JPH0424433Y2 - - Google Patents

Description

[Detailed description of the invention] (a) Industrial application field This invention relates to a sample dispenser used in child analyzers and the like.

(b) Conventional technology A conventional liquid pipettor used in automatic analyzers, etc. aspirates a sample through a sample nozzle that is filled with an internal liquid in advance, pushes it out with the internal liquid, and injects it into a reaction tube. It basically performs the operation. Then, the specimen is collected by suction not only with the required amount of specimen needed for analysis, but also with a certain amount of surplus regardless of the amount of specimen required, and when the analysis is completed, the remaining specimen is pushed out with internal fluid and discarded. The sample nozzle is filled with internal liquid. When the required amount of sample is large (when the same sample has many analysis items or the same analysis is repeated frequently), it is not possible to increase the surplus amount of sample, and the sample is sucked into the deep part of the sample nozzle. is diluted by the internal liquid adhering to the inner wall of the sample nozzle, which increases the influence and causes analysis errors. Therefore, empirically, a certain appropriate surplus amount of specimen is collected by aspiration. On the other hand, when the required amount of specimen is small, the effect of dilution due to the internal solution as described above is small, so a smaller surplus amount is sufficient than when the required amount of specimen is large, but the amount of discarded specimen relative to the required amount of specimen is sufficient. is being wasted to a large extent.

(c) Purpose The purpose of this device is to increase the surplus amount of specimen when the required amount of specimen is large and to reduce the effect of dilution of the specimen by internal fluid, and on the other hand, when the required amount of specimen is small, to increase the surplus amount of specimen. To provide a specimen dispenser that increases or decreases the surplus specimen amount in accordance with the required amount for assay and collects a necessary and sufficient surplus specimen amount so as to reduce wasteful disposal of the specimen.

(D) Structure This invention includes an internal liquid suction nozzle, a specimen nozzle for suctioning and discharging a liquid sample, and a plunger that is selectively communicated with the internal liquid suction nozzle or the specimen nozzle by a switching means. It comprises at least a pump means and a means for controlling the operation of these means, and the control means includes a means for setting a required sample amount A, a means for setting a constant K by which the required sample amount is multiplied,
means for setting a constant sample amount B, and calculating means for calculating the amount of aspirated sample [A(1+K+B)] based on the signals from these means and outputting an operating signal to the plunger pump means for aspirating and discharging this sample amount. The present invention provides a sample dispenser characterized by comprising:

The sample dispenser of this invention aspirates the total amount of the required sample amount A, a surplus amount AK proportional to this, and a constant surplus amount B independent of A, and transfers each required amount into a reaction tube. can be injected into. The surplus amount B is a necessary amount because the surplus amount AK alone is insufficient when the required sample amount A is extremely small. The numerical values of K and B are appropriately selected and set depending on the analysis items.

(e) Embodiment This invention will be explained by way of an embodiment shown in FIG. 1, but this invention is not limited to this invention.

The sample dispenser 1 in FIG. 1 is composed of an internal liquid suction nozzle 2, a sample nozzle 3, a switching valve 4, a plunger pump 5, a pulse motor 6 that operates the plunger pump, and a controller 7, and 8 is a sample pipette. A sample cup containing S, 9 is a reaction tube.

In the initial state of the sample dispenser 1, the internal liquid suction nozzle 2 and the sample nozzle are filled with internal liquid. Close b of the switching valve 3, open a and c, and use the plunger pump 5 to aspirate a specified amount of the sample S in the sample cup 8 through the sample nozzle 3. Next, the plunger pump 5 discharges and injects the required amount of the specimen into the reaction tube 9 for analysis. When the analysis is completed, the remaining sample is pushed out and discarded using the plunger pump 5, and the sample nozzle 3 and internal liquid nozzle 2 are filled with internal liquid.

Further, the controller 7 is equipped with a control means for performing the above operations, and also has a required sample amount A as shown in FIG.
setting means 11 for setting a constant K by which the required sample amount is multiplied, a setting means 12 for setting a constant sample amount B, and signals from these means to determine the amount of aspirated sample [A(1
+K)+B] is provided with a calculation means 14 which outputs the result to the pulse motor 6 which operates the plunger pump 5 to aspirate the amount of sample using the lever.
+K)+B amount of specimen can be aspirated and discharged. That is, first, a required sample amount A, for example, 15μ1 is set by the setting means 11, a constant K, for example 0.5, by which the required sample amount is multiplied is set by the setting means 12,
When a constant sample amount B, for example 10 μm, is set by the setting means 13, the calculation means 14 receives signals from each of these setting means and calculates the aspirated sample amount [A(1+K)+
B, that is, 15 (1 + 0.5) + 10 = 32.5μ1], and outputs a signal to the pulse motor 6 of the plunger pump 5 to aspirate this amount of sample, and 32.5μ1 of the sample is aspirated, and then the amount of sample required for the reaction tube 9 is aspirated. It is injected in small quantities and subjected to analysis.

By selecting and setting appropriate K and B values, the above device aspirates the necessary and surplus amount to reduce the influence of dilution of the specimen by internal fluid,
The required amount can be injected into the reaction tube.

(c) Effects According to the device of this invention, in response to the required amount of specimen, a sufficient surplus amount necessary and sufficient to reduce the influence of dilution of the specimen by the internal solution is collected by suction, and the required amount is injected into the reaction tube one by one. can do.

[Brief explanation of the drawing]

FIG. 1 is an explanatory diagram of the configuration of one embodiment of the device of this invention, and FIG. 2 is a block diagram illustrating the operation of a control section for operating the device of one embodiment of this invention. 1... Sample dispenser, 2... Internal liquid suction nozzle,
3...Sample nozzle, 4...Switching valve, 5...
Plunger pump, 6... Pulse motor, 7...
Controller, 8...Sample cup, 9...Reaction tube, 10
. . . Setting means for the required specimen amount A, 11 . . . Setting means for a constant K by which the required specimen amount is multiplied, 12 .

Claims (1)

[Claims for Utility Model Registration] An internal liquid suction nozzle, a specimen nozzle for suctioning and discharging a liquid sample, and a plunger pump selectively communicated with the internal liquid suction nozzle or the specimen nozzle by a switching means. comprising at least means and means for controlling the operation of these means;
This control means includes a means for setting the required sample amount A, a means for setting a constant K by which the required sample amount is multiplied, a means for setting a constant assay amount B, and a means for setting the aspirated sample amount [A(1+K)+B] by signals from these means. A sample dispenser comprising a calculation means for calculating the amount of the sample and outputting an operating signal to the plunger pump means for aspirating and discharging the amount of the sample.