JPH0376287B2 - - Google Patents
Info
- Publication number
- JPH0376287B2 JPH0376287B2 JP14852889A JP14852889A JPH0376287B2 JP H0376287 B2 JPH0376287 B2 JP H0376287B2 JP 14852889 A JP14852889 A JP 14852889A JP 14852889 A JP14852889 A JP 14852889A JP H0376287 B2 JPH0376287 B2 JP H0376287B2
- Authority
- JP
- Japan
- Prior art keywords
- crl40827
- dose
- administered
- acid
- fluorophenacyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 229940005513 antidepressants Drugs 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 9
- 230000001430 anti-depressive effect Effects 0.000 claims description 8
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- XTJMTDZHCLBKFU-UHFFFAOYSA-N 2-(tert-butylamino)-1-(2-fluorophenyl)ethanol Chemical compound CC(C)(C)NCC(O)C1=CC=CC=C1F XTJMTDZHCLBKFU-UHFFFAOYSA-N 0.000 claims description 3
- LSCVUAJOMDAVBB-UHFFFAOYSA-N 2-(tert-butylamino)-1-(2-fluorophenyl)ethanone Chemical compound CC(C)(C)NCC(=O)C1=CC=CC=C1F LSCVUAJOMDAVBB-UHFFFAOYSA-N 0.000 claims description 3
- FKDRSGGLIDRWBW-UHFFFAOYSA-N 1-(tert-butylamino)ethanol Chemical compound CC(O)NC(C)(C)C FKDRSGGLIDRWBW-UHFFFAOYSA-N 0.000 claims description 2
- 230000000694 effects Effects 0.000 description 25
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 21
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- 229960003147 reserpine Drugs 0.000 description 7
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- NXNFXCMJTRKWFF-UHFFFAOYSA-N 2-(tert-butylamino)-1-(2-fluorophenyl)ethanol;hydrochloride Chemical compound Cl.CC(C)(C)NCC(O)C1=CC=CC=C1F NXNFXCMJTRKWFF-UHFFFAOYSA-N 0.000 description 5
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- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 4
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- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 3
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- 206010010904 Convulsion Diseases 0.000 description 3
- 206010052804 Drug tolerance Diseases 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
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- 229910052794 bromium Inorganic materials 0.000 description 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
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- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
- YBZFXWWMNLPWHV-UHFFFAOYSA-N 1-(4-fluorophenyl)-2-(propan-2-ylamino)ethanone;hydrochloride Chemical compound Cl.CC(C)NCC(=O)C1=CC=C(F)C=C1 YBZFXWWMNLPWHV-UHFFFAOYSA-N 0.000 description 2
- ZDPACSAHMZADFZ-UHFFFAOYSA-N 1-[3-(2,4,6-Trimethoxybenzoyl)propyl]pyrrolidinium chloride Chemical group [Cl-].COC1=CC(OC)=CC(OC)=C1C(=O)CCC[NH+]1CCCC1 ZDPACSAHMZADFZ-UHFFFAOYSA-N 0.000 description 2
- YTWSXMSQRZJJCN-UHFFFAOYSA-N 2-(tert-butylamino)-1-(4-fluorophenyl)ethanol;hydrochloride Chemical compound Cl.CC(C)(C)NCC(O)C1=CC=C(F)C=C1 YTWSXMSQRZJJCN-UHFFFAOYSA-N 0.000 description 2
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- 208000020401 Depressive disease Diseases 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
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- -1 N-(2-fluorophenacyl)-t-butylamine hydrochloride Chemical compound 0.000 description 2
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- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14852889A JPH0228110A (ja) | 1989-06-13 | 1989-06-13 | 抗抑うつ剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14852889A JPH0228110A (ja) | 1989-06-13 | 1989-06-13 | 抗抑うつ剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5546081A Division JPS57169450A (en) | 1981-04-13 | 1981-04-13 | Fluorophenacyl-amine derivative and application to remedy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17771891A Division JPH04364154A (ja) | 1991-06-24 | 1991-06-24 | フルオルフェナシル−アミン誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0228110A JPH0228110A (ja) | 1990-01-30 |
| JPH0376287B2 true JPH0376287B2 (de) | 1991-12-05 |
Family
ID=15454799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14852889A Granted JPH0228110A (ja) | 1989-06-13 | 1989-06-13 | 抗抑うつ剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0228110A (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2679907B2 (ja) * | 1991-12-02 | 1997-11-19 | 富士通テン株式会社 | ミリ波レーダ距離速度測定装置 |
| WO2007145203A1 (ja) * | 2006-06-13 | 2007-12-21 | Daiichi Fine Chemical Co., Ltd. | 光学活性２－アミノ－１－（４－フルオロフェニル）エタノール |
-
1989
- 1989-06-13 JP JP14852889A patent/JPH0228110A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0228110A (ja) | 1990-01-30 |
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