JPH0422361A - Vessel for contact lens solution having antibacterial property - Google Patents

Vessel for contact lens solution having antibacterial property

Info

Publication number
JPH0422361A
JPH0422361A JP2127388A JP12738890A JPH0422361A JP H0422361 A JPH0422361 A JP H0422361A JP 2127388 A JP2127388 A JP 2127388A JP 12738890 A JP12738890 A JP 12738890A JP H0422361 A JPH0422361 A JP H0422361A
Authority
JP
Japan
Prior art keywords
solution
vessel
contact lens
container
glass
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2127388A
Other languages
Japanese (ja)
Inventor
Fujio Shimono
下野 富二雄
Tetsugorou Nakano
中野 鉄五郎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ishizuka Glass Co Ltd
Original Assignee
Ishizuka Glass Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ishizuka Glass Co Ltd filed Critical Ishizuka Glass Co Ltd
Priority to JP2127388A priority Critical patent/JPH0422361A/en
Publication of JPH0422361A publication Critical patent/JPH0422361A/en
Pending legal-status Critical Current

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Landscapes

  • Eyeglasses (AREA)
  • Packages (AREA)
  • Packaging Of Annular Or Rod-Shaped Articles, Wearing Apparel, Cassettes, Or The Like (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

PURPOSE:To provide possibility of fitting a clean contact lens at all times by forming a vessel therefore from a resin containing powder of dissolutive glass, which allows elusion of a proper amount of Ag ions in the solution, and thereby preventing attachment of germs to the contact leans accommodated in the vessel. CONSTITUTION:0.4-1.6%, by wt., Ag ions (converted into Ag2O) having excellent pasteurizing effect are included in a glass composition having a controlled dissolving speed for saline solution as a main component of a solution for contact leans, wherein crushing shall be made so as to give particle sizes ranging 5-60mum. As plastics for forming a vessel for the contact lens solution, any of those usually used to a soft vessel may be adopted, such as polyethylene or polypropylene. The adding amount of the dissolutive glass to the plastic is usually ranging 0.3-10.0 5 by wt. depending upon the nature of the plastic and the anti-bacterial effect.

Description

【発明の詳細な説明】 (産業上の利用分野) 本発明は容器自体に抗菌性を付与することにより角膜障
害を防止した抗菌性を有するコンタクトレンズ溶液用容
器に関するものである。
DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to a container for a contact lens solution having antibacterial properties that prevents corneal damage by imparting antibacterial properties to the container itself.

(従来の技術) 従来、コンタクトレンズの保存液や洗浄液等の溶液は合
成樹脂製の容器で市販されており、特にソフトレンズ保
存液は使い切った後は使用者が精製水に顆粒を溶かして
保存液を作成するようになっている。このようなコンタ
クトレンズ溶液用容器は完全に殺菌された状態で販売さ
れているが、開封後における使用者の取扱いや保管状態
が悪いと外部から浸入した細菌が容器の内部で繁殖し、
コンタクトレンズの使用者に角膜傷害を引き起こすおそ
れがあり、現実に細菌性角膜傷害の事例報告が多く発表
されている。また、角膜に傷害があっても自覚症状のな
い潜在的な患者も多いと言われている。
(Prior art) Conventionally, solutions such as contact lens storage solutions and cleaning solutions have been commercially available in containers made of synthetic resin, and in particular, after the soft lens storage solution is used up, the user dissolves the granules in purified water to store it. It is designed to create a liquid. These containers for contact lens solution are sold in a completely sterilized state, but if the user does not handle them properly after opening the container or if the container is poorly stored, bacteria that have entered from the outside can grow inside the container.
There is a risk of causing corneal damage to contact lens users, and many case reports of bacterial corneal damage have been published. Furthermore, it is said that there are many latent patients who do not have any symptoms even if they have corneal damage.

そこでコンタクトレンズに付着するタンパク賞や雑菌等
を洗い落とし、細菌の繁殖を防止するために洗浄液で洗
浄し保存液中に保管したり、ソフトコンタクトレンズに
付着する細菌を殺菌するために定期的に煮沸消毒をする
方法が指導されているが、実際にはこのいずれの処理法
も面倒であるので完全には行われていないのが実情であ
る。さらにまたコンタクトレンズ溶液用容器自体も煮沸
消毒することが望ましいのであるが、この容器はコンタ
クトレンズを流失させてしまうことなく少しずつ溶液を
押し出すことができるように軟質の合成樹脂製の容器と
されているため、耐熱性の点から煮沸消毒は不可能であ
る。
Therefore, contact lenses are washed to remove proteins and germs that adhere to them, and they are washed with a cleaning solution and stored in a storage solution to prevent the proliferation of bacteria, or they are regularly boiled to sterilize bacteria that adhere to soft contact lenses. Although instructions are given on how to disinfect, the reality is that all of these methods are cumbersome and are not fully implemented. Furthermore, it is desirable to sterilize the contact lens solution container itself by boiling, but this container is made of soft synthetic resin so that the solution can be squeezed out little by little without washing away the contact lenses. Therefore, sterilization by boiling is impossible due to heat resistance.

二のように、コンタクトレンズの使用者は常に細菌性角
膜傷害を起こす危険にさらされているのである。
Second, contact lens users are always at risk of bacterial corneal injury.

(発明が解決しようとする課題) 本発明はこのような従来の問題点を解決し、コンタクト
レンズ溶液用容器自体に抗菌性を付与することにより細
菌等の微生物が繁殖することを防止し、内容物であるコ
ンタクトレンズに細菌が付着することを防止し、常に清
潔にコンタクトレンズを装用できるようにしたコンタク
トレンズ溶液用容器を提供するために完成されたもので
ある。
(Problems to be Solved by the Invention) The present invention solves these conventional problems and prevents the proliferation of microorganisms such as bacteria by imparting antibacterial properties to the contact lens solution container itself. This was completed in order to provide a contact lens solution container that prevents bacteria from adhering to contact lenses and allows contact lenses to be worn at all times in a clean manner.

(課題を解決するための手段) 上記の課題を解決するためになされた本発明は、溶液中
に適量の銀イオンを溶出し得る溶解性硝子の粉末を含有
させた樹脂からなることを特徴とするコンタクトレンズ
溶液用容器を要旨とするものである。
(Means for Solving the Problems) The present invention, which has been made to solve the above problems, is characterized in that it is made of a resin containing soluble glass powder that can elute an appropriate amount of silver ions into a solution. The gist is a container for contact lens solution.

この発明で使用する溶解性硝子は、コンタクトレンズ用
溶液の主成分である食塩水に対して制御された溶解速度
を持つガラス組成中に、優れた殺菌効果を持つ銀イオン
を重量%で0.4〜1.6%(Ag to換算)含有さ
せたもので、その粒度が5〜60μmとなるように粉砕
したものとすることが好ましい。ここでガラス中の銀イ
オンの含有量が0.4%以下であると、充分なる抗菌性
を与えるためには合成樹脂中に多量の溶解性硝子を添加
する必要があり、合成樹脂の特性を損なうし、経済的で
もない。またガラス中の銀イオンの含有量が1.6%以
上であると、溶解性硝子を溶融する際に金属銀が析出し
て炉を傷めるし、経済的でもない、さらにその粒度が5
μm以下であると、樹脂からの銀の溶解速度が極端に遅
くなるために多量の溶解性硝子を添加する必要があり、
粒度、が60μm以上であると、合成樹脂に練り込むと
きに目詰まり等の工程トラブルを起こす可能性があり、
製品表面の滑らかさを損なうおそれがある。
The soluble glass used in this invention has a glass composition that has a controlled dissolution rate in saline, which is the main component of contact lens solutions, and contains 0.0% by weight of silver ions, which have an excellent bactericidal effect. It is preferable that the content be 4 to 1.6% (in terms of Ag to) and that the particle size be pulverized to a particle size of 5 to 60 μm. If the content of silver ions in the glass is 0.4% or less, it is necessary to add a large amount of soluble glass to the synthetic resin in order to provide sufficient antibacterial properties, which may affect the properties of the synthetic resin. It's damaging and not economical. Furthermore, if the content of silver ions in the glass is 1.6% or more, metallic silver will precipitate when melting the soluble glass and damage the furnace, which is not economical, and furthermore, the particle size of the glass will be 5%.
If it is less than μm, the dissolution rate of silver from the resin becomes extremely slow, so it is necessary to add a large amount of soluble glass.
If the particle size is 60 μm or more, it may cause process troubles such as clogging when kneading into synthetic resin.
There is a risk of damaging the smoothness of the product surface.

コンタクトレンズ溶液用容器を成形するための合成樹脂
としては、各種ポリエチレン、ポリプロピレン等の軟質
容器に使用されているものであれば、いずれの合成樹脂
も使用できる。また、合成樹脂に対する溶解性硝子の添
加量は、合成樹脂の性質及び期待する抗菌効果によって
異なるが、船釣には0.3〜10.0%(重量%)の添
加で好結果が得られる。添加量が0.3%以下では、充
分なる抗菌性が得られず、10.0%以上の添加である
と、樹脂の特性、特に成形性を損なうおそれがある。
As the synthetic resin for molding the contact lens solution container, any synthetic resin used for soft containers such as various polyethylene and polypropylene can be used. Additionally, the amount of soluble glass added to the synthetic resin varies depending on the properties of the synthetic resin and the expected antibacterial effect, but good results can be obtained by adding 0.3 to 10.0% (wt%) for boat fishing. . If the amount added is 0.3% or less, sufficient antibacterial properties cannot be obtained, and if the amount added is 10.0% or more, the properties of the resin, particularly the moldability, may be impaired.

さらにまた、溶解性硝子を添加した合成樹脂で作られた
容器からの銀イオンの溶出量が、本発明の目的である抗
菌性に最も大きく影響するので、その量を実験的に確認
して、生理食塩水中における20℃×24時間のテスト
で、1〜60ng/cjの溶出量が適量であることを確
認した。即ち、銀イオンの溶出量がlog/ai以下で
は充分なる抗菌性が得られず、菌の種類、数によっては
、菌の繁殖を阻止できなかった。逆に銀イオンの溶出量
が60ng /d以上となると、過剰の銀イオンが溶液
中の食塩と反応し、塩化銀の沈澱物が溶液中に析出する
おそれがある。
Furthermore, since the amount of silver ions eluted from a container made of synthetic resin to which soluble glass has been added has the greatest effect on the antibacterial properties that are the object of the present invention, the amount was experimentally confirmed. In a test conducted in physiological saline at 20° C. for 24 hours, it was confirmed that an elution amount of 1 to 60 ng/cj was appropriate. That is, if the amount of silver ions eluted was less than log/ai, sufficient antibacterial properties could not be obtained, and depending on the type and number of bacteria, the proliferation of bacteria could not be inhibited. On the other hand, if the amount of silver ions eluted is 60 ng/d or more, there is a risk that the excess silver ions will react with the common salt in the solution, and a precipitate of silver chloride will precipitate out in the solution.

以下に本発明の内容を実施例によりさらに明らかにする
The content of the present invention will be further clarified by examples below.

(実施例) 実施例1 13.0345+IO1%、Sin、 40mo1%、
NazO15mo1%を基礎組成とする硝子原料にAg
 、0を0.5wt%添加したバッチを溶融して溶解性
硝子を製造し、これを5〜25μmの粒径に粉砕した。
(Example) Example 1 13.0345+IO1%, Sin, 40mo1%,
Ag is added to the glass raw material whose basic composition is 15 mo1% NazO.
, 0 was added in an amount of 0.5 wt % to produce soluble glass, which was pulverized to a particle size of 5 to 25 μm.

次にこの溶解性硝子の粉末を低密度ポリエチレンに重量
比で1.5%添加して充分混練した後、ブロー成形し、
内容量20dのコンタクトレンズ溶液用容器を成形した
Next, 1.5% by weight of this soluble glass powder was added to low density polyethylene, thoroughly kneaded, and then blow molded.
A contact lens solution container with an internal capacity of 20 d was molded.

この容器からの銀イオン溶出量及び抗菌試験結果は次の
とおりである。
The amount of silver ions eluted from this container and the antibacterial test results are as follows.

■銀イオン溶出量 ■抗菌試験 (1)試験菌 (2)培地 緑膿菌 生理食塩水 (3)結果 −増殖せず、十増殖、十十増殖程度大、++十増殖程度
極大 以上のように、本発明の容器は目に対して悪影響を与え
る緑膿菌に対し、優れた抗菌効果のあることが明らかに
なった。
■ Silver ion elution amount ■ Antibacterial test (1) Test bacteria (2) Medium Pseudomonas aeruginosa saline (3) Results - No growth, 10 growths, 10 large growths, ++ 10 growths, more than the maximum It has been revealed that the container of the present invention has an excellent antibacterial effect against Pseudomonas aeruginosa, which has an adverse effect on the eyes.

実施例2 Bz(h 80mo1%、5iO110s+o1%、N
a、010s+o1%からなる基礎硝子原料組成に、A
gzo 1.0wt%を添加し、溶融した。得られた溶
解性硝子を10〜40μmの粒径に粉砕し、目的とする
溶解性硝子の粉末を得た。この溶解性硝子の粉末を低密
度ポリエチレン中に重量比で3%添加し、充分混合しブ
ロー成形法により容量100 cdのコンタクトレンズ
溶液用容器を作成した。この容器の銀イオン溶出量と抗
菌性能を実施例1と同様に試験した。
Example 2 Bz (h 80mo1%, 5iO110s+o1%, N
A, to the basic glass raw material composition consisting of 010s + o1%, A
1.0 wt% gzo was added and melted. The obtained soluble glass was pulverized to a particle size of 10 to 40 μm to obtain the desired soluble glass powder. This soluble glass powder was added to low-density polyethylene in an amount of 3% by weight, thoroughly mixed, and a contact lens solution container having a capacity of 100 cd was prepared by blow molding. The silver ion elution amount and antibacterial performance of this container were tested in the same manner as in Example 1.

■銀イオン溶出量 ■抗菌試験 (1)試験菌 大腸菌 (2)培地 1/lO濃度普通ブイ ヨン+生理食塩水 この結果から、 本発明のコンタク トレンズ溶液 用容器は大腸菌に対しても優れた殺菌作用のあることが
明らかとなった。
■ Silver ion elution amount ■ Antibacterial test (1) Test bacterium E. coli (2) Medium 1/lO concentration Ordinary broth + physiological saline From these results, the contact lens solution container of the present invention has an excellent bactericidal effect against E. coli. It became clear that there was.

実施例3 35mo1%、 ing 45mo1%、 Nan。Example 3 35mo1%, ing 45mo1%, Nan.

20mo1%を 基礎硝子組成とする原料組成に、ag、o 0.2wt
%添加し、溶融後に5〜25μmに粉砕して、目的とす
る溶解性硝子の粉末を得た。この溶解性硝子の粉末を高
密度ポリエチレン樹脂に0.5%添加し、充分混練後、
ブロー成形で内容量100dの容器を製造した。この容
器の性質を実施例1.2と同様にテストした結果、次の
とおりであった。
In the raw material composition with 20mo1% as the basic glass composition, ag, o 0.2wt
% was added, and after melting, it was ground to 5 to 25 μm to obtain the desired soluble glass powder. Add 0.5% of this soluble glass powder to high-density polyethylene resin, and after thorough kneading,
A container with an inner capacity of 100 d was manufactured by blow molding. The properties of this container were tested in the same manner as in Example 1.2, and the results were as follows.

■銀イオン溶出量 ■抗菌試験 (1)試験菌 黄色ブドウ状球菌 (2)培地  1/10濃度普通ブイヨン士生理食塩水
(3)結果(生菌数の増減) 本実施例では銀イオンの溶出量が実施例1.2と比較し
て少ないために、完全な抗菌作用を示すに至っていない
ものの、コントロールと比較すると、菌数はl/10〜
1/1000程度に減少していることが分かる。
■ Silver ion elution amount ■ Antibacterial test (1) Test bacteria Staphylococcus aureus (2) Medium 1/10 concentration normal broth saline (3) Results (increase/decrease in the number of viable bacteria) In this example, silver ions were eluted. Since the amount is small compared to Example 1.2, it does not show a complete antibacterial effect, but compared to the control, the number of bacteria is 1/10 ~
It can be seen that it has decreased to about 1/1000.

なお、上記の実施例ではいずれも溶解性硝子の粉末を容
器を構成する樹脂の全体に均一に分散させたが、容器を
多層樹脂容器とし、その最内層に集中的に溶解性硝子を
分散させることもできる。
In addition, in all of the above examples, the soluble glass powder was uniformly dispersed throughout the resin constituting the container, but the container is a multilayer resin container, and the soluble glass is concentratedly dispersed in the innermost layer. You can also do that.

さらに容器の内面に凹凸を付けて保存液との接触面積を
増加させ、銀イオンの溶出量を増加させることもできる
Furthermore, it is also possible to increase the amount of silver ions eluted by adding irregularities to the inner surface of the container to increase the contact area with the storage solution.

(発明の効果) 以上に説明したとおり、本発明のコンタクトレンズ溶液
用容器は、溶液の主成分である食塩水中に適量の銀イオ
ンを溶出し得る溶解性硝子の粉末を樹脂中に含有させた
ので、銀イオンの殺菌効果により容器内における各種の
細菌の繁殖を抑制し、長期間にわたって極めて清潔な状
態を保ち得るものである。従って本発明によれば容器自
体を煮沸消毒する必要もなく、コンタクトレンズの汚染
に起因する細菌性角膜傷害の防止に優れた効果を発揮す
ることができる。
(Effects of the Invention) As explained above, the contact lens solution container of the present invention contains in the resin soluble glass powder that can elute an appropriate amount of silver ions into the saline solution, which is the main component of the solution. Therefore, the sterilizing effect of silver ions suppresses the proliferation of various bacteria within the container, allowing the container to remain extremely clean for a long period of time. Therefore, according to the present invention, there is no need to sterilize the container itself by boiling, and an excellent effect can be exhibited in preventing bacterial corneal damage caused by contamination of contact lenses.

よって本発明は従来の問題点を解決したコンタクトレン
ズ溶液用容器として、その効果はきわめて大きいものが
ある。
Therefore, the present invention has extremely great effects as a contact lens solution container that solves the conventional problems.

Claims (1)

【特許請求の範囲】[Claims] 溶液中に適量の銀イオンを溶出し得る溶解性硝子の粉末
を含有させた樹脂からなることを特徴とする抗菌性を有
するコンタクトレンズ溶液用容器
A container for contact lens solution having antibacterial properties, characterized in that it is made of a resin containing soluble glass powder that can elute an appropriate amount of silver ions into the solution.
JP2127388A 1990-05-17 1990-05-17 Vessel for contact lens solution having antibacterial property Pending JPH0422361A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2127388A JPH0422361A (en) 1990-05-17 1990-05-17 Vessel for contact lens solution having antibacterial property

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2127388A JPH0422361A (en) 1990-05-17 1990-05-17 Vessel for contact lens solution having antibacterial property

Publications (1)

Publication Number Publication Date
JPH0422361A true JPH0422361A (en) 1992-01-27

Family

ID=14958761

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2127388A Pending JPH0422361A (en) 1990-05-17 1990-05-17 Vessel for contact lens solution having antibacterial property

Country Status (1)

Country Link
JP (1) JPH0422361A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5320843A (en) * 1992-12-10 1994-06-14 Polymer Technology Corporation Method for improving antibacterial properties of ophthalmic solutions
WO2000016815A1 (en) * 1998-09-21 2000-03-30 Mdle Medical Device Laboratories Europe Gmbh Device for contact lens care
JP2007332131A (en) * 2006-05-15 2007-12-27 Tottori Univ Gradually disintegrating antibacterial agent, antibacterial liquid by using the same and device for forming the antibacterial liquid
WO2012111038A1 (en) 2011-02-14 2012-08-23 株式会社メニコン Contact lens case
US9417187B2 (en) 2011-11-28 2016-08-16 Axalta Coating Systems Ip Co., Llc Method for determining the surface gloss of a colour standard

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5796605A (en) * 1980-10-14 1982-06-16 Titmus Eurocon Kontaktlinsen Apparatus for repairing and/or keeping contact lens
JPH0233379A (en) * 1988-07-20 1990-02-02 Asahi Chem Ind Co Ltd Composite cloth-like product containing copper ion and/or silver ion

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5796605A (en) * 1980-10-14 1982-06-16 Titmus Eurocon Kontaktlinsen Apparatus for repairing and/or keeping contact lens
JPH0233379A (en) * 1988-07-20 1990-02-02 Asahi Chem Ind Co Ltd Composite cloth-like product containing copper ion and/or silver ion

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5320843A (en) * 1992-12-10 1994-06-14 Polymer Technology Corporation Method for improving antibacterial properties of ophthalmic solutions
WO2000016815A1 (en) * 1998-09-21 2000-03-30 Mdle Medical Device Laboratories Europe Gmbh Device for contact lens care
JP2007332131A (en) * 2006-05-15 2007-12-27 Tottori Univ Gradually disintegrating antibacterial agent, antibacterial liquid by using the same and device for forming the antibacterial liquid
WO2012111038A1 (en) 2011-02-14 2012-08-23 株式会社メニコン Contact lens case
US9095195B2 (en) 2011-02-14 2015-08-04 Menicon Co., Ltd. Contact lens case with lens loading surface
US9417187B2 (en) 2011-11-28 2016-08-16 Axalta Coating Systems Ip Co., Llc Method for determining the surface gloss of a colour standard

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