JP3087863B2 - Antibacterial particles - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to antibacterial particles containing an inorganic antibacterial powder.

[0002]

2. Description of the Related Art Since the climate of Japan is high temperature and high humidity, microorganisms and bacteria that spoil water and foods, or microorganisms and bacteria that damage industrial materials and products are liable to propagate. Various antibacterial agents have been developed and put to practical use in order to prevent the growth of such microorganisms and bacteria. As this kind of antibacterial agent,
Conventionally, organic antibacterial agents are mainly used, and are easily mixed into plastics and the like, so that there is an advantage that processing is easy.
However, this antibacterial agent has a drawback that its antibacterial property generally decreases with time.

On the other hand, an inorganic antibacterial agent having long-lasting antibacterial properties has been developed in recent years (JP-B-61-22977,
JP-B-63-28402, JP-B-63-54013, JP-B
1-32254). This kind of antibacterial agent is composed of, for example, zeolite solid powder which is a kind of ceramic,
It is kneaded into synthetic resin and is applied to synthetic leather shoes and the like. Such inorganic antibacterial powders include E. coli,
It is used for brushing teeth to prevent the growth of Salmonella, black mold, etc. It can be used as a bag to cover fruits in an orchard because it kills.

By the way, the inorganic antibacterial powder composed of the above-mentioned zeolite solid powder and the like has the advantage of being low in toxicity, maintaining antibacterial properties for a long time, acting on various microorganisms and bacteria, and having excellent heat resistance and weather resistance. is there. However, this inorganic antibacterial powder has, for example, an average particle size of about 2 μm,
It is a very fine powder having a specific gravity of about 2.1. For this reason,
When an inorganic antibacterial powder of this type is used, for example, to maintain antibacterial properties in a synthetic resin molded product, it is kneaded into a base resin at a fixed ratio and injection molded. On the other hand, in a water tank, a pool, a water purifier, and the like of a ship that sails for a long period of time, it is required to prevent bacteria and mold from growing and maintain freshness of water.

[0005]

In a water tank or a pool,
At present, water is disinfected using chlorine or ozone in order to maintain the freshness of water, but it has been pointed out that these disinfectants are toxic to the human body. In order to address such a problem, it is conceivable to use the above-mentioned inorganic antibacterial powder for water treatment. However, as described above, this kind of antibacterial powder is a fine powder, and is not preferable because it is swallowed with water when directly put into a water tank.
Further, when the water is directly introduced into a pool or the like, the amount of water used when water is constantly replaced is increased, which is very uneconomical.

An inorganic antibacterial powder is kneaded into a synthetic resin,
It is also conceivable to place the obtained molded article in water. However, in this case, since only the antibacterial agent that has appeared on the surface of the molded product performs an antibacterial action, bacteria and mold may be generated in a water tank or the like within several days. The present invention has been made by paying attention to the above points, and in particular, an antibacterial granule that can surely perform sterilization of water and prevent the growth of microorganisms and bacteria and that requires a small amount of an antibacterial agent. It is intended to provide.

[0007]

SUMMARY OF THE INVENTION The present invention provides an antibacterial granule comprising a base material made of a granular thermoplastic, and an inorganic antibacterial powder directly adhered when the surface of the base material is melted. It is.

[0008]

Since the inorganic antibacterial powder is supported on the surface of the base material, it can be directly introduced into a water tank or a pool through a storage means such as a bag. Since the inorganic antibacterial powder adheres to the surface of the base material, the antibacterial property is excellent. In addition, the use of inorganic antibacterial powder
Because the powder is directly attached, the effects of toxicity on the human body
There is no.

[0009]

Embodiments of the present invention will be described below in detail with reference to the drawings. FIG. 1 is an enlarged view showing an antibacterial granule 1 according to the present invention. The antibacterial particles 1 include a spherical base material 2 and an inorganic antibacterial powder 3 attached to the entire surface of the base material 2. The base material 2 is made of a transparent plastic (synthetic resin) and has a diameter of about 3 to 5 mm. The inorganic antibacterial powder 3 is composed of a zeolite solid powder, has an average particle size of 2 micrometers, and has a specific gravity of 2.1 to 2.2. The inorganic antibacterial powder 3 is attached at a ratio of about 3 g to 100 g of the base material 2. The zeolite solid powder is, for example, one in which a natural or synthetic zeolite made of aluminosilicate is supported by silver ion exchange.

[0010] The antibacterial granules 1 of the present invention having the above structure
Is manufactured as follows. That is, a large number of base materials 2 are put into a mixer, and the mixer is rotated at a high speed. This allows
The base materials 2 contact each other, and the surfaces thereof generate heat and melt.
When the surface of the base material 2 is melted, an organic solvent as a melting promoter, for example, toluene is charged into the mixer. Thereafter, a predetermined amount of the inorganic antibacterial powder 3 is put into the mixer, and the mixer is again rotated at a high speed. Thereby, the surface of each base material 2 is melted, and the inorganic antibacterial powder 3 collides with the base material 2 at a high speed, so that the inorganic antibacterial powder 3 adheres to the surface of the base material 2 almost uniformly.

Next, an antibacterial test using the antibacterial granules according to the present invention will be described. First, Escherichia coli and Pseudomonas aeruginosa were selected as test cells, and these bacteria were each cultured on an agar medium at 37 ° C.
The cells were cultured at 18 ° C. for 18 hours, and each was suspended in a phosphate buffer. On the other hand, a suspension of 10 8 cells / ml was prepared using these cultured bacteria and diluted appropriately.
Next, the test was performed by the shake flask method. That is, the antibacterial granules 1 of the present invention were placed in four 200 ml Erlenmeyer flasks each containing 100 ml of the phosphate buffer solution, and each of the flasks contained 0.025 of the flask.
% And 0.05%, and the previously prepared suspension of each test bacterium was added to 10 5 cells / ml, and the Erlenmeyer flask was shaken at 25 ° C. ± 5 ° C. And
The number of bacteria was measured over time.

FIG. 2 is a table showing test results when Escherichia coli is used as a test cell. The starting bacterial count of Escherichia coli was 3.9 × 10 6 cells / ml. When 0.025% of the antibacterial granule 1 of the present invention was introduced, the bacterial count was measured after 1 hour. .8 × 10 squared cells /
ml, and was "0" after 3 hours. In addition, when 0.05% of the antibacterial particles 1 of the present invention are added, 1
After elapse of time, the number of bacteria was 1.8 × 10 squared cells / ml, and after three hours, it was “0”. On the other hand, in the Erlenmeyer flask into which the antibacterial granules 1 of the present invention were not added, the number of E. coli cells was 4.2 × 10 6 cells / ml, 3 hours after 1 hour.
After the elapse of time, it was 4.0 × 10 6 cells / ml.

FIG. 3 is a table showing test results when Pseudomonas aeruginosa was used. The starting bacterial count of Pseudomonas aeruginosa is 1.8 ×
It was 10 6 cells / ml. The antibacterial granules 1 of the present invention
When 0.025% was added, when the number of bacteria was measured after 1 hour, it was 1.1 × 10 3 cells / ml, and was “0” after 3 hours. When 0.05% of the antibacterial granules 1 of the present invention were added, the number of bacteria was 9.7 × 10 cells / ml after 1 hour, and became “0” after 3 hours. On the other hand, in the Erlenmeyer flask to which the antibacterial granules 1 of the present invention were not added, the number of Pseudomonas aeruginosa cells was 1.2 × 10 6 cells / ml after 1 hour, and 1.7 × after 3 hours.
It was 10 6 cells / ml.

Experimental Example 1 As shown in FIG. 4, 57 liters of tap water 5 is put in a container 4 and the antibacterial particles 1 of the present invention are put in a cloth bag 6.
Then, the bag 6 was put into the container 4. Ten days later, 1 ml of sample tap water was collected from the container 4 and the number of bacteria (fall) was measured to be "0". This experiment is 60
Continued for days, but remained sterile. For comparison, when 57 liters of tap water 5 was simply put in the container 4 and allowed to stand, chlorine in the tap water evaporated, and on the third day, 22 bacteria were detected in 1 ml. After that, 1.5 × 10 5 to the 10th day in 1 ml and 7.2 × 105 in 20 days.
5th power, 5.3 × 10 5th power in 30 days, 6.4 in 40 days
5 × 10 5 bacteria, 8.9 × 10 5 bacteria on 50 days, and 3.7 × 10 5 bacteria on 60 days were detected.

[Experimental example 2] The antibacterial property of the present invention was applied to a fishbowl containing about 50 liters of water.
10 g of the granules 1 were charged . The number of goldfish was four. As a result, the water exchange cycle was completed in about two weeks. Conventionally, it was necessary to change the water every week. Therefore, it is possible to improve the survival rate of live fish during transportation.

The antibacterial granules 1 of the present invention can be applied to other water treatments, for example, sterilization treatment of pools, sterilization treatment of wells, sewage treatment, prevention of algae generation in water coolers, antibacterial treatment, antifungal treatment, ships It can be used for maintaining the freshness of drinking water, and for preventing mold in bath water. Alternatively, water that is sterilized by adding the antibacterial granules 1 of the present invention may be sprayed on vegetables. In this case, the antibacterial metal ions are eluted in the water and the water itself has the antibacterial property, so that the freshness of the vegetables can be maintained for a long time.

In the above embodiment, the base material 2 can be made of glass, various metals, or inorganic objects, and the shape can be selected from various shapes such as a columnar shape and an elliptical shape. The inorganic antibacterial powder 3 can be adhered using an agent. Further, the antibacterial particles 1 of the present invention may be contained in a mesh-shaped container or the like outside the bag through which water or air passes.

[0018]

As described above, according to the present invention,
Antibacterial particles are formed by directly attaching inorganic antibacterial powder to the surface of the base material made of granular thermoplastic plastic, so the antibacterial properties are remarkably improved and sterilization of water and propagation of microorganisms are ensured. In addition, the antibacterial agent can be used in a bag or the like, so that the amount of the antibacterial agent used is small, which is very economical. Moreover, there is almost no toxic effect on the human body.

[Brief description of the drawings]

FIG. 1 is an enlarged view of an antibacterial granule according to the present invention.

FIG. 2 is a table showing the results of a bactericidal test of Escherichia coli according to the present invention.

FIG. 3 is a table showing the results of a sterilization test of Pseudomonas aeruginosa according to the present invention.

FIG. 4 is a schematic sectional view showing an experimental example according to the present invention.

[Explanation of symbols]

1 Antibacterial granules 2 Base material 3 Inorganic antibacterial powder

──────────────────────────────────────────────────続 き Continued on the front page (58) Field surveyed (Int. Cl. ⁷ , DB name) A61L 2/00-2/26 A01N 25/00-25/34 C02F 1/50

Claims (1)

(57) [Claims] An antibacterial particle comprising a base material made of a granular thermoplastic and an inorganic antibacterial powder directly adhered to the surface of the base material when the surface is melted. Body .