JP2021000354A - Dissolving apparatus - Google Patents
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- 238000000502 dialysis Methods 0.000 claims abstract description 116
- 239000011550 stock solution Substances 0.000 claims abstract description 68
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 52
- 238000003860 storage Methods 0.000 claims abstract description 34
- 238000001514 detection method Methods 0.000 claims abstract description 14
- 239000000243 solution Substances 0.000 claims abstract description 12
- 238000002156 mixing Methods 0.000 claims abstract description 5
- 238000004090 dissolution Methods 0.000 claims description 69
- 239000000843 powder Substances 0.000 claims description 29
- 239000007788 liquid Substances 0.000 claims description 13
- 238000002844 melting Methods 0.000 claims description 7
- 230000008018 melting Effects 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 4
- 239000008280 blood Substances 0.000 description 14
- 210000004369 blood Anatomy 0.000 description 14
- 238000000746 purification Methods 0.000 description 6
- 238000010586 diagram Methods 0.000 description 4
- 239000000385 dialysis solution Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000002934 lysing effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- 238000000227 grinding Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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本発明は、透析用粉末薬剤を溶解して所定濃度の透析用原液を作製するための溶解装置に関する。 The present invention relates to a dissolving device for dissolving a dialysis powder drug to prepare a dialysis stock solution having a predetermined concentration.
血液透析治療は、透析患者の血液を体外循環路に取出して血液浄化器に導き入れ、血液浄化器内で半透膜を介して透析液と接触させ、限外濾過と拡散の原理によって、血液中の老廃物や余剰水分を除去するとともに、透析液中に含まれる薬剤成分によって血液中の電解質の調整等を行った後、浄化された血液を患者の体内に戻す治療である。 In hemodialysis treatment, the blood of a dialysis patient is taken out into the extracorporeal circulation route and introduced into a blood purifier, and the blood is brought into contact with the dialysate through a semitransparent membrane in the blood purifier. It is a treatment that removes waste products and excess water in the blood, adjusts the electrolyte in the blood with the drug component contained in the dialysate, and then returns the purified blood to the patient's body.
透析治療で用いられる透析液は、Ａ原液とＢ原液という異なる２種類の濃縮薬液と、高度に清浄化された清浄水（ＲＯ水）とを、製薬メーカの指定した比率で混合させて調製される。一人の患者の治療に 毎分５００〜８００ｍＬの透析液を、一回の治療時間である ３〜４時間のあいだ血液浄化器へ向けて流し続ける必要がある。 The dialysate used in dialysis treatment is prepared by mixing two different concentrated chemicals, A stock solution and B stock solution, and highly purified clean water (RO water) at a ratio specified by the pharmaceutical manufacturer. To. For the treatment of one patient, 500-800 mL of dialysate per minute should continue to flow into the blood purifier for 3-4 hours, which is the duration of one treatment.
Ａ原液とＢ原液とは、過去には専用の密閉ポリ容器に充填した液状の『リキッドタイプ』として流通していたが、透析施設に広い保管スペースが必要となり、重量物である薬液容器の搬送に関する医療スタッフの負担が大きく、さらに経時的に薬液成分が劣化する懸念などを理由として『粉末化』が試みられ、現在は軟質の包袋に充填された透析用粉末剤を清浄水で溶解して透析用原液を得ることが一般的となっている。 In the past, the A stock solution and the B stock solution were distributed as a liquid "liquid type" filled in a dedicated closed plastic container, but a large storage space is required in the dialysis facility, and the heavy chemical liquid container is transported. "Powdering" has been attempted because of the heavy burden on medical staff and the concern that the chemical components will deteriorate over time. Currently, the dialysis powder packed in a soft container is dissolved in clean water. It is common to obtain a stock solution for dialysis.
『粉末化』の当初は、２００Ｌ程度のタンクに医療スタッフが透析用粉末剤を投入して洗浄水で希釈・混合していたが、大量の透析用原液を溜め置くことは衛生的ではなく、混合・撹拌作業中に大気中の浮遊菌の混入が懸念され、さらに医療スタッフの作業負担も大きいことから、特許文献１のような、紛体の供給から溶解までを自動で行うことができる溶解装置が開発され、今ではこの溶解装置は、血液浄化システムにとっては欠かせないものとなっている。 At the beginning of "powdering", medical staff put dialysis powder into a tank of about 200 L and diluted and mixed it with washing water, but it is not hygienic to store a large amount of dialysis stock solution. Since there is a concern that airborne bacteria may be mixed in during the mixing / stirring work and the work load of the medical staff is heavy, a dissolving device capable of automatically performing from the supply of the powder to the dissolution as in Patent Document 1. Has been developed and is now an integral part of the blood purification system.
一般的な溶解装置は、医療スタッフにより、２０〜３０袋分の透析用粉末剤が包袋を開封されて粉末剤供給部の上部のホッパーに投入され、上限水位と下限水位を予め設定して固定した溶解槽に、この水位間分の一定量の加温した清浄水を導入して、清浄水を撹拌させながら、ホッパー下部のスクリューフィーダを回転させて透析用粉末剤を自動投入しながら、溶解槽の循環ラインに設置した電導度計で濃度を測定して、所定の濃度になるように調整する。作製された透析用原液は、溶解槽の下流の貯留槽が受入可能な状態であることを条件として貯留槽へ移送され、溶解槽での次回の溶解動作を可能にする。 In a general dissolving device, 20 to 30 bags of dialysis powder are opened by medical staff and put into the hopper at the top of the powder supply unit, and the upper and lower water levels are set in advance. While introducing a certain amount of warmed clean water between the water levels into the fixed dissolution tank and stirring the clean water, the screw feeder at the bottom of the hopper is rotated to automatically add the dialysis powder. Measure the concentration with a conductivity meter installed in the circulation line of the melting tank and adjust it to the specified concentration. The prepared stock solution for dialysis is transferred to the storage tank on condition that the storage tank downstream of the dissolution tank is in an acceptable state, and enables the next dissolution operation in the dissolution tank.
水位検知用の検知手段に汎用で安価な液面計を適用でき、その検知精度も十分に信頼できるレベルであることかあら、このように毎回溶解槽で一定量の透析用原液を作製するいわゆる『バッチ式』の溶解装置が広く普及している。 A general-purpose and inexpensive liquid level gauge can be applied to the detection means for water level detection, and the detection accuracy is at a sufficiently reliable level. In this way, a fixed amount of undiluted solution for dialysis is prepared in the dissolution tank every time. "Batch type" melting equipment is widely used.
医療スタッフによるホッパーへの透析用粉末剤の投入作業を一度に完了させるため、多くの粉末剤を投入できるようホッパーはある程度の容積を有することが望ましいが、溶解された時点から経時的な変化や劣化が懸念される透析用原液の作製量や貯留量は少ないことが望ましい。血液浄化システムでの透析液の使用量を賄える溶解を行うとともに、可能な限り小分けした溶解を行うために、溶解装置の溶解槽の容積は１０Ｌ以下とされることが多い。 In order to complete the work of adding dialysis powder to the hopper by medical staff at once, it is desirable that the hopper has a certain volume so that a large amount of powder can be added, but it may change over time from the time of dissolution. It is desirable that the amount of dialysis stock solution produced and stored, which may deteriorate, is small. In many cases, the volume of the dissolution tank of the dissolution device is 10 L or less in order to perform dissolution that can cover the amount of dialysate used in the blood purification system and to perform dissolution in as small portions as possible.
いわゆるバッチ式の溶解装置では、はじめからある程度の余剰分の透析用原液を作製することを想定していたものの、経時的な変化や劣化によって次回の透析治療に使用することができずに廃棄せざるを得ないこの余剰分の透析用原液について、コスト面や環境面から、可能な限り少なく抑えることができる溶解装置が求められている。 In the so-called batch-type dissolution device, it was assumed from the beginning that a certain amount of excess dialysis stock solution would be prepared, but due to changes and deterioration over time, it could not be used for the next dialysis treatment and was discarded. There is a need for a dissolution device that can reduce the excess amount of undiluted solution for dialysis as much as possible from the viewpoint of cost and environment.
透析治療が終了するまでに必要な透析液量に合わせて透析用原液を作製して、完全に近い形で使い切るのが望ましいが、バッチ式の溶解装置は毎回の使用量が一定であることから、このような仕様を叶えることはできず、最悪の場合、ほぼ１バッチ分の透析用原液を廃棄せざるを得ない。 It is desirable to prepare a stock solution for dialysis according to the amount of dialysate required by the end of dialysis treatment and use it up in a nearly complete form, but since the amount used each time is constant for batch-type dissolution equipment. However, such specifications cannot be achieved, and in the worst case, almost one batch of undiluted solution for dialysis must be discarded.
本発明は、バッチ式の溶解装置において、透析治療終了時に大量の透析用原液が残ってしまうという事態を解消できる溶解装置を提供する。 The present invention provides a batch-type lysing device capable of eliminating a situation in which a large amount of undiluted dialysis solution remains at the end of dialysis treatment.
上記課題を解決するために、本発明に係る溶解装置は、透析用粉末剤供給手段、下限水位検知手段、上限水位検知手段および濃度測定手段を備え、供給された透析用粉末剤および清浄水を溶解混合して透析用原液を作製する溶解槽と、受入水位検知手段を備えた貯留槽と、前記透析用原液を前記溶解槽から前記貯留槽へ移送する移送手段と、前記透析用原液を前記貯留槽から下流側へ送液する送液手段と、を備えたバッチ式の溶解装置であって、前記透析用原液が溶解槽の上限水位に達し、かつ、前記透析用原液が前記貯留槽の受入可能水位にあることを条件として、透析治療を終了するまでに使用される前記透析用原液の推定使用量を算出する算出手段を備えたことを特徴とするものからなる。このような溶解装置によれば、透析用原液を無駄なく使用できるよう計画的に作製することができる。 In order to solve the above problems, the dissolving device according to the present invention includes a dialysis powder supply means, a lower limit water level detecting means, an upper limit water level detecting means and a concentration measuring means, and supplies the supplied dialysis powder and clean water. A dissolution tank for preparing a stock solution for dialysis by dissolving and mixing, a storage tank provided with receiving water level detecting means, a transfer means for transferring the stock solution for dialysis from the dissolution tank to the storage tank, and the stock solution for dialysis. A batch-type dissolution device provided with a liquid feeding means for sending liquid from the storage tank to the downstream side, wherein the dialysis stock solution reaches the upper limit water level of the dissolution tank and the dialysis stock solution is in the storage tank. It is characterized by being provided with a calculation means for calculating an estimated amount of the undiluted solution for dialysis used until the end of dialysis treatment, provided that the water level is acceptable. According to such a dissolving device, the stock solution for dialysis can be systematically prepared so that it can be used without waste.
本発明に係る溶解装置の一態様として、前記算出手段が算出した透析治療を終了するまでに使用される前記透析用原液の推定使用量が１バッチ分の透析用原液作製量の１倍以上２倍未満である場合に、予め設定した１バッチ未満の所定量の前記透析用原液を前記溶解槽から前記貯留槽に移送した後、前記溶解槽の上限水位に達するまで清浄水を前記溶解槽に導入し、前記透析用粉末剤を前記溶解槽に供給して前記透析用原液をさらに作製する構成が採用できる。具体的には、前記１バッチ未満の所定量の前記透析用原液を、予め設定した運転時間または回転数で作動する移送ポンプで前記溶解槽から前記貯留槽へ移送する態様が採用可能であり、あるいは前記移送手段に設けられた開閉弁を予め設定した時間だけ開くことにより、前記１バッチ未満の所定量の前記透析用原液を前記溶解槽から前記貯留槽へ移送する態様も採用可能である。 As one aspect of the dissolution apparatus according to the present invention, the estimated amount of the dialysis stock solution used until the completion of the dialysis treatment calculated by the calculation means is one or more times the amount of the dialysis stock solution prepared for one batch. If it is less than double, after transferring a predetermined amount of the dialysis stock solution of less than one batch preset from the dissolution tank to the storage tank, clean water is poured into the dissolution tank until the upper limit water level of the dissolution tank is reached. A configuration can be adopted in which the dialysis powder is introduced and the dialysis powder is supplied to the dissolution tank to further prepare the dialysis stock solution. Specifically, it is possible to adopt a mode in which a predetermined amount of the dialysis stock solution less than one batch is transferred from the dissolution tank to the storage tank by a transfer pump that operates at a preset operation time or rotation speed. Alternatively, a mode in which a predetermined amount of the dialysis stock solution less than one batch is transferred from the dissolution tank to the storage tank can be adopted by opening the on-off valve provided in the transfer means for a preset time.
本発明に係る溶解装置の他の態様として、前記算出手段が算出した透析治療を終了するまでに使用される前記透析用原液の推定使用量が１バッチ分の透析用原液作製量の１倍以上２倍未満である場合に、前記推定使用量から１バッチ分の透析用原液作製量を差し引いた量に予め設定した量を加算した量の前記透析用原液を前記溶解槽から前記貯留槽に移送した後、前記溶解槽の上限水位に達するまで清浄水を前記溶解槽に導入し、前記透析用粉末剤を前記溶解槽に供給して前記透析用原液をさらに作製する構成も採用できる。 As another aspect of the dissolving apparatus according to the present invention, the estimated amount of the dialysis stock solution used until the completion of the dialysis treatment calculated by the calculation means is one or more times the amount of the dialysis stock solution prepared for one batch. When it is less than twice, the dialysis stock solution in an amount obtained by subtracting the preparation amount of the dialysis stock solution for one batch from the estimated usage amount plus a preset amount is transferred from the dissolution tank to the storage tank. After that, clean water is introduced into the dissolution tank until the upper limit water level of the dissolution tank is reached, and the dialysis powder is supplied to the dissolution tank to further prepare the stock solution for dialysis.
本発明に係る溶解装置によれば、透析用原液を無駄なく使用できるよう計画的に作製することができる。 According to the dissolving apparatus according to the present invention, the undiluted solution for dialysis can be systematically produced so that it can be used without waste.
図１は、本発明の透析用粉末剤溶解装置の構成を示す。溶解槽１と貯留槽２が設置され、溶解槽の上部には粉末剤供給部３が設置される。溶解槽には上限水位センサ４と下限水位センサ５が設けられ、溶解槽から貯留槽への移送ライン６には移送ポンプ７が設けられ、移送ラインから分岐した循環ライン９には、透析用原液の濃度を測定する濃度測定手段８が設置される。貯留槽には少なくとも貯留槽が空の状態を検知する受入水位検知センサ１０が設置されるとともに、血液浄化システムにおける下流の装置へ透析用原液を供給する送液ポンプ１２が設置された送液ライン１１が接続される。
FIG. 1 shows the configuration of the powder agent dissolving device for dialysis of the present invention. A dissolution tank 1 and a
医療スタッフによって包袋が開封された透析用粉末剤が、粉末剤供給部の上部のホッパーに投入される。溶解装置は、医療スタッフによる溶解開始スイッチの操作や、血液浄化システム内の他の装置からの溶解開始信号の受信等によって溶解動作を開始する。図示しないが、血液浄化システム内の逆浸透式精製水製造装置（以下ＲＯ装置ともいう）で精製されたＲＯ水が、設定温度まで加温された状態で溶解槽へ供給され、溶解槽は上限水位検知センサによって、１バッチ分の透析用原液を作製するのに必要な量のＲＯ水を受け入れる。粉末供給部には、透析用粉末剤を少量ずつ切り出せる、例えばスクリューフィーダのような供給部材が設けられ、溶解槽のＲＯ水を撹拌・循環させ、循環ラインの濃度計で濃度を測定しながら、粉末供給部は透析用粉末剤を溶解槽へ投入し、予め設定した濃度の透析用原液を作製する。 The dialysis powder whose packaging bag has been opened by the medical staff is put into the hopper at the upper part of the powder supply unit. The dissolution device starts the dissolution operation by operating the dissolution start switch by the medical staff, receiving the dissolution start signal from another device in the blood purification system, and the like. Although not shown, RO water purified by a reverse osmosis type purified water production device (hereinafter also referred to as RO device) in a blood purification system is supplied to a dissolution tank while being heated to a set temperature, and the upper limit of the dissolution tank is The water level detection sensor receives the amount of RO water required to prepare a batch of undiluted dialysis solution. The powder supply unit is provided with a supply member such as a screw feeder that can cut out dialysis powder little by little, agitates and circulates RO water in the dissolution tank, and measures the concentration with a concentration meter on the circulation line. , The powder supply unit puts the dialysis powder into the dissolution tank to prepare a dialysis stock solution having a preset concentration.
図２は、透析用原液の作製が完了し、さらに貯留槽の水位が溶解槽からの移送が可能な状態を示す。このとき、溶解装置内に透析用原液は常に１バッチ分が残されており、溶解装置はこの状態で、現時点から透析治療を終了するまでに使用する予定の透析用原液の量を算出する。透析用原液の使用予定量は、血液浄化システムの中央管理サーバが保有する、透析装置の稼働台数・患者人数・現在時刻・透析完了時刻に基づく方法や、溶解動作を起動する間隔から時間当たりの透析用原液の減り方を求めて、透析終了の時刻までの使用量を算出する方法、過去の透析治療における、曜日・患者数・時刻ごとの透析用原液消費実績データなどと照合する方法などが考えられる。 FIG. 2 shows a state in which the preparation of the stock solution for dialysis is completed and the water level in the storage tank can be transferred from the dissolution tank. At this time, one batch of the dialysis stock solution is always left in the lysing device, and the lysing device calculates the amount of the dialysis stock solution to be used from the present time until the end of the dialysis treatment in this state. The planned amount of undiluted solution for dialysis is based on the number of operating dialysis machines, the number of patients, the current time, and the completion time of dialysis held by the central management server of the blood purification system, and the interval per hour from the interval at which the dissolution operation is started. There are methods such as finding how to reduce the amount of dialysis stock solution and calculating the amount used until the end of dialysis, and collating it with past dialysis treatment data such as the actual consumption data of dialysis stock solution for each day, number of patients, and time. Conceivable.
算出した透析用原液の使用予定量と、１バッチ分の透析用原液作製量とを比較して、使用予定量が２バッチ分を超えている場合は、溶解槽の全ての透析用原液を貯留槽へ移送して、通常の溶解動作を再開する。 Compare the calculated amount of dialysis stock solution to be used for one batch of dialysis stock solution, and if the amount to be used exceeds two batches, store all dialysis stock solutions in the dissolution tank. Transfer to the tank and resume normal melting operation.
透析用原液の使用予定量が、１バッチ以上で且つ２バッチ未満の場合、使用予定量から１バッチ分の差し引いた容積を算出し、その容積に若干量を加算した量の透析用原液を、溶解槽から貯留槽へ移送する。この移送量は、移送ポンプの駆動時間・移送ポンプの駆動モータの回転数・移送弁の開放時間などで調整する。図３は、１バッチ未満の透析用原液を溶解槽から貯留槽へ移送した状態を示す。 When the planned amount of dialysis stock solution is 1 batch or more and less than 2 batches, the volume obtained by subtracting 1 batch from the planned use amount is calculated, and the amount of dialysis stock solution obtained by adding a small amount to the volume is used. Transfer from the melting tank to the storage tank. This transfer amount is adjusted by the drive time of the transfer pump, the rotation speed of the drive motor of the transfer pump, the opening time of the transfer valve, and the like. FIG. 3 shows a state in which less than one batch of undiluted dialysis solution is transferred from the dissolution tank to the storage tank.
図４のように、１バッチ未満の透析用原液の移送を完了してから、再び溶解槽の水位が上限になるまでＲＯ水を導入してから、通常の溶解動作と同様に溶解槽内の液体を撹拌・循環させ、濃度を測定しながら粉末剤を投入して、貯留槽に移送した透析用原液と同量の、追加作成分２１の透析用原液を作製して、以降は溶解動作を行わずに透析治療の終了を迎える。 As shown in FIG. 4, after completing the transfer of less than one batch of undiluted dialysis solution, RO water is introduced again until the water level in the dissolution tank reaches the upper limit, and then in the dissolution tank in the same manner as in the normal dissolution operation. The liquid is stirred and circulated, the powder is added while measuring the concentration, and the same amount of the dialysis stock solution as the dialysis stock solution transferred to the storage tank is prepared, and the dissolution operation is performed thereafter. The end of dialysis treatment is reached without doing so.
本発明は、透析用原液を作製するための溶解装置として広く利用可能である。 The present invention can be widely used as a dissolving device for preparing a stock solution for dialysis.
１ 溶解槽
２ 貯留槽
３ 粉末剤供給部
４ 上限水位検知センサ
５ 下限水位検知センサ
６ 移送ライン
７ 移送ポンプ
８ 濃度測定手段
９ 循環ライン
１０ 受入水位検知センサ
１１ 送液ライン
１２ 送液ポンプ
１３ スクリューフィーダ
１４ モータ
１５ 循環弁
１６ 移送弁
１７ 送液弁
１８ エアフィルタ
１９ 透析用粉末剤
２０ 透析用原液
２１ 追加作製分
1
Claims (5)
受入水位検知手段を備えた貯留槽と、
前記透析用原液を前記溶解槽から前記貯留槽へ移送する移送手段と、
前記透析用原液を前記貯留槽から下流側へ送液する送液手段と、を備えたバッチ式の溶解装置であって、
前記透析用原液が溶解槽の上限水位に達し、かつ、前記透析用原液が前記貯留槽の受入可能水位にあることを条件として、透析治療を終了するまでに使用される前記透析用原液の推定使用量を算出する算出手段を備えたことを特徴とする溶解装置。 A dissolution tank provided with a dialysis powder supply means, a lower limit water level detection means, an upper limit water level detection means and a concentration measuring means, and prepared by dissolving and mixing the supplied dialysis powder and clean water to prepare a stock solution for dialysis.
A storage tank equipped with a receiving water level detection means,
A transfer means for transferring the undiluted solution for dialysis from the dissolution tank to the storage tank, and
A batch-type dissolution device including a liquid feeding means for feeding the stock solution for dialysis from the storage tank to the downstream side.
Estimating the dialysis stock solution to be used until the end of dialysis treatment, provided that the dialysis stock solution reaches the upper limit water level of the dissolution tank and the dialysis stock solution is at the acceptable water level of the storage tank. A melting device provided with a calculation means for calculating the amount used.
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| DE102013220274B4 (en) | 2012-10-17 | 2021-10-21 | Toyota Boshoku Kabushiki Kaisha | OIL MIST SEPARATOR |
| JP7464866B2 (en) | 2022-06-20 | 2024-04-10 | 東亜ディーケーケー株式会社 | Dissolving Equipment |
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| JP2001009026A (en) * | 1999-06-30 | 2001-01-16 | Nikkiso Co Ltd | Dissolving device and its use method |
| JP2007236532A (en) * | 2006-03-07 | 2007-09-20 | Nikkiso Co Ltd | Dissolution apparatus and dissolution method by that |
| JP2017169779A (en) * | 2016-03-23 | 2017-09-28 | 東亜ディーケーケー株式会社 | Dissolution apparatus |
| US20170304519A1 (en) * | 2014-10-25 | 2017-10-26 | Fresenius Medical Care Deutschland Gmbh | Method And Device For Supplying Dialysis Liquid To A Dialysis Apparatus |
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| JP2001009026A (en) * | 1999-06-30 | 2001-01-16 | Nikkiso Co Ltd | Dissolving device and its use method |
| JP2007236532A (en) * | 2006-03-07 | 2007-09-20 | Nikkiso Co Ltd | Dissolution apparatus and dissolution method by that |
| US20170304519A1 (en) * | 2014-10-25 | 2017-10-26 | Fresenius Medical Care Deutschland Gmbh | Method And Device For Supplying Dialysis Liquid To A Dialysis Apparatus |
| JP2017169779A (en) * | 2016-03-23 | 2017-09-28 | 東亜ディーケーケー株式会社 | Dissolution apparatus |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102013220274B4 (en) | 2012-10-17 | 2021-10-21 | Toyota Boshoku Kabushiki Kaisha | OIL MIST SEPARATOR |
| JP7464866B2 (en) | 2022-06-20 | 2024-04-10 | 東亜ディーケーケー株式会社 | Dissolving Equipment |
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