JPH0366622A - Preparation of dialyzing fluid, agent for preparing same fluid and dialyzing fluid preparing device - Google Patents

Abstract

PURPOSE:To obtain a dialyzing fluid preparing agent capable of readily producing a dialyzing fluid by a simple operation without causing precipitation of carbonate and almost without evolving a carbon dioxide gas, containing sodium bicarbonate and electrolytic substance and having water content in a specific range. CONSTITUTION:A solid agent containing 20-28wt.%, especially 22-26wt.% sodium bicarbonate and 72-80wt.%, especially 74-78wt.% electrolytic substance (e.g. sodium chloride or calcium chloride) and having water content adjusted to <=6wt.%. The solid agent may further contain 5-20wt.% glucose. A dialyzing fluid having desired concentration can be readily prepared by blending the solid agent with water and a pH adjuster such as hydrochloric acid, acetic acid or solid organic acid. The solid agent does not require a wide storage place and is easily transportable because of being solid agent.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a dialysate preparation method, a dialysate preparation agent, and a dialysate preparation device. More specifically, a dialysate preparation method that can be easily prepared with fewer preparation steps, a dialysate preparation agent that is easy to handle and transport and that does not take up storage space, and a dialysate with an appropriate concentration that can be easily prepared. The present invention relates to a dialysate preparation device that can be used.

[Prior Art and Problems to be Solved by the Invention] Conventionally, dialysate was manufactured in the following manner.

That is, fill a dialysate preparation container with a predetermined amount of water, and then add concentrated sodium bicarbonate solution (hereinafter sometimes referred to as high-carbohydrate solution), sodium chloride, potassium chloride, calcium chloride, magnesium chloride, sodium acetate, etc. An electrolyte solution prepared by adding a pH adjuster such as acetic acid or hydrochloric acid to the electrolyte is placed in the dialysate preparation container and thoroughly mixed.As a result, a dialysate is prepared.

However, the above method for preparing a dialysate has the following problems.

That is, there are many complicated operations such as adding a bicarbo solution to water in a dialysate preparation container, adding an electrolyte solution, and sufficiently dissolving the bicarbo solution and electrolyte solution.

Since both the bicarb solution and the electrolyte solution are in a solution state, preparing a predetermined amount of dialysate requires a large amount of storage space, and it is difficult to mill their heavy weight. Since dialysis fluid cannot be stored for long periods of time, it must be prepared and used when needed. Considering that dialysis fluid is often prepared by nurses and doctors in hospitals, bicarb, which is a one-weight product, is not suitable for long-term storage. Difficulties in storing and transporting fluids and electrolytes pose a significant impediment to the rapid and accurate preparation of dialysate fluids.

An object of the present invention is to provide a dialysate preparation method, a dialysate preparation agent, and a dialysate preparation device that can easily prepare dialysate through simple preparation operations without taking up storage space. Make it.

[Means for Solving the Problem] The invention according to claim 1 for solving the problem is a dialysate preparation agent containing sodium bicarbonate and an electrolyte substance and having a water content of 6% by weight or less. A dialysate m12 method is characterized in that the dialysate is mixed with water and a pH adjuster.The invention according to claim 2 is the dialysate preparation agent according to claim 1.

The invention according to claim 3 provides a means for supplying a dialysate preparation copper agent, which is formed by enclosing a certain amount of the agent for preparing dialysate according to claim 2, and a pH adjuster supply means for supplying a pH adjuster. , f
a supply system having a dilution water metering supply means for supplying dilution water, and the dialysate preparation agent supplied from the dialysate preparation copper agent supply means and the pH adjustment supplied from the pH adjustment agent supply means. a mixing tank for accommodating the agent and dilution water supplied from the dilution water metering and supply means;
a concentration measuring means for measuring the concentration of the dialysate prepared in the mixing tank by a dissolving and mixing means for dissolving and mixing the dialysate preparation agent, the pH adjusting agent, and the dilution water respectively contained in the mixing tank; and a discharge means for discharging the dialysate having an appropriate concentration measured by the concentration measuring means, and the invention according to claim 4 provides the dialysate preparation copper agent supply means. However, a band-shaped package formed by connecting a plurality of metering containers each containing a certain amount of a dialysate preparation agent, and an opening means for sequentially and individually opening each metering container constituting the band-shaped package. The dialysate preparation device according to claim 3, wherein the dialysate preparation agent supplying means is configured to attach and detach a metering container containing a certain amount of a dialysate preparation agent. The dialysate preparation device according to claim 3, further comprising an unsealing means for unsealing the quantitative container, and the dialysate preparation device according to claim 6, wherein It comprises a flow path and an internal solution circulation means for circulating the solution in the mixing tank through the circulation flow path, and the dialysate preparation agent supply means is connected to a constriction formed in the circulation flow path. The dialysate preparation device according to any one of claims 3 to 5, and the invention according to claim 7, wherein the dialysate preparation agent supply means includes a grinding means and a filtration means for the dialysate preparation agent. The dialysate preparation device according to any one of claims 3 to 5, wherein the invention according to claim 8 is characterized in that a rotating nozzle is installed in the mixing tank. 7. The dialysate preparation device according to any one of 7.

[Function] In the invention according to claim 2, by reducing the water content to 6% by weight or less, sodium bicarbonate and the electrolyte substance can coexist. A dialysate preparation agent can be prepared as a single agent, and according to the invention described in claim 1, a dialysate is prepared by dissolving this dialysate preparation agent and a pH 1l adjuster in water. be done. When preparing this dialysate, the dialysate preparation agent and the pH adjusting agent can be added to the wood at the same time, so the dialysate preparation requires an extremely simple preparation procedure. Although the formulation contains both sodium bicarbonate and electrolyte material, it does not precipitate carbonates such as calcium carbonate.

Since the above-mentioned dialysate preparation agents are not in a solution state, they do not occupy a large space for storage.

When used with a dialysate preparation agent containing sodium bicarbonate and an electrolyte substance and having a water content of 6% by weight or less and a pHW adjustment agent, the dialysate preparation device according to claims 3 to 8 provides the following effects: Dialysate of accurate concentration can be automatically prepared without carbonate precipitation.

[Example〕 Hereinafter, preferred embodiments of the present invention will be described in detail.

1. Dialysate preparation agent 1. The dialysate preparation agent of the present invention is a solid preparation containing sodium bicarbonate and an electrolyte substance and having a water content of 6% by weight or less. The dosage form is not particularly limited as long as it is a solid dosage form, and may be any of granules, tablets, and powders.

In the dialysate preparation agent of the present invention, the sodium bicarbonate is not particularly limited, and any sodium bicarbonate conventionally used in the preparation of dialysate may be used.

In addition, as the electrolyte substance, any substance conventionally used in the preparation of dialysate can be used without any particular restriction.
Examples include sodium chloride, potassium chloride, calcium chloride, magnesium chloride, and sodium acetate. The electrolyte material may have water of crystallization or may be anhydrous, preferably anhydrous.

Further, examples of the pH adjuster include hydrochloric acid, acetic acid, solid organic acids, and the like.

The content of sodium bicarbonate in the dialysate preparation agent of this invention is usually 20 to 28% by weight, particularly 22 to 26% by weight.
% by weight, and the content of electrolyte substances.

Usually from 72 to 80% by weight, especially from 74 to 78% by weight.

It is preferable that the dialysate preparation agent of this invention does not substantially contain water. Therefore, when storing the dialysate preparation agent of this invention, waterproofing measures such as storing it in a waterproof container are necessary. It is necessary to apply Note that "substantially" means that water contained as crystal water in the electrolyte material is not excluded. However, in the dialysate preparation agent of the present invention, its water content must be adjusted to 6% by weight or less; if the water content exceeds 6% by weight, the reaction between sodium bicarbonate and the electrolytic agent will occur. As a result, charcoal salts are formed in the dialysate preparation agent.

Furthermore, the dialysate preparation agent of the present invention may contain glucose, in which case the content ratio of glucose is as follows:
It is usually 5 to 20% by weight, particularly 8 to 12% by weight based on the total amount.

1. Method for producing dialysate g4 - The dialysate preparation method of the present invention includes mixing the dialysate: the All agent, the pH adjuster, and water.

A specific experimental example of the dialysate preparation method is shown below.

(Experimental Example) A dialysate preparation agent having a water content of 4.8% by weight was prepared as follows.

Sodium chloride 29.4g, potassium chloride 0.94g,
Calcium chloride 21 (*0 1-31g, Magnesium chloride 6 H200, 77g, Sodium acetate 3
H*0 4.16g, sodium bicarbonate 12.8
g of powder were mixed.

A dialysate was prepared by dissolving 34 g of this dialysate preparation agent and 0.42 g of a pH adjuster consisting of glacial acetic acid in water. However, it was dissolved beforehand with the pH adjuster.

- Dialysate Preparation Apparatus - In the above-mentioned dialysate preparation method, it is preferable to use the dialysate preparation apparatus shown below.

As shown in Fig. 1, on the dialysate tension device, the dialysis supplying means 3, which supplies a predetermined dialysate tension agent in a mixture tank 2, and the PHJL integration is mixed 2 before mixed. a pH adjusting agent supplying means 4 to be supplied to the mixing tank 2; a dilution water metering and supplying means 5 to supply a certain amount of dilution water to the mixing tank 2; tank 2, the dialysate preparation agent contained in the mixing tank 2, and the pH 8
A concentration measuring means 7 for measuring the concentration of the dialysate prepared in the mixing tank 2 by the dissolving and mixing means for dissolving and mixing the M agent and the dilution water; A discharge means 8 for discharging the liquid is provided.

In the dialysate preparation apparatus 1 shown in FIG. 1, dilution water is supplied into the mixing tank 2 by the island-shaped water metering and supplying means 5. And, as this dilution water, warmed water heated to 20 to 35° C. can be preferably used. Therefore, it is preferable that the island-shaped water metering and supplying means 5 has a heating means (not shown). At the same time, the pH adjuster is supplied from the pH adjuster supply means 4.

The dialysate preparation agent according to claim 2 can be suitably used as the dialysate preparation agent supplied from the dialysate preparation agent supply means 3 into the mixing tank 2.

The dosage form may be, for example, either a granule, one tablet, or a powder.

pH adjuster and pH 1l adjuster is supplied from the front means 4 p
As the H adjuster, for example, hydrochloric acid, glacial acetic acid, solid organic acid, etc. can be suitably used.

The dialysate preparation agent, the pH adjusting agent, and the dilution water thus contained in the mixing tank 2 are dissolved and mixed by the dissolving and mixing means 6.

For example, as shown in FIG.
41Ilt can be obtained by b.

Then, the mixture is dissolved and mixed by the dissolving and mixing means, and the mixture is mixed in the mixing tank 2.
The concentration of the dialysate prepared therein is measured by the concentration measuring means 7, and the dialysate having an appropriate concentration is discharged by the discharge means 8 toward, for example, a storage tank 70 or a dialysis means (not shown). . In addition, in the apparatus shown in FIG.
A drain valve is used as the discharge means 8. Also, in Figure 1,
5 (+ is drain.

As described above, a dialysate having an appropriate concentration is automatically prepared by the dialysate preparation apparatus shown in FIG.

In this dialysate preparation device 1, various design changes as shown below are possible.

For example, the configuration of the dialysate preparation agent supplying means 3 is not particularly limited as long as it supplies a predetermined amount of dialysate preparation agent into the mixing tank 2, but preferred embodiments include the following: Examples include means for supplying a dialysate preparation layer agent.

That is, a band-shaped package 12 (see FIG. 2) formed by connecting a plurality of metering containers 11 each containing a predetermined amount of a dialysate preparation agent, and each metering container 11 constituting the band-shaped package 12.
an unsealing means (not shown), such as a cutter (not shown), for opening the strips individually and sequentially, and a feeding means (not shown, for example, a conveyor belt) for feeding the band-shaped package 12 so that the strip-shaped package 12 faces the opening means. and an introduction means (not shown), such as an introduction pipe, for introducing into the mixing tank 2 the dialysate preparation agent taken out from the quantitative container 11 opened by the opening means.

According to the dialysate preparation layer supply means configured as described above, dialysate preparation can be carried out by a simple operation of sequentially opening the plurality of metering containers 11 constituting the band-shaped package one by one using an opening means such as a cutter. The preparation can be supplied to the mixing tank 2. According to this dialysate preparation layer agent supplying means, it is convenient to supply the dialysate preparation layer little by little to the mixing tank to prepare a small amount of dialysate.

Moreover, the following structure can be shown as a dialysate preparation layer agent supply means.

As shown in FIG. 3, a dialysate preparation agent supply means 13 (hereinafter sometimes referred to as a second dialysate preparation agent supply means) and a valve 14 are interposed in the piping.

This dialysate preparation agent supply means 13 is removably equipped with a cylindrical metering container 16 (see FIG. 4) filled with a dialysate preparation agent and having thin l8Ils stretched on both ends. The opening 18 of the piping 9d on the valve 14 side, which has a sharp tooth 17 at the tip, faces its mounting position, and the concentration measuring means 7 is interposed at a position facing the opening 18. The distal end of the pipe 9b is a sharp cutter 19, and as shown in FIG. 4, a forward and backward movement opening 2o facing the pipe 9b allows movement forward and backward. Then, the piping 9 on the valve 14 side
The quantitative container 16 can be attached between the opening 18 of d and the forward/backward opening 20 of the pipe 9b in which the concentration measuring means 7 is inserted.

In this second dialysate preparation agent supplying means 13, when the metering container 16 is fed by a feeding device (not shown), the forward and backward moving opening 20 moves forward, and the metering container 16 moves forward.
As the reciprocating opening 20 moves further forward, it is pressed against the opening 18 of the pipe 9d on the valve 14 side, which is the other end of the quantitative container 16. Then, the thin film stretched over the other end of the metering container (2) is pierced by the sharp teeth 17 provided at the opening 18 of the pipe 9d, and as shown in FIG. Both ends of the pipes 9d and 9b are airtightly attached to the openings 18 and 19 of the pipes 9d and 9b, respectively.

Note that the quantitative container 16 is connected to the pipes 9d and 9b as described above.
valve 10. prior to being fitted into opening 18.19 of valve 10.
14, the pipes 9b and 9d are blocked, and the mixing tank 2
The liquid inside will not leak out.

Then, when the quantitative container 16 is installed in the pipes 9b and 9d, the dissolving and mixing pump 6a is activated as described above, and the liquid in the mixing tank 2 is transferred to the pipes 9, 9a, 9b.

9d, and the dialysate preparation agent in the quantitative container 15 is washed away into the mixing tank 2.

In the second dialysate preparation agent supply means 13, the dialysate preparation agent in the quantitative container 16 is washed out with the liquid in the mixing tank 2, so that the dialysate preparation agent can be dissolved in water without waste. Furthermore, since the quantitative container 16 is of a cartridge type, handling and operation are extremely simple.

Furthermore, there is a dialysate preparation layer agent supply means (hereinafter sometimes referred to as a third dialysate preparation layer agent supply means) shown in FIG. 6, for example.

The third dialysate preparation supply means shown in FIG.
It is installed in the piping interposed between the

As shown in FIG. 6, the inner diameter of the pipe 9e interposed between the mixing tank 2 and the concentration measuring means 7 is narrowed down to a small diameter, and in this small diameter portion 21, the dialysate preparation agent 60 The mounting port 24 of the hopper 22 filled with water is open, and by inserting the hopper 22 into the mounting port 24 (the insertion direction is indicated by an arrow in FIG. 6), the hopper 22 and the inside of the pipe 9e are communicated. . Note that the hopper 22 is provided with an air vent 25.

In the third dialysate preparation agent supply means configured as described above, when the liquid is caused to flow into the pipe 9e (the direction of flow is indicated by an arrow in FIG. 6), the small diameter portion 21 of the liquid flows. The liquid flows at a higher speed than in the large diameter portion 23, and this high-speed flowing liquid generates negative pressure, and the dialysate preparation agent 60 in the hopper 22 is sucked into the pipe 9e.

This third dialysate preparation agent supply means has a simple configuration because it does not require a special drive device for supplying the dialysate preparation agent 60 from the inside of the hopper 22 into the pipe 9e.

The other dialysate preparation agent supply means (sometimes referred to as the fourth dialysate preparation agent supply means) include a dialysate preparation agent supply section (not shown) controlled by the control device, and a dialysate preparation agent supply section (not shown) controlled by the controller. As shown in FIG. 7 and FIG.
It consists of a cylindrical melting tank 27, which connects a pipe communicating with the tank to the bottom thereof, and a pipe 28 extending from the pipe 9b shown in FIG. be done. The tip opening of the pipe 28 is opened so as to form a vortex inside the cylindrical dissolving tank 27.

In the fourth dialysate preparation agent supply means having such a configuration, first, the dialysate m dosage agent is supplied into the cylindrical dissolution tank 27 from a dialysate preparation agent supply section (not shown). As water is ejected from the tip of the pipe 28, a strong vortex is formed within the cylindrical melting tank 27. Riding this whirlpool,
The dialysate preparation agent 60 in the cylindrical dissolution tank 27 swirls violently, and the dialysate preparation agent 6 rides on this swirling flow.
0 collides with a protrusion 26 formed on the inner peripheral surface, and the vortex is disturbed by the protrusion 26, resulting in a violent stirring action.

As a result, even if the dialysate preparation agent is in the form of granules, single particles, or tablets, it will quickly dissolve in water. The aqueous solution in which the dialysate preparation agent is dissolved is filtered through the filter net 40 and then passed from the bottom of the cylindrical dissolution tank 27 to the mixing tank 2 via piping.
transferred within.

In this fourth dialysate preparation agent supply means, granular 1
It is convenient for dissolving particulate or tablet-shaped dialysate preparation agents. In addition, since the driving force is water agitation, the structure is simple as it does not require a driving source such as an agitation motor.

In this dialysate preparation device 1, stirring in the mixing tank can be performed by a stirring device such as a stirring blade, but if the rotary nozzle 29 shown in sections 9 to 11 is used, the drive motor The liquid in the mixing tank can be stirred without the need for such a stirring power source.

This rotating nozzle 29, as shown in FIG.
installed within.

In the mixing tank 2, the liquid extracted from the mixing tank 2 is transferred to the mixing tank 2.
As shown in FIG. 10, an opening 3 is provided on the circumferential side of the tip of the pipe 30 to be returned to the inside, and a housing 32 is rotatably placed over the tip of the pipe 30. A pair of ejection pipes 33 extend in opposite directions on the circumferential side of the
As shown in FIG.

In the case of a rotary nozzle 29 having a configuration in which each tip is provided with an ejection hole 34 opened in opposite directions, the piping is heated by a dissolving and mixing pump 6a provided in the middle of the piping 30. When the liquid is pumped to the tip of 30, the liquid is ejected from the opening 31 into the casing 31, and the liquid ejected into the casing 32 is guided through a pair of ejection pipes 33 and flows through the ejection holes 34. They erupt in opposite directions from each other. As a result, the pair of ejection pipes 33 rotate due to the reaction of the ejection, and the rotation of the ejection pipes 33 causes the ejected liquid to be scattered within the mixing tank 2 . As a result, the liquid in the mixing tank 2 is vigorously stirred.

By using the rotary nozzle 29 in this way, the liquid in the mixing tank 2 can be efficiently stirred without a power source.

Although one embodiment of the dialysate preparation device of the present invention has been described above in detail, the present invention is not limited to the above embodiment, and can be implemented with appropriate design changes within the scope of the present invention. .

For example, the concentration measuring means may be installed in the mixing tank 2, or the mixing tank 2 may be equipped with a measuring means for detecting the level of diluted water, etc. As shown, it is also possible to install a plurality of mixing tanks 2 and operate them alternately.

[Effects of the invention] According to this invention, (1) It does not take up much space to store and is easy to handle;
It is possible to provide a dialysate preparation agent containing sodium bicarbonate and an electrolyte substance, which is easy to transport, and which has a water content of 6% by weight or less; By using a liquid preparation agent, it is possible to provide a dialysate preparation method in which a dialysate can be easily prepared by dissolving this solid agent in water before adding a pHEI preparation agent, (3) and By using the dialysate preparation device of the present invention, dialysate with an accurate concentration can be easily and automatically prepared.

[Brief explanation of drawings]

FIG. 1 is an explanatory diagram showing one embodiment of the dialysate preparation device of the present invention, FIG. 2 is an explanatory diagram showing an example of a band-shaped package to be loaded into the dialysate preparation device, and FIG. FIG. 4 is an explanatory diagram showing another embodiment of the dialysate preparation device of the present invention, and FIG. 4 is a perspective view showing an example of a metering container in the dialysate preparation layer agent supply means incorporated in the dialysate preparation device; FIG. 5 is a cross-sectional view showing a state in which the quantitative container is attached to piping, and FIG. 6 is a cross-sectional view showing another example of a dialysate preparation layer agent supply means incorporated in the dialysate preparation device. 7 and 8 are explanatory diagrams showing other examples of dialysate preparation layer agent supply means incorporated in the dialysate preparation device, and FIG. 9 is a rotary nozzle incorporated in the dialysate preparation device of the present invention. FIG. 10 is a sectional view showing the main part of the rotary nozzle, FIG. 11 is a perspective view of the rotary nozzle, and FIG. 12 is a diagram illustrating the dialysate preparation of the present invention. It is an explanatory view showing still another example of a device. FIG. 2 1... Dialysate preparation device, 2... Mixing tank, 3... Dialysate preparation layer agent supply means, 4... pH adjuster supply means,
5... Box-shaped water metering and supply means. Dan...dissolving and mixing means, 7...concentration measuring means, 60.
...Dialysate preparation agent. Figure 3 Figure 5 Figure 6 Figure 7 Figure 9 Figure 10

Claims (8)

[Claims] (1) A method for preparing a dialysate, which comprises mixing in water a dialysate preparation agent containing sodium bicarbonate and an electrolyte substance and having a water content of 6% by weight or less, and a pH adjuster. (2) The dialysate preparation agent according to claim 1. (3) A dialysate preparation agent supplying means that includes a certain amount of the dialysate preparation agent according to claim 2 enclosed therein, a pH adjustment agent supplying means for supplying a pH adjustment agent, and a supplying dilution water. a supply system having a dilution water measuring and supplying means, and measuring the dialysate preparation agent supplied from the dialysate preparation agent supply means, the pH adjuster supplied from the pH adjuster supply means, and the dilution water. A mixing tank is provided for accommodating dilution water supplied from a supply means, and a dissolving and mixing means for dissolving and mixing the dialysate preparation agent, the pH adjusting agent, and the dilution water contained in the mixing tank, respectively. 1. A dialysate preparation apparatus comprising: a concentration measuring means for measuring the concentration of a dialysate prepared in a mixing tank; and a discharge means for discharging a dialysate having an appropriate concentration measured by the concentration measuring means. (4) The dialysate preparation agent supply means includes a band-shaped package formed by connecting a plurality of quantitative containers each containing a predetermined amount of a dialysate preparation agent, and each metering container constituting the band-shaped package. ,
4. The dialysate preparation device according to claim 3, further comprising opening means for sequentially and individually opening the seals. (5) The dialysate preparation agent supply means includes a removably built-in metering container containing a predetermined amount of dialysate preparation agent, and has an unsealing device for opening the metering container. dialysate preparation equipment. (6) The dissolving and mixing means includes a circulation channel connected to the mixing tank, and an internal solution circulation means for circulating the solution in the mixing tank through the circulation channel, and supplies the dialysate preparation agent. The dialysate preparation device according to any one of claims 3 to 5, wherein the means is connected to a constriction formed in the circulation channel. (7) Claims 3 to 5, wherein the dialysate preparation agent supplying means comprises a dialysate preparation agent crushing means and filtration means.
The dialysate preparation device according to any one of the above. (8) The dialysate preparation device according to any one of claims 3 to 7, further comprising a rotating nozzle installed in the mixing tank.