JPH0466202B2 - - Google Patents
Info
- Publication number
- JPH0466202B2 JPH0466202B2 JP19026084A JP19026084A JPH0466202B2 JP H0466202 B2 JPH0466202 B2 JP H0466202B2 JP 19026084 A JP19026084 A JP 19026084A JP 19026084 A JP19026084 A JP 19026084A JP H0466202 B2 JPH0466202 B2 JP H0466202B2
- Authority
- JP
- Japan
- Prior art keywords
- aqueous solution
- concentration
- freeze
- temperature
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 20
- 239000007864 aqueous solution Substances 0.000 claims description 19
- 229940079593 drug Drugs 0.000 claims description 16
- 239000013078 crystal Substances 0.000 claims description 15
- 230000005496 eutectics Effects 0.000 claims description 14
- 238000004108 freeze drying Methods 0.000 claims description 6
- 238000001556 precipitation Methods 0.000 claims description 6
- 238000002425 crystallisation Methods 0.000 claims description 3
- 230000008025 crystallization Effects 0.000 claims description 3
- 238000007710 freezing Methods 0.000 claims description 3
- 230000008014 freezing Effects 0.000 claims description 3
- 238000001035 drying Methods 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 7
- 238000007796 conventional method Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000002244 precipitate Substances 0.000 description 5
- 229960003408 cefazolin sodium Drugs 0.000 description 4
- FLKYBGKDCCEQQM-WYUVZMMLSA-M cefazolin sodium Chemical compound [Na+].S1C(C)=NN=C1SCC1=C(C([O-])=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 FLKYBGKDCCEQQM-WYUVZMMLSA-M 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000001816 cooling Methods 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000002542 deteriorative effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012931 lyophilized formulation Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000003186 pharmaceutical solution Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Landscapes
- Drying Of Solid Materials (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19026084A JPS6168412A (ja) | 1984-09-10 | 1984-09-10 | 医薬品の凍結乾燥方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19026084A JPS6168412A (ja) | 1984-09-10 | 1984-09-10 | 医薬品の凍結乾燥方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6168412A JPS6168412A (ja) | 1986-04-08 |
| JPH0466202B2 true JPH0466202B2 (da) | 1992-10-22 |
Family
ID=16255181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP19026084A Granted JPS6168412A (ja) | 1984-09-10 | 1984-09-10 | 医薬品の凍結乾燥方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6168412A (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5044091B1 (en) * | 1989-04-18 | 1997-12-30 | Sankyo Co | Method of preparing a freeze-dried formulation of a drug |
| DE4327063A1 (de) | 1993-08-12 | 1995-02-16 | Kirsten Dr Westesen | Ubidecarenon-Partikel mit modifizierten physikochemischen Eigenschaften |
| WO2002005787A1 (fr) * | 2000-07-17 | 2002-01-24 | Takeda Chemical Industries, Ltd. | Fabrication pour produits lyophilises |
-
1984
- 1984-09-10 JP JP19026084A patent/JPS6168412A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6168412A (ja) | 1986-04-08 |
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