JPH05341240A - Antibacterial holder for contact lens - Google Patents

Abstract

PURPOSE:To eliminate the worry about the injury on the eyes and allergy as there is no degradation in the effect of an antibacterial metal, enables the care of contact lenses to keep the lenses hygienic over a long period of time with high safety and there is no need for incorporating undesirable antiseptics into the holder. CONSTITUTION:This antibacterial holder for the contact lenses is obtd. by molding form a resin contg. an ion exchanger deposited with the antibacterial metal by an ion exchange. The antibacterial metal is at least one kind of the metals selected from silver, copper, zinc and gold or the compd. thereof and contains titanium, zinc or the compd. thereof as a light resistance improving agent.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a contact lens holder. More specifically, the present invention is characterized in that in a holder for holding a contact lens, it is useful for preventing microbial contamination of the contact lens and the holder and microbial contamination of the storage solution.

[0002]

2. Description of the Related Art Contact lenses are generally stored and held in a plastic holder made of synthetic resin such as polyethylene resin, polypropylene resin, ethylene vinyl acetate resin, urethane resin, polyethylene terephthalate resin, polyamide resin by injection molding. Then, after all-day or continuous wear, the contact lens was removed from the eye and washed with a special cleaning agent, or it was stored and washed as it was in a storage container together with an immersion cleaning agent. At the time of use, contact lenses were taken out from these containers, rinsed with tap water or a special rinse agent, etc., and the containers and holders were washed with tap water and then placed on a wash basin or the like to be naturally dried.

[0003]

However, in the above-mentioned general washing and preserving method, microorganisms such as coliform bacteria, Bacillus subtilis, blue mold, black mold and the like are contact lenses, containers and holders even when stains can be sufficiently removed. May be attached to. In addition, the microorganisms attached to the fingers may attach to the holder or the container, which may further contaminate the contact lens. In addition, if stains are not adequately removed or if the removed stain components remain in the container, these act as nutrient sources for the growth of microorganisms and induce eye damage (bacterial corneal erosion, etc.) due to microorganisms. I have something to do. Particularly, in the case of long-term storage, the storage solution may become turbid due to the growth of microorganisms, and mold may be generated and adhere to the contact lens, which may render the contact lens unusable. Furthermore, when such contact lenses are worn, in the worst case, eye infection may occur.

In order to solve these problems, measures for preventing microbial contamination are widely used, such as careful cleaning and drying of contact lenses, containers and holders, addition of preservatives and bactericides to the cleaning and preservation solution, but they are satisfactory. Insufficient to do. In addition, Japanese Patent Laid-Open No. 4-22361 and Japanese Utility Model Laid-Open No.
As disclosed in Japanese Patent No. 35437 and Japanese Utility Model Laid-Open No. 4-35436, a container for a contact lens solution, which comprises a resin containing a glass powder having a controlled silver elution solubility in a contact lens solution, is disclosed. The method to use is proposed. However, in this method, silver ions are eluted from the resin, and the silver ions in the solution exhibit an antibacterial action, and this method has the following drawbacks. That is,
There are problems such as a decrease in antibacterial efficacy due to elution of silver ions such as formation of silver salt, a decrease in lens performance due to adsorption of silver ions on contact lenses, and a safety problem due to eluted silver ions. Further, in the elution test of contact lens standards for vision correction according to the Ministry of Health and Welfare Notification No. 302 (Showa 45), which defines safety standards for contact lenses, it is not preferable because it is a compatibility problem with elution of heavy metals. In addition, the antibacterial action is not exhibited unless it elutes into silver ions.
Therefore, even if the contact lens is in direct contact with the antibacterial resin, no antibacterial action is exhibited, and thus sufficient antibacterial activity cannot be obtained. In addition, there is a problem that the antibacterial resin is oxidized and discolored by being exposed to oxygen and ultraviolet rays in the air, and the antibacterial activity is lost.

Therefore, it is a technical object of the present invention to provide an antibacterial holder for a contact lens which safely and surely prevents microbial contamination of the contact lens, the holder and the preservation solution.

[0006]

The technical means taken in the present invention to solve the above problems is a contact obtained by molding from a resin containing an ion exchanger carrying an antibacterial metal by ion exchange. It has been found that this object can be achieved by using a lens holder and by incorporating titanium, zinc or a compound thereof as a light resistance improving agent for preventing oxidation and discoloration of antibacterial resin. That is, by using a holder obtained by processing a resin containing an ion exchanger having an antibacterial action according to the present invention by injection molding or the like which is generally used as a holder for a contact lens, prevention of microbial contamination can be prevented. Safely without affecting the
It can be done without discoloration. The antibacterial mechanism of the present invention is that silver ions carried by a strong ionic bond with an ion exchanger act as a catalyst for oxygen in liquid or air to partially generate active oxygen. .. This active oxygen destroys the protein of the cell components of the microorganism, inhibits energy metabolism and kills it. Further, due to the action of the antibacterial metal on the surface of the resin, the antibacterial action is further enhanced in the portion of the contact lens which is in direct contact with the resin.

More specifically, the antibacterial metal used in the present invention is at least one metal selected from silver, copper, zinc and gold, which has been recognized for its antibacterial effect, or a compound thereof. Yes, for example silver, copper, zinc,
Examples thereof include gold, silver oxide, copper oxide, zinc oxide, silver nitrate, copper sulfate and zinc acetate. Among these, silver or a compound thereof is preferable in terms of antibacterial efficacy and safety.

The ion exchanger carrying the antibacterial metal used in the present invention by ion exchange is preferably one having excellent heat resistance, chemical resistance and light resistance. For example, examples of the inorganic type include complex oxides such as zeolite, kaolinite, calcium phosphate, hydroxyapatite, and aluminum oxide. Examples of the organic system include styrene-divinylbenzene copolymer, polystyrene resin, methyl acrylate-styrene copolymer and the like. Further, the particle diameter is preferably 15 μm or less, and 15 μm
If it exceeds, dispersibility in the resin and moldability of the resin are not preferable.

Zeolite, which is an ion exchanger used in the present invention, is an aluminosilicate composite having a three-dimensional skeleton structure, and xM ₂ / nO based on Al ₂ O _3.
· Al ₂ O ₃ · ySiO represented by ₂ · zH ₂ O, M is a ion-exchangeable metal ion, n represents corresponding to the valence. x and y are coefficients, and z is the number of water of crystallization. In the present invention, the SiO ₂ / Al ₂ O ₃ molar ratio is 1.3 to.
A zeolite of 8.0 is used. Further, it is preferable that the specific surface area of the zeolite is 200 m ² / g or more. These conditions are because the effective absolute amount of the antibacterial metal supported on the zeolite is different depending on the amount of the ion exchange groups, the exchange rate, the ion exchange amount, and the accessibility of the zeolite. Therefore, when the SiO ₂ / Al ₂ O ₃ molar ratio is less than 1.3 or the specific surface area is less than 200 m ² / g, the effective absolute amount of the antibacterial metal carried is small, which is not preferable. When the SiO ₂ / Al ₂ O ₃ molar ratio exceeds 8.0, the effective absolute amount of the antibacterial metal supported becomes very large, which is uneconomical, and the supporting capacity is weakened, and the antibacterial effect is lowered and the safety is improved. It is not preferable in terms of sex.

The ion exchanger carrying the antibacterial metal used in the present invention by ion exchange has a resin content of about 0.0
It is preferably formulated so as to contain 1 to 15%, more preferably about 0.1 to 7%. If it is less than about 0.01%, sufficient antibacterial effect is not exhibited, and if it exceeds about 15%, not only a non-uniform product is formed due to a decrease in dispersibility, but also the moldability of the resin is deteriorated to cause discoloration by deformation. It is not preferable because it causes

The light resistance improver used in the present invention is preferably one having excellent efficacy and durability, and the light resistance improvers suitable for this condition are titanium, zinc and compounds thereof. Titanium and its compounds are widely used as basic bases for cosmetics, and their safety and the like are recognized. Zinc and its compounds are also widely used as cosmetic bases and products listed in the Japanese Pharmacopoeia, and their safety is high. These light resistance improvers are different from organic ones in that
The effect is exhibited by blocking ultraviolet rays of m or less. Therefore, almost no deterioration with time or deterioration of the effect is observed unlike the conventional organic system. In the present invention, by containing 0 to 5% of the light resistance improver in the resin, light resistance suitable for various conditions can be obtained. When it is 5% or more, the effect of the antibacterial metal is masked and the effect is lowered, which is not preferable.

The resin used in the present invention is not problematic as long as it is generally used, but is preferably a flexible resin such as polyvinyl alcohol resin, polyethylene resin, polypropylene resin, ethylene vinyl acetate resin, chloride. Vinyl resin and polyurethane resin are preferred.

Any known component may be added to the resin containing an ion exchanger carrying the antibacterial metal of the present invention by ion exchange. For example, plasticizers to improve moldability, colorants to improve appearance, other UV absorbers and infrared absorbers to prevent deterioration of resin and antibacterial metal, and surface active agents to prevent static electricity. Agents, other antibacterial agents and the like.

In addition, at the time of production, molding can be carried out by adding an ion exchanger carrying an antibacterial metal by ion exchange to a resin raw material or pellets at an arbitrary step, but resin pellets added and prepared by a masterbatch method are used. Is convenient for manufacturing.

The antibacterial holder for contact lenses of the present invention not only prevents microbial contamination due to antibacterial action but also has an effect of preventing odors derived from microorganisms, so that proper and hygienic care of contact lenses is facilitated. In addition, it is safe and surely possible for a long period of time.

[0016]

By using the antibacterial holder for a contact lens according to the present invention to hold the contact lens, the microorganisms on the surface of the contact lens and on the preservation solution are killed by the antibacterial action of the generated active oxygen, so that the contact lens is safe from microbial contamination Can be prevented. Furthermore, care of contact lenses can be made hygienic and highly safe, and eye disorders such as bacterial infections can be prevented.

[0017]

EXAMPLES The present invention will be described in detail, but the invention is not limited to these examples.

(Example 1) 0.2 M silver nitrate aqueous solution 100
0ml synthetic A-type zeolite (SiO ₂ / Al ₂ O ₃ molar ratio = 1.4 to 2.4) 500 g was added, was subjected to ion exchange by stirring for 30 hours at room temperature. Obtained silver substitution A
The type zeolite was collected by filtration, excess silver ions were removed with distilled water, and dried at about 100 ° C. for 2 hours. The dried particles were crushed to obtain an antibacterial zeolite (average particle size of about 2 to 5 μm). X-ray analysis showed a silver content of about 50 μg / g. 100 g of this antibacterial zeolite is polyethylene resin 990
0 g was mixed and injection-molded to form resin beads having a concentration of about 1% as an antibacterial agent. Using these beads, a contact lens holder was molded by injection molding.

1) Antibacterial Test The following tests were carried out in order to investigate the antibacterial effect of the contact lens holder obtained as described above. A bacterial suspension obtained by culturing E. coli (ATCC No. 8739) in a soybean casein liquid medium for 2 days had a bacterial count of about 1 × 10 ^5.
It was aseptically adjusted with sterile physiological saline so that the number of cells / ml was set. A contact lens (manufactured by Seiko Contact Lens Co., Ltd., Polycon) was immersed in this solution for 24 hours, and then the contact lens was set in the obtained holder and stored in a lens case containing about 2 ml of sterilized physiological saline. After about 8 and 16 hours of storage, the contact lens was taken out from the lens case, rinsed with 5 ml of sterilized physiological saline, and then put into 1 ml of sterilized physiological saline and stirred. This solution was mixed with BTB agar medium and cultured at 35 ° C. for 24 hours, and colonies of developing bacteria were counted. As a result, the occurrence of Escherichia coli was not observed and a good antibacterial effect was exhibited. Further, 1 ml of physiological saline in the lens case was similarly cultured, but no generation of E. coli was observed.

2) Discoloration deformation and antibacterial efficacy reduction test The holder was set in a contact lens case, and a sunshine meter (manufactured by Suga Test Instruments Co., Ltd.) was used at 75 ° C for 10 days.
A 0-hour test was performed and the presence or absence of discoloration deformation was visually observed. As a result, no discoloration deformation was observed as confirmed by the naked eye. Further, when this holder was used to perform the same evaluation as in the antibacterial activity test of 1), no colonies were observed and good antibacterial effect was exhibited. (Example 2) 0.1 M aqueous silver nitrate solution 1000ml synthetic X-type zeolite (SiO ₂ / Al ₂ O ₃ molar ratio = 2.0
(3.0) (500 g) was added, and the mixture was stirred at room temperature for 30 hours for ion exchange. The obtained silver-substituted X-type zeolite is filtered, excess silver ions are removed with distilled water, and the temperature is about 100 ° C.
And dried for 2 hours. The dried particles were crushed to obtain an antibacterial zeolite (average particle size of about 1 to 5 μm). X-ray analysis showed a silver content of about 45 μg / g. 10 g of this antibacterial zeolite was mixed with 9990 g of polyethylene resin and injection molded to form resin beads having a concentration of about 0.01% as an antibacterial agent. Using these beads, a contact lens holder was molded by injection molding. Similar to Example 1, good results were obtained in the antibacterial activity test, discoloration deformation and antibacterial efficacy reduction test. The results are shown in Table 1.

(Example 3) 0.15M silver nitrate / 0.05
Synthetic Y-type zeolite (S
500 g of iO ₂ / Al ₂ O ₃ molar ratio = 3.0 to 6.0) was added, and the mixture was stirred at room temperature for 30 hours for ion exchange. The obtained silver / copper substituted Y-type zeolite was filtered, excess silver / copper ions were removed with distilled water, and dried at about 100 ° C. for 2 hours. The dried particles were pulverized to obtain an antibacterial zeolite (average particle size: about 3 to 6 μm). X-ray analysis showed a silver content of about 40 μg / g and a copper content of about 8 μg / g. 500 g of this antibacterial zeolite was mixed with 4500 g of ethylene vinyl acetate resin and injection-molded to form resin beads having a concentration of about 10% as an antibacterial agent. Using these beads, a contact lens holder was molded by injection molding. Similar to Example 1, good results were obtained in the antibacterial activity test, discoloration deformation and antibacterial efficacy reduction test. The results are shown in Table 1.

(Example 4) 0.15M silver nitrate / 0.2M
Synthetic Y-type zeolite (S
500 g of iO ₂ / Al ₂ O ₃ molar ratio = 3.0 to 6.0) was added, and the mixture was stirred at room temperature for 30 hours for ion exchange. The obtained silver / zinc-substituted Y-type zeolite was filtered, excess silver / zinc ions were removed with distilled water, and dried at about 100 ° C. for 2 hours. The dried particles were crushed to obtain an antibacterial zeolite (average particle size: about 4 to 9 μm). X-ray analysis showed a silver content of about 36 μg / g and a zinc content of about 12 μg / g. 10 g of this antibacterial zeolite was mixed with 4990 g of ethylene vinyl acetate resin, and injection molding was performed to mold resin beads having a concentration of about 0.2% as an antibacterial agent. Using these beads, a contact lens holder was molded by injection molding. Similar to Example 1, good results were obtained in the antibacterial activity test, discoloration deformation and antibacterial efficacy reduction test. The results are shown in Table 1.

(Example 5) 0.2 M silver nitrate aqueous solution 100
0ml synthetic A-type zeolite (SiO ₂ / Al ₂ O ₃ molar ratio = 1.4 to 2.4) 500 g was added, was subjected to ion exchange by stirring for 30 hours at room temperature. Obtained silver substitution A
The type zeolite was collected by filtration, excess silver ions were removed with distilled water, and dried at about 100 ° C. for 2 hours. The dried particles were crushed to obtain an antibacterial zeolite (average particle size of about 2 to 5 μm). X-ray analysis showed a silver content of about 50 μg / g. Ethylene vinyl acetate resin 44 with 500 g of this antibacterial zeolite and 50 g of titanium oxide (average particle size of about 1 μm)
The mixture was mixed with 50 g and injection-molded to form resin beads having a concentration of about 10% as an antibacterial agent. Using these beads, a contact lens holder was molded by injection molding. Example 1
Similar to the above, good results were obtained in the antibacterial activity test, discoloration deformation and antibacterial efficacy reduction test. The results are shown in Table 1.

(Comparative Example 1) 0.2 M silver nitrate aqueous solution 100
0ml synthetic A-type zeolite (SiO ₂ / Al ₂ O ₃ molar ratio = 1.4 to 2.4) 500 g was added, was subjected to ion exchange by stirring for 30 hours at room temperature. Obtained silver substitution A
The type zeolite was collected by filtration, excess silver ions were removed with distilled water, and dried at about 100 ° C. for 2 hours. The dried particles were crushed to obtain an antibacterial zeolite (average particle size of about 2 to 5 μm). X-ray analysis showed a silver content of about 50 μg / g. 5 g of this antibacterial zeolite is 9995 g of polyethylene resin
Was mixed and injection-molded to form resin beads having a concentration of about 0.005% as an antibacterial agent. Using these beads, a contact lens holder was molded by injection molding. Example 1
The antibacterial activity test, the discoloration deformation and the antibacterial efficacy reduction test were conducted in the same manner as, but the antibacterial efficacy was not sufficient. The results are shown in Table 1.

(Comparative Example 2) 0.15M silver nitrate / 0.05
Synthetic Y-type zeolite (S
500 g of iO ₂ / Al ₂ O ₃ molar ratio = 3.0 to 6.0) was added, and the mixture was stirred at room temperature for 30 hours for ion exchange. The obtained silver / copper substituted Y-type zeolite was filtered, excess silver / copper ions were removed with distilled water, and dried at about 100 ° C. for 2 hours. The dried particles were pulverized to obtain an antibacterial zeolite (average particle size: about 3 to 6 μm). X-ray analysis showed a silver content of about 40 μg / g and a copper content of about 8 μg / g. 1 g of this antibacterial zeolite was mixed with 4999 g of ethylene vinyl acetate resin and injection-molded to give about 0.
Resin beads having a concentration of 001% were molded. Using these beads, a contact lens holder was molded by injection molding. In the same manner as in Example 1, the antibacterial activity test, discoloration deformation and antibacterial efficacy reduction test were carried out. Antibacterial activity test as in Example 1,
Discoloration deformation and antibacterial efficacy reduction tests were conducted, but they did not show sufficient antibacterial efficacy. The results are shown in Table 1.

(Comparative Example 3) 0.15M silver nitrate / 0.05
Synthetic Y-type zeolite (S
500 g of iO ₂ / Al ₂ O ₃ molar ratio = 3.0 to 6.0) was added, and the mixture was stirred at room temperature for 30 hours for ion exchange. The obtained silver / copper substituted Y-type zeolite was filtered, excess silver / copper ions were removed with distilled water, and dried at about 100 ° C. for 2 hours. The dried particles were pulverized to obtain an antibacterial zeolite (average particle size: about 3 to 6 μm). X-ray analysis showed a silver content of about 40 μg / g and a copper content of about 8 μg / g. 800 g of this antibacterial zeolite is added to polypropylene resin 42
The mixture was mixed with 00 g and injection-molded to form resin beads having a concentration of about 16% as an antibacterial agent. Using these beads, a contact lens holder was molded by injection molding, but could not be molded along the mold.

(Comparative Example 4) A 0.2 M silver nitrate aqueous solution 100
500 g of molecular sieves (SiO ₂ / Al ₂ O ₃ molar ratio = 14-18) was added to 0 ml, and the mixture was stirred at room temperature for 30 hours for ion exchange. The obtained silver-substituted molecular sieve was filtered, excess silver ions were removed with distilled water, and dried at about 100 ° C. for 2 hours. The dried particles are crushed to form an antibacterial zeolite (average particle size of about 5-10 μm)
Got X-ray analysis showed a silver content of about 21 μg / g.
200 g of this antibacterial zeolite is added to polyethylene resin 48
It was mixed with 00 g and injection-molded to form resin beads having a concentration of about 4.0% as an antibacterial agent. Using these beads, a contact lens holder was molded by injection molding. An antibacterial activity test, discoloration deformation and antibacterial efficacy reduction test were carried out in the same manner as in Example 1. However, sufficient antibacterial effect was not shown and discoloration was observed by the light resistance test. The results are shown in Table 1.

[0028]

[Table 1]

[0029]

INDUSTRIAL APPLICABILITY The antibacterial holder for contact lenses according to the present invention contains an ion exchanger carrying an antibacterial metal by ion exchange, whereby contamination by microorganisms can be prevented, and hygienic and safe for a long period of time. Enables contact lens care. Further, since it is not necessary to include an unfavorable preservative in the preservative or the cleaning agent, there is an effect that it can be used more safely without worrying about eye damage or allergy.

Claims (6)

[Claims] 1. An antibacterial holder for a contact lens, which is obtained by molding a resin containing an ion exchanger carrying an antibacterial metal by ion exchange. 2. The antibacterial holder for a contact lens according to claim 1, wherein the antibacterial metal is at least one metal selected from silver, copper, zinc and gold, or a compound thereof. 3. The antibacterial holder for a contact lens according to claim 1, wherein the ratio of the ion exchanger supporting the antibacterial metal to the resin is 0.01 to 14%. 4. The antibacterial holder for a contact lens according to claim 1, wherein the ion exchanger is zeolite, and its SiO ₂ / Al ₂ O ₃ molar ratio is 1.3 to 8.0. .. 5. The antibacterial holder for a contact lens according to claim 1, wherein the zeolite, which is an ion exchanger, has a specific surface area of 200 m ² / g or more. 6. A light resistance improver containing titanium, zinc or a compound thereof in an amount of 0 to 5%.
An antibacterial holder for a contact lens according to the items 4 and 4.