JP2609562B2 - Cream for allergic dermatitis and method for producing the same - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an allergic skin dermatitis <br/> cream and its preparation, allergies, and in particular metal, cosmetics, effective contact dermatitis such as lacquer allergy
Dermatitis cream.

[0002]

2. Description of the Related Art Cell-mediated allergic reactions in which antibodies are not found in serum and are called type IV allergic reactions include reactions associated with infections such as bacteria and viral mold,
Contact dermatitis such as metals, cosmetics, and urushi belong to this category.

[0003] In the case of a reaction associated with infection by bacteria or the like, there is a countermeasure by removing the bacteria or the like. However, no appropriate treatment other than steroid hormones has been proposed for allergy and contact dermatitis.

However, licorice root has long been known as a medicinal herb having an anti-inflammatory effect, and its active ingredient glycyrrhizic acid has an anti-inflammatory, anti-allergic, anti-peptic ulcer effect, etc., so that acute and chronic dermatitis Others have been added to basic cosmetics and dentifrice as being effective for aphthous stomatitis and the like.

[0005] The effect of Orgon in Chinese medicine is "removed from inflammation, excluding water poisoning, and has the effect of cooling antipyretic and urinating" (Shinmoto herbs). As for the general pharmacological action of gongon, it has been confirmed that it has a laxative action and a urinary action.
In addition, anti-inflammatory activity was examined as a so-called vitamin P-like activity from the fact that the component of pentagon is a flavonoid, and an effect comparable to that of aspirin was recognized. Further, regarding the antiallergic effect of gongo, a strong inhibitory effect is observed when the Schultz-Dale reaction is observed in the isolated ileum of the sensitized guinea pig.

[0006] Oubaku is a crude drug containing berberine as a main component together with spinach and ogon, but its usage in Chinese medicine is often different from spinach and ogon. There are many uses of oak for estimating bactericidal effects such as digestive effects and eye diseases. Also, the efficacy of oubaku is characterized by its use as an external preparation, and berberine is reported as a topical bactericide to have a wound healing promoting action that cannot be explained by mere bactericidal action.

[0007] Clara is mainly made of matrine and is used for skin diseases such as eczema and athlete's foot, stomatitis and the like.

[0008]

[Problems to be solved by the invention] However, these are conventionally used as Chinese herbal medicines, so-called decoction,
Although it is used as an ointment, its general pharmacology is almost at the experimental stage, and there has been no method of combining these to produce a synergistic effect.

[0009]

[Means for Solving the Problems] Accordingly, in the present invention, both Oubak and Ougon are crude drugs containing berberine as the main component, but each of them has a distinct difference from the drug efficacy represented by berberine. Focusing on the fact that the usage in Chinese medicine is often varied and different, each component is utilized effectively, and furthermore, it has a skin disorder healing effect, and contains 6 to 14% of a triterpenoid glycoside having an antiallergic effect,
Its representative components glycyrrhizin and glalri
A licorice that can utilize a large number of sapogenins, such as cadid and gabbrolide, a large number of flavonoids, and flavones, and is tailored to a cream for allergic dermatitis that is effective for contact dermatitis, and is mainly composed of glycyrrhizic acid. A cream for allergic dermatitis characterized by containing 0.05 to 0.5% of the extract, and squalane, petrolatum and liquid paraffin as base materials are mixed and dissolved by heating, and a preservative is contained therein. Allergic skin characterized by adding heat-purified water to emulsify, adding a licorice extract mainly composed of glycyrrhizic acid, a pentagon extract, a oak extract and a Clara extract, and then cooling while stirring. It is intended to propose a method for producing a flame cream.

[0010]

The present invention will be described below in detail with reference to examples. First, glyceryl monostearate as an emulsifier,
Polyoxyethylene hydrogenated castor oil and butyl parahydroxybenzoate as a preservative are mixed and dissolved by heating. To this is added hot purified water in which a preservative, methyl parahydroxybenzoate, is dissolved to emulsify. This is licorice extract, but glycy
glycyrrheti of rrhizin and its genin
C acid has a number of pharmacological effects such as a water electrolyte in the adrenal cortex, a carbohydrate-like action, an estrogen action, an antitussive action, an anti-inflammatory action, an anti-allergic action, and up to 0.05 to 0.5% based on this. To be included. Licorice contains a large number of glycyrrhizic acids. Monoacmonium and potassium glycyrrhizinates dissolve in hot water, but form a gel when left to cool, and are difficult to dissolve in cold water. P-glycyrrhizic acid is easily soluble in pyridine, and in many cases insoluble in water, such as insoluble in water, and dipotassium glycyrrhizinate is 85% soluble in water at room temperature, so that it is easy to use. or,
Tocopherol as an antioxidant, especially acetic acid-dl-α
-Add an appropriate amount of tocopherol.

Next, the pentagon is a flavonoid whose main component is b.
aicalin 4.3%, baicalein, wog
onin0.5%, woginin glucuron
ide, orxylin A, and other active ingredients for the antiallergic action of gon, which contains steroids and saccharides, are ba
icalin and its glucon baical
ein is a medi equivalent to baicalin in molar ratio
active structure since showed ator release suppression effect baic
in the lein part. bailein is anaphy
Not only suppresses lexis-type reaction,
It also suppresses the atopic type reaction caused by the

Also, risodi, an atopic inhibitor,
um chromoglycate (DSCG) is bai
It has a chromono skeleton common to Calein,
DSCCG can suppress only the reaction due to reagent, whereas baicalein can also suppress the reaction due to non-reagin. From the above, b
It can be seen that aicalein acts on the site of action of the allergic reaction that is lower than that of conventional drugs. In addition, it has been claimed that Orgon has antibacterial activity against Shigella, Salmonella typhi, Pseudomonas aeruginosa, staphylococci, hemolytic streptococci and the like.

These gougins are obtained by dissolving an extract of the Japanese gougon with ethanol in 1.3-butylene glycol, and containing 0.15 to 0.25% w / v baicalin.
But add 1-10% of the total.

As described above, oak has a bactericidal action, but a growth inhibitory action against staphylococci was observed at 5%.
B. pneumoniae has the strongest antibacterial activity, berberine 0.62
5% and oak powder showed an inhibitory effect up to a concentration of 0.015%.

The efficacy of oak has a wound healing effect that cannot be explained by the strength of mere bactericidal action. For example, in rabbits, the healing of a fresh wound of 2 cm ² reaching the muscle formed on the back skin is healed as compared to berberine compared to acrinol. The solution treatment group was clearly faster. Since the bactericidal efficacy in test tubes is clearly weaker than synthetic bactericides, it is likely that astringent anti-inflammatory effects are involved in promoting healing. In addition, esters of linoleic acid, palmitic acid and phytosterin have been identified as components other than oak alkaloids.

[0016] Since ancient times, powdered oak powder has been used for burns and soaking, and in recent years, strong anti-inflammatory action has been detected in screening studies of anti-inflammatory action using fertilized eggs. That is,
When the activity of the filter paper disc in which the specimen was immersed in the embryo of the fertilized chicken egg was allowed to act to inhibit the granulation formation as an index, the crude extract of 50% methanol extracted from oak was 50%.
At a dose of 0 μg / dise, the granulation inhibitory effect was 53%. Berberine hydrochloride is 6 at a dose of 50 μg / dise.
8.8% inhibition was shown. The components involved in oak inflammation are unclear. Berberine was converted to berberine chloride in a 1.3-butylene glycol extract of Oubaku Japan Pharmacopoeia.
Use those containing 15 to 0.25 w / v%,
Contains 10%.

Clara is a sophora fla
vecens Aiton root as it is 50v / v%
A mixture of 1.3-butylene glycol and purified water added to an ethanol-extracted solution, containing (+)-matrine, the main component of alkaloids, and (+)-oxynatrine, a minor component, and Xanthoumol, isolanthoh as flavonos
amol etc. They are used for skin diseases, skin infections, hot flashes, sores, genital pruritus and the like. or,
When combined with snakebed, itching effect is enhanced. The Clara liquor contains 1 to 10% of the whole.

To the above-mentioned emulsifier, 1-10% each of a licorice extract, of which dipotassium glycylate, an antioxidant dl-α-tocopherol acetic acid, a pentagon extract, an oak extract and a Clara extract, are added, followed by stirring. While cooling, get the product.

[Practical Example 1] dipotassium glycyrrhizinate 0.05% acetic acid-dl-α-tocopherol 0.05% squalane 10.0% petrolatum 25.0% liquid paraffin 15.0% behenyl alcohol 2.0% polyoxytetraoleate Ethylene sorbite (60BO) 2.0% Glycerin monostearate 7.0% Polyoxyethylene hydrogenated castor oil 5.0% Appropriate amount of butyl parahydroxybenzoate Ogon extract 1.0% Purified water residue

Practical Example 2 Dipotassium glycyrrhizinate 0.3% -d1-α-tocopherol acetate 1.0% Squalane 15.0% Vaseline 15.0% Liquid paraffin 15.0% Behenyl alcohol 5.0% Tetraoleic acid Polyoxyethylene sorbite (60BO) 2.0% Glycerin monostearate 7.0% Polyoxyethylene hydrogenated castor oil 5.0% Butyl paraoxybenzoate qs Oung extract 1.0% Oubak extract 7.0% Purification Water remaining It was found that the above cream has an antiallergic effect, but also has a higher bactericidal effect.

[Practical Example 3] Dipotassium glycyrrhizinate 0.08% -d1-α-tocopherol acetate 0.05% Squalane 10.0% Vaseline 20.0% Liquid paraffin 15.0% Behenyl alcohol 2.0% Tetraoleic acid Polyoxyethylene sorbit (60BO) 2.0% Glycerin monostearate 6.0% Polyoxyethylene hydrogenated castor oil 6.0% Butyl paraoxybenzoate Appropriate amount Ougon extract 1.0% Oubak extract 1.0% Clara Extract 10.0% Methyl parahydroxybenzoate Appropriate amount Purified water residue The above cream was found to have an excellent antipruritic effect.

For each practical example, many hairdressers who are in daily contact with hair washing shampoo, rinse, etc. and have inflammation on the skin have used it. Even within a few weeks, itching disappeared, and the inflammation healed or diminished. There are few cases of differences between the practical examples, and it takes time to find out.

The effects of the usage example of practical example 1 will be described below. Effective Rate for Hand Dermatitis by Practical Example 1

The effects of the practical example 2 will be described below. Effective Rate for Hand Dermatitis by Practical Example 2

Further, it was found that each practical example is highly effective against atopic dermatitis. Allegern is not a single substance but a complex substance, so the combined use of this product provides a symptomatic effect. In addition, clophenylamine maleate was added as an antihistamine to these practical examples, but it was found that the stimulation of itching was neutralized and effective.

2 shows the effective rate of atopic dermatitis according to Example 3 to the lichenosis type of eczema. The lower part shows a usage example of the antihistamine compound.

[0027]

According to the present invention as described above, a licorice extract mainly containing glycyrrhizic acid is used in an amount of 0.05 to 0.5.
%, 1-10% of pentagon extract, 1 part of pentagon extract
Heat purified squalane, petrolatum, and liquid paraffin are mixed and dissolved in a cream for allergic dermatitis containing 10% to 10% of Clara extract and heat purified water containing a preservative. And emulsify, add glycyrrhiz
The licorice extract mainly composed of carboxylic acid and the extract of pentagon, the extract of oak, the extract of oak, and the extract of Clara were added and cooled with stirring. Anti-inflammatory action, anti-allergic action, atopy-type reaction suppression action as a flavonoid, promotion of wound healing based on astringent anti-inflammatory action by berberine, alkaloid, etc. in oak extract, anti-inflammatory action, Clara extraction To provide an extremely excellent cream for allergic dermatitis by combining the respective abilities of the main alkaloid having the liquid, such as matrine ulcer occurrence prevention ability and the ability to respond to skin infections, with synergistic effects together with the respective effects. Can be done.

Claims (3)

(57) [Claims] 1. A licorice extract mainly composed of glycyrrhizic acid in an amount of 0.05 to 1.0%, and an extract of a pentagon in an amount of 0.1 to 5%.
% For allergic dermatitis. 2. The cream for allergic dermatitis according to claim 1, wherein the extract contains oat extract at 0.1 to 10%. 3. Squalane, Vaseline, Liquid para
Heat and mix and dissolve the fins.
Add water and emulsify to make glycyrrhizic acid the main component.
After adding the licorice extract and pentagon extract,
Allergic dermatitis characterized by cooling while cooling
Method of making cream for use.