JPH0425020B2 - - Google Patents
Info
- Publication number
- JPH0425020B2 JPH0425020B2 JP59198998A JP19899884A JPH0425020B2 JP H0425020 B2 JPH0425020 B2 JP H0425020B2 JP 59198998 A JP59198998 A JP 59198998A JP 19899884 A JP19899884 A JP 19899884A JP H0425020 B2 JPH0425020 B2 JP H0425020B2
- Authority
- JP
- Japan
- Prior art keywords
- collagen
- solution
- gel
- sterilization
- sterilized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000008186 Collagen Human genes 0.000 claims description 84
- 108010035532 Collagen Proteins 0.000 claims description 84
- 229920001436 collagen Polymers 0.000 claims description 84
- 230000001954 sterilising effect Effects 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 17
- 238000004659 sterilization and disinfection Methods 0.000 claims description 17
- 239000000512 collagen gel Substances 0.000 claims description 15
- 230000001678 irradiating effect Effects 0.000 claims description 5
- 239000000499 gel Substances 0.000 description 25
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 12
- 238000001914 filtration Methods 0.000 description 8
- 210000002435 tendon Anatomy 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 6
- 238000004113 cell culture Methods 0.000 description 6
- 239000002244 precipitate Substances 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000001963 growth medium Substances 0.000 description 5
- 235000011121 sodium hydroxide Nutrition 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 229920001817 Agar Polymers 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 238000012258 culturing Methods 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 102000057297 Pepsin A Human genes 0.000 description 2
- 108090000284 Pepsin A Proteins 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229940030225 antihemorrhagics Drugs 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000001879 gelation Methods 0.000 description 2
- 239000002874 hemostatic agent Substances 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 229940111202 pepsin Drugs 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000002834 transmittance Methods 0.000 description 2
- 241000228245 Aspergillus niger Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- GUTLYIVDDKVIGB-OUBTZVSYSA-N Cobalt-60 Chemical compound [60Co] GUTLYIVDDKVIGB-OUBTZVSYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 101100491263 Oryza sativa subsp. japonica AP2-4 gene Proteins 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 231100000987 absorbed dose Toxicity 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- -1 artificial skin Substances 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000012136 culture method Methods 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
Landscapes
- Apparatus For Disinfection Or Sterilisation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19899884A JPS6176161A (ja) | 1984-09-22 | 1984-09-22 | コラ−ゲンの滅菌法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19899884A JPS6176161A (ja) | 1984-09-22 | 1984-09-22 | コラ−ゲンの滅菌法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6176161A JPS6176161A (ja) | 1986-04-18 |
| JPH0425020B2 true JPH0425020B2 (enExample) | 1992-04-28 |
Family
ID=16400397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP19899884A Granted JPS6176161A (ja) | 1984-09-22 | 1984-09-22 | コラ−ゲンの滅菌法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6176161A (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61207340A (ja) * | 1985-03-13 | 1986-09-13 | Koken:Kk | コラーゲン基質の細胞増殖性向上処理方法 |
| GB8807380D0 (en) * | 1988-03-29 | 1988-05-05 | Gunn A | Blood processing apparatus |
| US6022694A (en) * | 1997-04-04 | 2000-02-08 | Regeneron Pharmaceuticals, Inc. | Assay for ligands to tyrosine kinase receptors |
-
1984
- 1984-09-22 JP JP19899884A patent/JPS6176161A/ja active Granted
Non-Patent Citations (2)
| Title |
|---|
| CHEMICAL ABSTRACTS=1972 * |
| COLLAGEN SYMPOSIUM 8=1970 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6176161A (ja) | 1986-04-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |