JPH0366621A - Preparation of dialyzing fluid, agent for preparing same fluid and dialyzing fluid preparing device - Google Patents

Abstract

PURPOSE:To obtain a dialyzing fluid preparing agent capable of readily producing a dialyzing fluid by a simple operation without causing precipitation of carbonate and almost without evolving a carbon dioxide gas, containing sodium bicarbonate, electrolytic substance and pH adjusting solution and having water content in a specific range. CONSTITUTION:A solid agent containing 20-28wt.%, especially 22-26wt.% sodium bicarbonate, 72-80wt.%, especially 74-78wt.% electrolytic substance (e.g. sodium chloride or calcium chloride) and 0.2-0.5wt.%, especially 0.3-0.4wt.% pH adjusting solution (e.g. glacial acetic acid or calcium chloride) and having water content adjusted to <=6wt.%. The solid agent may further contain 5-20wt.% glucose. A dialyzing fluid having desired concentration can be readily prepared by blending the solid agent with water. The solid agent does not require a wide storage place and is easily transportable because of being solid agent.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a dialysate preparation method, a dialysate preparation agent, and a dialysate preparation device. More specifically, a dialysate preparation method that can be easily prepared with fewer preparation steps, a dialysate preparation agent that is easy to handle and transport and that does not take up storage space, and a dialysate with an appropriate concentration that can be easily prepared. The present invention relates to a dialysate preparation device that can be used.

[Prior Art and Problems to be Solved by the Invention] Conventionally, dialysate was prepared as follows.

That is, fill a dialysate preparation container with a predetermined amount of water, and then add a concentrated sodium bicarbonate solution (hereinafter referred to as "concentrated sodium bicarbonate solution").

Sometimes called bicarbohydrate. ) and an electrolyte solution prepared by adding a pH adjusting solution such as acetic acid or hydrochloric acid to an electrolyte such as sodium chloride, potassium chloride, calcium chloride, magnesium chloride, or sodium acetate, and mix thoroughly in the dialysate preparation container. As a result, a dialysate is prepared.

However, the above method for preparing a dialysate has the following problems.

That is, there are many complicated operations such as adding a bicarbo solution to water in a dialysate preparation container, adding an electrolyte solution, and sufficiently dissolving the bicarbo solution and electrolyte solution.

Since both the bicarb solution and the electrolyte solution are in a solution state, preparing a predetermined amount of dialysate requires a large amount of storage space, and it is difficult to transport them as they are heavy objects. Since dialysis fluid cannot be stored for long periods of time, it is prepared and used when needed, and considering that dialysis fluid is often prepared by nurses and doctors in hospitals, bicarbohydric fluids are heavy. Difficulties in storing and transporting dialysate and electrolyte solutions pose a significant hindrance to the rapid and accurate preparation of dialysate.

An object of the present invention is to provide a dialysate preparation method, a dialysate preparation agent, and a dialysate preparation device that can easily prepare dialysate through simple preparation operations without taking up storage space. Make it.

[Means for Solving the Problems] The invention according to claim 1 for solving the problems described above provides a dialysis method which contains sodium bicarbonate, an electrolyte substance, and a pH adjusting solution and has a water content of 6% by weight or less. A dialysate preparation method characterized by mixing a solution preparation agent with water, the invention according to claim 2 being the dialysate preparation agent according to claim 1, and according to claim 3 The present invention provides a supply system comprising a dialysate preparation agent supply means which includes a predetermined amount of the dialysate preparation agent according to claim 2, and a dilution water metering supply means for supplying dilution water; A mixing tank is provided for accommodating the dialysate preparation agent supplied from the dialysate preparation agent supply means and dilution water supplied from the dilution water metering and supply means, and a dialyzer accommodated in the mixing tank, respectively. a concentration measuring means for measuring the concentration of the dialysate prepared in the mixing tank by a dissolving and mixing means for dissolving and mixing a solution preparation agent and the dilution water; and a dialysate having an appropriate concentration measured by the concentration measuring means. 4. A dialysate preparation device characterized by comprising a discharge means for discharging the dialysate, and the invention according to claim 4 is characterized in that the dialysate preparation agent supply means encloses a certain amount of a dialysate preparation agent. 4. The dialysate preparation device according to claim 3, comprising: a band-shaped package formed by connecting a plurality of metering containers, and an opening means for sequentially and individually opening each metering container constituting the band-shaped package.

In the invention according to claim 5, the dialysate preparation agent supplying means detachably incorporates a metering container in which a certain amount of dialysate preparation agent is enclosed, and an unsealing means for opening the metering container. 3. The dialysate preparation apparatus according to claim 3, wherein the dissolving and mixing means includes a circulation flow path connected to the mixing tank, and a dialysate preparation device having the following: 6. The dialysis device according to claim 3, further comprising: internal solution circulation means for circulating through a channel, and wherein the dialysate preparation layer agent supply means is connected to a constriction formed in the circulation flow channel. The invention according to claim 7 is a liquid preparation device, and the invention according to claim 7 is a liquid preparation device. The dialysate preparation apparatus according to any one of claims 3 to 5, comprising a preparation vessel supply means, a means for crushing a dialysate preparation agent, and a filtration means.

The invention according to claim 8 is the dialysate preparation apparatus according to any one of claims 3 to 7, wherein a rotating nozzle is installed in the mixing tank.

[Function] In the invention according to claim 2, by reducing the water content to 6% by weight or less, sodium bicarbonate, an electrolyte substance, and a pH adjusting solution can coexist, and thereby, sodium bicarbonate and A dialysate preparation agent can be prepared by combining an electrolyte substance and a pH adjustment solution, and according to the invention described in claim 1, by dissolving this dialysate preparation agent in water, dialysis A solution is prepared. When preparing this dialysate, it is only necessary to add the dialysate preparation agent to water, so the preparation of the dialysate requires an extremely simple preparation procedure. Although it contains both sodium bicarbonate and electrolyte substances, it does not precipitate carbonates such as calcium carbonate because there is no water as a solvent. Despite the presence of carbon dioxide, almost no carbon dioxide gas is generated.

Since the above-mentioned dialysate preparation agents are not in a solution state, they do not occupy a large space for storage.

When a dialysate preparation agent containing sodium bicarbonate, an electrolytic substance, and a pH adjustment liquid and having a water content of 6% by weight or less is used, the dialysate preparation device according to claims 3 to 8 can Dialysate of accurate concentration can be automatically prepared without carbonate precipitation.

[Example] Hereinafter, preferred embodiments of the present invention will be described in detail.

1. Dialysate Preparation Agent 1. The dialysate preparation agent of the present invention is a solid preparation containing sodium bicarbonate, an electrolyte substance, and a pH adjusting solution and having a water content of 6% by weight or less. There is no particular restriction on the dosage form as long as it is a solid dosage form, and for example, it may be either a granule, one tablet, or a powder.

In the dialysate W wearing agent of the present invention, there is no particular restriction on the sodium heavy acid, and any sodium salt conventionally used in the preparation of dialysate may be used.

In addition, as the electrolyte substance, substances conventionally used in the preparation of dialysate can be used without particular restrictions.
Examples include sodium chloride, potassium chloride, calcium chloride, magnesium chloride, and sodium acetate. This electrolyte material may contain water of crystallization or may be anhydrous, but anhydrous is preferred.

Examples of the pH1i adjusting solution include glacial acetic acid and acetic anhydride.

The content of sodium bicarbonate in the dialysate preparation agent of the present invention is usually 20 to 28% by weight, particularly 22 to 26% by weight.
% by weight, and the content of the electrolyte substance is usually 72 to 72%.
80% by weight, especially 74-78% by weight, pHTAM
! The armpit usually contains 0.2 to 0.5% by weight, especially 0.3 to 0.
．． It is 4% by weight.

The dialysate preparation agent of the present invention preferably contains substantially no water. Therefore, when storing the dialysate preparation agent of the present invention, it is necessary to take waterproof measures such as storing it in a waterproof container. Note that "substantially" means that water contained as crystal water in the electrolyte material is not excluded. However, in the dialysate preparation agent of this invention, its water content must be adjusted to 6% by weight or less; if the water content exceeds 6% by weight, a reaction between sodium bicarbonate and the electrolyte substance will occur. carbonate is produced in the dialysate preparation agent, and carbon dioxide gas is produced by the reaction between sodium bicarbonate and acetic acid.
H adjustment becomes difficult.

Furthermore, the dialysate preparation agent of the present invention may contain glucose, in which case the content ratio of glucose is as follows:
It is usually 5 to 20% by weight, particularly 8 to 12% by weight based on the total amount.

1. Dialysate Preparation Method 1. The dialysate plasticizing method of the present invention includes mixing the dialysate preparation agent and water.

A specific experimental example of the dialysate preparation method is shown below.

(Experimental Example) A dialysate preparation agent having a water content of 4.8% by weight was prepared as follows.

Sodium chloride 29.4g, potassium chloride 0.94g,
Calcium chloride 2H, 01,31g, Magnesium chloride 6H* 00.77g, Sodium acetate 3)
1204.16 g of powder, 12.3 g of sodium bicarbonate, and 0.61 g of glacial acetic acid were mixed.

Dissolve 34.4 g of this dialysate preparation agent in water to give 3.54 g.
1. A dialysate was prepared.

- Dialysate Preparation Apparatus - In the above-mentioned dialysate preparation method, it is preferable to use the following dialysate preparation apparatus.

As shown in FIG. 1, this dialysate preparation device 1 includes a dialysate preparation agent supply means 3 that supplies a predetermined amount of dialysate preparation agent into a mixing tank 2, and a dialysate preparation agent supply means 3 that supplies dilution water to the mixing tank 2. a mixing tank 2 for mixing the dialysate preparation agent and dilution water, and a dialysate g! contained in the mixing tank 2. A concentration measuring means 6 for measuring the concentration of the dialysate prepared in the mixing tank 2 by the dissolving and mixing means 5 for dissolving and mixing the preparation and the dilution water, and the appropriate concentration measured by the concentration measuring means 6. A discharge means 7 is provided for discharging the dialysate.

In the dialysate preparation apparatus 1 shown in FIG. 1, dilution water is supplied into the mixing tank 2 by the dilution water metering and supply means 4. As the dilution water, warmed water heated to 20 to 35°C can be preferably used. Therefore, it is preferable that the dilution water metering supply means 5 includes a heating means (not shown).Furthermore, in the mixing tank 2, a predetermined amount of dialysate preparation agent is supplied from the dialysate preparation agent supply means 3 into the mixing tank 2. agent is supplied.

The dialysate preparation agent according to claim 2 can be suitably used as the dialysate preparation agent supplied from the dialysate preparation agent supply means 3 into the mixing tank z, and its dosage form is: For example, it may be in the form of granules, tablets or powders.

The dialysate preparation agent and the dilution water thus stored in the mixing tank 2 are dissolved and mixed by the dissolving and mixing means.

As shown in FIG. 1, the dissolving and mixing means can be comprised of internal solution circulation means, such as a dissolving and mixing pump 5a, and a circulation channel 5b.

Then, the mixture is dissolved and mixed by the dissolving and mixing means, and the mixture is mixed in the mixing tank 2.
The concentration of the dialysate prepared therein is measured by a concentration measuring means 6, and the dialysate having an appropriate concentration is discharged by a discharge means 7 toward, for example, a storage tank 9 or a dialysis means (not shown). . In the apparatus shown in FIG. 1, a drain valve is used as the drain means 7. Also, in Figure 1, 50
is the drain.

As described above, a dialysate having an appropriate concentration is automatically prepared by the dialysate preparation apparatus shown in FIG.

In this dialysate preparation device 1, various design changes as shown below are possible.

For example, the configuration of the dialysate preparation agent supplying means 3 is not particularly limited as long as it supplies a predetermined amount of dialysate preparation agent into the mixing tank 2, but preferred embodiments include the following: Examples include means for supplying a crude agent for dialysate preparation.

That is, a band-shaped package 12 (see FIG. 2) formed by connecting a plurality of metering containers 11 each containing a predetermined amount of a dialysate preparation agent, and each metering container 11 constituting the band-shaped package 12.
an unsealing means (not shown), such as a cutter (not shown), for opening the strips individually and sequentially; and a feeding means (not shown), for example, a conveyor belt, for feeding the band-shaped package 12 so that the strip-shaped package 12 faces the opening means. and an introduction means (not shown), for example, an introduction vibrator, for introducing the dialysate preparation agent taken out from the quantitative container 11 opened by the opening means into the mixing #I2.

According to the dialysate preparation rough agent supply means configured as described above, the dialysate can be prepared by simply opening the plurality of metering containers 11 constituting the band-shaped package one by one using H-sealing means such as a cutter. A preparation agent can be supplied to the mixing tank 2. According to this dialysate preparation crude agent supply means, it is convenient to supply a dialysate preparation agent little by little to the mixing tank to prepare a small amount of dialysate.

Moreover, the following structure can be shown as a dialysate preparation rough agent supply means.

As shown in FIG. 3, a dialysate preparation agent supply means 13 (hereinafter sometimes referred to as a second dialysate preparation agent supply means) and a valve 14 are interposed in the piping.

This dialysate preparation agent supply means 13 is removably equipped with a cylindrical metering container 16 (WA in FIG. 4) filled with a dialysate preparation agent and having a thin film 15 stretched on both ends. , the opening 18 of the piping 8d on the valve 14 side, which has a sharp tooth 17 at the tip, faces its mounting position, and the concentration measuring means 6 is interposed at a position facing the opening 18. The distal end of the piping 8b is a sharp cutter 19, and faces the #J backward opening 2o that allows forward and backward movement, as shown in figure s4. Then, the piping 8 on the valve 14 side
The quantitative container 16 can be attached between the opening 18 of d and the backward opening 20 of the pipe 8b in which the concentration measuring means 6 is inserted.

In this second dialysate preparation agent supplying means 13, when the metering container 16 is fed by a feeding device (not shown), the forward and backward moving opening 20 moves forward, and the metering container 15 moves forward.
The thin film 15 is broken through, and the reciprocating opening 20 moves further forward, thereby pressing the other end of the quantitative container 16 against the opening 18 of the pipe 8d on the valve 14 side. Then, the thin film stretched over the other end of the metering container 16 is pierced by the sharp teeth I7 provided at the opening 18 of the pipe 8d, and as shown in FIG. Both ends of the pipes 8d and 8b are airtightly attached to the openings 18 and 19 of the pipes 8d and 8b, respectively.

Note that the quantitative container 16 is connected to the pipes 8d and 8b as described above.
valve 10. prior to being fitted into opening 18.19 of valve 10.
14, the pipes 8b and 8d are blocked, and the mixing tank 2
The liquid inside will not leak out.

Then, when the metering container 16 is installed in the pipes 8b and 8d, the dissolving and mixing pump 5a is operated as described above, and the liquid in the mixing #a2 is mixed with the pipes 8, 8a, 8b.

8d, and the dialysate preparation agent in the quantitative container 16 is washed away into the mixing tank 2.

In the second dialysate preparation agent supply means 13, the dialysate preparation agent in the quantitative container 16 is washed out with the liquid in the mixing tank 2, so that the dialysate preparation agent can be dissolved in water without waste. Further, since the quantitative container 16 is of a cartridge type, handling and operation are extremely simple.

Further, for example, there is a dialysate preparation coarse agent supply means (hereinafter sometimes referred to as a third dialysate preparation agent supply means) shown in FIG.

The third dialysate preparation supply means shown in FIG.
It is installed in the piping interposed between the

As shown in FIG. 6, the inner diameter of the pipe 8e interposed between the mixing tank 2 and the concentration measuring means 6 is narrowed down to a small diameter, and in this small diameter portion 21, the dialysate preparation agent 60 The mounting port 24 of the hopper 22 filled with the hopper 22 is open, and by inserting the hopper 22 into the mounting port 24 (the insertion direction is indicated by an arrow in FIG. 6), the hopper 22 and the inside of the pipe 8e are communicated Note that the hopper 22 is provided with an air vent 25.

In the third dialysate preparation agent supply means configured in this way, when the liquid is allowed to flow into the distribution vBe (in FIG. 6, the direction of flow is indicated by an arrow), in the narrow diameter portion 21 The liquid flows at a higher speed than in the large diameter portion 23, and this high-speed flowing liquid generates negative pressure, and the dialysis L1 preparation 60 in the hopper 22 is sucked into the pipe 8e.

This third dialysate preparation agent supply means has a simple configuration because it does not require a special drive device for supplying the dialysate preparation agent 60 from inside the hopper 22 into the pipe Be.

Another dialysate preparation layer agent supply means (sometimes referred to as a fourth dialysate preparation agent supply means) includes a dialysate preparation agent supply section (not shown) and FIGS. 7 and 8. As shown in
A cylindrical dissolving tank 27 has a large number of protrusions 26 and a filtering means 40, for example, a filter net, and connects a pipe communicating with the mixing tank 2 to the bottom thereof, and a cylindrical dissolving tank 27 that extends from the pipe 8b shown in FIG. It is composed of a pipe 28 arranged along the circumferential side inside the cylindrical dissolving tank 27. Said piping 2
The tip opening of 8 is opened so as to form a vortex inside the cylindrical dissolving tank 27.

In the fourth dialysate preparation agent supply means having such a configuration, first, the dialysate preparation agent is supplied into the cylindrical dissolution tank 27 from a dialysate preparation agent supply section (not shown). As water is ejected from the tip of the pipe 28, a strong vortex is formed within the cylindrical melting tank 27. Riding this whirlpool,
The dialysate preparation agent 60 in the cylindrical dissolution tank 27 swirls violently, and the dialysate preparation agent 6 rides on this swirling flow.
0 collides with a protrusion 26 formed on the inner peripheral surface, and the vortex is disturbed by the protrusion 26, resulting in a violent stirring action.

As a result, even if the dialysate preparation agent is in the form of granules, particles, or tablets, it will quickly dissolve in water. After the aqueous solution in which the dialysate preparation agent is dissolved is filtered through the filter net 40, it is passed from the bottom of the cylindrical dissolution tank 27 to the mixing tank z via piping.
transferred within.

In this fourth dialysate preparation agent supply means.

It is convenient for dissolving granular, particulate or tablet preparation agents for dialysate. In addition, since the driving force is water agitation, the structure is simple as it does not require a driving source such as a stirring motor.

In this dialysate preparation device 1, stirring in the mixing tank can be performed by a stirring device such as a stirring blade, but if a rotating nozzle 29 shown in FIGS. 9 to 11 is used, the drive motor The liquid in the mixing tank can be stirred without the need for such a stirring power source.

This rotating nozzle 29 is installed in the mixing tank 2 as shown in FIG.

In the mixing tank 2, the liquid extracted from the mixing tank 2 is transferred to the mixing tank 2.
As shown in FIG. 1O, an opening 31 is provided on the circumferential side of the tip of the pipe 30 to be returned inside, and a housing 32 is rotatably placed over the tip of the pipe 30. A pair of ejection pipes 33 extend in opposite directions on the circumferential side,
As shown in FIG. 11, each tip is provided with an ejection hole 34 that is opened in opposite directions.

In the rotary nozzle 29 having such a configuration, the piping 30
The pipe 30 is connected to the pipe 30 by the dissolving and mixing pump 5a provided midway.
When the liquid is pumped to the tip of the opening 31, the liquid is ejected into the housing 31 from the opening 31, and the liquid ejected into the housing 32 is guided through the pair of ejection pipes 33 and flows through the ejection hole 4. They erupt in opposite directions from each other. As a result, the pair of ejection pipes 33 rotate due to the reaction of the ejection, and the rotation of the ejection pipes 33 causes the ejected liquid to be scattered within the mixing tank 2 . As a result, the liquid in the mixing tank 2 is vigorously stirred.

By using the rotary nozzle 29 in this way, the liquid in the mixing tank 2 can be efficiently stirred without a power source.

Although one embodiment of the dialysate preparation device of the present invention has been described above in detail, the present invention is not limited to the above embodiment, and can be implemented with appropriate design changes within the scope of the present invention. .

For example, the concentration measuring means may be installed in the mixing tank 2, or the mixing tank 2 may be provided with a measuring means for detecting the level of the diluted water.
As shown in Figure 2, it is also possible to install a plurality of mixing tanks and operate them alternately.

[Effects of the invention] According to this invention, (1) It does not take up much space to store and is easy to handle;
It is possible to provide a dialysate preparation agent containing sodium bicarbonate, an electrolyte substance, and a pH adjusting solution, which is easy to transport, and which has a water content of 6% by weight or less.

(2) When the above-mentioned agent for preparing a dialysate is used, it is possible to provide a method for preparing a dialysate in which a dialysate can be easily prepared by dissolving this solid agent in water; (3) Also, the present invention Using this dialysate preparation device, dialysate of precise concentration can be easily and automatically prepared.

[Brief explanation of drawings]

FIG. 1 is an explanatory diagram showing one embodiment of the dialysate preparation device of the present invention, FIG. 2 is an explanatory diagram showing an example of a band-shaped package to be loaded into the dialysate preparation device, and FIG. FIG. 4 is an explanatory view showing another embodiment of the dialysate preparation device of the present invention, and FIG. 4 is a perspective view showing an example of a metering container in the dialysate preparation drug supply means incorporated in the dialysate preparation device; FIG. 5 is a sectional view showing a state in which the quantitative container is attached to piping, and FIG. 6 is a sectional view showing another example of a dialysate preparation agent supply means incorporated in the dialysate preparation device. 7 and 8 are explanatory diagrams showing other examples of the dialysate preparation agent supply means incorporated in the dialysate preparation device, and FIG. 9 is a rotary nozzle incorporated in the dialysate preparation device of the present invention. FIG. 10 is a sectional view showing the main part of the rotating nozzle, FIG. 11 is a perspective view showing the rotating nozzle, and FIG. 12 is a dialysis fluid according to the present invention. It is an explanatory view showing still another example of a preparation device. Fig. 2 1... Dialysate preparation device, 2... Mixing tank, 3... Dialysate preparation agent supply means, 4... Dilution water metering supply means,
dan...dissolving and mixing means, 6...concentration measuring means, 60.
...Dialysate preparation agent. Figure 3 Figure 5 Figure 6 Figure 7 Figure 9 Figure 10

Claims (8)

[Claims] (1) A method for preparing a dialysate, which comprises mixing in water a dialysate preparation agent containing sodium bicarbonate, an electrolyte, and a pH adjusting solution and having a water content of 6% by weight or less. (2) The dialysate preparation agent according to claim 1. (3) A supply system comprising a dialysate preparation agent supply means which includes a predetermined amount of the dialysate preparation agent according to claim 2, and a dilution water metering supply means for supplying dilution water; A mixing tank is provided for accommodating the dialysate preparation agent supplied from the dialysate preparation agent supply means and dilution water supplied from the dilution water metering supply means, and the dialysate is stored in each of the mixing tanks. a concentration measuring means for measuring the concentration of the dialysate prepared in the mixing tank by a dissolving and mixing means for dissolving and mixing the preparation agent and the dilution water; and a dialysate having an appropriate concentration measured by the concentration measuring means. A dialysate preparation device comprising a discharge means for discharging the dialysate. (4) The dialysate preparation agent supply means includes a band-shaped package formed by connecting a plurality of quantitative containers each containing a predetermined amount of a dialysate preparation agent, and each metering container constituting the band-shaped package. ,
4. The dialysate preparation device according to claim 3, further comprising opening means for sequentially and individually opening the seals. (5) The dialysate preparation agent supply means includes a removably built-in metering container containing a predetermined amount of dialysate preparation agent, and has an unsealing device for opening the metering container. dialysate preparation equipment. (6) The dissolving and mixing means includes a circulation channel tangential to the mixing tank, and an internal solution circulation means for circulating the solution in the mixing tank through the circulation channel, and supplies the dialysate preparation agent. The dialysate preparation device according to any one of claims 3 to 5, wherein the means is connected to a constriction formed in the circulation channel. (7) Claims 3 to 5, wherein the dialysate preparation agent supplying means comprises a dialysate preparation agent crushing means and filtration means.
The dialysate preparation device according to any one of the above. (8) The dialysate preparation device according to any one of claims 3 to 7, further comprising a rotating nozzle installed in the mixing tank.