition, a technique of a conventionally known enteral nutrition can be used as it is.

When the composition is used as a medicament, it can be made into tablets, granules, powders, capsules, powders, liquids, drinks and suppositories according to a conventional method.
It can be administered orally or enterally.

The active ingredient according to the present invention has no or very low toxicity because of its natural origin and is extremely safe (LD ₅₀ > 65 g / kg po: rat). In addition, the dose thereof, when used as a medicine, may be referred to conventionally known enteral nutrition according to the patient's symptoms,
When used for preventive, health or food and drink purposes,
There is no particular limitation, and it may be the same as ordinary food and drink.

[0017]

[Effects] Energy intake (1400 kca), which is the least energy required in nutritional requirements, is over 80 years old.
1 / day), its protein requirement (55 g / day)
Days) can be secured.

It is possible to ingest ω-series polyunsaturated fatty acids and dietary fiber, and it is expected to maintain the balance of essential fatty acids and enhance the digestive tract function, which is more physiological. .

Since the potassium content is reduced by using whey-removed fermented milk, it is possible to prevent the occurrence of hyperkalemia in long-term use of the fermented milk product. At the same time, reduction of sodium content enabled prevention of hypertension.

Hereinafter, Production Examples and Examples of the present invention will be described in detail.

[0021]

[Production Example 1] After sterilizing 5 tons of skim milk by heating, Lactobacillusbulgaricu was used as a starter.
s, Streptococcus thermophi
rus was added in a conventional manner, fermented at about 40 ° C., stirred, cooled (pH 4.0 ± 0.1), and sterilized by heating.

Next, the whey is removed by centrifugation and concentration.
After adding 0.2% of locust bean gum and homogenizing, it is cooled and 992 kg of a component obtained by removing whey from fermented milk
Was obtained and filled in a container.

[0023]

Example 1 100 ml (energy 100 kcal)
31 g of ingredients (obtained in Production Example 1) except for whey from fermented milk (honey), 8 g of honey, 5.7 g of dextrin, 1 g of sucrose, water-soluble dietary fiber (pectin and guar gum enzyme) 1.4 g of an equal mixture of decomposition products)
And ω-3 series polyunsaturated fatty acid-enriched oil and fat (comprising sardine oil) in a ratio of 2.8 g, and furthermore, vitamins and minerals in Tables 1 and 2 below (100 kcal of a liquid food according to Example 1 of the present invention). Per component / composition (component amount)), and a product according to the present invention was produced.

[0024]

[Table 1]

[0025]

[Table 2]

As is clear from the above results, this product
-3 series of polyunsaturated fatty acids fortifying dietary fatty acids and enhancing dietary fiber, which is said to be in short supply for modern people, is extremely effective as a liquid diet for long-term care patients The product is completed.

[0027]

Example 2 100 ml (energy 100 kcal)
35 g of ingredients (obtained in Production Example 1) except for whey from fermented milk (9 g of honey, 4.2 g of dextrin, 1 g of sucrose, water-soluble dietary fiber (pectin and guar gum enzyme) 1.7 g of an equal mixture of decomposition products)
And ω-3 series polyunsaturated fatty acid-enriched oil and fat (comprising sardine oil) in a ratio of 2.8 g, and furthermore, vitamins and minerals shown in Tables 3 and 4 below (liquid food 100 kcal according to Example 2 of the present invention) Per component / composition (component amount)), and a product according to the present invention was produced.

[0028]

[Table 3]

[0029]

[Table 4]

As is clear from the above results, this product
-3 series of polyunsaturated fatty acids fortifying dietary fatty acids and enhancing dietary fiber, which is said to be in short supply for modern people, is extremely effective as a liquid diet for long-term care patients The product is completed.

[0031]

According to the present invention, ω-3 series polyunsaturated fatty acids and dietary fiber, which tend to be insufficient for long-term care patients, can be ingested, and a nutritional composition closer to a general diet can be ingested. Was. In addition, the composition is an excellent composition that can be used not only for long-term care patients but also for post-sick, sick, and elderly healthy people.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification code FI A23L 2/52 A61P 3/02 A61K 38/00 A23L 2/00 F A61P 3/02 A61K 37/02 (72) Inventor Yamamoto Yoshiro 1-21-3 Sakaecho, Higashimurayama-shi, Tokyo Meiji Dairies Co., Ltd. Central Research Laboratory (58) Field surveyed (Int. Cl. ⁷ , DB name) A23L 1/29-1/305 A23C 9/12-9 / 14 A23L 2/38 A23L 2/52 A61K 38/00

Claims (12)

(57) [Claims] 1. A food or drink comprising an ingredient obtained by removing whey from fermented milk and honey. 2. An orally administered nutritional supplement comprising an ingredient obtained by removing whey from fermented milk and honey. 3. 30~35g per energy 100kcal component content excluding whey from fermented milk pharmaceuticals food, drink or nutraceutical, protein content of components excluding whey from fermented milk food or drink or a nutritional The food or drink according to claim 1 or the food or drink according to claim 2, wherein the weight is 4.0 to 4.5 g per 100 kcal of the energy of the drug.
Nutrition supplements . 4. A pharmaceutical for nutrition according to food or drink or claim 2 according to claim 1, honey content characterized in that it is a 5.0~10g per energy 100kcal pharmaceutical food, drink or nutraceutical . 5. A pharmaceutical for nutrition according to food or drink or claim 2 according to claim 1, lactose content, characterized in that a 5.0~10g per energy 100kcal pharmaceutical food, drink or nutraceutical . 6. The dietary fiber content is 1.4-2.0 per 100 kcal energy of food or drink or nutritional supplement.
The food or drink according to claim 1 or the nutritional supplement according to claim 2, wherein dietary fiber is blended so as to obtain g.
Supply drugs. 7. An ω-3 series polyunsaturated fatty acid is blended so that the content of the ω-3 series polyunsaturated fatty acid is 70 to 100 mg per 100 kcal of energy of the food or drink or nutritional supplement. The food or drink according to claim 1 or the pharmaceutical for nutritional supplement according to claim 2. 8. The sodium content is 20-80 m per 100 kcal energy of pharmaceuticals for food and drink or nutritional supplement.
The food or drink according to claim 1 or the pharmaceutical for nutritional supplement according to claim 2, which is g. 9. Potassium content of 45 to 160 m per 100 kcal energy of food or drink or nutritional supplement
The food or drink according to claim 1 or the pharmaceutical for nutritional supplement according to claim 2, which is g. 10. The food or drink according to claim 1, wherein the pH is 3.5 to 4.5.
Nutrition supplements . 11. An ingredient obtained by removing whey from fermented milk, an ingredient obtained by removing whey by centrifugation and / or filtration of fermented milk of lactic acid bacteria, an ingredient obtained by adding a polysaccharide to the ingredient, or a more homogenous ingredient. 11. The method according to claim 1, wherein the component is selected from the group consisting of a processed component, or a processed product such as concentration, dilution, and drying of the component. The food or drink or the nutritional supplement drug described in the above. 12. The method according to claim 1, wherein the patient is a long-term care patient.
The food or drink or the nutritional supplement drug according to any one of claims 1 to 7.