JPH0521091B2 - - Google Patents
Info
- Publication number
- JPH0521091B2 JPH0521091B2 JP60045365A JP4536585A JPH0521091B2 JP H0521091 B2 JPH0521091 B2 JP H0521091B2 JP 60045365 A JP60045365 A JP 60045365A JP 4536585 A JP4536585 A JP 4536585A JP H0521091 B2 JPH0521091 B2 JP H0521091B2
- Authority
- JP
- Japan
- Prior art keywords
- musk
- extract
- present
- solvent
- sheep
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000284 extract Substances 0.000 claims description 31
- 241001494479 Pecora Species 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 13
- 210000002149 gonad Anatomy 0.000 claims description 12
- 239000002904 solvent Substances 0.000 claims description 12
- 239000004615 ingredient Substances 0.000 claims description 9
- 238000009826 distribution Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000003960 organic solvent Substances 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 241000402754 Erythranthe moschata Species 0.000 description 23
- 230000000694 effects Effects 0.000 description 22
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
- 210000001550 testis Anatomy 0.000 description 17
- 241000699670 Mus sp. Species 0.000 description 10
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
- 206010030113 Oedema Diseases 0.000 description 8
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical class CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- 239000004475 Arginine Substances 0.000 description 5
- 241001416180 Moschidae Species 0.000 description 5
- 102000035195 Peptidases Human genes 0.000 description 5
- 108091005804 Peptidases Proteins 0.000 description 5
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 5
- 230000000144 pharmacologic effect Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 238000004440 column chromatography Methods 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 235000019833 protease Nutrition 0.000 description 4
- 210000001913 submandibular gland Anatomy 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 241000282887 Suidae Species 0.000 description 3
- 241001493546 Suina Species 0.000 description 3
- 235000010418 carrageenan Nutrition 0.000 description 3
- 229920001525 carrageenan Polymers 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- CBMYJHIOYJEBSB-UHFFFAOYSA-N (10S)-3t.17t-Dihydroxy-10r.13c-dimethyl-(5cH.8cH.9tH.14tH)-hexadecahydro-1H-cyclopenta[a]phenanthren Natural products C1C(O)CCC2(C)C3CCC(C)(C(CC4)O)C4C3CCC21 CBMYJHIOYJEBSB-UHFFFAOYSA-N 0.000 description 2
- CBMYJHIOYJEBSB-GCXXXECGSA-N 5beta-androstane-3alpha,17beta-diol Chemical compound C1[C@H](O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@@H]21 CBMYJHIOYJEBSB-GCXXXECGSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 229960002895 phenylbutazone Drugs 0.000 description 2
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 2
- 230000001766 physiological effect Effects 0.000 description 2
- 239000002798 polar solvent Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- 240000000662 Anethum graveolens Species 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 description 1
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
- 235000011201 Ginkgo Nutrition 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- 235000008100 Ginkgo biloba Nutrition 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 238000005377 adsorption chromatography Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 210000001643 allantois Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000000991 chicken egg Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000002497 edematous effect Effects 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 210000001126 granulation tissue Anatomy 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229940105631 nembutal Drugs 0.000 description 1
- 239000012454 non-polar solvent Substances 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- -1 steroid compounds Chemical class 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP60045365A JPS61204129A (ja) | 1985-03-06 | 1985-03-06 | ジヤコウ類似効果成分の製法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP60045365A JPS61204129A (ja) | 1985-03-06 | 1985-03-06 | ジヤコウ類似効果成分の製法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS61204129A JPS61204129A (ja) | 1986-09-10 |
JPH0521091B2 true JPH0521091B2 (de) | 1993-03-23 |
Family
ID=12717242
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP60045365A Granted JPS61204129A (ja) | 1985-03-06 | 1985-03-06 | ジヤコウ類似効果成分の製法 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS61204129A (de) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06145184A (ja) * | 1991-08-22 | 1994-05-24 | Koukandou:Kk | 循環器に影響を及ぼす成分の製法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5829711A (ja) * | 1981-08-17 | 1983-02-22 | Koukandou:Kk | ジャコウ類似生薬 |
-
1985
- 1985-03-06 JP JP60045365A patent/JPS61204129A/ja active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5829711A (ja) * | 1981-08-17 | 1983-02-22 | Koukandou:Kk | ジャコウ類似生薬 |
Also Published As
Publication number | Publication date |
---|---|
JPS61204129A (ja) | 1986-09-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR102387044B1 (ko) | 단백질-결합된 칸나비노이드 조성물 | |
RU2349337C2 (ru) | Фармацевтическая композиция, содержащая стероидные сапонины, способ ее получения и ее применение | |
US4948785A (en) | Plant polysaccharide fractions inducing prolactin in mammals | |
WO2006056129A1 (fr) | Compositions d'alcaloides d'huperzia serrata comportant de l'huperzine a et de l'huperzine b et preparation de ces compositions | |
JPH0543469A (ja) | β−グルクロニダーゼ阻害剤 | |
JP2019509332A (ja) | バイカリンマグネシウム化合物、その製造方法及び使用 | |
WO2010032269A2 (en) | Anti-inflammatory activity of the iridoid glycosides | |
DK164866B (da) | Fremgangsmaade til isolering af isosilybinfrit silibinin | |
Brownie et al. | The in vitro enzymic hydroxylation of steroid hormones. 2. Enzymic 11β-hydroxylation of progesterone by ox-adrenocortical mitochondria | |
JP2000503686A (ja) | 黄栢皮とオミナエシ植物の混合抽出物を含有するc型肝炎治療用製薬組成物 | |
RU2240304C2 (ru) | Производные гиперфорина, их использование и препараты, содержащие эти производные | |
JPH0521091B2 (de) | ||
IE50062B1 (en) | Pharmaceutical compositions containing climbing ivy extracts | |
KR20120068898A (ko) | 감염성 질환의 예방, 제거 및 치료를 위한 현삼과 추출물 | |
JPH0418019A (ja) | シアリダーゼ阻害剤 | |
JP3623247B2 (ja) | 茶葉サポニン類を含む薬剤 | |
US3361630A (en) | Cardiac glycoside | |
US4489067A (en) | Lipid reducing agents | |
JP2631686B2 (ja) | 新規ステロイドサポニンおよびその製造法ならびにこれらの誘導体の新規用途 | |
JPH0368516A (ja) | Na↑+,K↑+‐ATPase阻害剤 | |
JPS6217598B2 (de) | ||
BG111420A (bg) | Състав на екстракт от hippeastrum papilio за производство на лекарствени средства и хранителни добавки | |
JPS6140678B2 (de) | ||
JPH0285211A (ja) | 新規フェネチルアルコール配糖体および免疫抑制剤 | |
CA1169433A (en) | Method for preparing an antihypertensive agent comprising 1-0-alkyl-2-acetoyl-sn-glycero-3- phosphocholine |