JPH0464707B2 - - Google Patents
Info
- Publication number
- JPH0464707B2 JPH0464707B2 JP59199659A JP19965984A JPH0464707B2 JP H0464707 B2 JPH0464707 B2 JP H0464707B2 JP 59199659 A JP59199659 A JP 59199659A JP 19965984 A JP19965984 A JP 19965984A JP H0464707 B2 JPH0464707 B2 JP H0464707B2
- Authority
- JP
- Japan
- Prior art keywords
- suspension
- protein
- tank
- precipitant
- fraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004169 proteins and genes Human genes 0.000 claims description 135
- 108090000623 proteins and genes Proteins 0.000 claims description 135
- 239000000725 suspension Substances 0.000 claims description 120
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 64
- 239000002245 particle Substances 0.000 claims description 43
- 238000010992 reflux Methods 0.000 claims description 43
- 238000000034 method Methods 0.000 claims description 35
- 239000000872 buffer Substances 0.000 claims description 25
- 239000012460 protein solution Substances 0.000 claims description 22
- 239000000243 solution Substances 0.000 claims description 22
- 239000002244 precipitate Substances 0.000 claims description 14
- 239000006228 supernatant Substances 0.000 claims description 14
- 239000007864 aqueous solution Substances 0.000 claims description 13
- 238000000926 separation method Methods 0.000 claims description 13
- 239000007853 buffer solution Substances 0.000 claims description 12
- 239000000047 product Substances 0.000 claims description 11
- 238000003860 storage Methods 0.000 claims description 10
- 239000003595 mist Substances 0.000 claims description 6
- 238000005507 spraying Methods 0.000 claims description 6
- 230000001376 precipitating effect Effects 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 238000009826 distribution Methods 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 235000018102 proteins Nutrition 0.000 description 103
- 238000001556 precipitation Methods 0.000 description 10
- 239000007921 spray Substances 0.000 description 10
- 102000009027 Albumins Human genes 0.000 description 8
- 108010088751 Albumins Proteins 0.000 description 8
- 239000007788 liquid Substances 0.000 description 7
- 238000004925 denaturation Methods 0.000 description 4
- 230000036425 denaturation Effects 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000002826 coolant Substances 0.000 description 3
- 238000005187 foaming Methods 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 238000011027 product recovery Methods 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 102000002572 Alpha-Globulins Human genes 0.000 description 2
- 108010068307 Alpha-Globulins Proteins 0.000 description 2
- 102000006734 Beta-Globulins Human genes 0.000 description 2
- 108010087504 Beta-Globulins Proteins 0.000 description 2
- 102000008946 Fibrinogen Human genes 0.000 description 2
- 108010049003 Fibrinogen Proteins 0.000 description 2
- 238000010923 batch production Methods 0.000 description 2
- 210000001772 blood platelet Anatomy 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 229940012952 fibrinogen Drugs 0.000 description 2
- 108010074605 gamma-Globulins Proteins 0.000 description 2
- 238000013021 overheating Methods 0.000 description 2
- 230000006920 protein precipitation Effects 0.000 description 2
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59199659A JPS6179465A (ja) | 1984-09-26 | 1984-09-26 | 蛋白質分画方法及び装置 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59199659A JPS6179465A (ja) | 1984-09-26 | 1984-09-26 | 蛋白質分画方法及び装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6179465A JPS6179465A (ja) | 1986-04-23 |
| JPH0464707B2 true JPH0464707B2 (enrdf_load_stackoverflow) | 1992-10-15 |
Family
ID=16411501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59199659A Granted JPS6179465A (ja) | 1984-09-26 | 1984-09-26 | 蛋白質分画方法及び装置 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6179465A (enrdf_load_stackoverflow) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997009751A1 (en) | 1995-09-04 | 1997-03-13 | Nakasu Denki Kabushikigaisya | Parts and tool for obtaining conduction for use at electrical connection |
-
1984
- 1984-09-26 JP JP59199659A patent/JPS6179465A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6179465A (ja) | 1986-04-23 |
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