JPH04305519A - Skin humectant for external use - Google Patents

Abstract

PURPOSE:To obtain a humectant excellent in both effects and feeling of use. CONSTITUTION:A skin humectant for external use containing an extract of a saffron as an active ingredient. The extract of the saffron refers to an extract obtained by extracting ingredients of a stigma and a stylar upper part of the saffron. The aforementioned extract may be prepared by a method for drying e.g. the stigma and stylar upper part, adding a solvent (e.g. water, a 30-70wt.% aqueous solution of ethanol, ethanol, propylene glycol, 1,3-butylene glycol or isopropanol) to the dried stigma or stylar upper part, extracting the ingredients at ambient temperature for several days (e.g. 5-8 days) and filtering the obtained liquid.

Description

[Detailed description of the invention]

0001

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a moisturizer for external use on the skin containing saffron extract as an active ingredient.

0002

BACKGROUND OF THE INVENTION Many external skin preparations such as cosmetics and pharmaceuticals are intended to enhance the moisturizing effect of the skin. The purpose of these products is to maintain normal skin moisturizing properties and to compensate for the decline in moisturizing ability caused by dryness or rough skin caused by detergent use. So far, polyhydric alcohols such as glycerin, propylene glycol, and sorbitol, and animal extracts such as hyaluronic acid and chondroitin sulfate have been used as substances with moisturizing effects. On the other hand, saffron can be used as an oral medicine to treat menstrual irregularities.
In addition to being used in women's medicines and health medicines for treating sensitivity to cold,
In recent years, anti-blood coagulation effects have been reported, but the moisturizing effect of the extract, particularly in external skin preparations, has not been known so far.

0003

[Problems to be Solved by the Invention] Conventionally used humectants have the following drawbacks. For example, polyhydric alcohols have a sticky feel when used, and it has been difficult to incorporate them into formulations at an effective concentration. In addition, animal extracts are expensive, and because they are polymeric substances, they have poor percutaneous absorption, and cannot be said to be fully satisfactory.

0004

[Means for solving the problem] Therefore, the present inventors
In order to develop a moisturizer that is excellent in all aspects, including effectiveness, safety, and usability, we conducted research mainly on plant extracts, and discovered that saffron extract has excellent moisturizing effects. The invention has been completed. That is, the present invention is an external skin moisturizer containing saffron extract as an active ingredient. In the present invention, saffron extract refers to saffron stigma,
It refers to the extracted components of the upper part of the style, and its preparation method includes, for example, drying the stigma and upper part of the style of saffron and adding a solvent (e.g., water, 30 to 70% by weight aqueous ethanol solution, ethanol, propylene glycol, 3-
butylene glycol, isopropanol, etc.)
It may be prepared by filtering a liquid extracted at room temperature for several days (for example, 5 to 8 days).

[0005] The blending amount of the saffron extract is, for example, 200 g of a 30% ethanol aqueous solution per 100 g of saffron stigma.
ml and left at room temperature for 5 days and then filtered, the amount is 0.1 to 5% by weight based on the total amount of the preparation.

[0006] The external skin moisturizer of the present invention includes cleansing creams, cleansing lotions, detergents such as soaps, various lotions, creams such as emollient creams, massage creams, sunscreen creams, and lip balms, emollient lotions, and moisturizing lotions. , lotions and emulsions such as milky lotion, nourishing lotion, and massage lotion, hair preparations such as hair tonics, hair tonics, and hair conditioners, keratin softeners, antifungal agents (so-called athlete's foot treatment agents), acne treatment agents,
It can be combined with anti-inflammatory drugs (topical steroids) and applied to human skin. Depending on the purpose of the preparation, adrenocortical hormones (e.g., hydrocortisone acetate,
hydronyltisone propionate butyrate), antihistamines (e.g., diphenhydramine hydrochloride, isotibenzyl hydrochloride, etc.), local anesthetics (e.g., dibucaine hydrochloride, lidocaine hydrochloride, etc.), peripheral vasodilators (e.g., vitamin E acetate, benzyl nicotinate, Panax ginseng extract) , Jasperia japonica extract, capsicum tincture, carpronium chloride, minoxidil, etc.), anti-inflammatory agents (e.g., glycyrrhetinic acid, guaiazulene, etc.), keratolytic agents (e.g., urea, salicylic acid, etc.), bactericidal agents (e.g., chlorhexidine gluconate, isopropyl Methylphenol, quaternary ammonium salts, hinokitiol, etc.), antifungal agents (for example, clitorimazole, miconazole nitrate, etc.), etc. can be blended within a range that does not impair the effects of the present invention.

[0007] The skin external moisturizer of the present invention can be used several times a day (
Apply an appropriate amount to the skin (preferably 2 to 3 times).

[0008]

[Effects of the Invention] According to the present invention, it has become possible to provide a moisturizing agent that is excellent in both effectiveness and usability.

[0009]

[Examples] The present invention will be explained in more detail below with reference to Examples and Test Examples. The saffron extract used in the Examples and Test Examples was 30% per 100g of saffron stigma.
It was prepared by adding 200 ml of an aqueous ethanol solution and letting the solution stand at room temperature for 5 days, then filtering the solution. Example 1 (Cleansing Cream) 5 parts by weight of paraffin, 1.5 parts by weight of cetanol, 28 parts by weight of liquid paraffin, 18 parts by weight of petrolatum, 3 parts by weight of glyceryl monostearate, polyoxyethylene (20 parts by weight)
) 3 parts by weight of monolaurate were dissolved by stirring while heating. 0.2 parts by weight of saffron extract, 2 parts by weight of propylene glycol, 0.1 parts by weight of ethyl paraoxybenzoate, and 39.2 parts by weight of purified water were dissolved in advance by stirring while heating, and a solution was added to the solution, and the mixture was stirred. A cleansing cream was prepared by emulsification.

Example 2 (emollient cream) 2 parts by weight of glycerin monostearate, polyoxyethylene (
20) Sorbitan monolaurate 2 parts by weight, beeswax 6 parts by weight, cetanol 5 parts by weight, reduced lanolin 8 parts by weight
Parts by weight, squalane 35.3 parts by weight, cetyl alcohol 2 parts by weight, stearyl alcohol 2 parts by weight, vitamin E
0.2 parts by weight of acetate was stirred and dissolved while heating. In advance, 0.5 parts by weight of saffron extract, 0.05 parts by weight of tetrasodium edetate, 0.05 parts by weight of dibutylhydroxytoluene, and 36.9 parts by weight of purified water were heated and dissolved with stirring, and then added to the above solution. The mixture was added, stirred, and emulsified to prepare an emollient cream.

Example 3 (emollient lotion) 15 parts by weight of ethanol, 0.1 part by weight of ethyl paraoxybenzoate, 1.5 parts by weight of polyoxyethylene (20) sorbitan monolaurate, 0.0 parts by weight of oleyl alcohol.
1 part by weight, 0.3 parts by weight of saffron extract, 0.0 parts by weight of kojic acid.
1 part by weight, vitamin C phosphate ester magnesium salt 0
．． 2 parts by weight, 0.05 parts by weight of tetrasodium etetate, and 0.05 parts by weight of dibutylhydroxytoluene were added and dissolved, and 82.6 parts by weight of purified water was added to make the mixture homogeneous to prepare an emollient lotion.

Example 4 (Ointment for dermatitis) 3 parts by weight of stearyl alcohol, 8 parts by weight of white beeswax, and 70 parts by weight of white petrolatum were heated and melted and mixed, and 3 parts by weight of cholesterol was added and dissolved. . After stopping heating and cooling while stirring, add white petrolatum 13.
6 parts by weight, 0.1 part by weight of saffron extract, 0.1 part by weight of hydrocortisone acetate, 1 part by weight of diphenhydramine hydrochloride, 0.1 part by weight of chlorhexidine hydrochloride, 0.1 part by weight of vitamin E acetate, 1 part by weight of sorbitan monooleate. A homogeneous mixture of parts by weight was added and stirred until homogeneous to prepare an oily ointment.

Example 5 (hair nourishing tonic) 3 parts by weight of Oriental japonica extract, 0.2 parts by weight of hinokitiol, 0.0008 parts by weight of β-estradiol, 0 parts by weight of vitamin E acetate
．． 2 parts by weight, 0.5 parts by weight of 1-menthol, 1 part by weight of saffron extract, 55 parts by weight of ethanol, 2 parts by weight of polyoxyethylene (20) polyoxypropylene (6) decyltetradecyl ether, 0 parts by weight of tetrasodium ethetate .0
5 parts by weight of dibutylhydroxytoluene, 0.05 parts by weight of dibutylhydroxytoluene, and 37.9992 parts by weight of purified water were mixed and dissolved to prepare a tonic type hair tonic.

Test Example According to Example 2, samples 1 to 4 were prepared with the formulation shown in Table 1, and for comparison, samples were prepared with a formulation containing propylene glycol, glycerin, hyaluronic acid, and sodium chondroitin sulfate, which are said to have a moisturizing effect. 5 to 8 were prepared. For samples 1 to 8, the conductance (unit: u▲mo-▼
, the same in Tables 2 and 3) were determined. The test conditions are shown below. Subjects: 7 healthy people (4 women, 3 men) Application site:
Inner left and right upper arms, approximately 10 cm2 Application amount: approximately 30 mg Measurement environment: 23+1°C, 50+5% RH Impedance meter: IBS Model 1B-354 The results of measuring the moisturizing effect are shown in Tables 2 and 3. Moreover, the results of samples 4 to 8 are also shown in FIG. 1. These results show that saffron extract is superior to conventional products, especially
The moisturizing effect is long-lasting.

[0015]

[Table 1]

[0016]

[Table 2]

*1 The values in the table represent the average value ± standard deviation.

[0018]

[Table 3]

*2 The values in the table represent the average value ± standard deviation.

[Brief explanation of the drawing]

FIG. 1 is a graph comparing the moisturizing effects of a saffron extract-containing preparation of the present invention and a commercially available moisturizing agent-containing preparation. In the figure, the vertical axis represents conductivity, and the horizontal axis represents time.

Claims (1)

[Claims] Claim 1: An external skin moisturizer containing saffron extract as an active ingredient.