JPH0463857B2 - - Google Patents

Info

Publication number

JPH0463857B2

JPH0463857B2 JP58502179A JP50217983A JPH0463857B2 JP H0463857 B2 JPH0463857 B2 JP H0463857B2 JP 58502179 A JP58502179 A JP 58502179A JP 50217983 A JP50217983 A JP 50217983A JP H0463857 B2 JPH0463857 B2 JP H0463857B2

Authority

JP

Japan

Prior art keywords

berberine

heart

compounds

cardiac

group

Prior art date

1983-05-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Links

• Espacenet
• Global Dossier
• Discuss

• QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 252
• 229940093265 berberine Drugs 0.000 description 251
• YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 249
• 150000001875 compounds Chemical class 0.000 description 214
• 230000000694 effects Effects 0.000 description 154
• 210000002216 heart Anatomy 0.000 description 143
• 241000282472 Canis lupus familiaris Species 0.000 description 116
• 238000011282 treatment Methods 0.000 description 112
• 230000000747 cardiac effect Effects 0.000 description 99
• 239000003814 drug Substances 0.000 description 94
• 240000001879 Digitalis lutea Species 0.000 description 93
• 230000002861 ventricular Effects 0.000 description 85
• 229940079593 drug Drugs 0.000 description 82
• 230000007423 decrease Effects 0.000 description 81
• 230000001965 increasing effect Effects 0.000 description 76
• 206010019280 Heart failures Diseases 0.000 description 74
• 206010003119 arrhythmia Diseases 0.000 description 74
• 230000006793 arrhythmia Effects 0.000 description 73
• 230000003247 decreasing effect Effects 0.000 description 61
• 238000002474 experimental method Methods 0.000 description 58
• 239000000203 mixture Substances 0.000 description 51
• 241001465754 Metazoa Species 0.000 description 43
• 238000002347 injection Methods 0.000 description 43
• 239000007924 injection Substances 0.000 description 43
• 210000004369 blood Anatomy 0.000 description 42
• 239000008280 blood Substances 0.000 description 42
• 230000004872 arterial blood pressure Effects 0.000 description 41
• 230000017531 blood circulation Effects 0.000 description 34
• 230000035939 shock Effects 0.000 description 33
• 230000035487 diastolic blood pressure Effects 0.000 description 32
• 230000008859 change Effects 0.000 description 31
• 230000003288 anthiarrhythmic effect Effects 0.000 description 30
• 230000001225 therapeutic effect Effects 0.000 description 29
• -1 methylenedioxy group Chemical group 0.000 description 28
• 238000000034 method Methods 0.000 description 27
• 230000009471 action Effects 0.000 description 26
• 238000001802 infusion Methods 0.000 description 26
• UICBHOXXGLYZJH-UHFFFAOYSA-N 5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium Chemical class C1=CC=C2CC[N+]3=CC4=CC=CC=C4C=C3C2=C1 UICBHOXXGLYZJH-UHFFFAOYSA-N 0.000 description 25
• 229930182470 glycoside Natural products 0.000 description 24
• 150000002338 glycosides Chemical class 0.000 description 24
• 230000035488 systolic blood pressure Effects 0.000 description 24
• 244000166550 Strophanthus gratus Species 0.000 description 23
• 125000004435 hydrogen atom Chemical group [H]* 0.000 description 23
• 230000002107 myocardial effect Effects 0.000 description 23
• 230000036772 blood pressure Effects 0.000 description 22
• LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 description 22
• 150000003839 salts Chemical class 0.000 description 22
• AEQDJSLRWYMAQI-KRWDZBQOSA-N tetrahydropalmatine Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3C[C@H]2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-KRWDZBQOSA-N 0.000 description 22
• AEQDJSLRWYMAQI-UHFFFAOYSA-N Tetrahydropalmatine Natural products C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 description 21
• 229930013930 alkaloid Natural products 0.000 description 21
• 210000003205 muscle Anatomy 0.000 description 21
• 230000009885 systemic effect Effects 0.000 description 21
• 230000006870 function Effects 0.000 description 20
• 229960003343 ouabain Drugs 0.000 description 20
• LPMXVESGRSUGHW-UHFFFAOYSA-N Acolongiflorosid K Natural products OC1C(O)C(O)C(C)OC1OC1CC2(O)CCC3C4(O)CCC(C=5COC(=O)C=5)C4(C)CC(O)C3C2(CO)C(O)C1 LPMXVESGRSUGHW-UHFFFAOYSA-N 0.000 description 19
• VKJGBAJNNALVAV-UHFFFAOYSA-M Berberine chloride (TN) Chemical compound [Cl-].C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 VKJGBAJNNALVAV-UHFFFAOYSA-M 0.000 description 19
• 206010007559 Cardiac failure congestive Diseases 0.000 description 19
• LPMXVESGRSUGHW-GHYGWZAOSA-N Ouabain Natural products O([C@@H]1[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O1)[C@H]1C[C@@H](O)[C@@]2(CO)[C@@](O)(C1)CC[C@H]1[C@]3(O)[C@@](C)([C@H](C4=CC(=O)OC4)CC3)C[C@@H](O)[C@H]21 LPMXVESGRSUGHW-GHYGWZAOSA-N 0.000 description 19
• 230000009286 beneficial effect Effects 0.000 description 19
• 208000019622 heart disease Diseases 0.000 description 19
• 230000036581 peripheral resistance Effects 0.000 description 19
• 229910052698 phosphorus Inorganic materials 0.000 description 19
• 230000002829 reductive effect Effects 0.000 description 19
• 230000035485 pulse pressure Effects 0.000 description 18
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 17
• OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 17
• 239000003795 chemical substances by application Substances 0.000 description 17
• 239000011574 phosphorus Substances 0.000 description 17
• 241000700159 Rattus Species 0.000 description 16
• 239000003416 antiarrhythmic agent Substances 0.000 description 16
• 229940097217 cardiac glycoside Drugs 0.000 description 16
• 239000002368 cardiac glycoside Substances 0.000 description 16
• 230000000297 inotrophic effect Effects 0.000 description 16
• AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 description 16
• 230000009090 positive inotropic effect Effects 0.000 description 16
• 229930002534 steroid glycoside Natural products 0.000 description 16
• 208000024891 symptom Diseases 0.000 description 16
• 238000012360 testing method Methods 0.000 description 16
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 15
• 230000009467 reduction Effects 0.000 description 15
• 230000001154 acute effect Effects 0.000 description 14
• 239000008121 dextrose Substances 0.000 description 14
• 230000036284 oxygen consumption Effects 0.000 description 14
• 150000008143 steroidal glycosides Chemical class 0.000 description 14
• 125000000217 alkyl group Chemical group 0.000 description 13
• 230000008602 contraction Effects 0.000 description 13
• 230000034994 death Effects 0.000 description 13
• 231100000517 death Toxicity 0.000 description 13
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 13
• 230000002526 effect on cardiovascular system Effects 0.000 description 13
• 230000006872 improvement Effects 0.000 description 13
• 210000000709 aorta Anatomy 0.000 description 12
• 230000008901 benefit Effects 0.000 description 12
• 201000010099 disease Diseases 0.000 description 12
• 230000000004 hemodynamic effect Effects 0.000 description 12
• 238000010253 intravenous injection Methods 0.000 description 12
• 238000005259 measurement Methods 0.000 description 12
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 12
• 230000002093 peripheral effect Effects 0.000 description 12
• 230000002792 vascular Effects 0.000 description 12
• 241000124008 Mammalia Species 0.000 description 11
• 239000002585 base Substances 0.000 description 11
• LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 11
• 230000010102 embolization Effects 0.000 description 11
• 238000001990 intravenous administration Methods 0.000 description 11
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 11
• 210000004165 myocardium Anatomy 0.000 description 11
• 230000036513 peripheral conductance Effects 0.000 description 11
• 230000000144 pharmacologic effect Effects 0.000 description 11
• 230000024883 vasodilation Effects 0.000 description 11
• 206010007556 Cardiac failure acute Diseases 0.000 description 10
• 150000001299 aldehydes Chemical class 0.000 description 10
• 238000004458 analytical method Methods 0.000 description 10
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 10
• 230000001684 chronic effect Effects 0.000 description 10
• 229910052760 oxygen Inorganic materials 0.000 description 10
• 239000001301 oxygen Substances 0.000 description 10
• 206010040560 shock Diseases 0.000 description 10
• 239000000243 solution Substances 0.000 description 10
• 241000894007 species Species 0.000 description 10
• 239000000126 substance Substances 0.000 description 10
• 231100001274 therapeutic index Toxicity 0.000 description 10
• 206010003671 Atrioventricular Block Diseases 0.000 description 9
• LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 9
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 9
• 229960005156 digoxin Drugs 0.000 description 9
• LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 9
• 239000002207 metabolite Substances 0.000 description 9
• 210000000056 organ Anatomy 0.000 description 9
• 230000033764 rhythmic process Effects 0.000 description 9
• 208000001871 Tachycardia Diseases 0.000 description 8
• 239000002253 acid Substances 0.000 description 8
• 239000004480 active ingredient Substances 0.000 description 8
• 150000003797 alkaloid derivatives Chemical class 0.000 description 8
• RNLQIBCLLYYYFJ-UHFFFAOYSA-N amrinone Chemical compound N1C(=O)C(N)=CC(C=2C=CN=CC=2)=C1 RNLQIBCLLYYYFJ-UHFFFAOYSA-N 0.000 description 8
• 230000015572 biosynthetic process Effects 0.000 description 8
• 229910052799 carbon Inorganic materials 0.000 description 8
• 239000004041 inotropic agent Substances 0.000 description 8
• 230000028161 membrane depolarization Effects 0.000 description 8
• 238000000718 qrs complex Methods 0.000 description 8
• 230000006794 tachycardia Effects 0.000 description 8
• 231100000331 toxic Toxicity 0.000 description 8
• 230000002588 toxic effect Effects 0.000 description 8
• 208000003663 ventricular fibrillation Diseases 0.000 description 8
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
• 206010063081 Acute left ventricular failure Diseases 0.000 description 7
• 241000196324 Embryophyta Species 0.000 description 7
• 125000003545 alkoxy group Chemical group 0.000 description 7
• 229960002105 amrinone Drugs 0.000 description 7
• 230000003126 arrythmogenic effect Effects 0.000 description 7
• 150000001721 carbon Chemical group 0.000 description 7
• 125000004432 carbon atom Chemical group C* 0.000 description 7
• 230000004087 circulation Effects 0.000 description 7
• 231100000673 dose–response relationship Toxicity 0.000 description 7
• 239000012530 fluid Substances 0.000 description 7
• 230000004217 heart function Effects 0.000 description 7
• 210000005240 left ventricle Anatomy 0.000 description 7
• 239000007788 liquid Substances 0.000 description 7
• 210000004185 liver Anatomy 0.000 description 7
• 230000036316 preload Effects 0.000 description 7
• 229930001510 protoberberine alkaloid Natural products 0.000 description 7
• 238000011160 research Methods 0.000 description 7
• 125000001424 substituent group Chemical group 0.000 description 7
• 238000003786 synthesis reaction Methods 0.000 description 7
• 210000001519 tissue Anatomy 0.000 description 7
• 240000000724 Berberis vulgaris Species 0.000 description 6
• 206010011086 Coronary artery occlusion Diseases 0.000 description 6
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
• WDJUZGPOPHTGOT-OAXVISGBSA-N Digitoxin Natural products O([C@H]1[C@@H](C)O[C@@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@@](C)([C@H](C6=CC(=O)OC6)CC5)CC4)CC3)CC2)C[C@H]1O)[C@H]1O[C@@H](C)[C@H](O[C@H]2O[C@@H](C)[C@@H](O)[C@@H](O)C2)[C@@H](O)C1 WDJUZGPOPHTGOT-OAXVISGBSA-N 0.000 description 6
• 241000282326 Felis catus Species 0.000 description 6
• 241000282412 Homo Species 0.000 description 6
• 206010028980 Neoplasm Diseases 0.000 description 6
• 241000283973 Oryctolagus cuniculus Species 0.000 description 6
• 239000007864 aqueous solution Substances 0.000 description 6
• 210000001367 artery Anatomy 0.000 description 6
• 150000003832 berberine derivatives Chemical class 0.000 description 6
• 150000003836 berberines Chemical class 0.000 description 6
• 210000004204 blood vessel Anatomy 0.000 description 6
• GLYPKDKODVRYGP-UHFFFAOYSA-N burberrubine Natural products C12=CC=3OCOC=3C=C2CCN2C1=CC1=CC=C(OC)C(=O)C1=C2 GLYPKDKODVRYGP-UHFFFAOYSA-N 0.000 description 6
• 229960000648 digitoxin Drugs 0.000 description 6
• WDJUZGPOPHTGOT-XUDUSOBPSA-N digitoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O WDJUZGPOPHTGOT-XUDUSOBPSA-N 0.000 description 6
• 235000013399 edible fruits Nutrition 0.000 description 6
• 230000005764 inhibitory process Effects 0.000 description 6
• XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 description 6
• 239000000902 placebo Substances 0.000 description 6
• 229940068196 placebo Drugs 0.000 description 6
• 230000029058 respiratory gaseous exchange Effects 0.000 description 6
• 230000004044 response Effects 0.000 description 6
• 230000002936 tranquilizing effect Effects 0.000 description 6
• 210000002700 urine Anatomy 0.000 description 6
• 208000019553 vascular disease Diseases 0.000 description 6
• XFSBVAOIAHNAPC-XTHSEXKGSA-N 16-Ethyl-1alpha,6alpha,19beta-trimethoxy-4-(methoxymethyl)-aconitane-3alpha,8,10alpha,11,18alpha-pentol, 8-acetate 10-benzoate Chemical compound O([C@H]1[C@]2(O)C[C@H]3[C@@]45C6[C@@H]([C@@]([C@H]31)(OC(C)=O)[C@@H](O)[C@@H]2OC)[C@H](OC)[C@@H]4[C@]([C@@H](C[C@@H]5OC)O)(COC)CN6CC)C(=O)C1=CC=CC=C1 XFSBVAOIAHNAPC-XTHSEXKGSA-N 0.000 description 5
• XFSBVAOIAHNAPC-UHFFFAOYSA-N Aconitin Natural products CCN1CC(C(CC2OC)O)(COC)C3C(OC)C(C(C45)(OC(C)=O)C(O)C6OC)C1C32C4CC6(O)C5OC(=O)C1=CC=CC=C1 XFSBVAOIAHNAPC-UHFFFAOYSA-N 0.000 description 5
• 208000024172 Cardiovascular disease Diseases 0.000 description 5
• 206010012735 Diarrhoea Diseases 0.000 description 5
• 239000004698 Polyethylene Substances 0.000 description 5
• 206010040070 Septic Shock Diseases 0.000 description 5
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 5
• 230000005856 abnormality Effects 0.000 description 5
• 229940039750 aconitine Drugs 0.000 description 5
• STDXGNLCJACLFY-UHFFFAOYSA-N aconitine Natural products CCN1CC2(COC)C(O)CC(O)C34C5CC6(O)C(OC)C(O)C(OC(=O)C)(C5C6OC(=O)c7ccccc7)C(C(OC)C23)C14 STDXGNLCJACLFY-UHFFFAOYSA-N 0.000 description 5
• 230000000202 analgesic effect Effects 0.000 description 5
• 150000003943 catecholamines Chemical class 0.000 description 5
• 210000000038 chest Anatomy 0.000 description 5
• 230000005796 circulatory shock Effects 0.000 description 5
• 210000004351 coronary vessel Anatomy 0.000 description 5
• 238000010586 diagram Methods 0.000 description 5
• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 5
• 210000001105 femoral artery Anatomy 0.000 description 5
• 230000010247 heart contraction Effects 0.000 description 5
• 230000000302 ischemic effect Effects 0.000 description 5
• 150000002537 isoquinolines Chemical class 0.000 description 5
• 210000003734 kidney Anatomy 0.000 description 5
• 238000004519 manufacturing process Methods 0.000 description 5
• 239000004005 microsphere Substances 0.000 description 5
• 208000010125 myocardial infarction Diseases 0.000 description 5
• 229920000573 polyethylene Polymers 0.000 description 5
• 230000008092 positive effect Effects 0.000 description 5
• 230000003389 potentiating effect Effects 0.000 description 5
• 230000003405 preventing effect Effects 0.000 description 5
• 210000002784 stomach Anatomy 0.000 description 5
• 230000004873 systolic arterial blood pressure Effects 0.000 description 5
• 238000002560 therapeutic procedure Methods 0.000 description 5
• 229940125725 tranquilizer Drugs 0.000 description 5
• 239000003204 tranquilizing agent Substances 0.000 description 5
• 206010047302 ventricular tachycardia Diseases 0.000 description 5
• JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 4
• BEIZGBSEZACCGQ-UHFFFAOYSA-N 2,9,10-trimethoxy-6,8,13,13a-tetrahydro-5h-isoquinolino[2,1-b]isoquinolin-1-ol Chemical compound C1=CC(OC)=C(OC)C2=C1CC1C3=C(O)C(OC)=CC=C3CCN1C2 BEIZGBSEZACCGQ-UHFFFAOYSA-N 0.000 description 4
• FTOAOBMCPZCFFF-UHFFFAOYSA-N 5,5-diethylbarbituric acid Chemical compound CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 4
• QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 4
• 206010002091 Anaesthesia Diseases 0.000 description 4
• 206010003658 Atrial Fibrillation Diseases 0.000 description 4
• 208000005189 Embolism Diseases 0.000 description 4
• 102000051325 Glucagon Human genes 0.000 description 4
• 108060003199 Glucagon Proteins 0.000 description 4
• FZAGOOYMTPGPGF-UHFFFAOYSA-N Lambertine Chemical compound C1=C2C3=CC4=CC=C(OC)C(OC)=C4CN3CCC2=CC2=C1OCO2 FZAGOOYMTPGPGF-UHFFFAOYSA-N 0.000 description 4
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
• 206010047139 Vasoconstriction Diseases 0.000 description 4
• 206010047281 Ventricular arrhythmia Diseases 0.000 description 4
• 239000000808 adrenergic beta-agonist Substances 0.000 description 4
• 239000000556 agonist Substances 0.000 description 4
• 230000037005 anaesthesia Effects 0.000 description 4
• 125000003118 aryl group Chemical group 0.000 description 4
• 125000004104 aryloxy group Chemical group 0.000 description 4
• 230000001746 atrial effect Effects 0.000 description 4
• OJVABJMSSDUECT-UHFFFAOYSA-L berberin sulfate Chemical compound [O-]S([O-])(=O)=O.C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2.C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 OJVABJMSSDUECT-UHFFFAOYSA-L 0.000 description 4
• 230000037396 body weight Effects 0.000 description 4
• 201000011510 cancer Diseases 0.000 description 4
• 239000000496 cardiotonic agent Substances 0.000 description 4
• 230000003177 cardiotonic effect Effects 0.000 description 4
• 210000000748 cardiovascular system Anatomy 0.000 description 4
• 210000001715 carotid artery Anatomy 0.000 description 4
• 239000003638 chemical reducing agent Substances 0.000 description 4
• 230000003001 depressive effect Effects 0.000 description 4
• VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 4
• 239000002158 endotoxin Substances 0.000 description 4
• 238000005516 engineering process Methods 0.000 description 4
• MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 description 4
• 229960004666 glucagon Drugs 0.000 description 4
• 230000009931 harmful effect Effects 0.000 description 4
• 230000001976 improved effect Effects 0.000 description 4
• 239000003701 inert diluent Substances 0.000 description 4
• 229940039009 isoproterenol Drugs 0.000 description 4
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
• 230000033001 locomotion Effects 0.000 description 4
• 230000007246 mechanism Effects 0.000 description 4
• 208000031225 myocardial ischemia Diseases 0.000 description 4
• 229910052757 nitrogen Inorganic materials 0.000 description 4
• 125000004433 nitrogen atom Chemical group N* 0.000 description 4
• 230000003647 oxidation Effects 0.000 description 4
• 238000007254 oxidation reaction Methods 0.000 description 4
• 210000005259 peripheral blood Anatomy 0.000 description 4
• 239000011886 peripheral blood Substances 0.000 description 4
• AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 4
• GPTFURBXHJWNHR-UHFFFAOYSA-N protopine Chemical compound C1=C2C(=O)CC3=CC=C4OCOC4=C3CN(C)CCC2=CC2=C1OCO2 GPTFURBXHJWNHR-UHFFFAOYSA-N 0.000 description 4
• LOUPRKONTZGTKE-LHHVKLHASA-N quinidine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-LHHVKLHASA-N 0.000 description 4
• 230000011514 reflex Effects 0.000 description 4
• 229920006395 saturated elastomer Polymers 0.000 description 4
• 230000001568 sexual effect Effects 0.000 description 4
• 238000007619 statistical method Methods 0.000 description 4
• 230000000638 stimulation Effects 0.000 description 4
• 239000000725 suspension Substances 0.000 description 4
• 208000011580 syndromic disease Diseases 0.000 description 4
• 230000002195 synergetic effect Effects 0.000 description 4
• 229940124549 vasodilator Drugs 0.000 description 4
• 239000003071 vasodilator agent Substances 0.000 description 4
• 239000000052 vinegar Substances 0.000 description 4
• 235000021419 vinegar Nutrition 0.000 description 4
• 210000001835 viscera Anatomy 0.000 description 4
• 230000009278 visceral effect Effects 0.000 description 4
• SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 3
• 229930008281 A03AD01 - Papaverine Natural products 0.000 description 3
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
• 241000283690 Bos taurus Species 0.000 description 3
• VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
• 241000283086 Equidae Species 0.000 description 3
• 208000010496 Heart Arrest Diseases 0.000 description 3
• 208000032843 Hemorrhage Diseases 0.000 description 3
• 208000001953 Hypotension Diseases 0.000 description 3
• 206010021137 Hypovolaemia Diseases 0.000 description 3
• 241000699670 Mus sp. Species 0.000 description 3
• 238000000692 Student's t-test Methods 0.000 description 3
• 208000009729 Ventricular Premature Complexes Diseases 0.000 description 3
• 239000000654 additive Substances 0.000 description 3
• 230000000996 additive effect Effects 0.000 description 3
• 230000002411 adverse Effects 0.000 description 3
• 150000001450 anions Chemical class 0.000 description 3
• 125000004429 atom Chemical group 0.000 description 3
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 3
• 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 description 3
• 239000002876 beta blocker Substances 0.000 description 3
• 229940097320 beta blocking agent Drugs 0.000 description 3
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
• 230000004882 diastolic arterial blood pressure Effects 0.000 description 3
• 230000003205 diastolic effect Effects 0.000 description 3
• 239000002934 diuretic Substances 0.000 description 3
• 210000003743 erythrocyte Anatomy 0.000 description 3
• 230000029142 excretion Effects 0.000 description 3
• 238000009472 formulation Methods 0.000 description 3
• 230000002008 hemorrhagic effect Effects 0.000 description 3
• 230000001939 inductive effect Effects 0.000 description 3
• 239000004615 ingredient Substances 0.000 description 3
• 230000007774 longterm Effects 0.000 description 3
• 238000011418 maintenance treatment Methods 0.000 description 3
• 238000007726 management method Methods 0.000 description 3
• 230000001404 mediated effect Effects 0.000 description 3
• 231100000957 no side effect Toxicity 0.000 description 3
• 231100000252 nontoxic Toxicity 0.000 description 3
• 230000003000 nontoxic effect Effects 0.000 description 3
• 230000001151 other effect Effects 0.000 description 3
• 229960001789 papaverine Drugs 0.000 description 3
• WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 3
• 230000010412 perfusion Effects 0.000 description 3
• 230000001766 physiological effect Effects 0.000 description 3
• 239000000843 powder Substances 0.000 description 3
• 230000002028 premature Effects 0.000 description 3
• 230000002265 prevention Effects 0.000 description 3
• 238000012545 processing Methods 0.000 description 3
• BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 3
• 238000005086 pumping Methods 0.000 description 3
• 238000000306 qrs interval Methods 0.000 description 3
• 230000002285 radioactive effect Effects 0.000 description 3
• 230000000717 retained effect Effects 0.000 description 3
• FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
• 235000000346 sugar Nutrition 0.000 description 3
• 230000001629 suppression Effects 0.000 description 3
• 230000002889 sympathetic effect Effects 0.000 description 3
• 238000012353 t test Methods 0.000 description 3
• 230000001988 toxicity Effects 0.000 description 3
• 231100000419 toxicity Toxicity 0.000 description 3
• SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 2
• AEQDJSLRWYMAQI-QGZVFWFLSA-N (13ar)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5h-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3C[C@@H]2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-QGZVFWFLSA-N 0.000 description 2
• FSKPDOZBWMKQBY-INIZCTEOSA-N (13as)-2,10,11-trimethoxy-6,8,13,13a-tetrahydro-5h-isoquinolino[2,1-b]isoquinolin-3-ol Chemical compound C1C2=CC(OC)=C(OC)C=C2CN2[C@@H]1C(C=C(C(=C1)O)OC)=C1CC2 FSKPDOZBWMKQBY-INIZCTEOSA-N 0.000 description 2
• DIHXHTWYVOYYDC-INIZCTEOSA-N (13as)-2,3,9-trimethoxy-6,8,13,13a-tetrahydro-5h-isoquinolino[2,1-b]isoquinolin-10-ol Chemical compound C1CN2CC(C(=C(O)C=C3)OC)=C3C[C@H]2C2=C1C=C(OC)C(OC)=C2 DIHXHTWYVOYYDC-INIZCTEOSA-N 0.000 description 2
• UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 2
• 229930182837 (R)-adrenaline Natural products 0.000 description 2
• VZTUIEROBZXUFA-INIZCTEOSA-N (S)-canadine Chemical compound C1=C2[C@@H]3CC4=CC=C(OC)C(OC)=C4CN3CCC2=CC2=C1OCO2 VZTUIEROBZXUFA-INIZCTEOSA-N 0.000 description 2
• BHLYRWXGMIUIHG-HNNXBMFYSA-N (S)-reticuline Chemical compound C1=C(O)C(OC)=CC=C1C[C@H]1C2=CC(O)=C(OC)C=C2CCN1C BHLYRWXGMIUIHG-HNNXBMFYSA-N 0.000 description 2
• TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 description 2
• 206010002383 Angina Pectoris Diseases 0.000 description 2
• 241000269350 Anura Species 0.000 description 2
• 241000894006 Bacteria Species 0.000 description 2
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical group [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
• VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
• 244000304921 Charybdis maritima Species 0.000 description 2
• 206010008631 Cholera Diseases 0.000 description 2
• 102000009016 Cholera Toxin Human genes 0.000 description 2
• 108010049048 Cholera Toxin Proteins 0.000 description 2
• BWUQAWCUJMATJS-HNNXBMFYSA-N Coreximine Chemical compound C1C2=CC(OC)=C(O)C=C2C[C@@H]2N1CCC1=C2C=C(O)C(OC)=C1 BWUQAWCUJMATJS-HNNXBMFYSA-N 0.000 description 2
• PAPMYQLKLNRZIR-UHFFFAOYSA-N Cotarnine Chemical compound C1CN(C)C(O)C2=C1C=C1OCOC1=C2OC PAPMYQLKLNRZIR-UHFFFAOYSA-N 0.000 description 2
• FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
• 206010013012 Dilatation ventricular Diseases 0.000 description 2
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
• VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
• 208000005577 Gastroenteritis Diseases 0.000 description 2
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
• 241000735429 Hydrastis Species 0.000 description 2
• 206010020772 Hypertension Diseases 0.000 description 2
• 206010021138 Hypovolaemic shock Diseases 0.000 description 2
• 206010061216 Infarction Diseases 0.000 description 2
• MXTLAHSTUOXGQF-UHFFFAOYSA-O Jatrorrhizine Chemical compound COC1=CC=C2C=C3C(C=C(C(=C4)O)OC)=C4CC[N+]3=CC2=C1OC MXTLAHSTUOXGQF-UHFFFAOYSA-O 0.000 description 2
• 206010024119 Left ventricular failure Diseases 0.000 description 2
• 208000021642 Muscular disease Diseases 0.000 description 2
• 102100026933 Myelin-associated neurite-outgrowth inhibitor Human genes 0.000 description 2
• 201000009623 Myopathy Diseases 0.000 description 2
• 206010028851 Necrosis Diseases 0.000 description 2
• KKMPSGJPCCJYRV-UHFFFAOYSA-N Nitidine Chemical compound C1=C2C3=[N+](C)C=C4C=C(OC)C(OC)=CC4=C3C=CC2=CC2=C1OCO2 KKMPSGJPCCJYRV-UHFFFAOYSA-N 0.000 description 2
• SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 2
• 239000000006 Nitroglycerin Substances 0.000 description 2
• 229910019142 PO4 Inorganic materials 0.000 description 2
• PTPHDVKWAYIFRX-UHFFFAOYSA-N Palmatine Natural products C1C2=C(OC)C(OC)=CC=C2C=C2N1CCC1=C2C=C(OC)C(OC)=C1 PTPHDVKWAYIFRX-UHFFFAOYSA-N 0.000 description 2
• 241000287462 Phalacrocorax carbo Species 0.000 description 2
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical class [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
• WDVSHHCDHLJJJR-UHFFFAOYSA-N Proflavine Chemical compound C1=CC(N)=CC2=NC3=CC(N)=CC=C3C=C21 WDVSHHCDHLJJJR-UHFFFAOYSA-N 0.000 description 2
• GTRPODKMSBFDOI-UHFFFAOYSA-N Protopine Natural products CN1Cc2c3OCOc3ccc2C4C1Cc5cc6OCOc6cc5C4=O GTRPODKMSBFDOI-UHFFFAOYSA-N 0.000 description 2
• ZAALQOFZFANFTF-UHFFFAOYSA-N Pseudoprotipine Natural products C1=C2C(=O)CC3=CC=4OCOC=4C=C3CN(C)CCC2=CC2=C1OCO2 ZAALQOFZFANFTF-UHFFFAOYSA-N 0.000 description 2
• INVGWHRKADIJHF-UHFFFAOYSA-N Sanguinarin Chemical compound C1=C2OCOC2=CC2=C3[N+](C)=CC4=C(OCO5)C5=CC=C4C3=CC=C21 INVGWHRKADIJHF-UHFFFAOYSA-N 0.000 description 2
• 206010040047 Sepsis Diseases 0.000 description 2
• BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
• 206010040741 Sinus bradycardia Diseases 0.000 description 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
• 241000282887 Suidae Species 0.000 description 2
• 206010042600 Supraventricular arrhythmias Diseases 0.000 description 2
• 239000000150 Sympathomimetic Substances 0.000 description 2
• PQECCKIOFCWGRJ-UHFFFAOYSA-N Tetrahydro-berberine Natural products C1=C2C3CC4=CC=C(OC)C(O)=C4CN3CCC2=CC2=C1OCO2 PQECCKIOFCWGRJ-UHFFFAOYSA-N 0.000 description 2
• 206010047289 Ventricular extrasystoles Diseases 0.000 description 2
• 206010060953 Ventricular failure Diseases 0.000 description 2
• 230000002159 abnormal effect Effects 0.000 description 2
• 238000010521 absorption reaction Methods 0.000 description 2
• 230000001133 acceleration Effects 0.000 description 2
• OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 2
• 229960004373 acetylcholine Drugs 0.000 description 2
• 150000007513 acids Chemical class 0.000 description 2
• DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical compound C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 2
• 239000002671 adjuvant Substances 0.000 description 2
• UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 2
• 230000001800 adrenalinergic effect Effects 0.000 description 2
• 230000001476 alcoholic effect Effects 0.000 description 2
• 239000003513 alkali Substances 0.000 description 2
• 125000002947 alkylene group Chemical group 0.000 description 2
• 150000001408 amides Chemical class 0.000 description 2
• 238000002583 angiography Methods 0.000 description 2
• 230000003042 antagnostic effect Effects 0.000 description 2
• 239000003242 anti bacterial agent Substances 0.000 description 2
• 230000000844 anti-bacterial effect Effects 0.000 description 2
• 230000003466 anti-cipated effect Effects 0.000 description 2
• 230000003110 anti-inflammatory effect Effects 0.000 description 2
• 230000002921 anti-spasmodic effect Effects 0.000 description 2
• 229940088710 antibiotic agent Drugs 0.000 description 2
• BZKUYNBAFQJRDM-UHFFFAOYSA-N aporphine Chemical compound C12=CC=CC=C2CC2N(C)CCC3=CC=CC1=C32 BZKUYNBAFQJRDM-UHFFFAOYSA-N 0.000 description 2
• 230000002763 arrhythmic effect Effects 0.000 description 2
• 230000001580 bacterial effect Effects 0.000 description 2
• 229960002319 barbital Drugs 0.000 description 2
• 230000003542 behavioural effect Effects 0.000 description 2
• BRLDZKPJJNASGG-UHFFFAOYSA-N berbine Chemical compound C1=CC=C2CN3CCC4=CC=CC=C4C3CC2=C1 BRLDZKPJJNASGG-UHFFFAOYSA-N 0.000 description 2
• 230000000975 bioactive effect Effects 0.000 description 2
• 230000004071 biological effect Effects 0.000 description 2
• 210000004556 brain Anatomy 0.000 description 2
• 239000011575 calcium Substances 0.000 description 2
• 229910052791 calcium Inorganic materials 0.000 description 2
• 238000004364 calculation method Methods 0.000 description 2
• 206010061592 cardiac fibrillation Diseases 0.000 description 2
• 210000004027 cell Anatomy 0.000 description 2
• 210000003169 central nervous system Anatomy 0.000 description 2
• GHKISGDRQRSCII-ZOCIIQOWSA-N chelidonine Chemical compound C1=C2[C@H]3N(C)CC4=C(OCO5)C5=CC=C4[C@H]3[C@@H](O)CC2=CC2=C1OCO2 GHKISGDRQRSCII-ZOCIIQOWSA-N 0.000 description 2
• SAFQLLBOPKXYLB-UHFFFAOYSA-N chembl2270082 Chemical compound [Cl-].C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C(O)=C3C2=CC2=C1OCO2 SAFQLLBOPKXYLB-UHFFFAOYSA-N 0.000 description 2
• 230000002057 chronotropic effect Effects 0.000 description 2
• LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 2
• 230000015271 coagulation Effects 0.000 description 2
• 238000005345 coagulation Methods 0.000 description 2
• YYFOFDHQVIODOQ-UHFFFAOYSA-O columbamine Chemical compound COC1=CC=C2C=C(C3=C(C=C(C(=C3)O)OC)CC3)[N+]3=CC2=C1OC YYFOFDHQVIODOQ-UHFFFAOYSA-O 0.000 description 2
• CYOURJWVXZHEPP-UHFFFAOYSA-N columbamine Natural products COc1cc2CCN3Cc4c(OC)c(OC)ccc4C=C3c2cc1O CYOURJWVXZHEPP-UHFFFAOYSA-N 0.000 description 2
• 238000007906 compression Methods 0.000 description 2
• 230000006835 compression Effects 0.000 description 2
• 208000028831 congenital heart disease Diseases 0.000 description 2
• 230000001276 controlling effect Effects 0.000 description 2
• 208000029078 coronary artery disease Diseases 0.000 description 2
• RHJBGPMDJNBXPF-UHFFFAOYSA-N cryptopine Natural products COc1cc2CCN(C)c3cc4OCOc4cc3CCC(=O)c2cc1OC RHJBGPMDJNBXPF-UHFFFAOYSA-N 0.000 description 2
• XPOJSWHIKCNLEQ-UHFFFAOYSA-N cryptopine Chemical compound C1CN(C)CC2=C(OCO3)C3=CC=C2CC(=O)C2=C1C=C(OC)C(OC)=C2 XPOJSWHIKCNLEQ-UHFFFAOYSA-N 0.000 description 2
• 230000006378 damage Effects 0.000 description 2
• OBATZBGFDSVCJD-UHFFFAOYSA-N de-O-acetyl-lanatoside C Natural products CC1OC(OC2CC3C(C4C(C5(CCC(C5(C)C(O)C4)C=4COC(=O)C=4)O)CC3)(C)CC2)CC(O)C1OC(OC1C)CC(O)C1OC(OC1C)CC(O)C1OC1OC(CO)C(O)C(O)C1O OBATZBGFDSVCJD-UHFFFAOYSA-N 0.000 description 2
• 230000000994 depressogenic effect Effects 0.000 description 2
• 229960001324 deslanoside Drugs 0.000 description 2
• OBATZBGFDSVCJD-LALPQLPRSA-N deslanoside Chemical compound O([C@H]1[C@@H](O)C[C@@H](O[C@@H]1C)O[C@H]1[C@@H](O)C[C@@H](O[C@@H]1C)O[C@H]1[C@@H](O)C[C@@H](O[C@@H]1C)O[C@@H]1C[C@@H]2[C@]([C@@H]3[C@H]([C@]4(CC[C@@H]([C@@]4(C)[C@H](O)C3)C=3COC(=O)C=3)O)CC2)(C)CC1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O OBATZBGFDSVCJD-LALPQLPRSA-N 0.000 description 2
• 230000006866 deterioration Effects 0.000 description 2
• 238000011161 development Methods 0.000 description 2
• 230000018109 developmental process Effects 0.000 description 2
• 238000003745 diagnosis Methods 0.000 description 2
• 208000021264 digitalis poisoning Diseases 0.000 description 2
• CHWPMFMUQATVNK-ARYYTZDLSA-N dihydrosporogen AO-1 Natural products O[C@H]1[C@]2(C(C)=C)O[C@@H]2[C@]2(C)[C@@H](C)[C@H](O)CCC2=C1 CHWPMFMUQATVNK-ARYYTZDLSA-N 0.000 description 2
• 229940030606 diuretics Drugs 0.000 description 2
• 229960001089 dobutamine Drugs 0.000 description 2
• 229960003638 dopamine Drugs 0.000 description 2
• 238000001647 drug administration Methods 0.000 description 2
• 239000000839 emulsion Substances 0.000 description 2
• FPJQGFLUORYYPE-UHFFFAOYSA-N epiberberine Chemical compound C1=C2C=C(C3=C(C=C(C(=C3)OC)OC)CC3)[N+]3=CC2=C2OCOC2=C1 FPJQGFLUORYYPE-UHFFFAOYSA-N 0.000 description 2
• 229960005139 epinephrine Drugs 0.000 description 2
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
• 238000011156 evaluation Methods 0.000 description 2
• 206010016256 fatigue Diseases 0.000 description 2
• 230000002600 fibrillogenic effect Effects 0.000 description 2
• 235000013305 food Nutrition 0.000 description 2
• 239000012458 free base Substances 0.000 description 2
• 230000005251 gamma ray Effects 0.000 description 2
• 210000005095 gastrointestinal system Anatomy 0.000 description 2
• 229960003711 glyceryl trinitrate Drugs 0.000 description 2
• 210000002837 heart atrium Anatomy 0.000 description 2
• 229920000669 heparin Polymers 0.000 description 2
• 229960002897 heparin Drugs 0.000 description 2
• FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 2
• 229910052739 hydrogen Inorganic materials 0.000 description 2
• 230000002209 hydrophobic effect Effects 0.000 description 2
• 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 2
• 230000001077 hypotensive effect Effects 0.000 description 2
• 238000003384 imaging method Methods 0.000 description 2
• 238000000338 in vitro Methods 0.000 description 2
• 230000007574 infarction Effects 0.000 description 2
• 230000002401 inhibitory effect Effects 0.000 description 2
• 208000014674 injury Diseases 0.000 description 2
• 230000003601 intercostal effect Effects 0.000 description 2
• 210000000936 intestine Anatomy 0.000 description 2
• 230000002427 irreversible effect Effects 0.000 description 2
• 238000006317 isomerization reaction Methods 0.000 description 2
• 229930013397 isoquinoline alkaloid Natural products 0.000 description 2
• 210000004731 jugular vein Anatomy 0.000 description 2
• 235000014655 lactic acid Nutrition 0.000 description 2
• 230000036723 left ventricular dilatation Effects 0.000 description 2
• 230000003902 lesion Effects 0.000 description 2
• 231100000053 low toxicity Toxicity 0.000 description 2
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
• 238000012423 maintenance Methods 0.000 description 2
• 238000009115 maintenance therapy Methods 0.000 description 2
• 239000003550 marker Substances 0.000 description 2
• 239000000463 material Substances 0.000 description 2
• 230000002503 metabolic effect Effects 0.000 description 2
• 150000007522 mineralic acids Chemical class 0.000 description 2
• 230000004048 modification Effects 0.000 description 2
• 238000012986 modification Methods 0.000 description 2
• BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
• 230000003680 myocardial damage Effects 0.000 description 2
• 208000037891 myocardial injury Diseases 0.000 description 2
• 230000017074 necrotic cell death Effects 0.000 description 2
• 210000005036 nerve Anatomy 0.000 description 2
• 210000000653 nervous system Anatomy 0.000 description 2
• FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 description 2
• 231100000956 nontoxicity Toxicity 0.000 description 2
• 229960002748 norepinephrine Drugs 0.000 description 2
• SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 2
• 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 description 2
• ZHYQCBCBTQWPLC-UHFFFAOYSA-N oxyberberine Chemical compound C12=CC=3OCOC=3C=C2CCN2C1=CC1=CC=C(OC)C(OC)=C1C2=O ZHYQCBCBTQWPLC-UHFFFAOYSA-N 0.000 description 2
• QUCQEUCGKKTEBI-UHFFFAOYSA-N palmatine Chemical compound COC1=CC=C2C=C(C3=C(C=C(C(=C3)OC)OC)CC3)[N+]3=CC2=C1OC QUCQEUCGKKTEBI-UHFFFAOYSA-N 0.000 description 2
• 230000001575 pathological effect Effects 0.000 description 2
• 230000007170 pathology Effects 0.000 description 2
• 229960001412 pentobarbital Drugs 0.000 description 2
• 239000000810 peripheral vasodilating agent Substances 0.000 description 2
• 229960002116 peripheral vasodilator Drugs 0.000 description 2
• 239000008194 pharmaceutical composition Substances 0.000 description 2
• 239000000546 pharmaceutical excipient Substances 0.000 description 2
• 235000021317 phosphate Nutrition 0.000 description 2
• 150000003017 phosphorus Chemical class 0.000 description 2
• 239000011591 potassium Substances 0.000 description 2
• 229910052700 potassium Inorganic materials 0.000 description 2
• 239000002243 precursor Substances 0.000 description 2
• 238000002360 preparation method Methods 0.000 description 2
• 239000003755 preservative agent Substances 0.000 description 2
• REQCZEXYDRLIBE-UHFFFAOYSA-N procainamide Chemical compound CCN(CC)CCNC(=O)C1=CC=C(N)C=C1 REQCZEXYDRLIBE-UHFFFAOYSA-N 0.000 description 2
• 229960000244 procainamide Drugs 0.000 description 2
• 229960000286 proflavine Drugs 0.000 description 2
• 230000000750 progressive effect Effects 0.000 description 2
• 229960003598 promazine Drugs 0.000 description 2
• 229960003712 propranolol Drugs 0.000 description 2
• 102000004169 proteins and genes Human genes 0.000 description 2
• 108090000623 proteins and genes Proteins 0.000 description 2
• 210000001147 pulmonary artery Anatomy 0.000 description 2
• KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical compound NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 description 2
• 150000003242 quaternary ammonium salts Chemical class 0.000 description 2
• 229960001404 quinidine Drugs 0.000 description 2
• 108020003175 receptors Proteins 0.000 description 2
• 102000005962 receptors Human genes 0.000 description 2
• 238000012552 review Methods 0.000 description 2
• 230000036303 septic shock Effects 0.000 description 2
• 210000001013 sinoatrial node Anatomy 0.000 description 2
• 239000007787 solid Substances 0.000 description 2
• 239000008247 solid mixture Substances 0.000 description 2
• 238000000527 sonication Methods 0.000 description 2
• 210000000952 spleen Anatomy 0.000 description 2
• 230000002269 spontaneous effect Effects 0.000 description 2
• 239000008223 sterile water Substances 0.000 description 2
• 150000003431 steroids Chemical class 0.000 description 2
• 230000004936 stimulating effect Effects 0.000 description 2
• 150000003467 sulfuric acid derivatives Chemical class 0.000 description 2
• 238000001356 surgical procedure Methods 0.000 description 2
• 230000002459 sustained effect Effects 0.000 description 2
• 229910052713 technetium Inorganic materials 0.000 description 2
• GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 2
• DIHXHTWYVOYYDC-UHFFFAOYSA-N tetrahydropalmatin Natural products C1CN2CC(C(=C(O)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 DIHXHTWYVOYYDC-UHFFFAOYSA-N 0.000 description 2
• 229910052716 thallium Inorganic materials 0.000 description 2
• BKVIYDNLLOSFOA-UHFFFAOYSA-N thallium Chemical compound [Tl] BKVIYDNLLOSFOA-UHFFFAOYSA-N 0.000 description 2
• 229940124597 therapeutic agent Drugs 0.000 description 2
• 238000011287 therapeutic dose Methods 0.000 description 2
• 229960004605 timolol Drugs 0.000 description 2
• 239000003053 toxin Substances 0.000 description 2
• 231100000765 toxin Toxicity 0.000 description 2
• 108700012359 toxins Proteins 0.000 description 2
• 210000003437 trachea Anatomy 0.000 description 2
• VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
• 230000009466 transformation Effects 0.000 description 2
• 230000001052 transient effect Effects 0.000 description 2
• 230000008733 trauma Effects 0.000 description 2
• 230000003639 vasoconstrictive effect Effects 0.000 description 2
• 239000005526 vasoconstrictor agent Substances 0.000 description 2
• 230000000304 vasodilatating effect Effects 0.000 description 2
• 210000003462 vein Anatomy 0.000 description 2
• 229960001722 verapamil Drugs 0.000 description 2
• 238000005303 weighing Methods 0.000 description 2
• QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 description 1
• RUPUUZZJJXCDHS-UHFFFAOYSA-N (+)-orientaline Natural products C1=C(O)C(OC)=CC(CC2C3=CC(O)=C(OC)C=C3CCN2C)=C1 RUPUUZZJJXCDHS-UHFFFAOYSA-N 0.000 description 1
• XEEQGYMUWCZPDN-DOMZBBRYSA-N (-)-(11S,2'R)-erythro-mefloquine Chemical compound C([C@@H]1[C@@H](O)C=2C3=CC=CC(=C3N=C(C=2)C(F)(F)F)C(F)(F)F)CCCN1 XEEQGYMUWCZPDN-DOMZBBRYSA-N 0.000 description 1
• HUEYSSLYFJVUIS-MRFSYGAJSA-N (2s,3r,11bs)-2-[[(1r)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1h-benzo[a]quinolizine;hydron;chloride Chemical compound Cl.N1CCC2=CC(OC)=C(OC)C=C2[C@H]1C[C@H]1C[C@H]2C3=CC(OC)=C(OC)C=C3CCN2C[C@@H]1CC HUEYSSLYFJVUIS-MRFSYGAJSA-N 0.000 description 1
• YSCJAYPKBYRXEZ-HZPINHDXSA-N (2s,3s,4s,5r,6r)-6-[[(3s,4ar,6ar,6bs,8as,12as,14ar,14br)-4,4,6a,6b,11,11,14b-heptamethyl-8a-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3-hydroxy-4-[(2s,3r,4s, Chemical compound O([C@H]1[C@H](O)[C@H](O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2C1(C)C)C)(C)CC[C@]1(CCC(C[C@H]14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C(O)=O)[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O YSCJAYPKBYRXEZ-HZPINHDXSA-N 0.000 description 1
• DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 description 1
• LYFPBWOBIJJASK-INIZCTEOSA-N (S)-(-)-Canadine Natural products O(C)c1c(OC)ccc2c1C[N+]1[C@H](c3c(cc4OCOc4c3)CC1)C2 LYFPBWOBIJJASK-INIZCTEOSA-N 0.000 description 1
• YLRXAIKMLINXQY-ZDUSSCGKSA-O (S)-magnoflorine Chemical compound C1=C(OC)C(O)=C2C3=C(O)C(OC)=CC=C3C[C@@H]3[N+](C)(C)CCC1=C23 YLRXAIKMLINXQY-ZDUSSCGKSA-O 0.000 description 1
• DKCQBFHZGAIJOJ-UHFFFAOYSA-N -form-Stepharotine Natural products OC1=CC2=C(CN3CCC4=C(C3C2)C=C(C(=C4)OC)OC)C(=C1OC)OC DKCQBFHZGAIJOJ-UHFFFAOYSA-N 0.000 description 1
• BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
• BITVSRNAFFZUFW-UHFFFAOYSA-N 5-ethyl-6-phenylphenanthridin-5-ium-3,8-diamine;chloride Chemical compound [Cl-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 BITVSRNAFFZUFW-UHFFFAOYSA-N 0.000 description 1
• FHHIBFLHBNYRCB-UHFFFAOYSA-N 6-methyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinoline-7-ol Chemical compound C12=CC=CC=C2C(O)C2N(C)CCC3=CC=CC1=C32 FHHIBFLHBNYRCB-UHFFFAOYSA-N 0.000 description 1
• ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
• RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
• 241000251468 Actinopterygii Species 0.000 description 1
• 206010001497 Agitation Diseases 0.000 description 1
• 102000007698 Alcohol dehydrogenase Human genes 0.000 description 1
• 108010021809 Alcohol dehydrogenase Proteins 0.000 description 1
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
• 238000010953 Ames test Methods 0.000 description 1
• 231100000039 Ames test Toxicity 0.000 description 1
• 206010002198 Anaphylactic reaction Diseases 0.000 description 1
• 244000030795 Annona lutescens Species 0.000 description 1
• 206010003130 Arrhythmia supraventricular Diseases 0.000 description 1
• 206010003225 Arteriospasm coronary Diseases 0.000 description 1
• 206010003677 Atrioventricular block second degree Diseases 0.000 description 1
• 241000271566 Aves Species 0.000 description 1
• 208000035143 Bacterial infection Diseases 0.000 description 1
• 231100000699 Bacterial toxin Toxicity 0.000 description 1
• 239000005711 Benzoic acid Substances 0.000 description 1
• DFOCUWZXJBAUSQ-URLMMPGGSA-N Berbamine Chemical compound C([C@@H]1N(C)CCC=2C=C(C(OC=3C(OC)=C(OC)C=C4CCN(C)[C@@H](C=34)CC=3C=C(C(=CC=3)O)O3)=CC=21)OC)C1=CC=C3C=C1 DFOCUWZXJBAUSQ-URLMMPGGSA-N 0.000 description 1
• DFOCUWZXJBAUSQ-UHFFFAOYSA-N Berbamine Natural products O1C(C(=CC=2)O)=CC=2CC(C=23)N(C)CCC3=CC(OC)=C(OC)C=2OC(=CC=23)C(OC)=CC=2CCN(C)C3CC2=CC=C1C=C2 DFOCUWZXJBAUSQ-UHFFFAOYSA-N 0.000 description 1
• VFCGRXCCUHLLIP-UHFFFAOYSA-N Berberastine Chemical compound C1=C2C(O)C[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 VFCGRXCCUHLLIP-UHFFFAOYSA-N 0.000 description 1
• ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical class N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 description 1
• LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
• 206010005746 Blood pressure fluctuation Diseases 0.000 description 1
• 229910001369 Brass Inorganic materials 0.000 description 1
• WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
• 241000269420 Bufonidae Species 0.000 description 1
• 229930008564 C01BA04 - Sparteine Natural products 0.000 description 1
• RZZPDXZPRHQOCG-OJAKKHQRSA-O CDP-choline(1+) Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OCC[N+](C)(C)C)O[C@H]1N1C(=O)N=C(N)C=C1 RZZPDXZPRHQOCG-OJAKKHQRSA-O 0.000 description 1
• 229940127291 Calcium channel antagonist Drugs 0.000 description 1
• 244000025254 Cannabis sativa Species 0.000 description 1
• 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 description 1
• 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 description 1
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
• BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
• 208000020446 Cardiac disease Diseases 0.000 description 1
• 206010007558 Cardiac failure chronic Diseases 0.000 description 1
• 206010007572 Cardiac hypertrophy Diseases 0.000 description 1
• 208000006029 Cardiomegaly Diseases 0.000 description 1
• 241000700198 Cavia Species 0.000 description 1
• 241000282994 Cervidae Species 0.000 description 1
• 241000270617 Cheloniidae Species 0.000 description 1
• 235000003913 Coccoloba uvifera Nutrition 0.000 description 1
• 241000272203 Columba Species 0.000 description 1
• 208000002330 Congenital Heart Defects Diseases 0.000 description 1
• 244000247747 Coptis groenlandica Species 0.000 description 1
• 235000002991 Coptis groenlandica Nutrition 0.000 description 1
• 229920000832 Cutin Polymers 0.000 description 1
• 101710088194 Dehydrogenase Proteins 0.000 description 1
• 208000020401 Depressive disease Diseases 0.000 description 1
• 229920001353 Dextrin Polymers 0.000 description 1
• 239000004375 Dextrin Substances 0.000 description 1
• 241000790917 Dioxys <bee> Species 0.000 description 1
• 241000255925 Diptera Species 0.000 description 1
• JRWZLRBJNMZMFE-UHFFFAOYSA-N Dobutamine Chemical compound C=1C=C(O)C(O)=CC=1CCNC(C)CCC1=CC=C(O)C=C1 JRWZLRBJNMZMFE-UHFFFAOYSA-N 0.000 description 1
• 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
• 241000257465 Echinoidea Species 0.000 description 1
• LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
• FCEXWTOTHXCQCQ-UHFFFAOYSA-N Ethoxydihydrosanguinarine Natural products C12=CC=C3OCOC3=C2C(OCC)N(C)C(C2=C3)=C1C=CC2=CC1=C3OCO1 FCEXWTOTHXCQCQ-UHFFFAOYSA-N 0.000 description 1
• 206010015856 Extrasystoles Diseases 0.000 description 1
• 102000020897 Formins Human genes 0.000 description 1
• 108091022623 Formins Proteins 0.000 description 1
• 241000233866 Fungi Species 0.000 description 1
• 241000287828 Gallus gallus Species 0.000 description 1
• 108010010803 Gelatin Proteins 0.000 description 1
• OCEDEAQHBIGPTE-UHFFFAOYSA-N Gitoxin Natural products CC1OC(CC(O)C1O)OC2C(O)CC(OC3C(O)CC(OC4CCC5(C)C(CCC6C5CCC7(C)C(C(O)CC67O)C8=CCOC8=O)C4)OC3C)OC2C OCEDEAQHBIGPTE-UHFFFAOYSA-N 0.000 description 1
• 241001608331 Gonyaulax digitale Species 0.000 description 1
• 206010019233 Headaches Diseases 0.000 description 1
• 208000032456 Hemorrhagic Shock Diseases 0.000 description 1
• 108010003272 Hyaluronate lyase Proteins 0.000 description 1
• 102000001974 Hyaluronidases Human genes 0.000 description 1
• 241000243328 Hydridae Species 0.000 description 1
• MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 1
• 206010020565 Hyperaemia Diseases 0.000 description 1
• 206010020751 Hypersensitivity Diseases 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• 206010022998 Irritability Diseases 0.000 description 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
• 102000006835 Lamins Human genes 0.000 description 1
• 108010047294 Lamins Proteins 0.000 description 1
• 229930188389 Lanatoside Natural products 0.000 description 1
• KGPAYJZAMGEDIQ-KRWDZBQOSA-N Laudanosine Chemical compound C1=C(OC)C(OC)=CC=C1C[C@H]1C2=CC(OC)=C(OC)C=C2CCN1C KGPAYJZAMGEDIQ-KRWDZBQOSA-N 0.000 description 1
• 241000222736 Leishmania tropica Species 0.000 description 1
• 241000288902 Lemur catta Species 0.000 description 1
• 208000009378 Low Cardiac Output Diseases 0.000 description 1
• KYEAXNAYHSCLMT-CVVGWEDFSA-N Magnoflorine Natural products C[C@H]1OC=C2[C@@H]3[C@@H]1CN4CCc5c([nH]c6ccccc56)[C@@H]4[C@@H]3OC2=O KYEAXNAYHSCLMT-CVVGWEDFSA-N 0.000 description 1
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 1
• 108010007843 NADH oxidase Proteins 0.000 description 1
• 206010028813 Nausea Diseases 0.000 description 1
• GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
• MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
• 208000002193 Pain Diseases 0.000 description 1
• 229930194309 Papaverrubine Natural products 0.000 description 1
• 208000031481 Pathologic Constriction Diseases 0.000 description 1
• 239000005643 Pelargonic acid Substances 0.000 description 1
• 208000008469 Peptic Ulcer Diseases 0.000 description 1
• CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 description 1
• VQDBNKDJNJQRDG-UHFFFAOYSA-N Pirbuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=N1 VQDBNKDJNJQRDG-UHFFFAOYSA-N 0.000 description 1
• 208000005374 Poisoning Diseases 0.000 description 1
• 239000002202 Polyethylene glycol Substances 0.000 description 1
• 239000004793 Polystyrene Substances 0.000 description 1
• 208000000418 Premature Cardiac Complexes Diseases 0.000 description 1
• ZGUGWUXLJSTTMA-UHFFFAOYSA-N Promazinum Chemical compound C1=CC=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZGUGWUXLJSTTMA-UHFFFAOYSA-N 0.000 description 1
• OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
• 240000008976 Pterocarpus marsupium Species 0.000 description 1
• 206010037423 Pulmonary oedema Diseases 0.000 description 1
• 239000005700 Putrescine Substances 0.000 description 1
• 244000184734 Pyrus japonica Species 0.000 description 1
• LCQMZZCPPSWADO-UHFFFAOYSA-N Reserpilin Natural products COC(=O)C1COCC2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12 LCQMZZCPPSWADO-UHFFFAOYSA-N 0.000 description 1
• QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 description 1
• QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 description 1
• 235000012377 Salvia columbariae var. columbariae Nutrition 0.000 description 1
• 240000005481 Salvia hispanica Species 0.000 description 1
• 235000001498 Salvia hispanica Nutrition 0.000 description 1
• 241000031708 Saprospiraceae Species 0.000 description 1
• 241000555745 Sciuridae Species 0.000 description 1
• 206010049771 Shock haemorrhagic Diseases 0.000 description 1
• 206010040736 Sinoatrial block Diseases 0.000 description 1
• 206010041349 Somnolence Diseases 0.000 description 1
• 229920002472 Starch Polymers 0.000 description 1
• DKCQBFHZGAIJOJ-INIZCTEOSA-N Stepharotine Natural products O(C)c1c(OC)c2c(cc1O)C[C@@H]1N(C2)CCc2c1cc(OC)c(OC)c2 DKCQBFHZGAIJOJ-INIZCTEOSA-N 0.000 description 1
• 241000287181 Sturnus vulgaris Species 0.000 description 1
• 229930006000 Sucrose Natural products 0.000 description 1
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
• 208000003734 Supraventricular Tachycardia Diseases 0.000 description 1
• 241000282898 Sus scrofa Species 0.000 description 1
• FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
• GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
• LQGRWSKECPQNES-INIZCTEOSA-O Thalidastine Natural products O(C)c1c(O)ccc2c1c[n+]1c(-c3c([C@@H](O)C1)cc1OCOc1c3)c2 LQGRWSKECPQNES-INIZCTEOSA-O 0.000 description 1
• QCMQEZNBBPGFKQ-UHFFFAOYSA-N Thalisopynine Natural products CN1CCC2=C(OC)C(OC)=C(OC)C3=C2C1CC1=C3C=C(OC)C(O)=C1 QCMQEZNBBPGFKQ-UHFFFAOYSA-N 0.000 description 1
• FOCVUCIESVLUNU-UHFFFAOYSA-N Thiotepa Chemical class C1CN1P(N1CC1)(=S)N1CC1 FOCVUCIESVLUNU-UHFFFAOYSA-N 0.000 description 1
• ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
• 206010070863 Toxicity to various agents Diseases 0.000 description 1
• 206010046788 Uterine haemorrhage Diseases 0.000 description 1
• 206010057469 Vascular stenosis Diseases 0.000 description 1
• 206010047700 Vomiting Diseases 0.000 description 1
• YOAUKNYXWBTMMF-KRWDZBQOSA-N Xylopinine Chemical compound C1C2=CC(OC)=C(OC)C=C2C[C@@H]2N1CCC1=C2C=C(OC)C(OC)=C1 YOAUKNYXWBTMMF-KRWDZBQOSA-N 0.000 description 1
• YOAUKNYXWBTMMF-UHFFFAOYSA-N Xylopinine Natural products C1C2=CC(OC)=C(OC)C=C2CC2N1CCC1=C2C=C(OC)C(OC)=C1 YOAUKNYXWBTMMF-UHFFFAOYSA-N 0.000 description 1
• YFGQJKBUXPKSAW-ZUDKKNPISA-N [(2r,3r,4s)-6-[(2r,3s,4s)-4-hydroxy-6-[(2r,3s,4s)-4-hydroxy-6-[[(3s,9s,10s,13r,17r)-14-hydroxy-10,13-dimethyl-17-(5-oxo-2h-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]-2-methyloxan-3-yl]oxy-2-methyloxan-3-y Chemical compound O([C@H]1[C@@H](OC(C)=O)CC(O[C@@H]1C)O[C@H]1[C@@H](O)CC(O[C@@H]1C)O[C@H]1[C@@H](O)CC(O[C@@H]1C)O[C@@H]1CC2[C@]([C@@H]3C(C4(CC[C@@H]([C@@]4(C)CC3)C=3COC(=O)C=3)O)CC2)(C)CC1)C1O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]1O YFGQJKBUXPKSAW-ZUDKKNPISA-N 0.000 description 1
• 238000002835 absorbance Methods 0.000 description 1
• NOSIYYJFMPDDSA-UHFFFAOYSA-N acepromazine Chemical compound C1=C(C(C)=O)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 NOSIYYJFMPDDSA-UHFFFAOYSA-N 0.000 description 1
• 229960005054 acepromazine Drugs 0.000 description 1
• 235000011054 acetic acid Nutrition 0.000 description 1
• 150000001242 acetic acid derivatives Chemical class 0.000 description 1
• FXAGBTBXSJBNMD-UHFFFAOYSA-N acetic acid;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound CC(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O FXAGBTBXSJBNMD-UHFFFAOYSA-N 0.000 description 1
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
• 230000004913 activation Effects 0.000 description 1
• 208000012873 acute gastroenteritis Diseases 0.000 description 1
• 206010000891 acute myocardial infarction Diseases 0.000 description 1
• 102000030621 adenylate cyclase Human genes 0.000 description 1
• 108060000200 adenylate cyclase Proteins 0.000 description 1
• 230000036586 afterload Effects 0.000 description 1
• 125000001931 aliphatic group Chemical group 0.000 description 1
• 239000012670 alkaline solution Substances 0.000 description 1
• 208000026935 allergic disease Diseases 0.000 description 1
• SLRCCWJSBJZJBV-UHFFFAOYSA-N alpha-isosparteine Natural products C1N2CCCCC2C2CN3CCCCC3C1C2 SLRCCWJSBJZJBV-UHFFFAOYSA-N 0.000 description 1
• 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
• 230000036783 anaphylactic response Effects 0.000 description 1
• 208000003455 anaphylaxis Diseases 0.000 description 1
• 230000008485 antagonism Effects 0.000 description 1
• 230000001004 anti-acetylcholinic effect Effects 0.000 description 1
• 230000000398 anti-amebic effect Effects 0.000 description 1
• 230000001773 anti-convulsant effect Effects 0.000 description 1
• 230000001142 anti-diarrhea Effects 0.000 description 1
• 230000003474 anti-emetic effect Effects 0.000 description 1
• 230000001387 anti-histamine Effects 0.000 description 1
• 230000003276 anti-hypertensive effect Effects 0.000 description 1
• 230000002467 anti-pepsin effect Effects 0.000 description 1
• 239000001961 anticonvulsive agent Substances 0.000 description 1
• 229960003965 antiepileptics Drugs 0.000 description 1
• 239000000739 antihistaminic agent Substances 0.000 description 1
• 229940111121 antirheumatic drug quinolines Drugs 0.000 description 1
• 239000003699 antiulcer agent Substances 0.000 description 1
• 210000002376 aorta thoracic Anatomy 0.000 description 1
• CAWXSAHEALOABD-HXPMCKFVSA-N apocavidine Natural products COc1ccc2[C@H]3[C@@H](C)c4ccc5OCOc5c4CN3CCc2c1 CAWXSAHEALOABD-HXPMCKFVSA-N 0.000 description 1
• 230000004596 appetite loss Effects 0.000 description 1
• 125000003710 aryl alkyl group Chemical group 0.000 description 1
• 238000003556 assay Methods 0.000 description 1
• 206010003668 atrial tachycardia Diseases 0.000 description 1
• 210000001992 atrioventricular node Anatomy 0.000 description 1
• YEESUBCSWGVPCE-UHFFFAOYSA-N azanylidyneoxidanium iron(2+) pentacyanide Chemical compound [Fe++].[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.N#[O+] YEESUBCSWGVPCE-UHFFFAOYSA-N 0.000 description 1
• 208000022362 bacterial infectious disease Diseases 0.000 description 1
• 239000000688 bacterial toxin Substances 0.000 description 1
• 229940125717 barbiturate Drugs 0.000 description 1
• RQPZNWPYLFFXCP-UHFFFAOYSA-L barium dihydroxide Chemical compound [OH-].[OH-].[Ba+2] RQPZNWPYLFFXCP-UHFFFAOYSA-L 0.000 description 1
• 229910001863 barium hydroxide Inorganic materials 0.000 description 1
• 235000015278 beef Nutrition 0.000 description 1
• 235000013405 beer Nutrition 0.000 description 1
• 230000006399 behavior Effects 0.000 description 1
• 235000010233 benzoic acid Nutrition 0.000 description 1
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
• 230000002457 bidirectional effect Effects 0.000 description 1
• 230000033228 biological regulation Effects 0.000 description 1
• 230000005540 biological transmission Effects 0.000 description 1
• 230000002051 biphasic effect Effects 0.000 description 1
• 230000006406 biphasic response Effects 0.000 description 1
• 230000000740 bleeding effect Effects 0.000 description 1
• 230000000903 blocking effect Effects 0.000 description 1
• 210000000601 blood cell Anatomy 0.000 description 1
• 230000023555 blood coagulation Effects 0.000 description 1
• 210000001772 blood platelet Anatomy 0.000 description 1
• 230000036471 bradycardia Effects 0.000 description 1
• 208000006218 bradycardia Diseases 0.000 description 1
• 239000010951 brass Substances 0.000 description 1
• 210000000481 breast Anatomy 0.000 description 1
• GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
• 229910052794 bromium Inorganic materials 0.000 description 1
• 244000309464 bull Species 0.000 description 1
• 210000004375 bundle of his Anatomy 0.000 description 1
• 229910000019 calcium carbonate Inorganic materials 0.000 description 1
• 239000000480 calcium channel blocker Substances 0.000 description 1
• 235000009120 camo Nutrition 0.000 description 1
• VZTUIEROBZXUFA-UHFFFAOYSA-N canadine Chemical compound C1=C2C3CC4=CC=C(OC)C(OC)=C4CN3CCC2=CC2=C1OCO2 VZTUIEROBZXUFA-UHFFFAOYSA-N 0.000 description 1
• 239000002775 capsule Substances 0.000 description 1
• 239000002371 cardiac agent Substances 0.000 description 1
• 210000004903 cardiac system Anatomy 0.000 description 1
• 230000001426 cardiotropic effect Effects 0.000 description 1
• 230000009084 cardiovascular function Effects 0.000 description 1
• 230000005800 cardiovascular problem Effects 0.000 description 1
• 210000001159 caudate nucleus Anatomy 0.000 description 1
• JTZZGWPIBBTYNE-FKIZINRSSA-N cavidine Chemical compound C1C2=C3OCOC3=CC=C2[C@H](C)[C@H]2N1CCC1=C2C=C(OC)C(OC)=C1 JTZZGWPIBBTYNE-FKIZINRSSA-N 0.000 description 1
• JTZZGWPIBBTYNE-UHFFFAOYSA-N cavidine Natural products C1C2=C3OCOC3=CC=C2C(C)C2N1CCC1=C2C=C(OC)C(OC)=C1 JTZZGWPIBBTYNE-UHFFFAOYSA-N 0.000 description 1
• 235000005607 chanvre indien Nutrition 0.000 description 1
• GHKISGDRQRSCII-UHFFFAOYSA-N chelidonine Natural products C1=C2C3N(C)CC4=C(OCO5)C5=CC=C4C3C(O)CC2=CC2=C1OCO2 GHKISGDRQRSCII-UHFFFAOYSA-N 0.000 description 1
• 238000006243 chemical reaction Methods 0.000 description 1
• 238000011976 chest X-ray Methods 0.000 description 1
• 235000014167 chia Nutrition 0.000 description 1
• 235000013330 chicken meat Nutrition 0.000 description 1
• ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 description 1
• 239000000812 cholinergic antagonist Substances 0.000 description 1
• 206010009887 colitis Diseases 0.000 description 1
• 238000004891 communication Methods 0.000 description 1
• 230000000052 comparative effect Effects 0.000 description 1
• 230000001447 compensatory effect Effects 0.000 description 1
• 230000002860 competitive effect Effects 0.000 description 1
• 239000002131 composite material Substances 0.000 description 1
• 239000007891 compressed tablet Substances 0.000 description 1
• 239000012141 concentrate Substances 0.000 description 1
• 235000008504 concentrate Nutrition 0.000 description 1
• 239000004020 conductor Substances 0.000 description 1
• 239000000039 congener Substances 0.000 description 1
• 230000002517 constrictor effect Effects 0.000 description 1
• 239000002872 contrast media Substances 0.000 description 1
• ZAODQVCWAXRSRG-UHFFFAOYSA-N coralydine Natural products CC1C2=CC(OC)=C(OC)C=C2CC2N1CCC1=C2C=C(OC)C(OC)=C1 ZAODQVCWAXRSRG-UHFFFAOYSA-N 0.000 description 1
• VTOBHWOZXDRRAP-UHFFFAOYSA-N coreximine Natural products OC1=C(OC)C=C2C(=O)N3CCC(C=C(C(=C4)O)OC)=C4C3CC2=C1 VTOBHWOZXDRRAP-UHFFFAOYSA-N 0.000 description 1
• 238000009109 curative therapy Methods 0.000 description 1
• LKLWVKCEYSPQHL-KKSFZXQISA-O cyclanoline Chemical compound C12=CC(O)=C(OC)C=C2CC[N@+]2(C)[C@H]1CC1=CC=C(OC)C(O)=C1C2 LKLWVKCEYSPQHL-KKSFZXQISA-O 0.000 description 1
• 208000031513 cyst Diseases 0.000 description 1
• 238000007405 data analysis Methods 0.000 description 1
• 230000007547 defect Effects 0.000 description 1
• 230000007812 deficiency Effects 0.000 description 1
• 230000003111 delayed effect Effects 0.000 description 1
• 230000001419 dependent effect Effects 0.000 description 1
• 235000019425 dextrin Nutrition 0.000 description 1
• 229940039227 diagnostic agent Drugs 0.000 description 1
• 239000000032 diagnostic agent Substances 0.000 description 1
• 229940082657 digitalis glycosides Drugs 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• FSKPDOZBWMKQBY-UHFFFAOYSA-N discretine Natural products C1C2=CC(OC)=C(OC)C=C2CN2C1C(C=C(C(=C1)O)OC)=C1CC2 FSKPDOZBWMKQBY-UHFFFAOYSA-N 0.000 description 1
• 208000035475 disorder Diseases 0.000 description 1
• 239000002270 dispersing agent Substances 0.000 description 1
• 238000007323 disproportionation reaction Methods 0.000 description 1
• 238000010494 dissociation reaction Methods 0.000 description 1
• 230000005593 dissociations Effects 0.000 description 1
• 238000004090 dissolution Methods 0.000 description 1
• 238000009826 distribution Methods 0.000 description 1
• 230000001882 diuretic effect Effects 0.000 description 1
• 239000002552 dosage form Substances 0.000 description 1
• 239000000975 dye Substances 0.000 description 1
• 230000004064 dysfunction Effects 0.000 description 1
• 230000001700 effect on tissue Effects 0.000 description 1
• 230000005611 electricity Effects 0.000 description 1
• 238000002635 electroconvulsive therapy Methods 0.000 description 1
• 239000003792 electrolyte Substances 0.000 description 1
• 230000008030 elimination Effects 0.000 description 1
• 238000003379 elimination reaction Methods 0.000 description 1
• 229960001923 emetine hydrochloride Drugs 0.000 description 1
• 239000003995 emulsifying agent Substances 0.000 description 1
• 230000002124 endocrine Effects 0.000 description 1
• 230000007689 endotoxicity Effects 0.000 description 1
• 238000005265 energy consumption Methods 0.000 description 1
• 239000003623 enhancer Substances 0.000 description 1
• 230000002708 enhancing effect Effects 0.000 description 1
• 230000007613 environmental effect Effects 0.000 description 1
• 150000002148 esters Chemical class 0.000 description 1
• LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
• 229940093471 ethyl oleate Drugs 0.000 description 1
• 230000000763 evoking effect Effects 0.000 description 1
• 230000002349 favourable effect Effects 0.000 description 1
• 210000003191 femoral vein Anatomy 0.000 description 1
• 238000001595 flow curve Methods 0.000 description 1
• 230000037406 food intake Effects 0.000 description 1
• 235000003599 food sweetener Nutrition 0.000 description 1
• 210000000245 forearm Anatomy 0.000 description 1
• 238000005194 fractionation Methods 0.000 description 1
• 239000001530 fumaric acid Substances 0.000 description 1
• 230000008717 functional decline Effects 0.000 description 1
• 125000000524 functional group Chemical group 0.000 description 1
• 210000001035 gastrointestinal tract Anatomy 0.000 description 1
• 229920000159 gelatin Polymers 0.000 description 1
• 239000008273 gelatin Substances 0.000 description 1
• 235000019322 gelatine Nutrition 0.000 description 1
• 235000011852 gelatine desserts Nutrition 0.000 description 1
• 230000014509 gene expression Effects 0.000 description 1
• 238000007429 general method Methods 0.000 description 1
• 229950000974 gitoxin Drugs 0.000 description 1
• LKRDZKPBAOKJBT-CNPIRKNPSA-N gitoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(C[C@H](O)[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LKRDZKPBAOKJBT-CNPIRKNPSA-N 0.000 description 1
• 239000008103 glucose Substances 0.000 description 1
• 229930182478 glucoside Natural products 0.000 description 1
• 150000008131 glucosides Chemical class 0.000 description 1
• 239000008187 granular material Substances 0.000 description 1
• 230000009422 growth inhibiting effect Effects 0.000 description 1
• 125000005843 halogen group Chemical group 0.000 description 1
• 230000035876 healing Effects 0.000 description 1
• 230000036541 health Effects 0.000 description 1
• 230000005831 heart abnormality Effects 0.000 description 1
• 210000005003 heart tissue Anatomy 0.000 description 1
• 238000010438 heat treatment Methods 0.000 description 1
• 239000011487 hemp Substances 0.000 description 1
• 239000003906 humectant Substances 0.000 description 1
• 229960002773 hyaluronidase Drugs 0.000 description 1
• YOJQZPVUNUQTDF-UHFFFAOYSA-N hydrastinine Chemical compound C1=C2C(O)N(C)CCC2=CC2=C1OCO2 YOJQZPVUNUQTDF-UHFFFAOYSA-N 0.000 description 1
• 150000003840 hydrochlorides Chemical class 0.000 description 1
• XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
• WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
• 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
• 230000009610 hypersensitivity Effects 0.000 description 1
• 239000012216 imaging agent Substances 0.000 description 1
• 238000005470 impregnation Methods 0.000 description 1
• 238000001727 in vivo Methods 0.000 description 1
• 208000015181 infectious disease Diseases 0.000 description 1
• 239000003112 inhibitor Substances 0.000 description 1
• 230000000977 initiatory effect Effects 0.000 description 1
• 230000000968 intestinal effect Effects 0.000 description 1
• 238000011835 investigation Methods 0.000 description 1
• 230000026045 iodination Effects 0.000 description 1
• 238000006192 iodination reaction Methods 0.000 description 1
• PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
• 229910052740 iodine Inorganic materials 0.000 description 1
• 239000011630 iodine Substances 0.000 description 1
• 238000005342 ion exchange Methods 0.000 description 1
• 230000007794 irritation Effects 0.000 description 1
• 208000037906 ischaemic injury Diseases 0.000 description 1
• 208000021803 junctional tachycardia Diseases 0.000 description 1
• 230000003907 kidney function Effects 0.000 description 1
• 238000002372 labelling Methods 0.000 description 1
• 239000004310 lactic acid Substances 0.000 description 1
• 239000008101 lactose Substances 0.000 description 1
• 210000005053 lamin Anatomy 0.000 description 1
• KGPAYJZAMGEDIQ-UHFFFAOYSA-N laudanosine Natural products C1=C(OC)C(OC)=CC=C1CC1C2=CC(OC)=C(OC)C=C2CCN1C KGPAYJZAMGEDIQ-UHFFFAOYSA-N 0.000 description 1
• 231100000636 lethal dose Toxicity 0.000 description 1
• 210000000265 leukocyte Anatomy 0.000 description 1
• 150000002632 lipids Chemical class 0.000 description 1
• 229940057995 liquid paraffin Drugs 0.000 description 1
• FVRABHGHBLRNNR-UHFFFAOYSA-N liriodenine Natural products O=C1C=CC=c2c1cc3nccc4cc5OCOc5c2c34 FVRABHGHBLRNNR-UHFFFAOYSA-N 0.000 description 1
• 230000003908 liver function Effects 0.000 description 1
• 238000011866 long-term treatment Methods 0.000 description 1
• 208000019017 loss of appetite Diseases 0.000 description 1
• 235000021266 loss of appetite Nutrition 0.000 description 1
• 239000000314 lubricant Substances 0.000 description 1
• 210000004072 lung Anatomy 0.000 description 1
• 150000002668 lysine derivatives Chemical class 0.000 description 1
• 235000019359 magnesium stearate Nutrition 0.000 description 1
• 230000014759 maintenance of location Effects 0.000 description 1
• 206010025482 malaise Diseases 0.000 description 1
• 201000004792 malaria Diseases 0.000 description 1
• VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
• 239000011976 maleic acid Substances 0.000 description 1
• 150000002688 maleic acid derivatives Chemical class 0.000 description 1
• 230000007257 malfunction Effects 0.000 description 1
• 230000003211 malignant effect Effects 0.000 description 1
• 230000010534 mechanism of action Effects 0.000 description 1
• 238000002483 medication Methods 0.000 description 1
• 229960001962 mefloquine Drugs 0.000 description 1
• 201000003102 mental depression Diseases 0.000 description 1
• 229960000901 mepacrine Drugs 0.000 description 1
• WABYCCJHARSRBH-UHFFFAOYSA-N metaclazepam Chemical compound C12=CC(Br)=CC=C2N(C)C(COC)CN=C1C1=CC=CC=C1Cl WABYCCJHARSRBH-UHFFFAOYSA-N 0.000 description 1
• 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
• 208000019267 mild heart failure Diseases 0.000 description 1
• 230000000116 mitigating effect Effects 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 230000000051 modifying effect Effects 0.000 description 1
• 229960005181 morphine Drugs 0.000 description 1
• 230000004118 muscle contraction Effects 0.000 description 1
• 231100000243 mutagenic effect Toxicity 0.000 description 1
• LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 description 1
• 230000008693 nausea Effects 0.000 description 1
• 239000003176 neuroleptic agent Substances 0.000 description 1
• 230000000701 neuroleptic effect Effects 0.000 description 1
• 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
• BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
• HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 1
• 229960001597 nifedipine Drugs 0.000 description 1
• 150000002823 nitrates Chemical class 0.000 description 1
• 229910017604 nitric acid Inorganic materials 0.000 description 1
• 229960002460 nitroprusside Drugs 0.000 description 1
• 238000010606 normalization Methods 0.000 description 1
• 238000009206 nuclear medicine Methods 0.000 description 1
• 235000008390 olive oil Nutrition 0.000 description 1
• 239000004006 olive oil Substances 0.000 description 1
• 210000004789 organ system Anatomy 0.000 description 1
• 150000007524 organic acids Chemical class 0.000 description 1
• 150000002895 organic esters Chemical class 0.000 description 1
• 239000003960 organic solvent Substances 0.000 description 1
• 230000008520 organization Effects 0.000 description 1
• OLIRVMPRFWLUGS-UHFFFAOYSA-N oxyberberine Natural products COc1ccc2C=C3N(CCc4cc5OCCOc5cc34)C(=O)c2c1OC OLIRVMPRFWLUGS-UHFFFAOYSA-N 0.000 description 1
• 125000004430 oxygen atom Chemical group O* 0.000 description 1
• 230000036407 pain Effects 0.000 description 1
• 229940096717 pamine Drugs 0.000 description 1
• 210000000496 pancreas Anatomy 0.000 description 1
• 239000002245 particle Substances 0.000 description 1
• 230000004963 pathophysiological condition Effects 0.000 description 1
• 230000007310 pathophysiology Effects 0.000 description 1
• 208000011906 peptic ulcer disease Diseases 0.000 description 1
• 230000000737 periodic effect Effects 0.000 description 1
• 230000002085 persistent effect Effects 0.000 description 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
• 229960002036 phenytoin Drugs 0.000 description 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
• 239000010452 phosphate Substances 0.000 description 1
• 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
• 239000006187 pill Substances 0.000 description 1
• 229960001416 pilocarpine Drugs 0.000 description 1
• 229960005414 pirbuterol Drugs 0.000 description 1
• 231100000572 poisoning Toxicity 0.000 description 1
• 230000000607 poisoning effect Effects 0.000 description 1
• 229920001223 polyethylene glycol Polymers 0.000 description 1
• YEBIHIICWDDQOL-YBHNRIQQSA-N polyoxin Chemical compound O[C@@H]1[C@H](O)[C@@H](C(C=O)N)O[C@H]1N1C(=O)NC(=O)C(C(O)=O)=C1 YEBIHIICWDDQOL-YBHNRIQQSA-N 0.000 description 1
• 229920001282 polysaccharide Polymers 0.000 description 1
• 239000005017 polysaccharide Substances 0.000 description 1
• 229920002223 polystyrene Polymers 0.000 description 1
• 230000003449 preventive effect Effects 0.000 description 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
• MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
• 229960004919 procaine Drugs 0.000 description 1
• 230000008569 process Effects 0.000 description 1
• 230000002035 prolonged effect Effects 0.000 description 1
• 229940043274 prophylactic drug Drugs 0.000 description 1
• 230000000069 prophylactic effect Effects 0.000 description 1
• 238000011321 prophylaxis Methods 0.000 description 1
• 230000001681 protective effect Effects 0.000 description 1
• 208000005333 pulmonary edema Diseases 0.000 description 1
• 210000001747 pupil Anatomy 0.000 description 1
• 230000001698 pyrogenic effect Effects 0.000 description 1
• GPKJTRJOBQGKQK-UHFFFAOYSA-N quinacrine Chemical compound C1=C(OC)C=C2C(NC(C)CCCN(CC)CC)=C(C=CC(Cl)=C3)C3=NC2=C1 GPKJTRJOBQGKQK-UHFFFAOYSA-N 0.000 description 1
• HREHOXSRYOZKNT-UHFFFAOYSA-N quinolin-2-ylmethanol Chemical compound C1=CC=CC2=NC(CO)=CC=C21 HREHOXSRYOZKNT-UHFFFAOYSA-N 0.000 description 1
• 150000003248 quinolines Chemical class 0.000 description 1
• 230000005855 radiation Effects 0.000 description 1
• 239000000941 radioactive substance Substances 0.000 description 1
• 239000002994 raw material Substances 0.000 description 1
• 238000011084 recovery Methods 0.000 description 1
• 230000000306 recurrent effect Effects 0.000 description 1
• 230000034622 regulation of systemic arterial blood pressure by atrial baroreceptor feedback Effects 0.000 description 1
• 230000034225 regulation of ventricular cardiomyocyte membrane depolarization Effects 0.000 description 1
• 230000001105 regulatory effect Effects 0.000 description 1
• 230000003578 releasing effect Effects 0.000 description 1
• 230000002336 repolarization Effects 0.000 description 1
• QEVHRUUCFGRFIF-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C(C5=CC=C(OC)C=C5N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 QEVHRUUCFGRFIF-MDEJGZGSSA-N 0.000 description 1
• 229960003147 reserpine Drugs 0.000 description 1
• 210000002345 respiratory system Anatomy 0.000 description 1
• 230000004043 responsiveness Effects 0.000 description 1
• BNUZUOWRDKPBQR-UHFFFAOYSA-N reticuline Natural products CN1CCC2=CC(OC)=CC=C2C1CC1=CC=C(OC)C(O)=C1 BNUZUOWRDKPBQR-UHFFFAOYSA-N 0.000 description 1
• 230000002441 reversible effect Effects 0.000 description 1
• 210000005245 right atrium Anatomy 0.000 description 1
• 210000005241 right ventricle Anatomy 0.000 description 1
• MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 1
• 229910052701 rubidium Inorganic materials 0.000 description 1
• IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical compound [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 description 1
• 239000012266 salt solution Substances 0.000 description 1
• 229940084560 sanguinarine Drugs 0.000 description 1
• YZRQUTZNTDAYPJ-UHFFFAOYSA-N sanguinarine pseudobase Natural products C1=C2OCOC2=CC2=C3N(C)C(O)C4=C(OCO5)C5=CC=C4C3=CC=C21 YZRQUTZNTDAYPJ-UHFFFAOYSA-N 0.000 description 1
• 235000013580 sausages Nutrition 0.000 description 1
• LSMIOFMZNVEEBR-ICLSSMQGSA-N scilliroside Chemical compound C=1([C@@H]2[C@@]3(C)CC[C@H]4[C@@]([C@]3(CC2)O)(O)C[C@H](C2=C[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)CC[C@@]24C)OC(=O)C)C=CC(=O)OC=1 LSMIOFMZNVEEBR-ICLSSMQGSA-N 0.000 description 1
• CXYRUNPLKGGUJF-RAFJPFSSSA-M scopolamine methobromide Chemical compound [Br-].C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3[N+]([C@H](C2)[C@@H]2[C@H]3O2)(C)C)=CC=CC=C1 CXYRUNPLKGGUJF-RAFJPFSSSA-M 0.000 description 1
• 239000000932 sedative agent Substances 0.000 description 1
• 230000001624 sedative effect Effects 0.000 description 1
• 230000035945 sensitivity Effects 0.000 description 1
• 230000036332 sexual response Effects 0.000 description 1
• 238000004904 shortening Methods 0.000 description 1
• 210000002027 skeletal muscle Anatomy 0.000 description 1
• 230000004622 sleep time Effects 0.000 description 1
• 210000002460 smooth muscle Anatomy 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 239000011780 sodium chloride Substances 0.000 description 1
• 235000009518 sodium iodide Nutrition 0.000 description 1
• SLRCCWJSBJZJBV-AJNGGQMLSA-N sparteine Chemical compound C1N2CCCC[C@H]2[C@@H]2CN3CCCC[C@H]3[C@H]1C2 SLRCCWJSBJZJBV-AJNGGQMLSA-N 0.000 description 1
• 229960001945 sparteine Drugs 0.000 description 1
• 238000001228 spectrum Methods 0.000 description 1
• 230000009154 spontaneous behavior Effects 0.000 description 1
• 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
• 230000006641 stabilisation Effects 0.000 description 1
• 238000011105 stabilization Methods 0.000 description 1
• 239000003381 stabilizer Substances 0.000 description 1
• 238000011272 standard treatment Methods 0.000 description 1
• 239000008107 starch Substances 0.000 description 1
• 235000019698 starch Nutrition 0.000 description 1
• 230000036262 stenosis Effects 0.000 description 1
• 208000037804 stenosis Diseases 0.000 description 1
• 239000003206 sterilizing agent Substances 0.000 description 1
• 125000005415 substituted alkoxy group Chemical group 0.000 description 1
• 238000006467 substitution reaction Methods 0.000 description 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
• 239000005720 sucrose Substances 0.000 description 1
• 150000008163 sugars Chemical class 0.000 description 1
• 230000000153 supplemental effect Effects 0.000 description 1
• 239000000829 suppository Substances 0.000 description 1
• 239000000375 suspending agent Substances 0.000 description 1
• 239000003765 sweetening agent Substances 0.000 description 1
• 210000002820 sympathetic nervous system Anatomy 0.000 description 1
• 230000001975 sympathomimetic effect Effects 0.000 description 1
• 229940064707 sympathomimetics Drugs 0.000 description 1
• 238000001308 synthesis method Methods 0.000 description 1
• 230000002194 synthesizing effect Effects 0.000 description 1
• 239000006188 syrup Substances 0.000 description 1
• 235000020357 syrup Nutrition 0.000 description 1
• 239000000454 talc Substances 0.000 description 1
• 229910052623 talc Inorganic materials 0.000 description 1
• 239000011975 tartaric acid Substances 0.000 description 1
• 235000002906 tartaric acid Nutrition 0.000 description 1
• 229940095064 tartrate Drugs 0.000 description 1
• 238000010998 test method Methods 0.000 description 1
• 238000012956 testing procedure Methods 0.000 description 1
• ZCTJIMXXSXQXRI-UHFFFAOYSA-N thaliblastine Natural products CN1CCC2=CC(OC)=C(OC)C3=C2C1CC1=C3C=C(OC)C(OC2=C(CC3C4=CC(OC)=C(OC)C=C4CCN3C)C=C(C(=C2)OC)OC)=C1 ZCTJIMXXSXQXRI-UHFFFAOYSA-N 0.000 description 1
• ZCTJIMXXSXQXRI-KYJUHHDHSA-N thalicarpine Chemical compound CN1CCC2=CC(OC)=C(OC)C3=C2[C@@H]1CC1=C3C=C(OC)C(OC2=C(C[C@H]3C4=CC(OC)=C(OC)C=C4CCN3C)C=C(C(=C2)OC)OC)=C1 ZCTJIMXXSXQXRI-KYJUHHDHSA-N 0.000 description 1
• 229940126585 therapeutic drug Drugs 0.000 description 1
• 238000009210 therapy by ultrasound Methods 0.000 description 1
• 230000000451 tissue damage Effects 0.000 description 1
• 231100000827 tissue damage Toxicity 0.000 description 1
• 231100000816 toxic dose Toxicity 0.000 description 1
• 231100000041 toxicology testing Toxicity 0.000 description 1
• 238000002054 transplantation Methods 0.000 description 1
• 230000000472 traumatic effect Effects 0.000 description 1
• 238000011269 treatment regimen Methods 0.000 description 1
• RROQIUMZODEXOR-UHFFFAOYSA-N triforine Chemical compound O=CNC(C(Cl)(Cl)Cl)N1CCN(C(NC=O)C(Cl)(Cl)Cl)CC1 RROQIUMZODEXOR-UHFFFAOYSA-N 0.000 description 1
• 230000002485 urinary effect Effects 0.000 description 1
• 230000036325 urinary excretion Effects 0.000 description 1
• 210000001186 vagus nerve Anatomy 0.000 description 1
• 230000006496 vascular abnormality Effects 0.000 description 1
• 210000005166 vasculature Anatomy 0.000 description 1
• 239000002550 vasoactive agent Substances 0.000 description 1
• 230000025033 vasoconstriction Effects 0.000 description 1
• 230000001457 vasomotor Effects 0.000 description 1
• 235000015112 vegetable and seed oil Nutrition 0.000 description 1
• 239000008158 vegetable oil Substances 0.000 description 1
• 229920002554 vinyl polymer Polymers 0.000 description 1
• 230000008673 vomiting Effects 0.000 description 1
• 230000004580 weight loss Effects 0.000 description 1
• 238000009736 wetting Methods 0.000 description 1
• 239000000080 wetting agent Substances 0.000 description 1