JP2019130217A - Medicine storage container, medicine preparation device and medicine preparation method - Google Patents
Medicine storage container, medicine preparation device and medicine preparation method Download PDFInfo
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- 239000003814 drug Substances 0.000 title claims abstract description 280
- 238000003860 storage Methods 0.000 title claims abstract description 125
- 238000002360 preparation method Methods 0.000 title claims abstract description 119
- 229940079593 drug Drugs 0.000 title claims description 107
- 238000000034 method Methods 0.000 claims abstract description 9
- 239000000126 substance Substances 0.000 claims description 147
- 239000000243 solution Substances 0.000 claims description 104
- 239000002904 solvent Substances 0.000 claims description 60
- 239000008155 medical solution Substances 0.000 claims description 18
- 230000007723 transport mechanism Effects 0.000 claims description 15
- 239000011259 mixed solution Substances 0.000 claims description 13
- 238000005520 cutting process Methods 0.000 description 31
- 239000003795 chemical substances by application Substances 0.000 description 28
- 239000007788 liquid Substances 0.000 description 27
- 238000000502 dialysis Methods 0.000 description 20
- 230000007246 mechanism Effects 0.000 description 19
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- -1 polyethylene Polymers 0.000 description 9
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 239000001632 sodium acetate Substances 0.000 description 8
- 238000004090 dissolution Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 6
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000000385 dialysis solution Substances 0.000 description 6
- 235000017281 sodium acetate Nutrition 0.000 description 6
- 239000001509 sodium citrate Substances 0.000 description 6
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 5
- 239000003792 electrolyte Substances 0.000 description 5
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 241000135309 Processus Species 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 description 4
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 3
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 3
- 235000011054 acetic acid Nutrition 0.000 description 3
- 239000001110 calcium chloride Substances 0.000 description 3
- 229910001628 calcium chloride Inorganic materials 0.000 description 3
- 239000000428 dust Substances 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 229910001629 magnesium chloride Inorganic materials 0.000 description 3
- 239000003002 pH adjusting agent Substances 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- 239000001103 potassium chloride Substances 0.000 description 3
- 235000011164 potassium chloride Nutrition 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 229920003002 synthetic resin Polymers 0.000 description 3
- 239000000057 synthetic resin Substances 0.000 description 3
- WQNHWIYLCRZRLR-UHFFFAOYSA-N 2-(3-hydroxy-2,5-dioxooxolan-3-yl)acetic acid Chemical compound OC(=O)CC1(O)CC(=O)OC1=O WQNHWIYLCRZRLR-UHFFFAOYSA-N 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 229960004106 citric acid Drugs 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- OPGYRRGJRBEUFK-UHFFFAOYSA-L disodium;diacetate Chemical compound [Na+].[Na+].CC([O-])=O.CC([O-])=O OPGYRRGJRBEUFK-UHFFFAOYSA-L 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 235000017454 sodium diacetate Nutrition 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000001744 Sodium fumarate Substances 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 230000003113 alkalizing effect Effects 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 229960002303 citric acid monohydrate Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- WPUMTJGUQUYPIV-JIZZDEOASA-L disodium (S)-malate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](O)CC([O-])=O WPUMTJGUQUYPIV-JIZZDEOASA-L 0.000 description 1
- MSJMDZAOKORVFC-SEPHDYHBSA-L disodium fumarate Chemical compound [Na+].[Na+].[O-]C(=O)\C=C\C([O-])=O MSJMDZAOKORVFC-SEPHDYHBSA-L 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229940050411 fumarate Drugs 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 150000003893 lactate salts Chemical class 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 150000004701 malic acid derivatives Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 235000019265 sodium DL-malate Nutrition 0.000 description 1
- 229960000999 sodium citrate dihydrate Drugs 0.000 description 1
- 229940005573 sodium fumarate Drugs 0.000 description 1
- 235000019294 sodium fumarate Nutrition 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 239000001394 sodium malate Substances 0.000 description 1
- PRWXGRGLHYDWPS-UHFFFAOYSA-L sodium malonate Chemical compound [Na+].[Na+].[O-]C(=O)CC([O-])=O PRWXGRGLHYDWPS-UHFFFAOYSA-L 0.000 description 1
- 229940074404 sodium succinate Drugs 0.000 description 1
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
- 239000011973 solid acid Substances 0.000 description 1
- 229940126589 solid medicine Drugs 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 235000011044 succinic acid Nutrition 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Abstract
Description
本発明は、主として人工透析に用いる透析液の調製に使用され、粉末状または顆粒状とした固体透析用剤等の薬剤を収納するための薬剤収納容器、その薬剤収納容器を用いて薬剤を所定の濃度に調整するための薬液調製装置、および薬液調製方法に関する。 The present invention is mainly used for the preparation of a dialysis solution used for artificial dialysis, and contains a drug storage container for storing a drug such as a powdered or granular solid dialysis agent, and the drug storage container is used to store a predetermined drug. The present invention relates to a chemical solution preparation device and a chemical solution preparation method.
透析用剤は、透析液を作製するための薬剤である。透析液は、血液透析、血液濾過、腹膜透析等により、本来腎臓が行う機能に代わって体液の老廃物を取り去り、場合によっては血液中に必要な成分を補うために用いられるもので、体液に近い電解質組成を有する水溶液である。 The dialysis agent is a drug for preparing a dialysis solution. Dialysis fluid is used to remove waste fluid from the body instead of the function that the kidney originally performs by hemodialysis, blood filtration, peritoneal dialysis, etc., and in some cases is used to supplement the necessary components in the blood. It is an aqueous solution having a close electrolyte composition.
現在の透析用剤は、一般的には、ナトリウムイオンおよびカリウムイオン等を含む電解質成分である塩化ナトリウム、塩化カリウム、塩化マグネシウム、塩化カルシウムと、ブドウ糖と、ｐＨ調整剤（例えば、酢酸と酢酸ナトリウムまたはその混合物、もしくはクエン酸とクエン酸ナトリウム等）とを含む「透析用剤Ａ剤」と、炭酸水素ナトリウムを含む「透析用剤Ｂ剤」との２剤構成となっている。 Current dialysis agents are generally sodium chloride, potassium chloride, magnesium chloride, calcium chloride, glucose, and pH adjusters (for example, acetic acid and sodium acetate), which are electrolyte components containing sodium ions and potassium ions. Or a mixture thereof, or “dialysis agent A” containing citric acid and sodium citrate and the like and “dialysis agent B” containing sodium hydrogen carbonate.
透析用剤には、液体型と固体型の２種類の型がある。液体型の透析用剤は、その大部分が水で占められており、重量と容量が大きくなるため、透析医療従事者への運搬作業の負荷が大きく、保管スペースも大きくなってしまう。そのため、近年、透析液を使用する際に、自動の薬剤溶解装置に投入して、水に溶解させて透析液を調製する固体型の透析用剤が急速に普及している。この固体型の透析用剤を収納する容器は、現在、袋式とボトル式がある。 There are two types of dialysis agents, liquid and solid. Since most liquid-type dialysis agents are occupied by water, and the weight and capacity are increased, the load of transportation work for dialysis medical workers is increased, and the storage space is also increased. Therefore, in recent years, when using a dialysis solution, a solid-type dialysis agent that is introduced into an automatic drug dissolution apparatus and dissolved in water to prepare a dialysis solution is rapidly spreading. Currently, there are a bag type and a bottle type for storing the solid-type dialysis agent.
例えば、特許文献１には、袋式の薬剤収納容器を用いた薬剤溶解装置が提案されている。袋式の薬剤収納容器は、可撓性を有するシート材で袋体に構成されているので、使用後の嵩高を減少させることができる利点がある。しかし、袋式の薬剤収納容器は、容器支持部の開封および薬剤を薬剤溶解装置の溶解槽に移送する位置決めが難しく、自動の薬剤溶解装置への適用性にやや難がある。また、袋式の薬剤収納容器を１つ１つ吊り下げレールに取り付けるため、薬剤の投入間違いのリスクがある。さらに、薬剤投入時の薬剤の飛散により薬剤溶解装置の周辺が汚染する可能性がある等の点で改善の余地を残している。 For example, Patent Document 1 proposes a drug dissolution apparatus using a bag-type drug storage container. Since the bag-type medicine container is formed of a flexible sheet material into a bag body, there is an advantage that the bulk after use can be reduced. However, it is difficult for the bag-type medicine container to open the container support and to position the medicine to the dissolution tank of the medicine dissolution apparatus, and it is somewhat difficult to apply to an automatic medicine dissolution apparatus. Moreover, since the bag-type medicine storage containers are attached to the hanging rails one by one, there is a risk of mistaken drug injection. Furthermore, there is room for improvement in that the surroundings of the drug dissolution apparatus may be contaminated by the scattering of the drug when the drug is added.
ボトル式の薬剤収納容器は、自動の薬剤溶解装置にセットすれば、全自動で透析液の調製が可能となり、数量違いや異物混入の可能性は袋式に比べて低い。また、ボトル式は、薬剤の種類等によって、ボトルサイズを変更することによって薬剤の投入間違いを防止することができる。しかし、ボトルは、袋式に比べて剛性の高い材料で構成されているので、使用後空になっても、つぶして容量を小さくし難く、ゴミとして処分する際に嵩張るという問題がある。 If the bottle-type drug container is set in an automatic drug dissolution apparatus, dialysate can be prepared fully automatically, and the possibility of difference in quantity and mixing of foreign substances is lower than in the bag type. Further, in the bottle type, it is possible to prevent a mistake in inputting a medicine by changing the bottle size depending on the kind of the medicine. However, since the bottle is made of a material having higher rigidity than the bag type, there is a problem that even if it becomes empty after use, it is difficult to crush and reduce its capacity, and it becomes bulky when disposed as garbage.
本発明の目的は、自動の薬液調製装置への適用性に優れ、袋式と同様に保管時および使用後の嵩高を小さくすることができ、ボトル式と同様に薬剤の投入間違いのリスクを防止することができる薬剤収納容器、その薬剤収納容器を用いる薬液調製装置、および薬液調製方法を提供することにある。 The purpose of the present invention is excellent in applicability to automatic chemical preparation equipment, can reduce the bulkiness during storage and after use like the bag type, and prevents the risk of mistaken drug injection like the bottle type An object of the present invention is to provide a medicine container that can be used, a chemical solution preparation device that uses the chemical container, and a chemical solution preparation method.
本発明は、複数の薬剤収納部が１つのシート状に連結されている薬剤収納容器であって、前記薬剤収納部は、袋状に構成されており、前記薬剤収納容器を支持するための容器支持部を有する、薬剤収納容器である。 The present invention is a medicine storage container in which a plurality of medicine storage parts are connected in a single sheet, wherein the medicine storage part is configured in a bag shape, and a container for supporting the medicine storage container It is a medicine container having a support part.
前記薬剤収納容器において、前記薬剤収納部は、後端部から先端部に向かうにつれて細くなる袋状に構成されていることが好ましい。 In the medicine container, the medicine container is preferably configured in a bag shape that becomes narrower from the rear end toward the tip.
前記薬剤収納容器において、前記容器支持部は、穴または突起であり、１つ以上の前記穴または突起が、前記薬剤収納容器のシートの短手方向の両端部に沿って並んで形成されたものであることが好ましい。 In the medicine container, the container support part is a hole or a protrusion, and one or more holes or protrusions are formed side by side along both lateral ends of the sheet of the medicine container. It is preferable that
前記薬剤収納容器において、前記薬剤収納部の前記先端部からの一部および前記後端部からの一部を残してシートから切断されることにより、切断された薬剤収納部が、残された前記後端部からの一部に支持されて下方に垂れ下がり、前記先端部の側の開口された開口部から薬剤が排出されるように構成されていることが好ましい。 In the medicine storage container, the cut medicine storage part is left by being cut from the sheet leaving a part from the front end part and a part from the rear end part of the medicine storage part. It is preferable that the device is supported by a part from the rear end portion and hangs downward, and the medicine is discharged from the opening portion on the side of the tip portion.
前記薬剤収納容器において、前記薬剤収納部に収納される薬剤が、透析用剤であることが好ましい。 In the medicine container, the medicine stored in the medicine container is preferably a dialysis agent.
本発明は、薬剤を溶媒により所定の濃度に調整して薬液を調製するための薬液調製装置であって、前記薬剤と前記溶媒との混合液を収容可能な薬液調製槽と、前記薬液調製槽から排出された前記薬剤と前記溶媒との混合液をさらに前記薬液調製槽に循環供給するための循環配管を有する循環手段と、薬剤がそれぞれに収納された複数の薬剤収納部が１つのシート状に連結されており、前記薬剤収納部が袋状に構成されている薬剤収納容器における、前記薬剤収納容器を支持するための容器支持部を支持して動力を伝達することにより、前記薬剤収納容器の各薬剤収納部を前記薬液調製槽の上まで搬送する容器搬送機構と、を備える、薬液調製装置である。 The present invention relates to a chemical liquid preparation apparatus for preparing a chemical liquid by adjusting a chemical to a predetermined concentration with a solvent, the chemical liquid preparation tank capable of storing a mixed liquid of the chemical and the solvent, and the chemical liquid preparation tank A circulating means for circulating and supplying the mixed solution of the drug and the solvent discharged from the solvent to the chemical preparation tank, and a plurality of drug storage units each storing the drug in a single sheet form In the medicine container in which the medicine container is configured in a bag shape, the medicine container is supported by supporting a container support for supporting the medicine container and transmitting power. And a container transport mechanism for transporting each of the drug storage units to the top of the chemical solution preparation tank.
前記薬液調整装置で用いられる前記薬剤収納容器において、前記薬剤収納部は、後端部から先端部に向かうにつれて細くなる袋状に構成されていることが好ましい。 In the medicine container used in the chemical solution adjusting device, the medicine container is preferably configured in a bag shape that becomes narrower from the rear end toward the tip.
前記薬液調整装置で用いられる前記薬液収納容器において、前記容器支持部は、穴または突起であり、１つ以上の前記穴または突起が、前記薬剤収納容器のシートの短手方向の両端部に沿って並んで形成されたものであることが好ましい。 The said chemical | medical solution storage container used with the said chemical | medical solution adjustment apparatus WHEREIN: The said container support part is a hole or a processus | protrusion, and one or more said hole or processus | protrusion is along the both ends of the transversal direction of the sheet | seat of the said drug | medical storage container. It is preferable that they are formed side by side.
前記薬液調製装置において、前記薬剤収納部の前記先端部からの一部および前記後端部からの一部を残してシートを切断するための切断機構をさらに備え、前記切断機構により切断された薬剤収納部が、残された前記後端部からの一部に支持されて下方に垂れ下がり、前記先端部の側の開口された開口部から薬剤が前記薬液調製槽内に排出されるように構成されていることが好ましい。 The medicine preparation apparatus further comprising a cutting mechanism for cutting the sheet while leaving a part from the front end part and a part from the rear end part of the medicine storage part, and the medicine cut by the cutting mechanism The storage portion is supported by a part from the remaining rear end portion and hangs downward, and is configured so that the medicine is discharged into the liquid medicine preparation tank from the opening portion opened on the front end portion side. It is preferable.
前記薬液調整装置において、前記薬剤収納部に収納される薬剤が、透析用剤であることが好ましい。 In the liquid medicine adjusting device, it is preferable that the medicine stored in the medicine storage section is a dialysis agent.
本発明は、薬剤を溶媒により所定の濃度に調整して薬液を調製するための薬液調製方法であって、循環配管を通して、薬液調製槽から排出された前記薬剤と前記溶媒との混合液をさらに前記薬液調製槽に循環供給して循環する循環工程を含み、薬剤がそれぞれに収納された複数の薬剤収納部が１つのシート状に連結されており、前記薬剤収納部が袋状に構成されている薬剤収納容器における、前記薬剤収納容器を支持するための容器支持部を支持して動力を伝達することにより、前記薬剤収納容器の各薬剤収納部を前記薬液調製槽の上まで搬送する、薬液調製方法である。 The present invention provides a chemical solution preparation method for preparing a chemical solution by adjusting a drug to a predetermined concentration with a solvent, and further comprising a mixed solution of the drug and the solvent discharged from the chemical solution preparation tank through a circulation pipe. Including a circulation step of circulating and supplying to the chemical solution preparation tank, wherein a plurality of drug storage units each storing a drug are connected in a single sheet shape, and the drug storage unit is configured in a bag shape A chemical solution that conveys each drug storage portion of the drug storage container onto the drug solution preparation tank by transmitting power by supporting a container support portion for supporting the drug storage container in the drug storage container It is a preparation method.
前記薬液調整方法で用いられる前記薬剤収納容器において、前記薬剤収納部は、後端部から先端部に向かうにつれて細くなる袋状に構成されていることが好ましい。 In the medicine container used in the medicine solution adjustment method, the medicine container is preferably configured in a bag shape that becomes thinner from the rear end toward the tip.
前記薬液調整方法で用いられる前記薬液収納容器において、前記容器支持部は、穴または突起であり、１つ以上の前記穴または突起が、前記薬剤収納容器のシートの短手方向の両端部に沿って並んで形成されたものであることが好ましい。 The said chemical | medical solution storage container used with the said chemical | medical solution adjustment method WHEREIN: The said container support part is a hole or a processus | protrusion, and one or more said hole or processus | protrusion is along the both ends of the transversal direction of the sheet | seat of the said drug | medical storage container. It is preferable that they are formed side by side.
前記薬液調製方法において、前記薬剤収納部の前記先端部からの一部および前記後端部からの一部を残してシートを切断することによって、切断した薬剤収納部が、残された前記後端部からの一部に支持されて下方に垂れ下がり、前記先端部の側の開口された開口部から薬剤を前記薬液調製槽内に排出することが好ましい。 In the chemical solution preparation method, by cutting a sheet while leaving a part from the front end part and a part from the rear end part of the medicine storage part, the cut back medicine storage part is left behind. It is preferable that the medicine is supported by a part from the part and hangs downward, and the medicine is discharged into the chemical solution preparation tank from the opening part on the tip part side.
前記薬液調整方法において、前記薬剤収納部に収納される薬剤が、透析用剤であることが好ましい。 In the chemical solution adjusting method, it is preferable that the medicine stored in the medicine storage section is a dialysis agent.
本発明により、自動の薬液調製装置への適用性に優れ、袋式と同様に保管時および使用後の嵩高を小さくすることができ、ボトル式と同様に薬剤の投入間違いのリスクを防止することができる薬剤収納容器、その薬剤収納容器を用いる薬液調製装置、および薬液調製方法を提供することができる。 According to the present invention, it is excellent in applicability to an automatic chemical preparation device, can reduce the bulkiness during storage and after use as in the case of the bag type, and prevents the risk of erroneous drug injection as in the case of the bottle type. It is possible to provide a medicine container that can carry out the medicine, a chemical liquid preparation device that uses the chemical container, and a chemical liquid preparation method.
本発明の実施の形態について以下説明する。本実施形態は本発明を実施する一例であって、本発明は本実施形態に限定されるものではない。 Embodiments of the present invention will be described below. This embodiment is an example for carrying out the present invention, and the present invention is not limited to this embodiment.
本発明の実施形態に係る薬剤収納容器の一例の概略を図１に示し、その構成について説明する。図１に示す薬剤収納容器１０は、複数の薬剤収納部１２が１つのシート状に連結されており、薬剤収納部１２は、例えば、後端部から先端部に向かうにつれて細くなるテーパー状の袋状に構成されている。薬剤収納容器１０は、可撓性を有するシート材、例えばポリエチレン等の合成樹脂で構成されている。 An outline of an example of a medicine container according to an embodiment of the present invention is shown in FIG. A drug storage container 10 shown in FIG. 1 includes a plurality of drug storage portions 12 connected in a single sheet, and the drug storage portion 12 is, for example, a tapered bag that narrows from the rear end toward the front end. Configured. The medicine container 10 is made of a flexible sheet material, for example, a synthetic resin such as polyethylene.
薬剤収納容器１０は、薬剤収納容器１０を支持するための容器支持部１４をさらに有している。容器支持部１４は、例えば、穴であり、例えば、図１に示すように、１つ以上の穴が、シートの短手方向の両端部に沿って並んで形成されている。 The medicine container 10 further includes a container support 14 for supporting the medicine container 10. The container support portion 14 is, for example, a hole. For example, as shown in FIG. 1, one or more holes are formed side by side along both ends in the short direction of the sheet.
薬剤収納部１２に収納される薬剤は、例えば、糖質成分（例えば、ブドウ糖）、電解質成分（例えば、塩化ナトリウム、塩化カリウム、塩化マグネシウム、塩化カルシウム、酢酸ナトリウム、クエン酸ナトリウム）、ｐＨ調整剤（例えば、酢酸と酢酸ナトリウムもしくはその混合物、またはクエン酸とクエン酸ナトリウム等）、アルカリ化成分（例えば、炭酸水素ナトリウム）等が粉末状または顆粒状等にされた透析用剤であり、薬剤収納部１２の内部に所定量が密閉されて収納される。 The drug stored in the drug storage unit 12 is, for example, a sugar component (for example, glucose), an electrolyte component (for example, sodium chloride, potassium chloride, magnesium chloride, calcium chloride, sodium acetate, sodium citrate), a pH adjuster. (For example, acetic acid and sodium acetate or a mixture thereof, citric acid and sodium citrate, etc.), alkalizing components (for example, sodium bicarbonate), etc., are dialysis agents that are powdered or granulated, etc. A predetermined amount is sealed and stored inside the portion 12.
本発明の実施形態に係る薬液調製装置の一例の概略を図２に示し、その構成について説明する。図２に示す薬液調製装置１は、薬剤を溶媒により所定の濃度に調整して薬液を調製するための装置である。薬液調製装置１は、薬剤と溶媒との混合液を収容可能であり、薬剤を溶媒により所定の濃度に調整して薬液を調製可能な薬液調製槽２０と、薬液調製槽２０から排出された薬剤と溶媒との混合液を薬液調製槽２０に循環供給するための循環配管３４（配管２４、配管２６）を有する循環手段と、を備える。薬液調製槽２０には、溶媒を薬液調製槽２０内に供給するための溶媒供給配管４６が接続されていてもよく、溶媒供給配管４６には溶媒供給量測定手段として流量計等の溶媒供給量測定装置４８が設置されていてもよい。薬液調製装置１は、薬剤収納容器１０における、薬剤収納部１２の先端部からの一部および後端部からの一部を残してシートを切断するための切断機構１８を備えてもよい。薬液調製装置１は、循環手段として、例えば、循環配管３４の途中に設けられ、薬液調製槽２０から排出された薬剤と溶媒とを含む混合液を薬液調製槽２０に循環させるための循環ポンプ２２をさらに備えてもよい。薬液調製槽２０は、上面に槽開口部３６を有している。槽開口部３６の上方には、各薬剤収納部１２に薬剤３２が収納された、シート状の薬剤収納容器１０が、薬剤収納部１２が上方に向いた状態で設置されており、薬剤収納容器１０は、図示しない容器搬送機構により、図２の進行方向に自動または手動で移動可能である。 An outline of an example of a chemical liquid preparation apparatus according to an embodiment of the present invention is shown in FIG. 2 and the configuration thereof will be described. A chemical solution preparation apparatus 1 shown in FIG. 2 is an apparatus for preparing a chemical solution by adjusting a drug to a predetermined concentration with a solvent. The chemical solution preparation device 1 can store a mixed solution of a drug and a solvent, can adjust the drug to a predetermined concentration with the solvent, and can prepare a chemical solution, and the drug discharged from the chemical solution preparation tank 20 And a circulation means having a circulation pipe 34 (pipe 24, pipe 26) for circulatingly supplying the liquid mixture of the solvent and the solvent to the chemical solution preparation tank 20. A solvent supply pipe 46 for supplying a solvent into the chemical solution preparation tank 20 may be connected to the chemical solution preparation tank 20, and a solvent supply amount such as a flow meter as a solvent supply amount measuring unit is connected to the solvent supply pipe 46. A measuring device 48 may be installed. The drug solution preparing apparatus 1 may include a cutting mechanism 18 for cutting the sheet while leaving a part from the front end portion and a part from the rear end portion of the drug storage unit 12 in the drug storage container 10. The chemical liquid preparation device 1 is provided as a circulation means, for example, in the middle of the circulation pipe 34, and a circulation pump 22 for circulating a mixed liquid containing the medicine and solvent discharged from the chemical liquid preparation tank 20 to the chemical liquid preparation tank 20. May be further provided. The chemical solution preparation tank 20 has a tank opening 36 on the upper surface. Above the tank opening 36, a sheet-like medicine storage container 10 in which the medicine 32 is stored in each medicine storage section 12 is installed with the medicine storage section 12 facing upward. 10 can be moved automatically or manually in the traveling direction of FIG. 2 by a container transport mechanism (not shown).
薬液調製槽２０の排出口と循環ポンプ２２の吸入口との間は、配管２４により接続され、循環ポンプ２２の吐出口と薬液調製槽２０の流入口との間は、配管２６により接続され、薬液調製槽２０から排出された薬剤と溶媒とを含む混合液が配管２４，２６を通して薬液調製槽２０へ排出可能とされている。このようにして、薬剤および溶媒を含む混合液が薬液調製槽２０、配管２４、循環ポンプ２２、配管２６、薬液調製槽２０の順に循環されるように構成されている。 The discharge port of the chemical solution preparation tank 20 and the suction port of the circulation pump 22 are connected by a pipe 24, and the discharge port of the circulation pump 22 and the inflow port of the chemical solution preparation tank 20 are connected by a pipe 26, The liquid mixture containing the medicine and the solvent discharged from the chemical solution preparation tank 20 can be discharged to the chemical solution preparation tank 20 through the pipes 24 and 26. In this way, the liquid mixture containing the drug and the solvent is configured to circulate in the order of the chemical solution preparation tank 20, the pipe 24, the circulation pump 22, the pipe 26, and the chemical solution preparation tank 20.
図３に、薬剤収納容器１０を設置した薬液調製装置１を上方から見た上面図を示す。薬液調製装置１は、図３に示すように容器搬送機構１６（図２においては図示せず）を備え、容器搬送機構１６が薬剤収納容器１０の容器支持部１４に接続され、薬剤収納部１２が例えば薬液調製装置１の薬液調製槽２０の槽開口部３６の上方（例えば、直上）に自動または手動で搬送されるように構成されている。容器搬送機構１６は、例えば、シート状の薬剤収納容器１０の容器支持部１４（例えば、「穴」）を接続するためのピン等の支持部材を有する搬送用チェーンであり、容器支持部１４（例えば、「穴」）をピンに引っ掛けることで動力を伝達し、薬剤収納容器１０を搬送することができる。 FIG. 3 shows a top view of the chemical solution preparation apparatus 1 in which the medicine storage container 10 is installed as seen from above. As shown in FIG. 3, the drug solution preparing apparatus 1 includes a container transport mechanism 16 (not shown in FIG. 2), and the container transport mechanism 16 is connected to the container support portion 14 of the medicine storage container 10. Is configured to be automatically or manually conveyed above (for example, directly above) the tank opening 36 of the chemical liquid preparing tank 20 of the chemical liquid preparing apparatus 1. The container transport mechanism 16 is, for example, a transport chain having a support member such as a pin for connecting the container support portion 14 (for example, “hole”) of the sheet-like medicine storage container 10, and the container support portion 14 ( For example, power can be transmitted by hooking a “hole” on a pin, and the medicine container 10 can be conveyed.
薬液調製装置１は、制御手段として制御装置（図示せず）を備えてもよい。制御装置は、容器搬送機構１６、切断機構１８および循環ポンプ２２に電気的接続等により接続され、制御装置からの信号に基づいて容器搬送機構１６、切断機構１８および循環ポンプ２２が駆動制御可能とされている。なお、容器搬送機構１６、切断機構１８の駆動および循環ポンプ２２の駆動については、後述する。 The chemical solution preparation device 1 may include a control device (not shown) as control means. The control device is connected to the container transport mechanism 16, the cutting mechanism 18 and the circulation pump 22 by electrical connection or the like, and the container transport mechanism 16, the cutting mechanism 18 and the circulation pump 22 can be driven and controlled based on a signal from the control device. Has been. The driving of the container transport mechanism 16 and the cutting mechanism 18 and the driving of the circulation pump 22 will be described later.
図２に示すように、循環配管３４の途中部分（例えば、配管２４の途中部分）は、分岐配管３８により分岐され、この分岐配管３８は、排出バルブ４０を介して多人数用透析液供給装置（図示せず）等の透析液供給装置または個人用透析装置等に接続されていてもよい。また、配管のうち分岐部よりも下流側（循環ポンプ２２側）には、薬液濃度測定手段として電導度計等からなる濃度計４２を備え、循環配管３４内に流れる薬液（混合液）の濃度が所定値に到達したか否かを濃度計４２により測定して、薬剤が十分に溶媒により所定の濃度に調整されたか否か、言い換えると薬液の調製が完了したか否かを判断できるように構成されていてもよい。分岐配管３８による分岐部の位置は、循環配管３４の途中部分であればよく、特に制限はない。濃度計４２の設置位置は、循環配管３４の途中部分であればよく、特に制限はないが、薬液調製槽２０であってもよい。 As shown in FIG. 2, an intermediate part of the circulation pipe 34 (for example, an intermediate part of the pipe 24) is branched by a branch pipe 38, and this branch pipe 38 is connected to a multi-person dialysate supply device via a discharge valve 40. It may be connected to a dialysate supply device such as (not shown) or a personal dialyzer. Further, a concentration meter 42 composed of a conductivity meter or the like is provided as a chemical solution concentration measuring means on the downstream side (circulation pump 22 side) of the branch portion in the piping, and the concentration of the chemical solution (mixed solution) flowing in the circulation piping 34. Is measured by the densitometer 42 so that it can be determined whether or not the drug has been sufficiently adjusted to the predetermined concentration by the solvent, in other words, whether or not the preparation of the drug solution has been completed. It may be configured. The position of the branch portion by the branch pipe 38 is not particularly limited as long as it is in the middle of the circulation pipe 34. The concentration position of the concentration meter 42 is not particularly limited as long as it is in the middle of the circulation pipe 34, but may be the chemical solution preparation tank 20.
次に、薬剤収納容器１０を用いる薬液調製装置１における薬液調製方法について説明する。 Next, the chemical solution preparation method in the chemical solution preparation apparatus 1 using the chemical container 10 will be described.
まず、図２に示すように、薬液調製槽２０には、薬剤３２を所定の濃度に調整するための溶媒（例えば、水）３０を例えば溶媒供給配管４６を通して所定量（具体的には、例えば、薬剤収納部１２内に収納された薬剤３２の量を溶媒３０に混合した場合に、薬液として適した溶液成分濃度が得られるように設定された量）供給して予め貯留しておき、排出バルブ４０を閉状態として、薬液調製槽２０内の溶媒３０が循環ポンプ２２の吸入口へ流入するようにしておく。薬剤３２が薬液調製槽２０内に投入される前に薬液調製槽２０に溶媒３０が予め貯留されていなくてもよいが、薬剤３２が薬液調製槽２０内に投入される際の発塵等を抑制するためには、薬液調製槽２０に溶媒３０を予め貯留しておく方がよい。また、溶媒供給の手段によっては（例えば、流量計等の溶媒供給量測定装置４８を用いる場合）、予め全量の溶媒３０を薬液調製槽２０に供給しなくてもよく、粉末状等の薬剤の場合は発塵が抑制される程度の溶媒３０を薬液調製槽２０に供給して、循環ポンプ２２を稼働させて溶媒または混合液を循環させながら、溶媒３０を薬液調製槽２０に供給してもよい。 First, as shown in FIG. 2, in the chemical solution preparation tank 20, a predetermined amount (specifically, for example, a solvent (for example, water) 30 for adjusting the drug 32 to a predetermined concentration is supplied through, for example, a solvent supply pipe 46. When the amount of the medicine 32 stored in the medicine storage unit 12 is mixed with the solvent 30, the amount is set so as to obtain a solution component concentration suitable as a chemical solution) and is stored in advance and discharged. With the valve 40 closed, the solvent 30 in the chemical solution preparation tank 20 flows into the suction port of the circulation pump 22. The solvent 30 may not be stored in the chemical solution preparation tank 20 in advance before the drug 32 is charged into the chemical solution preparation tank 20, but dust generated when the drug 32 is charged into the chemical solution preparation tank 20 may be generated. In order to suppress, it is better to store the solvent 30 in the chemical solution preparation tank 20 in advance. Further, depending on the means for supplying the solvent (for example, when using the solvent supply measuring device 48 such as a flow meter), the entire amount of the solvent 30 may not be supplied to the chemical solution preparation tank 20 in advance, In this case, even if the solvent 30 is supplied to the chemical solution preparation tank 20 by supplying the solvent 30 to the extent that dust generation is suppressed and the circulation pump 22 is operated to circulate the solvent or the mixed solution, the solvent 30 may be supplied to the chemical preparation tank 20. Good.
図３に示すように、例えば、シート状の薬剤収納容器１０の短手方向の両端部に形成された容器支持部１４（例えば、「穴」）を、容器搬送機構１６（例えば、「搬送用チェーン」）に接続したピン等の支持部材に引っ掛けることで動力が伝達され、薬剤収納容器１０が移動されて、薬剤収納部１２が薬液調製槽２０の槽開口部３６の上方（例えば、直上）まで自動または手動で搬送される。 As shown in FIG. 3, for example, the container support portions 14 (for example, “holes”) formed at both ends in the short direction of the sheet-like medicine storage container 10 are connected to the container transport mechanism 16 (for example, “for transport”). Power is transmitted by being hooked on a support member such as a pin connected to the chain "), the medicine container 10 is moved, and the medicine container 12 is above the tank opening 36 of the drug solution preparation tank 20 (for example, immediately above). It is automatically or manually conveyed.
次に、図４に示すように、例えば、薬液調製槽２０の槽開口部３６の上方（例えば、直上）にある薬剤収納部１２に、図３に示すような略コの字型等の切断機構１８が上方から押し当てられることにより、薬剤収納部１２の先端部からの一部および後端部からの一部を残してシートから切断されることによって、すなわち、薬剤収納部１２の後端部の太い端面を切断せず、例えば、先端部の細い端面の一部を残すように切断することによって、図５に示すように、薬液調製槽２０の槽開口部３６の上方で切断された薬剤収納部１２が、薬剤収納部１２の残された後端部からの一部である太い端面部に支持されて下方の薬液調製槽２０側に垂れ下がり、先端部の側の開口された開口部４４から薬剤収納部１２内の薬剤３２が流れ落ちるように薬液調製槽２０内へ排出される。 Next, as shown in FIG. 4, for example, the drug container 12 located above (for example, directly above) the tank opening 36 of the chemical solution preparation tank 20 is cut into a substantially U-shape or the like as shown in FIG. 3. When the mechanism 18 is pressed from above, it is cut from the sheet while leaving a part from the front end part and a part from the rear end part of the medicine storage part 12, that is, the rear end of the medicine storage part 12 For example, by cutting so as to leave a part of the thin end surface of the tip portion without cutting the thick end surface of the portion, the portion was cut above the tank opening 36 of the chemical solution preparation tank 20 as shown in FIG. The medicine storage part 12 is supported by a thick end surface part that is a part from the remaining rear end part of the medicine storage part 12 and hangs down to the lower chemical solution preparation tank 20 side, and the opening part opened on the tip part side The medicine 32 so that the medicine 32 in the medicine storage section 12 flows down from 44. It is discharged to the preparation tank 20.
このように、例えば、薬剤収納部１２の先端部からの一部および後端部からの一部を残してシートから切断されることによって、すなわち、薬剤収納部１２の後端部の太い端面を切断せず、例えば、先端部の端面の一部を残すように切断することによって、開口部４４が細くなるように形成され、先端部の細い端面の開口部４４から薬剤３２が流れ落ちて薬液調製槽２０内へ投入されるため、自動の薬液調製装置への適用性に優れる。また、薬剤収納部１２の開口部４４から空気等の気体が巻き込まれにくく、薬剤３２が気流を乱さずにまとまって投入されるので投入の際の発塵が抑制され、薬液調製装置１の周辺部が汚染される、薬液調製装置を設置した環境が汚染される等の問題が抑制される。 Thus, for example, by cutting from the sheet leaving a part from the front end part and a part from the rear end part of the medicine storage part 12, that is, the thick end surface of the rear end part of the medicine storage part 12 For example, by cutting so as to leave a part of the end face of the distal end portion without cutting, the opening 44 is formed to be thin, and the drug 32 flows down from the opening 44 on the thin end face of the distal end portion, thereby preparing the drug solution. Since it is put into the tank 20, it is excellent in applicability to an automatic chemical preparation apparatus. In addition, a gas such as air is difficult to be caught from the opening 44 of the medicine container 12, and the medicine 32 is put together without disturbing the air flow, so that dust generation at the time of feeding is suppressed, and the periphery of the medicine preparation device 1 Problems such as contamination of the part and contamination of the environment in which the chemical preparation apparatus is installed are suppressed.
複数の薬剤収納部１２が１つのシート状に連結されていることにより、可撓性を有するシート材で袋体であっても薬剤収納部１２の開封および薬剤収納部１２内の薬剤３２を薬液調製槽２０に移送する位置決めがしやすく、薬液調製装置を自動化することができる。また、複数の薬剤収納部１２が１つのシート状に連結されているため、薬剤の投入間違いのリスクを防止することができ、また、大量の薬剤を一度に薬液調製装置にセットできる。 By connecting a plurality of medicine storage parts 12 in a single sheet shape, the medicine storage part 12 can be opened and the medicine 32 in the medicine storage part 12 can be stored in a chemical solution even if it is a bag with a flexible sheet material. Positioning to transfer to the preparation tank 20 is easy, and the chemical solution preparation apparatus can be automated. In addition, since the plurality of medicine storage units 12 are connected in a single sheet shape, the risk of mistaken drug insertion can be prevented, and a large amount of medicine can be set in the chemical solution preparation device at one time.
容器支持部１４と容器搬送機構１６とにより、薬剤収納容器１０が移動されて、薬剤収納部１２が薬液調製槽２０の槽開口部３６の上方（例えば、直上）まで的確に搬送される。薬剤収納部１２の開封および薬剤収納部１２内の薬剤３２を薬液調製槽２０に移送する位置決めがしやすく、容器搬送機構１６により薬剤収納容器１０を自動で搬送すれば薬液調製装置を自動化することができる。１袋毎の袋形状の容器の場合、移送の位置決めを行うのは困難である。 The drug storage container 10 is moved by the container support unit 14 and the container transfer mechanism 16, and the drug storage unit 12 is accurately transferred to above the tank opening 36 (for example, directly above) of the chemical solution preparation tank 20. It is easy to open the medicine container 12 and position the medicine 32 in the medicine container 12 to be transferred to the chemical solution preparation tank 20, and if the medicine container 10 is automatically conveyed by the container conveyance mechanism 16, the chemical solution preparation apparatus can be automated. Can do. In the case of a bag-shaped container for each bag, it is difficult to position the transfer.
そして、薬液調製装置１では、例えば制御部により循環ポンプ２２が駆動され、薬剤３２および溶媒３０の混合液が薬液調製装置１内の循環流路である循環配管３４により、薬液調製槽２０、配管２４、循環ポンプ２２、配管２６、薬液調製槽２０の順に循環され、薬剤３２が溶媒３０へ十分に混合されて所定の濃度の薬液が調製される。薬剤３２の薬液調製槽２０内への投入の前に循環ポンプ２２が駆動されてもよい。 In the chemical solution preparing apparatus 1, for example, the circulation pump 22 is driven by the control unit, and the mixed solution of the drug 32 and the solvent 30 is connected to the chemical solution preparing tank 20 and the piping by the circulation pipe 34 that is a circulation channel in the chemical solution preparing apparatus 1. 24, the circulation pump 22, the pipe 26, and the chemical solution preparation tank 20 are circulated in this order, and the drug 32 is sufficiently mixed with the solvent 30 to prepare a chemical solution with a predetermined concentration. The circulation pump 22 may be driven before charging the drug 32 into the chemical solution preparation tank 20.
電導度計等の濃度計４２により薬液が所定の濃度に達することで適切に濃度調整作業が完了されたことが確認された後に、例えば制御装置により循環ポンプ２２が停止される。薬液調製槽２０内の薬液は、排出バルブ４０が開状態とされて、分岐配管３８を通して多人数用透析液供給装置等の透析液供給装置等に薬液が供給される。 After it is confirmed by the concentration meter 42 such as a conductivity meter that the concentration adjustment operation has been properly completed by the chemical solution reaching a predetermined concentration, the circulation pump 22 is stopped by, for example, the control device. The chemical solution in the chemical solution preparation tank 20 is supplied to a dialysate supply device such as a multi-person dialysate supply device through the branch pipe 38 with the discharge valve 40 opened.
本実施形態に係る薬液調製装置１および薬液調製方法は、主として人工透析に用いる透析液の調製に使用され、粉末状または顆粒状とした固体透析用剤等の薬剤を所定の濃度に調整するためのものである。上記各実施形態では、薬液調製装置１で濃度を調整する薬剤として透析用剤を一例として説明したが、これに限定されない。すなわち、溶媒に溶解される固体の薬剤（顆粒剤や粉末剤）や、コロイド状態、濃厚液状態等の液体の薬剤等であればどのようなものでも利用することができる。 The chemical solution preparation apparatus 1 and the chemical solution preparation method according to the present embodiment are mainly used for preparation of a dialysis solution used for artificial dialysis, in order to adjust a drug such as a powdered or granular solid dialysis agent to a predetermined concentration. belongs to. In each of the above embodiments, the dialysis agent has been described as an example of the drug whose concentration is adjusted by the drug solution preparation device 1, but the present invention is not limited to this. That is, any solid drug (granule or powder) dissolved in a solvent or liquid drug such as a colloidal state or a concentrated liquid state can be used.
薬液調製槽２０は、所定量の溶媒３０、または薬剤３２と溶媒３０との混合液を収容可能であり、薬剤３２を溶媒３０により所定の濃度に調整して薬液を調製可能な槽であればよく、特に制限はない。薬液調製槽２０は、薬液調製槽２０内の溶媒３０、または薬剤３２と溶媒３０との混合液を撹拌するための撹拌羽根等を有する撹拌装置を備えてもよい。 If the chemical | medical solution preparation tank 20 can accommodate the predetermined amount of the solvent 30 or the liquid mixture of the chemical | medical agent 32 and the solvent 30, and can adjust the chemical | medical agent 32 to the predetermined | prescribed density | concentration with the solvent 30, it is a tank which can prepare a chemical | medical solution. Well, there are no particular restrictions. The chemical solution preparation tank 20 may include a stirring device having a stirring blade or the like for stirring the solvent 30 in the chemical solution preparation tank 20 or a mixed solution of the drug 32 and the solvent 30.
薬液調製槽２０は、切断された薬剤収納部１２が下方の薬液調製槽２０側に垂れ下がる際に、薬剤収納部１２内の薬剤３２ができるだけ飛散しないように、薬液調製槽２０の開口部４４の周囲の少なくとも一部に、開口部４４から上方の薬剤収納容器１０側に所定の角度で突出したガイド部２８を有していてもよい。ガイド部２８により、切断された薬剤収納部１２が下方の薬液調製槽２０側に垂れ下がる際に落ちた薬剤３２を、薬液調製槽２０内へ導くことができる。 The medicinal solution preparation tank 20 has an opening 44 of the medicinal solution preparation tank 20 so that the medicine 32 in the medicine storage unit 12 is not scattered as much as possible when the cut medicine storage unit 12 hangs down to the lower drug solution preparation tank 20 side. You may have the guide part 28 which protruded at the predetermined angle to the chemical | medical agent storage container 10 upper side from the opening part 44 in at least one part of circumference | surroundings. The guide part 28 can guide the medicine 32 that has fallen when the cut medicine storage part 12 hangs down to the lower side of the medicine preparation tank 20 into the medicine preparation tank 20.
溶媒供給量測定装置４８としては、溶媒供給配管４６に設置する流量計の他に、薬液調製槽２０に設置するフロートスイッチ、重量計等であってもよい。 The solvent supply amount measuring device 48 may be a float switch, a weight meter, or the like installed in the chemical solution preparation tank 20 in addition to a flow meter installed in the solvent supply pipe 46.
循環配管３４としては、溶媒３０、または薬剤３２および溶媒３０の混合液が流動することができるものであればよく、特に制限はないが、例えば、内径５〜２５ｍｍの樹脂製、金属性等の配管が用いられる。 The circulation pipe 34 is not particularly limited as long as the solvent 30 or a mixed solution of the drug 32 and the solvent 30 can flow. For example, the circulation pipe 34 is made of a resin having an inner diameter of 5 to 25 mm, metallic, or the like. Piping is used.
薬液濃度測定手段である濃度計４２としては、薬剤３２と溶媒３０との混合液中の薬剤３２の濃度を測定することができるものであればよく、特に制限はないが、例えば、電導度計、超音波濃度計、屈折計、分光光度計等が挙げられる。 The densitometer 42 which is a chemical concentration measuring unit is not particularly limited as long as it can measure the concentration of the drug 32 in the mixed solution of the drug 32 and the solvent 30. For example, an electric conductivity meter An ultrasonic densitometer, a refractometer, a spectrophotometer, and the like.
薬剤収納容器１０は、可撓性を有するシート材、例えばポリエチレン等の合成樹脂で構成されている。薬剤収納容器１０は、例えば、後端部から先端部に向かうにつれて細くなるテーパー状の複数の空洞部（袋体）がシートの長手方向に沿って並んで形成されるように、２枚以上の樹脂シートを貼り合わせて形成される。薬剤収納部１２の薬剤に接触する部分は、耐薬品性を有する材料、例えば、ポリエチレン、ポリプロピレン、ポリ塩化ビニル等の合成樹脂で構成されることが好ましい。薬剤収納容器１０の表面側は、ある程度の剛性を持たせるためにポリエチレンテレフタレート等により補強してもよい。薬剤収納容器１０は、可撓性を有するシート材で構成されているので、袋式と同様に保管時および使用後の嵩高を容易に減少させることができる。 The medicine container 10 is made of a flexible sheet material, for example, a synthetic resin such as polyethylene. The medicine storage container 10 is formed of, for example, two or more sheets such that a plurality of tapered hollow portions (bags) that become narrower from the rear end portion toward the front end portion are aligned along the longitudinal direction of the sheet. It is formed by laminating resin sheets. The portion of the medicine storage portion 12 that comes into contact with the medicine is preferably composed of a chemical-resistant material, for example, a synthetic resin such as polyethylene, polypropylene, or polyvinyl chloride. The surface side of the medicine container 10 may be reinforced with polyethylene terephthalate or the like in order to give a certain degree of rigidity. Since the medicine container 10 is made of a flexible sheet material, the bulkiness during storage and after use can be easily reduced in the same manner as the bag type.
薬剤収納部１２は、袋状に構成され、所定の量の薬剤を収納可能な大きさであればよい。１つの薬剤収納容器１０のシート内の薬剤収納部１２の数には特に制限はないが、例えば、２個〜１００個程度であり、通常は１０個〜５０個程度である。 The medicine storage unit 12 may be configured in a bag shape so long as a predetermined amount of medicine can be stored. There is no particular limitation on the number of drug storage units 12 in the sheet of one drug storage container 10, but it is, for example, about 2 to 100, and usually about 10 to 50.
薬剤収納部１２の形状は、袋状に構成されているものであればよく、特に制限はない。薬剤収納部１２の形状は、例えば、図１、図３および図６（ａ）や、図６（ｂ）に示すように、後端部から先端部に向かうにつれて細くなるテーパー状の袋状に構成されているものである。また、図６（ｃ），（ｄ），（ｅ），（ｆ）に示すように、後端部から先端部に向かう途中から、先端部にかけて細くなる袋状に構成されているものであってもよい。薬剤収納部１２の形状は、長方体等の袋状に構成されているものであってもよいが、後端部から先端部に向かうにつれて細くなるテーパー状の袋状に構成されているものであることが好ましい。 The shape of the medicine container 12 is not particularly limited as long as it is configured in a bag shape. The shape of the medicine container 12 is, for example, a tapered bag shape that becomes narrower from the rear end toward the front end as shown in FIGS. 1, 3, 6A, and 6B. It is configured. Further, as shown in FIGS. 6C, 6D, 6E, and 6F, it is configured in a bag shape that narrows from the middle toward the front end portion from the rear end portion toward the front end portion. May be. The shape of the medicine container 12 may be configured as a bag such as a rectangular parallelepiped, but is configured as a tapered bag that becomes thinner from the rear end toward the front end. It is preferable that
薬剤収納部１２の先端部のテーパー状の角度は、薬剤収納部１２に収納される薬剤の崩壊角よりも大きい角度の形状に設定されていることが好ましく、薬剤の安息角以上であることがより好ましい。 The taper-shaped angle of the distal end portion of the medicine storage portion 12 is preferably set to a shape having an angle larger than the collapse angle of the medicine stored in the medicine storage portion 12, and is greater than or equal to the repose angle of the medicine. More preferred.
薬剤を薬剤収納部１２内に収納するには、例えば、２枚のシートを後端部から先端部に向かうにつれて細くなるテーパー状になるような空洞部が形成されるように熱溶着する。次に、この空洞部に薬剤を充填した後に、開口した空洞部の末端を熱溶着することで薬剤収納部１２に薬剤を収納すればよい。 In order to store the drug in the drug storage unit 12, for example, two sheets are heat-welded so as to form a hollow portion that becomes tapered from the rear end portion toward the front end portion. Next, after filling the cavity with the drug, the drug may be stored in the drug storage unit 12 by thermally welding the end of the opened cavity.
切断機構１８は、薬剤収納部１２の先端部からの一部および後端部からの一部を残してシートから切断することができる、すなわち、薬剤収納部１２の後端部の太い端面を切断せず、先端部の端面の一部を残すように切断することができるものであればよく、特に制限はない。例えば、図３に示すような、後端部から先端部に向かうにつれて細くなるテーパー状の袋状に構成されている薬剤収納部１２の後端部の太い端面を切断せず、先端部の細い端面の一部を残すように切断することができる略コの字型のカッター等が挙げられるが、これに限定されない。ここで、「切断」とは、カッター（刃物）等の切断器具により所定の形状に「断ち切る」ことの他に、薬剤収納容器１０のシート部に予め所定の形状に形成したミシン目や切欠きのような脆弱部に押圧器具等により力を加えて「押し破る」こと等も含む。 The cutting mechanism 18 can cut from the sheet leaving a part from the front end part and a part from the rear end part of the medicine storage part 12, that is, cutting a thick end surface of the rear end part of the medicine storage part 12. No limitation is imposed as long as it can be cut so as to leave a part of the end face of the tip portion. For example, as shown in FIG. 3, the thick end surface of the rear end part of the medicine storage part 12 configured in a tapered bag shape that becomes thinner from the rear end part toward the front end part is not cut, and the front end part is thin. Examples include, but are not limited to, a substantially U-shaped cutter that can be cut to leave a part of the end face. Here, “cutting” means “cutting” into a predetermined shape with a cutting tool such as a cutter (cutlery), and perforations or notches formed in a predetermined shape in the sheet portion of the medicine container 10 in advance. It also includes “pushing and breaking” by applying a force to the fragile part with a pressing device or the like.
切断機構１８による切断は、薬剤収納部１２の先端部の側に開口部４４を形成し、開口部４４以外からは薬剤が漏れないようにし、後端部の太い端面部に薬剤収納部１２が支持されて下方に垂れ下がるように切断すればよく、切断形状には特に制限はない。例えば、図３に示すように、後端部から先端部に向かうにつれて細くなるテーパー状の袋状に構成されている薬剤収納部１２の後端部の太い端面を切断せず、先端部の細い端面の一部を残すように、略コの字型の形状で切断すればよい。また、図７（ａ）に示すように、長方体等の袋状に構成されている薬剤収納部１２の後端部の太い端面を切断せず、先端部の一方の角部を残すような形状で切断してもよく、図７（ｂ）に示すように、長方体等の袋状に構成されている薬剤収納部１２の後端部の太い端面を切断せず、先端部の一部を切り欠くように残すような形状で切断してもよく、図７（ｃ）に示すように、長方体等の袋状に構成されている薬剤収納部１２の後端部の太い端面を切断せず、先端部の両方の角部を残すような形状で切断してもよい。図７（ｃ）の切断の場合、薬剤収納部１２の袋の中央部（図７（ｃ）において点線で示す）を境に両側が垂れ下がり、薬剤が落ちる機構としてもよい。 In the cutting by the cutting mechanism 18, an opening 44 is formed on the side of the distal end portion of the medicine storage portion 12 so that the medicine does not leak from other than the opening 44, and the medicine storage portion 12 is formed on the thick end surface portion of the rear end portion. What is necessary is just to cut | disconnect so that it may be supported and hang down below, and there is no restriction | limiting in particular in a cut shape. For example, as shown in FIG. 3, the distal end portion is thin without cutting the thick end surface of the rear end portion of the medicine container 12 that is configured in a tapered bag shape that becomes thinner from the rear end portion toward the distal end portion. What is necessary is just to cut | disconnect by a substantially U-shaped shape so that a part of end surface may be left. Further, as shown in FIG. 7A, the thick end face of the rear end portion of the medicine storage portion 12 configured in a bag shape such as a rectangular parallelepiped is not cut, and one corner portion of the front end portion is left. As shown in FIG. 7B, the thick end face of the rear end portion of the medicine storage portion 12 configured in a bag shape such as a rectangular parallelepiped is not cut, and the tip end portion is cut. It may be cut in a shape so as to leave a part cut away, and as shown in FIG. 7C, the rear end portion of the medicine storage portion 12 configured in a bag shape such as a rectangular parallelepiped is thick. You may cut | disconnect in a shape which does not cut | disconnect an end surface but leaves both corner | angular parts of a front-end | tip part. In the case of the cutting shown in FIG. 7C, a mechanism may be adopted in which both sides hang down from the center of the bag of the medicine container 12 (indicated by a dotted line in FIG. 7C) and the medicine falls.
切断機構１８による切断において、薬剤収納部１２の先端部の薬剤３２の量をできるだけ少なくして開封のときの切断精度を向上させることが好ましい。この場合、薬剤収納部１２の先端部の薬剤３２の量ができるだけ少なくなるように、例えば、先端部が少し高くなる傾斜状態または水平状態で切断することが好ましい。 In the cutting by the cutting mechanism 18, it is preferable to improve the cutting accuracy at the time of opening by reducing the amount of the medicine 32 at the tip of the medicine container 12 as much as possible. In this case, for example, it is preferable that the cutting is performed in an inclined state or a horizontal state in which the tip part is slightly raised so that the amount of the medicine 32 at the tip part of the medicine storage unit 12 is as small as possible.
切断機構１８により形成される開口部４４の大きさは、薬剤収納部１２内の薬剤３２ができるだけ飛散せずに流れ落ちることができる程度の大きさであればよく、特に制限はない。薬剤３２の粒径、粘度、容量等を考慮して、できるだけ小さくなるように決定すればよい。 The size of the opening 44 formed by the cutting mechanism 18 is not particularly limited as long as it is a size that allows the medicine 32 in the medicine storage part 12 to flow down without being scattered as much as possible. What is necessary is just to determine so that the particle size, viscosity, capacity | capacitance, etc. of the chemical | medical agent 32 may be considered as small as possible.
容器搬送機構１６は、薬剤収納容器１０の容器支持部１４に接続され、薬剤収納部１２を薬液調製装置１の薬液調製槽２０の槽開口部３６の上方（例えば、直上）に自動または手動で、好ましくは自動で搬送することができるものであればよく、特に制限はない。容器搬送機構１６は、例えば、シート状の薬剤収納容器１０の短手方向の両端部に形成された容器支持部１４（例えば、「穴」）を接続するためのピン等の支持部材を有する搬送用チェーンであり、容器支持部１４（例えば、「穴」）を接続したピンに引っ掛けることで動力を伝達し、薬剤収納容器１０を移動して、薬剤収納部１２が薬液調製槽２０の槽開口部３６の上方（例えば、直上）に搬送することができる。容器搬送機構１６は、その他に、例えば、薬剤収納容器の短手方向の両端が載る位置に滑りにくいレールを設け、このレールを動かす方法、薬剤収納容器の端を挟んで運搬する方法によるものであってもよい。 The container transport mechanism 16 is connected to the container support part 14 of the medicine container 10 and automatically or manually places the medicine container 12 above (for example, directly above) the tank opening 36 of the chemical liquid preparation tank 20 of the chemical liquid preparation apparatus 1. Preferably, any material can be used as long as it can be automatically conveyed, and there is no particular limitation. The container transport mechanism 16 includes, for example, a support member such as a pin for connecting the container support portions 14 (for example, “holes”) formed at both ends in the short direction of the sheet-like medicine storage container 10. Power is transmitted by hooking on a pin to which a container support 14 (for example, “hole”) is connected, and the drug storage container 10 is moved so that the drug storage 12 is opened in the tank of the drug solution preparation tank 20. It can be conveyed above the part 36 (for example, directly above). In addition, the container transport mechanism 16 is provided by, for example, a method in which a non-slip rail is provided at a position where both ends of the drug container are placed in the short direction, and the rail is moved, and the drug container is transported with the end of the drug container sandwiched between them. There may be.
容器支持部１４は、容器搬送機構１６に接続できる形態であればよく、特に制限はない。容器支持部１４は、例えば、穴であり、１つ以上の穴が、薬剤収納容器１０のシートの短手方向の両端部に沿って並んで形成されたものである。容器支持部１４は、その他に、例えば、突起であり、１つ以上の突起が、薬剤収納容器１０のシートの短手方向の両端部に沿って並んで形成されたものであってもよい。 The container support part 14 should just be a form which can be connected to the container conveyance mechanism 16, and there is no restriction | limiting in particular. The container support portion 14 is, for example, a hole, and one or more holes are formed side by side along both lateral ends of the sheet of the medicine storage container 10. In addition, the container support part 14 is a protrusion, for example, and one or more protrusions may be formed side by side along both lateral ends of the sheet of the medicine container 10.
容器搬送機構１６による薬剤収納部１２の位置決めは、その他に、例えば、画像処理（例えば、色や線等のアンカー検出による）、厚みセンサ等の方法により行ってもよい。 The positioning of the medicine container 12 by the container transport mechanism 16 may be performed by other methods such as image processing (for example, by detecting anchors such as colors and lines) and a thickness sensor.
制御装置は、ＣＰＵ等の制御素子を含んで構成され、循環ポンプ２２や、切断機構１８、容器搬送機構１６等を制御する機能を有する。 The control device includes a control element such as a CPU, and has a function of controlling the circulation pump 22, the cutting mechanism 18, the container transport mechanism 16, and the like.
薬液調製装置１は、その他、記憶部、ユーザインターフェース、入力部等のうち少なくとも１つをさらに備えてもよい。記憶部は、例えば、半導体メモリ、ハードディスク、光ディスク装置等の記憶装置を含んで構成され、制御装置で処理されるプログラム、データ等の電子情報を格納および保持することができる。ユーザインターフェースは、モニタやタッチパネル等を含んで構成され、ユーザからの制御装置に対する指示等を受け付けたり、ユーザに対する情報を提示したりするために用いられる。入力部は、キーボード、マウス、タッチパネル等を含んで構成され、ユーザから処理に用いられる各種情報を取得するために用いられる。ユーザインターフェースがタッチパネル等の入力部を含む場合には入力部を備えなくてもよい。 In addition, the chemical solution preparation apparatus 1 may further include at least one of a storage unit, a user interface, an input unit, and the like. The storage unit includes, for example, a storage device such as a semiconductor memory, a hard disk, and an optical disk device, and can store and hold electronic information such as programs and data processed by the control device. The user interface is configured to include a monitor, a touch panel, and the like, and is used for receiving an instruction from the user to the control device and presenting information to the user. The input unit includes a keyboard, a mouse, a touch panel, and the like, and is used to acquire various types of information used for processing from the user. When the user interface includes an input unit such as a touch panel, the input unit may not be provided.
薬剤３２は、例えば、固体型の薬剤であり、例えば、粉末状または顆粒状等にされたものである。薬剤３２は、固体型の他に、ゲル状態等のコロイド状態や、濃厚液状態等の液体の薬剤であってもよい。薬剤３２は、例えば、電解質成分、ｐＨ調整剤、糖質成分、アルカリ化成分のうち少なくとも１つを含む透析用剤である。 The drug 32 is, for example, a solid drug, and is, for example, powdered or granulated. The medicine 32 may be a solid medicine, a colloidal state such as a gel state, or a liquid medicine such as a concentrated liquid state. The drug 32 is a dialysis agent containing at least one of an electrolyte component, a pH adjuster, a saccharide component, and an alkalinizing component, for example.
電解質成分としては、例えば、塩化ナトリウム、塩化カリウム、塩化マグネシウム、塩化カルシウム、酢酸ナトリウム、クエン酸ナトリウム等が挙げられる。 Examples of the electrolyte component include sodium chloride, potassium chloride, magnesium chloride, calcium chloride, sodium acetate, sodium citrate and the like.
ｐＨ調整剤としては、クエン酸無水物、リンゴ酸、乳酸、フマル酸、コハク酸、マロン酸等の有機固体酸や、クエン酸ナトリウム等のクエン酸塩、酢酸ナトリウム、二酢酸ナトリウム等の酢酸塩、乳酸ナトリウム等の乳酸塩、リンゴ酸ナトリウム等のリンゴ酸塩、フマル酸ナトリウム等のフマル酸塩、コハク酸ナトリウム等のコハク酸塩、マロン酸ナトリウム等のマロン酸塩等の有機酸塩等が挙げられる。これらのうち、好ましいｐＨ調整剤としては、クエン酸無水物の他に、クエン酸一水和物、クエン酸ナトリウム無水物、クエン酸ナトリウム二水和物、酢酸、二酢酸ナトリウム、酢酸ナトリウム無水物である。 Examples of pH adjusters include organic solid acids such as citric anhydride, malic acid, lactic acid, fumaric acid, succinic acid and malonic acid, citrates such as sodium citrate, acetates such as sodium acetate and sodium diacetate. , Lactates such as sodium lactate, malates such as sodium malate, fumarate such as sodium fumarate, succinate such as sodium succinate, organic acid salts such as malonate such as sodium malonate, etc. Can be mentioned. Among these, as a preferable pH adjuster, in addition to citric acid anhydride, citric acid monohydrate, sodium citrate anhydride, sodium citrate dihydrate, acetic acid, sodium diacetate, sodium acetate anhydride It is.
糖質成分としては、無水結晶ブドウ糖等のブドウ糖等が挙げられる。 Examples of the saccharide component include glucose such as anhydrous crystalline glucose.
アルカリ化成分としては、例えば、炭酸水素ナトリウム（重炭酸ナトリウム）等が挙げられる。 Examples of the alkalinizing component include sodium bicarbonate (sodium bicarbonate).
溶媒３０としては、例えば、水である。 An example of the solvent 30 is water.
用いる溶媒３０の量、すなわち薬液調製槽２０に予め貯留して溶媒３０の量は、例えば、薬剤収納部１２内に収納された薬剤３２の量を溶媒３０に混合した場合に、薬液として適した溶液成分濃度が得られるように設定された量とすればよい。 The amount of the solvent 30 to be used, that is, the amount of the solvent 30 stored in advance in the chemical solution preparation tank 20 is suitable as a chemical solution, for example, when the amount of the drug 32 stored in the drug storage unit 12 is mixed with the solvent 30. What is necessary is just to set it as the quantity set so that solution component concentration may be obtained.
溶媒の温度は、例えば、１０℃〜５０℃の範囲であればよい。 The temperature of the solvent may be in the range of 10 ° C to 50 ° C, for example.
薬液調製装置１の動作時の流量は、薬液調製槽２０内の薬剤３２と溶媒３０との混合液が循環配管３４を通して移動可能な流量であればよく、特に制限はないが、例えば、５リットル毎分〜４０リットル毎分の範囲とすればよい。 The flow rate during operation of the chemical solution preparation apparatus 1 is not particularly limited as long as the mixed solution of the drug 32 and the solvent 30 in the chemical solution preparation tank 20 can move through the circulation pipe 34. What is necessary is just to set it as the range for every minute-40 liters per minute.
１ 薬液調製装置、１０ 薬剤収納容器、１２ 薬剤収納部、１４ 容器支持部、１６ 容器搬送機構、１８ 切断機構、２０ 薬液調製槽、２２ 循環ポンプ、２４，２６ 配管、２８ ガイド部、３０ 溶媒、３２ 薬剤、３４ 循環配管、３６ 槽開口部、３８ 分岐配管、４０ 排出バルブ、４２ 濃度計、４４ 開口部、４６ 溶媒供給配管、４８ 溶媒供給量測定装置。 DESCRIPTION OF SYMBOLS 1 Chemical solution preparation apparatus, 10 chemical | medical agent storage container, 12 chemical | medical agent storage part, 14 container support part, 16 container conveyance mechanism, 18 cutting | disconnection mechanism, 20 chemical | medical solution preparation tank, 22 circulation pump, 24, 26 piping, 28 guide part, 30 solvent, 32 chemicals, 34 circulation piping, 36 tank opening, 38 branch piping, 40 discharge valve, 42 densitometer, 44 opening, 46 solvent supply piping, 48 solvent supply amount measuring device.
Claims (9)
前記薬剤収納部は、袋状に構成されており、
前記薬剤収納容器を支持するための容器支持部を有することを特徴とする薬剤収納容器。 A medicine storage container in which a plurality of medicine storage parts are connected in a single sheet,
The medicine container is configured in a bag shape,
A drug storage container comprising a container support for supporting the drug storage container.
前記薬剤収納部は、後端部から先端部に向かうにつれて細くなる袋状に構成されていることを特徴とする薬剤収納容器。 The medicine storage container according to claim 1,
The medicine storage container, wherein the medicine storage part is configured in a bag shape that becomes thinner from the rear end part toward the front end part.
前記容器支持部は、穴または突起であり、１つ以上の前記穴または突起が、前記薬剤収納容器のシートの短手方向の両端部に沿って並んで形成されたものであることを特徴とする薬剤収納容器。 The medicine container according to claim 1 or 2,
The container support portion is a hole or a protrusion, and one or more of the holes or protrusions are formed side by side along both ends in the short direction of the sheet of the medicine container. Medicine storage container.
前記薬剤と前記溶媒との混合液を収容可能な薬液調製槽と、
前記薬液調製槽から排出された前記薬剤と前記溶媒との混合液をさらに前記薬液調製槽に循環供給するための循環配管を有する循環手段と、
薬剤がそれぞれに収納された複数の薬剤収納部が１つのシート状に連結されており、前記薬剤収納部が袋状に構成されている薬剤収納容器における、前記薬剤収納容器を支持するための容器支持部を支持して動力を伝達することにより、前記薬剤収納容器の各薬剤収納部を前記薬液調製槽の上まで搬送する容器搬送機構と、
を備えることを特徴とする薬液調製装置。 A chemical solution preparation apparatus for preparing a chemical solution by adjusting a drug to a predetermined concentration with a solvent,
A chemical solution preparation tank capable of accommodating a mixed solution of the drug and the solvent;
A circulation means having a circulation pipe for circulating and supplying the mixed solution of the medicine and the solvent discharged from the chemical solution preparation tank to the chemical solution preparation tank;
A container for supporting the medicine storage container in a medicine storage container in which a plurality of medicine storage parts each containing a medicine are connected in a sheet shape and the medicine storage part is configured in a bag shape. A container transport mechanism for transporting each drug storage part of the drug storage container to the top of the chemical solution preparation tank by transmitting power by supporting the support part;
A chemical solution preparation apparatus comprising:
前記薬剤収納部は、後端部から先端部に向かうにつれて細くなる袋状に構成されていることを特徴とする薬液調製装置。 It is a chemical | medical solution preparation apparatus of Claim 4, Comprising:
The drug solution preparing device is characterized in that the drug container is configured in a bag shape that becomes thinner from the rear end toward the tip.
前記容器支持部は、穴または突起であり、１つ以上の前記穴または突起が、前記薬剤収納容器のシートの短手方向の両端部に沿って並んで形成されたものであることを特徴とする薬液調製装置。 It is a chemical | medical solution preparation apparatus of Claim 4 or 5,
The container support portion is a hole or a protrusion, and one or more of the holes or protrusions are formed side by side along both ends in the short direction of the sheet of the medicine container. A chemical preparation device.
循環配管を通して、薬液調製槽から排出された前記薬剤と前記溶媒との混合液をさらに前記薬液調製槽に循環供給して循環する循環工程を含み、
薬剤がそれぞれに収納された複数の薬剤収納部が１つのシート状に連結されており、前記薬剤収納部が袋状に構成されている薬剤収納容器における、前記薬剤収納容器を支持するための容器支持部を支持して動力を伝達することにより、前記薬剤収納容器の各薬剤収納部を前記薬液調製槽の上まで搬送することを特徴とする薬液調製方法。 A chemical solution preparation method for preparing a chemical solution by adjusting a drug to a predetermined concentration with a solvent,
Including a circulation step of circulating and supplying a mixed solution of the drug and the solvent discharged from the chemical solution preparation tank to the chemical preparation tank through a circulation pipe,
A container for supporting the medicine storage container in a medicine storage container in which a plurality of medicine storage parts each containing a medicine are connected in a sheet shape and the medicine storage part is configured in a bag shape. A method for preparing a drug solution, wherein each drug container of the drug container is conveyed onto the drug solution tank by supporting a support unit and transmitting power.
前記薬剤収納部は、後端部から先端部に向かうにつれて細くなる袋状に構成されていることを特徴とする薬液調製方法。 It is the chemical | medical solution preparation method of Claim 7, Comprising:
The method for preparing a drug solution, wherein the medicine container is configured in a bag shape that becomes thinner from the rear end to the front end.
前記容器支持部は、穴または突起であり、１つ以上の前記穴または突起が、前記薬剤収納容器のシートの短手方向の両端部に沿って並んで形成されたものであることを特徴とする薬液調製方法。 A method for preparing a chemical solution according to claim 7 or 8,
The container support portion is a hole or a protrusion, and one or more of the holes or protrusions are formed side by side along both ends in the short direction of the sheet of the medicine container. To prepare a chemical solution.
Priority Applications (1)
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006158823A (en) * | 2004-12-10 | 2006-06-22 | Nikkiso Co Ltd | Dialysis agent storing container |
| JP2006271835A (en) * | 2005-03-30 | 2006-10-12 | Nikkiso Co Ltd | Apparatus for dissolving medical agent |
| JP2008245603A (en) * | 2007-03-30 | 2008-10-16 | Iseki & Co Ltd | Seeding machine |
| JP2013514099A (en) * | 2009-12-16 | 2013-04-25 | フレゼニウス メディカル ケア ドイチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング | Double room bag |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006158823A (en) * | 2004-12-10 | 2006-06-22 | Nikkiso Co Ltd | Dialysis agent storing container |
| JP2006271835A (en) * | 2005-03-30 | 2006-10-12 | Nikkiso Co Ltd | Apparatus for dissolving medical agent |
| JP2008245603A (en) * | 2007-03-30 | 2008-10-16 | Iseki & Co Ltd | Seeding machine |
| JP2013514099A (en) * | 2009-12-16 | 2013-04-25 | フレゼニウス メディカル ケア ドイチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング | Double room bag |
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