JPH04346917A - Medicated cream and production thereof - Google Patents

Abstract

PURPOSE:To obtain medicated cream capable of synergistically exhibiting action which each ingredient has by combining extract of Glycyrrhize glabra consisting essentially of glycyrrhizic acid and Scutellariae radix extract or combining these extract and further Phellodendri Cortex extract and/or extract of Sophora angustifolia Sieb. CONSTITUTION:Squalan, vaseline, fluid paraffin which are bases are mixed and dissolved by heating and hot purified water containing antiseptic is added thereto to emulsify these bases and 0.05-1.0% extract of Glycyrrhiza glabra essentially consisting of glycyrrhizic acid, 0.1-5% Scutellariae radix extract and further preferably 0.1-10% Phellodendri Cortex extract or 1-10% Phellodendri Cortex extract and 0.1-10% extract of Sophora angustifolia Sieb are added thereto and the mixture is cooled while stirring to provide the objective medicated cream. The medicated cream is effective on allergy, especially contact dermatitis to metal, cosmetic, Japanese lacquer, etc.

Description

[Detailed description of the invention]

0001

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a medicated cream and a method for producing a medicated cream, and more particularly to a medicated cream that is effective against allergies, and particularly for contact dermatitis caused by metals, cosmetics, sumac, etc.

0002

[Prior Art] An allergic reaction in which antibodies are not detected in the serum and is mediated by cells is called a type IV allergic reaction. This includes sexual dermatitis.

[0003] In the case of a reaction associated with infection with bacteria, etc., countermeasures include removal of the bacteria, etc., but no appropriate treatment method other than steroid hormones has been proposed for allergies and contact dermatitis.

Licorice root has long been known as a medicinal herb with anti-inflammatory effects, and its active ingredients, glycyrrhizinic acid, have anti-inflammatory, anti-allergic, and anti-peptic ulcer effects, so they can be used to treat acute and chronic dermatitis. In addition, some are added to basic cosmetics and toothpastes because they are said to be effective against aphthous stomatitis.

[0005] In Chinese medicine, Scutellariae is said to have the effect of ``relieving inflammation, removing water poison, cooling, relieving fever, and urinating'' (Shinbonso Biyō). Regarding the general pharmacological effects of scutellariae, it has been confirmed that it has laxative and diuretic effects. Furthermore, since Scutellariae contains flavonoids, its anti-inflammatory effect has been investigated as a so-called vitamin P-like activity, and it has been found to have an effect comparable to that of aspirin. Furthermore, regarding the antiallergic effect of Scutellariae, a strong suppressive effect was observed when examining the Schultz-Dale reaction in the isolated ileum of sensitized guinea pigs.

[0006] Scutellariae is a herbal medicine containing berberine as a main component, along with Scutellaria scutellariae and Scutellariae scutellariae, but its usage in Chinese medicine is often different from that of Scutellaria scutellariae and Scutellariae. There are many uses for Aubaku that suggest bactericidal effects such as digestive effects and eye diseases. In addition, the medicinal efficacy of Auricularia spp. is characterized by its use as an external agent, and it has been reported that berberine, as an external disinfectant, has a wound healing promoting effect that cannot be explained by mere bactericidal action.

[0007] Clara has matrine as its main alkaloid and is used for skin diseases such as eczema and athlete's foot, stomatitis, etc.

[0008]

[Problems to be solved by the invention] However, these have been used as traditional Chinese herbal medicines, so-called decoctions, and ointments, but their general pharmacology is still at the experimental stage, and it is difficult to combine them. Conventionally, no method of use has been used to bring about this synergistic effect.

[0009]

[Means for solving the problem] Accordingly, in the present invention, Scutellariae and Scutellariae are both herbal medicines containing berberine as a main ingredient, but each has clearly different medicinal effects from the medicinal effects represented by berberine. In addition, we focused on the fact that there are many different uses in Chinese medicine, and made effective use of each ingredient.In addition, it contains 6 to 14% of triterpenoid glycosides, which have skin disorder healing effects and antiallergic effects. Ingredients glycyrrhizin and glarric
Many sapogenins such as acid and gabrolide,
This is a medicated cream that is effective for contact dermatitis, containing licorice that can utilize a large number of flavonoids and flavones, and contains 0.05 to 0.5% of licorice extract, which mainly contains glutyrrhizic acid. According to claims 2 and 3, the medicated cream is heated to mix and dissolve the base materials squalane, petrolatum, and liquid paraffin, and emulsify the mixture by adding hot purified water containing a preservative. The purpose of the present invention is to propose a method for producing a medicated cream, which is characterized by adding a licorice extract, a scutellariae extract, a scutellariae extract, and a clara extract, followed by cooling while stirring.

The present invention will be explained in detail below with reference to Examples. First, glyceryl monostearate as an emulsifier,
Polyoxyethylene hardened castor butter and butyl paraoxybenzoate as a preservative are mixed and dissolved by heating. Heat purified water in which the preservative methyl p-oxybenzoate is dissolved is added to this to emulsify. This is licorice extract, glycy
rrhizin and its genin glycyrrheti
C acid has many pharmacological effects such as water electrolyte and carbohydrate hormone-like effects on the adrenal cortex, estrogenic effects, antitussive effects, anti-inflammatory effects, and anti-allergic effects. Contain. Licorice contains a large number of glycyrrhizic acids, and monoachamonium and potassium glycyrrhizinate are soluble in hot water, but become gel-like when left to cool and are difficult to dissolve in cold water. P-glycyrrhizinic acid is easily soluble in pyridine, and there are many substances that are insoluble in water, such as hardly soluble in water, but dipotassium glycyrrhizinate is easy to use because it is 85% soluble in water at room temperature. In addition, as an antioxidant, tocopherol, acetic acid-dl-
Add an appropriate amount of α-tocopherol.

[0011] Next, the main component of flavonoids in Scutellariae is b.
aicalin4.3%, baicalin, wog
onin 0.5%, wogonin glucuro
The active ingredient of Scutellaria scutellariae's antiallergic effect, which contains nide, orxylin A, and other steroids and sugars, is b.
aicalin and its glucon baica
Lein has the same molar ratio as baicalin.
The active structure is bai because it showed an advantageous inhibitory effect on iator.
It's in the klein part. baiklein is anaph
In addition to suppressing ylexis-type reactions,
It also suppresses atopic reactions induced by n.

[0012] Also, risodi, which is an atopic type inhibitor,
um chromoglycate (DSCG) is ba
Although it has the same chromono skeleton as icalein, DSCG can only suppress reactions by reagin, whereas baicalein can only suppress reactions by reagin.
It is also possible to suppress reactions caused by From the above, it is clear that baicalein acts on a point of action in the mechanism of allergic reaction that is not reached by conventional drugs. There is also a claim that Scutellariae has antibacterial effects against Shigella, Salmonella typhi, Pseudomonas aeruginosa, Staphylococcus, and hemolytic Streptococcus.

[0013] These Scutellariae are prepared by dissolving an ethanol extract of Japanese Scutellariae in 1,3-butylene glycol, and contain 0.15 to 0.25 w/v% of baicalin.
However, it should be added to 1 to 10% of the total amount.

[0014] As mentioned above, Aubaku has a bactericidal effect, but it has also been found to inhibit the growth of staphylococci at 5%.
It shows the strongest antibacterial activity against Pneumococcus, with 0.62% of berberine
5%, and Aubacus powder showed an inhibitory effect up to a concentration of 0.015%.

[0015] Also, the medicinal effect of Aurubaku has a wound-healing effect that cannot be explained simply by the strength of its bactericidal effect; for example, in rabbits, berberine solution was more effective in healing a fresh wound of 2 cm2 that reached the muscles created on the back skin than acrilinol. The treatment group was clearly faster. Since the bactericidal efficacy in vitro is clearly weaker than that of synthetic bactericides, it is likely that the astringent anti-inflammatory effect is involved in promoting healing. Furthermore, esters of linoleic acid, palmitic acid, and phytosterin have been identified as components other than alkaloids.

[0016] Since ancient times, the powder has been used for burns and hot water sores, and in recent years, a strong anti-inflammatory effect has been detected in screening studies using fertilized eggs. That is,
When we examined the activity using a filter paper disk soaked with the sample on the embryo of a fertilized chicken egg, using the effect of inhibiting granulation formation as an indicator, we found that the crude extract of 50% methanol extract of A.
At a dose of 0 μg/dise, it showed a granulation inhibition effect of 53%. Berberine hydrochloride at a dose of 50 μg/dise68
．． showed an inhibition of 8%. It is not clear which components are involved in inflammation in Aerialis. 1.3 butylene glycol extract of Japanese Pharmacopoeia oubaku, 0.1 berberine as berberine chloride
Use one containing 5 to 0.25 w/v%, and 1 to 1 of the total
Contains 0%.

[0017] Clara is a beanful sophora fl
Avecens Aiton root as it is 50v/
A mixture of 1,3-butylene glycol and purified water is added to the extract with v% ethanol solution, and it contains (+)-matrine, which is the main component of alkaloids, and (+)-oxynatrine, which is a subcomponent. , and flavonoids such as Xanthoumol and isorantho.
Contains amol etc. These are used for skin diseases, skin infections, heat rash, sores, genital pruritus, etc. Also, when combined with jaboko, the anti-pruritic effect is enhanced. The Clara liquid is contained in an amount of 1 to 10% of the total amount.

To the above-mentioned emulsifier were added 1 to 10% each of licorice extract, dipotassium glyricylate, antioxidant -dl-α-tocopherol, and scutellariae extract, scutellariae extract, and clara extract, and then stirred. While cooling, obtain the product.

[Practical Example 1] Dipotassium glycyrrhizinate 0.
05% acetic acid-d1-α-tocopherol 0
．． 05% squalane
10.0% Vaseline
25.
0% liquid paraffin
15.0% behenyl alcohol
2.0% polyoxyethylene sorbitol tetraoleate (60B.O)
2.0% Glyceryl monostearate
7.0% polyoxyethylene hydrogenated castor oil
5.0% Butyl paraoxybenzoate
Appropriate amount of Scutellariae extract
1.0% purified water
Residue

[Practical example 2] Dipotassium glycyrrhizinate
0.3% acetic acid-d1-α-tocopherol
1.0% squalane
15.0% Vaseline
1
5.0% liquid paraffin
15.0% behenyl alcohol
5.0% polyoxyethylene sorbitol tetraoleate (60B.O)
2.0% Glyceryl monostearate
7.0% polyoxyethylene hydrogenated castor oil
5.0% Butyl paraoxybenzoate
Appropriate amount of Scutellariae extract
1.0% Aurubax extract
7.0% purified water
It has been found that the above cream has an anti-allergic effect and has an enhanced bactericidal effect.

[Practical Example 3] Dipotassium glycyrrhizinate 0.
08% acetic acid-d1-α-tocopherol
% squalane
10.0% Vaseline

20.0% liquid paraffin
15.0% behenyl alcohol
2.0% polyoxyethylene sorbitol tetraoleate (60B.
O) 2.0% glyceryl monostearate
6.0% polyoxyethylene hydrogenated castor oil
6.0% Butyl paraoxybenzoate
Appropriate amount of Scutellariae extract
1.0% Aurubax extract
1.0% Clara extract
10.0% methyl paraoxybenzoate appropriate amount purified water
The above cream was found to have excellent antipruritic effects.

[0022] Regarding each practical example, it was used by many hairdressers who come into contact with hair shampoos, conditioners, etc. every day and who also have skin irritation. Even in slow-acting patients, the itching subsides within a few weeks and the inflammation subsides or becomes less severe. There are few cases and it will take time to find out the differences between each practical example.

The effects of the usage example of Practical Example 1 are shown below.

The effects of the usage example of Practical Example 2 are shown below.

[0025] Furthermore, it was found that each practical example was highly effective against atopic dermatitis. Since Allegeln is not a single product but a compound, the compound product will have a symptomatic effect. Furthermore, for these practical examples, clopheniramine maleate was added as an antihistamine, which was found to be effective in neutralizing itching irritation.

[0026] The effectiveness rate against the lichenified lichenoid type of atopic dermatitis according to Example 3 is shown. The lower row shows an example of the use of antihistamine formulations.

[0027]

Effects of the Invention According to the present invention as described above, 0.05 to 0.5% of a licorice extract containing glucyrrhizinic acid as a main component,
1-10% Scutellaria extract, 1-1% Scutellaria extract
A medicated cream containing 0% Clara extract and 1 to 10% Clara extract is mixed and dissolved by heating the base squalane, petrolatum, and liquid paraffin, and then emulsified by adding hot purified water containing a preservative. , to which licorice extract and scutellariae extract,
After adding Scutellaria scutellariae extract and Clara extract, the product is manufactured by cooling while stirring, so that the anti-inflammatory effect of licorice extract, the anti-inflammatory effect as a flavonoid of Scutellaria extract, the anti-allergic effect, and the atopic type. Reaction suppressing effect, wound healing promoting effect based on the astringent anti-inflammatory effect of berberine, alkaloids, etc. of Auronicum extract, anti-inflammatory effect, ulcer prevention ability of matrine, the main alkaloid of Clara extract, skin By combining their respective abilities, such as the ability to deal with infectious diseases, we can create a synergistic effect with the effects of each, and provide an extremely excellent skin cream.

Claims (4)

[Claims] Claim 1: 0.05 to 1.0% of a licorice extract mainly composed of glutyrrhizic acid, and 0.1 to 1.0% of a scutellariae extract.
A medicated cream characterized by containing 5%. 2. The medicated cream according to claim 1, characterized in that it contains 0.1 to 10% of the extract of Aspergillus orientalis. 3. The medicated cream according to claim 1, characterized in that it contains 1 to 10% of the extract of Aspergillus oleracea and 0.1 to 10% of the extract of Clara. 4. The base materials squalane, petrolatum, and liquid paraffin are mixed and dissolved by heating, heat-purified water containing a preservative is added to emulsify the mixture, and licorice extract and scutellariae extract are added thereto. A method for producing a medicated cream, which comprises cooling while stirring.