JPH05148105A - Antibacterial gas or liquid fixation agent - Google Patents

Abstract

PURPOSE:To obtain an easily usable disinfecting or antibacterial preparation by dissolving or dispersing a liquid antibacterial compound easily liquefiable at ordinary temperature, e.g. ethylene oxide, in a fatty acid ester or paraffin. CONSTITUTION:The objective antibacterial gas or liquid fixation agent is produced by dissolving or dispersing a liquid antibacterial compound which is liquid at ordinary temperature (e.g. ethylene oxide, propylene oxide or ethanol) in a fatty acid ester (e.g. glycerol fatty acid ester, sorbitan fatty acid ester, phospholipid and higher alcohol fatty acid ester). The obtained liquid agent is solidified by cooling or absorbed, included or adsorbed to a gelatinous or solid material to obtain an antibacterial gas or liquid fixation agent. The agent can be used for the disinfection of medical tools in hospitals, etc., or the removal of microorganisms in plants and laboratories. It is also useful for preventing the degradation of various products caused by the proliferation of microorganisms.

Description

Detailed Description of the Invention

[0001]

The present invention can be used for sterilization of medical equipment in hospitals, etc., and for removal of microorganisms in production plants and research facilities, and in various products, prevents deterioration of quality due to proliferation of microorganisms. It can be used when necessary.

[0002]

2. Description of the Related Art Conventionally, steam sterilization and gas sterilization with ethylene oxid or propylene oxid are used to sterilize medical equipment in hospitals, used clothes contaminated with bacteria, and daily necessities, and sometimes ethanol is used. It has been used as a disinfectant.

[0003]

Steam sterilization kills microorganisms by heating steam, but there is a risk that the object to be sterilized will be destroyed by heat and moisture. Therefore, mainly for inorganic products such as metal and glass. There are limited drawbacks. Since gas sterilization does not use steam, it can be applied to other materials that are easily affected by heat and moisture, and is particularly suitable for sterilization of products having complicated shapes. In addition, gas sterilization is useful because it accommodates an object to be sterilized in a compartment with a large volume and sterilizes the entire compartment, so it can process a large amount of gas, but a gas cylinder or gas generator is required, However, it could not be easily used. It is known that ethanol, when gasified in a container, adheres to the surface of the articles contained in the container and exerts an antibacterial action to suppress the growth of microorganisms. However, it was difficult to control the gasification rate, and it was hard to say that it was a simple formulation. The reason why the use of antibacterial gas is not convenient is that they all have low boiling points: ethylene oxid is 10.7 ° C, propylene oxid is 34.2 ° C, and ethanol is 78.3.
This is because it is a compound that easily volatilizes at ℃. Therefore, a heavy gas cylinder for housing them and a complicated gasifier were required, so that they could not be used easily. The present invention relates to an antibacterial agent that solves each of the above problems.

[0004]

The present invention has been made as a result of various studies in view of the above circumstances, and provides a sterilizing or antibacterial preparation which is easy for anyone to use and easy to use.

The outline of the present invention is an antibacterial gas or liquid fixed preparation characterized in that a liquid antibacterial compound which is easily gasified at room temperature is dissolved or suspended in a fatty acid ester or paraffin. In the present invention, examples of the liquid antibacterial compound which is easily gasified at room temperature include the above-mentioned ethylene oxid, propylene oxid and ethanol.

In the present invention, the liquid antibacterial compound, which is easily gasified at room temperature, is dissolved or suspended in a fatty acid ester or paraffin, and then the liquid-fixed preparation is cooled and solidified or the preparation is a gel-like substance or solid. It is an antibacterial gas or liquid fixed preparation that is absorbed, hugged, or adsorbed to an object. The preparation of this preparation is usually carried out in a warmed state, because it is advantageous that the preparation is prepared by immersion in a gel or solid.

[0007]

The liquid antibacterial compound, which is easily gasified at room temperature, is dissolved or suspended in a fatty acid ester or paraffin, so that its volatility (vaporization rate) is fixed and restricted by the fatty acid ester or paraffin. Therefore, an antibacterial fixed preparation prepared by only dissolving or suspending an antibacterial compound in a fatty acid ester or paraffin is solidified by cooling to a temperature below the freezing point of the fatty acid ester or paraffin and formed into a shaped body such as granules or dice. Can be provided as. Further, a solution or suspension of fatty acid ester or paraffin is further filtered,
Non-woven fabrics, pulp mats, silica gel, activated carbon, oil-absorbing polysaccharides or resins are adsorbed and held on a support or encapsulated to prepare an antibacterial compound fixed preparation, or the liquid antibacterial compound in a closed container at low temperature. A fatty acid ester or paraffin having a melting point of room temperature or higher to, and if necessary, a support such as a polysaccharide, silica gel, activated carbon, diatomaceous earth, pulp mat, nonwoven fabric, or resin, and a melting point of a mixture with the fatty acid ester or paraffin. After heating and mixing as described above, it can be cooled to a temperature below the melting point and taken out as a solid to obtain an antibacterial fixed preparation.

[0008]

EXAMPLES Examples of the present invention will be described below. Example 1 Fats and oils containing 3.0 g of propylene oxyd in a stainless steel cup at 15 ° C. and 10 parts by weight of beef tallow, 20 parts by weight of rapeseed oil, 30 parts by weight of corn oil, 38 parts by weight of palm oil, and 2 parts by weight of soybean lecithin. Added to 0 g.
Further, the cup was dipped in a dry ice / acetone solution and cooled to prepare a propylene oxid-containing solid oil and fat. This stainless steel cup was stored in a nylon bag (30 cm x 50 cm) with a thickness of 30 µm together with a standard agar medium inoculated with staphylococcus and Escherichia coli at 37 ° C.
After culturing for a day, no microbial colony was observed.

On the other hand, a large number of microbial colonies were found on the standard agar medium cultured in the same nylon bag without the control stainless steel cup. From these results, the antibacterial gas-fixing preparation of the present invention was confirmed to have a bactericidal effect.

Example 2 To 40 g of a mixture consisting of 90 parts by weight of rapeseed oil, 10 parts by weight of beeswax and 5 parts by weight of candelilla wax was added 10 g of ethylene oxid solution and 450 g of silica gel, and the mixture was shaken at 53 ° C. for 6 hours in a closed container. Was added while heating, and then the mixture was cooled to −20 ° C. to prepare an ethylene oxid-containing preparation. This formulation containing ethylene oxide 10
0 g was stored in an acrylic container having an internal volume of 2 liters together with a commercially available indicator for gas sterilization. After 24 hours, this indicator was taken out and the bactericidal effect was confirmed.

Example 3 To 90 g of a mixture consisting of 80 parts by weight of sunflower oil, 14 parts by weight of soybean oil and 6 parts by weight of candelilla wax was added 10 g of ethylene oxid solution, and activated carbon 400 was added in a closed container.
The mixture was heated with shaking at 55 ° C. for 4 hours together with g. Thereafter, by cooling to -20 ° C, a preparation containing ethylene oxid was prepared. In the same manner as in Example 2, 50 g of this ethylene oxyd-containing preparation was placed in an acrylic container together with a commercially available indicator for gas sterilization. After 24 hours, the indicator was taken out and the sterilization effect was determined. As a result, sterilization was completed, and the bactericidal effect of this antibacterial gas-fixing preparation was confirmed.

Example 4 To 30 g of beeswax heated to 70 ° C., 6 g of ethanol was added and then cooled, and 32 g of a spherical antibacterial gas-fixed formulation having a diameter of 3 mm
Got This antibacterial gas-fixed spherical oil / fat (30 g) was stored in a glass container having an internal volume of 0.5 liter together with a sponge cake piece, which was sealed. As a control, a sponge cake alone was similarly stored in a container and used. As a result, the sponge cake stored with the spherical preparation was stored in good condition for 21 days, but the control had mold on the surface of the cake 14 days after the storage was started. From this, it was confirmed that the gas-fixing preparation of the present invention has an antibacterial action.

Example 5 100 g of a mixture of 50 parts by weight of liquid paraffin and 50 parts by weight of solid paraffin was heated to 70 ° C. and ethanol 20 was added.
g was added and suspended. A non-woven fabric (3 × 100 ×) placed on a stainless plate cooled to −20 ° C. while stirring
100 mm) to obtain an ethanol-fixed preparation. The entire formulation was placed in a glass container similar to that used in Example 4 and stored together with the cream puff. As a result, the cream puff added with this preparation was well preserved for 10 days, but the cream puff in the container to which nothing was added as a control was found to have mold on the surface on the 5th day. From this, it was confirmed that the gas-fixing preparation of the present invention has an antibacterial action.

[0014]

INDUSTRIAL APPLICABILITY The present invention dissolves or suspends the above-mentioned antibacterial substance that is easily gasified at room temperature in a fatty acid ester or paraffin and cools it only, or another gel-like substance or solid substance. By providing the antibacterial agent, it is possible to provide an antibacterial preparation having a controlled volatilization rate and thus exhibiting an antibacterial effect for a longer period of time.

 ─────────────────────────────────────────────────── ─── Continued Front Page (72) Inventor Koji Ishii 1-5-9 Seiwadai, Kita-ku, Kobe-shi, Hyogo

Claims (4)

[Claims] 1. An antibacterial gas or liquid fixed preparation characterized in that a liquid antibacterial compound which is easily gasified at room temperature is dissolved or suspended in a fatty acid ester or paraffin. 2. An antibacterial gas or liquid fixed preparation according to claim 1, which is a cooled and solidified molded product of the antibacterial gas or liquid fixed preparation or the preparation is absorbed, hugged or adsorbed in a gel-like substance or solid matter. 3. The antibacterial gas or liquid fixed preparation according to claim 1 or 2, wherein the liquid antibacterial compound which is easily gasified at room temperature is ethylene oxid, propylene oxid or ethanol. 4. The antibacterial gas or liquid fixed preparation according to claim 1 or 2, wherein the fatty acid ester is a compound selected from glycerin fatty acid ester, sorbitan fatty acid ester, phospholipid and higher alcohol fatty acid ester, alone or in combination.