JPH0411224B2 - - Google Patents
Info
- Publication number
- JPH0411224B2 JPH0411224B2 JP58502919A JP50291983A JPH0411224B2 JP H0411224 B2 JPH0411224 B2 JP H0411224B2 JP 58502919 A JP58502919 A JP 58502919A JP 50291983 A JP50291983 A JP 50291983A JP H0411224 B2 JPH0411224 B2 JP H0411224B2
- Authority
- JP
- Japan
- Prior art keywords
- platelet
- blood
- plasma
- container
- platelets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008280 blood Substances 0.000 description 70
- 210000004369 blood Anatomy 0.000 description 69
- 210000001772 blood platelet Anatomy 0.000 description 48
- 210000002381 plasma Anatomy 0.000 description 47
- 238000012546 transfer Methods 0.000 description 45
- 210000003743 erythrocyte Anatomy 0.000 description 42
- 238000000034 method Methods 0.000 description 42
- 239000000306 component Substances 0.000 description 40
- 238000003860 storage Methods 0.000 description 39
- 239000012528 membrane Substances 0.000 description 37
- 210000004623 platelet-rich plasma Anatomy 0.000 description 36
- 239000012503 blood component Substances 0.000 description 29
- 238000005119 centrifugation Methods 0.000 description 27
- 239000003634 thrombocyte concentrate Substances 0.000 description 22
- 239000012530 fluid Substances 0.000 description 20
- 238000000926 separation method Methods 0.000 description 20
- 238000004891 communication Methods 0.000 description 17
- 239000000463 material Substances 0.000 description 16
- 230000001413 cellular effect Effects 0.000 description 14
- 239000000243 solution Substances 0.000 description 12
- 230000001225 therapeutic effect Effects 0.000 description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 9
- 239000003146 anticoagulant agent Substances 0.000 description 9
- 229940127219 anticoagulant drug Drugs 0.000 description 9
- 238000001914 filtration Methods 0.000 description 9
- 239000012510 hollow fiber Substances 0.000 description 9
- 239000011780 sodium chloride Substances 0.000 description 9
- 238000000429 assembly Methods 0.000 description 8
- -1 polypropylene Polymers 0.000 description 8
- 230000000712 assembly Effects 0.000 description 7
- 230000000704 physical effect Effects 0.000 description 7
- 238000012545 processing Methods 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 230000033228 biological regulation Effects 0.000 description 6
- 238000004382 potting Methods 0.000 description 6
- 239000004743 Polypropylene Substances 0.000 description 5
- 235000010633 broth Nutrition 0.000 description 5
- 238000010276 construction Methods 0.000 description 5
- 238000005194 fractionation Methods 0.000 description 5
- 229920001155 polypropylene Polymers 0.000 description 5
- 210000003954 umbilical cord Anatomy 0.000 description 5
- YJLIKUSWRSEPSM-WGQQHEPDSA-N (2r,3r,4s,5r)-2-[6-amino-8-[(4-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound C=1C=C(C=2C=CC=CC=2)C=CC=1CNC1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O YJLIKUSWRSEPSM-WGQQHEPDSA-N 0.000 description 4
- 235000014469 Bacillus subtilis Nutrition 0.000 description 4
- 239000004803 Di-2ethylhexylphthalate Substances 0.000 description 4
- 206010018910 Haemolysis Diseases 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 230000012953 feeding on blood of other organism Effects 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 238000003306 harvesting Methods 0.000 description 4
- 230000008588 hemolysis Effects 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 210000000601 blood cell Anatomy 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000002439 hemostatic effect Effects 0.000 description 3
- 230000036512 infertility Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 230000013011 mating Effects 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 230000002572 peristaltic effect Effects 0.000 description 3
- 229920000915 polyvinyl chloride Polymers 0.000 description 3
- 239000004800 polyvinyl chloride Substances 0.000 description 3
- 238000011176 pooling Methods 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 230000037452 priming Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000005086 pumping Methods 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 244000063299 Bacillus subtilis Species 0.000 description 2
- KRADHMIOFJQKEZ-UHFFFAOYSA-N Tri-2-ethylhexyl trimellitate Chemical compound CCCCC(CC)COC(=O)C1=CC=C(C(=O)OCC(CC)CCCC)C(C(=O)OCC(CC)CCCC)=C1 KRADHMIOFJQKEZ-UHFFFAOYSA-N 0.000 description 2
- 239000003114 blood coagulation factor Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000005374 membrane filtration Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 229930024421 Adenine Natural products 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 208000031220 Hemophilia Diseases 0.000 description 1
- 208000009292 Hemophilia A Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229920012485 Plasticized Polyvinyl chloride Polymers 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000011358 absorbing material Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229960000643 adenine Drugs 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000011118 depth filtration Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920001684 low density polyethylene Polymers 0.000 description 1
- 239000004702 low-density polyethylene Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000002074 melt spinning Methods 0.000 description 1
- 238000010309 melting process Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000306 polymethylpentene Polymers 0.000 description 1
- 239000011116 polymethylpentene Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Landscapes
- Centrifugal Separators (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US411058 | 1982-08-24 | ||
| PCT/US1983/001266 WO1984000905A1 (fr) | 1982-08-24 | 1983-08-17 | Systemes et procedes d'extraction de composants sanguins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59501538A JPS59501538A (ja) | 1984-08-30 |
| JPH0411224B2 true JPH0411224B2 (fr) | 1992-02-27 |
Family
ID=22175407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58502919A Granted JPS59501538A (ja) | 1982-08-24 | 1983-08-17 | 血液成分採取セット |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59501538A (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5585007A (en) * | 1994-12-07 | 1996-12-17 | Plasmaseal Corporation | Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant |
| JP5946866B2 (ja) * | 2014-05-09 | 2016-07-06 | キム ホンＫｉｍ Ｈｏｎｇ | 高濃縮血漿抽出装置 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5762222A (en) * | 1980-10-03 | 1982-04-15 | Asahi Chem Ind Co Ltd | Preparation of concentrated solution of platelet, its device and part |
| JPS5764057A (en) * | 1980-10-03 | 1982-04-17 | Asahi Chemical Ind | Device for treating blood |
| JPS5778864A (en) * | 1980-11-06 | 1982-05-17 | Asahi Chemical Ind | Method and apparatus for centrifugally treating blood |
-
1983
- 1983-08-17 JP JP58502919A patent/JPS59501538A/ja active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5762222A (en) * | 1980-10-03 | 1982-04-15 | Asahi Chem Ind Co Ltd | Preparation of concentrated solution of platelet, its device and part |
| JPS5764057A (en) * | 1980-10-03 | 1982-04-17 | Asahi Chemical Ind | Device for treating blood |
| JPS5778864A (en) * | 1980-11-06 | 1982-05-17 | Asahi Chemical Ind | Method and apparatus for centrifugally treating blood |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS59501538A (ja) | 1984-08-30 |
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