JP7046626B2 - Drug storage container and drug solution preparation method - Google Patents

Description

The present invention is mainly used for preparing a dialysate used for artificial dialysis, and a drug storage container for storing a drug such as a powdery or granular solid dialysis agent, and a drug storage container for storing the drug. The present invention relates to a drug solution preparing device for adjusting the concentration of the drug solution, and a method for preparing the drug solution.

The dialysis agent is an agent for preparing a dialysate. Dialysis fluid is used to remove waste products from body fluids by replacing the functions originally performed by the kidneys by hemodialysis, hemofiltration, peritoneal dialysis, etc., and in some cases to supplement the necessary components in the blood. An aqueous solution having a similar electrolyte composition.

Current dialysis agents are generally sodium chloride, potassium chloride, magnesium chloride, calcium chloride, which are electrolyte components including sodium ion, potassium ion, etc., glucose, and pH regulators (eg, acetic acid and sodium acetate). Or a mixture thereof, or a "dialysis agent A" containing citrate and sodium citrate, etc.) and a "dialysis agent B" containing sodium hydrogen carbonate.

There are two types of dialysis agents, a liquid type and a solid type. Since most of the liquid type dialysis agent is occupied by water and the weight and volume are large, the load of the transportation work to the dialysis medical staff is large and the storage space is also large. Therefore, in recent years, when a dialysate is used, a solid-type dialysate that is put into an automatic drug-dissolving device and dissolved in water to prepare a dialysate has rapidly become widespread. Currently, there are two types of containers for storing this solid type dialysis agent: bag type and bottle type.

For example, Patent Document 1 proposes a drug dissolving device using a bag-type drug storage container. Since the bag-type drug storage container is made of a flexible sheet material in the bag body, there is an advantage that the bulkiness after use can be reduced. However, in the bag-type drug storage container, it is difficult to open the container support and position the drug to be transferred to the dissolution tank of the drug dissolving device, and there is some difficulty in applicability to the automatic drug dissolving device. In addition, since the bag-type drug storage container is attached to the hanging rail one by one, there is a risk of mistaken injection of the drug. Furthermore, there is room for improvement in that the surroundings of the drug dissolving device may be contaminated due to the scattering of the drug when the drug is added.

If the bottle-type drug storage container is set in an automatic drug-dissolving device, dialysate can be prepared fully automatically, and the possibility of quantity difference and foreign matter contamination is lower than that of the bag-type drug storage container. Further, in the bottle type, it is possible to prevent an error in charging the drug by changing the bottle size depending on the type of the drug and the like. However, since the bottle is made of a material having higher rigidity than the bag type, there is a problem that even if the bottle is emptied after use, it is difficult to crush it to reduce its capacity and it becomes bulky when it is disposed of as garbage.

Japanese Patent No. 4766898

An object of the present invention is excellent applicability to an automatic drug solution preparing device, the bulkiness during storage and after use can be reduced as in the bag type, and the risk of drug injection error is prevented as in the bottle type. It is an object of the present invention to provide a drug storage container which can be used, a drug solution preparation device using the drug storage container, and a drug solution preparation method.

The present invention is a drug storage container in which a plurality of drug storage units are connected in a single sheet shape, and the drug storage unit is configured in a bag shape and is a container for supporting the drug storage container. The container support portion has a support portion, and the container support portion is a drug storage container formed side by side along both ends of the sheet of the drug storage container in the lateral direction .

In the drug storage container, the drug storage portion is preferably configured in a bag shape that becomes thinner from the rear end portion toward the tip portion.

In the drug storage container, the container support portion is a hole or a protrusion, and one or more of the holes or protrusions are formed side by side along both ends of a sheet of the drug storage container in the lateral direction. Is preferable.

In the drug storage container, the cut drug storage section is left by cutting from the sheet leaving a part from the tip portion and a part from the rear end portion of the drug storage section. It is preferable that the drug is supported by a part from the rear end portion and hangs downward, and the drug is discharged from the open opening on the side of the tip portion.

In the drug storage container, the drug stored in the drug storage section is preferably a dialysis agent.

The present invention is a method for preparing a drug solution in which a drug is adjusted to a predetermined concentration with a solvent, and a mixed solution of the drug and the solvent discharged from the drug solution preparation tank is further added through a circulation pipe. A circulation step of circulating and supplying to the drug solution preparation tank to circulate is included, and a plurality of drug storage sections in which drugs are stored are connected in a single sheet shape, and the drug storage section is configured in a bag shape. A drug solution that transports each drug storage section of the drug storage container to the top of the drug solution preparation tank by supporting and transmitting power to the container support portion for supporting the drug storage container in the drug storage container. It is a preparation method.

In the drug storage container used in the drug solution adjusting method, the drug storage portion is preferably configured in a bag shape that becomes thinner from the rear end portion toward the tip portion.

In the chemical solution storage container used in the chemical solution adjusting method, the container support portion is a hole or a protrusion, and one or more of the holes or protrusions are along both ends of the sheet of the chemical solution storage container in the lateral direction. It is preferable that they are formed side by side.

In the drug solution preparation method, by cutting the sheet leaving a part from the tip portion and a part from the rear end portion of the drug storage portion, the cut drug storage portion is left at the rear end. It is preferable that the drug is supported by a part of the portion and hangs downward, and the drug is discharged into the drug solution preparation tank from the open opening on the side of the tip portion.

In the drug solution adjusting method, the drug stored in the drug storage section is preferably a dialysis agent.

INDUSTRIAL APPLICABILITY According to the present invention, it is excellent in applicability to an automatic chemical solution preparation device, it is possible to reduce the bulk during storage and after use as in the bag type, and it is possible to prevent the risk of drug injection error as in the bottle type. It is possible to provide a drug storage container capable of producing a drug, a drug solution preparation device using the drug storage container, and a drug solution preparation method.

It is a schematic block diagram which shows an example of the drug storage container which concerns on embodiment of this invention. It is a schematic block diagram which shows an example of the chemical liquid preparation apparatus which concerns on embodiment of this invention. It is a schematic diagram (top view) which shows an example of the drug solution preparation method by the drug solution preparation apparatus using the drug storage container which concerns on embodiment of this invention. It is a schematic diagram which shows an example of the drug solution preparation method by the drug solution preparation apparatus using the drug storage container which concerns on embodiment of this invention. It is a schematic diagram which shows an example of the drug solution preparation method by the drug solution preparation apparatus using the drug storage container which concerns on embodiment of this invention. It is a schematic diagram which shows the example of the shape of the medicine storage part in the medicine storage container which concerns on embodiment of this invention. It is a schematic diagram which shows the example of the cutting mechanism in the chemical liquid preparation apparatus which concerns on embodiment of this invention.

Embodiments of the present invention will be described below. The present embodiment is an example of carrying out the present invention, and the present invention is not limited to the present embodiment.

An outline of an example of a drug storage container according to an embodiment of the present invention is shown in FIG. 1, and its configuration will be described. In the drug storage container 10 shown in FIG. 1, a plurality of drug storage sections 12 are connected in a single sheet shape, and the drug storage section 12 is, for example, a tapered bag that becomes thinner from the rear end portion toward the tip portion. It is structured like a bag. The drug storage container 10 is made of a flexible sheet material, for example, a synthetic resin such as polyethylene.

The drug storage container 10 further has a container support portion 14 for supporting the drug storage container 10. The container support portion 14 is, for example, a hole, and for example, as shown in FIG. 1, one or more holes are formed side by side along both ends in the lateral direction of the sheet.

The drug stored in the drug storage unit 12 is, for example, a sugar component (for example, glucose), an electrolyte component (for example, sodium chloride, potassium chloride, magnesium chloride, calcium chloride, sodium acetate, sodium citrate), and a pH adjuster. (For example, acetic acid and sodium acetate or a mixture thereof, citric acid and sodium citrate, etc.), alkalizing components (for example, sodium hydrogencarbonate), etc. are powdered or granular dialysis agents, and are used for storing drugs. A predetermined amount is sealed and stored inside the portion 12.

An outline of an example of the drug solution preparing apparatus according to the embodiment of the present invention is shown in FIG. 2, and the configuration thereof will be described. The drug solution preparation device 1 shown in FIG. 2 is a device for preparing a drug solution by adjusting the drug to a predetermined concentration with a solvent. The drug solution preparing device 1 can accommodate a mixed solution of the drug and the solvent, and can prepare the drug solution by adjusting the drug to a predetermined concentration with the solvent, and the drug discharged from the drug solution preparation tank 20. A circulation means having a circulation pipe 34 (pipe 24, pipe 26) for circulating and supplying a mixed solution of the solvent to the chemical solution preparation tank 20 is provided. A solvent supply pipe 46 for supplying the solvent into the chemical solution preparation tank 20 may be connected to the chemical solution preparation tank 20, and the solvent supply pipe 46 may be connected to the solvent supply amount such as a flow meter as a means for measuring the solvent supply amount. The measuring device 48 may be installed. The drug solution preparing device 1 may include a cutting mechanism 18 for cutting the sheet in the drug storage container 10, leaving a part from the front end portion and a part from the rear end portion of the drug storage unit 12. The chemical solution preparation device 1 is provided as a circulation means, for example, in the middle of the circulation pipe 34, and is a circulation pump 22 for circulating a mixed solution containing the drug and the solvent discharged from the chemical solution preparation tank 20 to the chemical solution preparation tank 20. May be further provided. The chemical solution preparation tank 20 has a tank opening 36 on the upper surface. Above the tank opening 36, a sheet-shaped drug storage container 10 in which the drug 32 is stored in each drug storage section 12 is installed with the drug storage section 12 facing upward, and is a drug storage container. 10 can be automatically or manually moved in the traveling direction of FIG. 2 by a container transport mechanism (not shown).

The discharge port of the chemical solution preparation tank 20 and the suction port of the circulation pump 22 are connected by a pipe 24, and the discharge port of the circulation pump 22 and the inflow port of the chemical solution preparation tank 20 are connected by a pipe 26. The mixed solution containing the drug and the solvent discharged from the chemical solution preparation tank 20 can be discharged to the chemical solution preparation tank 20 through the pipes 24 and 26. In this way, the mixed solution containing the drug and the solvent is configured to be circulated in the order of the chemical solution preparation tank 20, the pipe 24, the circulation pump 22, the pipe 26, and the chemical solution preparation tank 20.

FIG. 3 shows a top view of the drug solution preparing device 1 in which the drug storage container 10 is installed, as viewed from above. As shown in FIG. 3, the drug solution preparing device 1 includes a container transport mechanism 16 (not shown in FIG. 2), the container transport mechanism 16 is connected to the container support portion 14 of the drug storage container 10, and the drug storage section 12 is provided. Is configured to be automatically or manually transported above (for example, directly above) the tank opening 36 of the chemical solution preparation tank 20 of the chemical solution preparation device 1, for example. The container transport mechanism 16 is, for example, a transport chain having a support member such as a pin for connecting the container support portion 14 (for example, “hole”) of the sheet-shaped drug storage container 10, and the container support portion 14 (for example). For example, by hooking a "hole") on a pin, power can be transmitted and the drug storage container 10 can be conveyed.

The drug solution preparing device 1 may include a control device (not shown) as a control means. The control device is connected to the container transport mechanism 16, the cutting mechanism 18, and the circulation pump 22 by electrical connection or the like, and the container transport mechanism 16, the cutting mechanism 18, and the circulation pump 22 can be driven and controlled based on the signal from the control device. Has been done. The drive of the container transport mechanism 16, the cutting mechanism 18, and the circulation pump 22 will be described later.

As shown in FIG. 2, an intermediate portion of the circulation pipe 34 (for example, an intermediate portion of the pipe 24) is branched by a branch pipe 38, and the branch pipe 38 is a multi-person dialysate supply device via a discharge valve 40. It may be connected to a dialysate supply device such as (not shown) or a personal dialysis device. Further, on the downstream side (circulation pump 22 side) of the pipe from the branch portion, a concentration meter 42 composed of a conductivity meter or the like is provided as a chemical liquid concentration measuring means, and the concentration of the chemical liquid (mixed liquid) flowing in the circulation pipe 34 is provided. Is measured by the densitometer 42 to determine whether or not the drug has reached the predetermined value, and it can be determined whether or not the drug has been sufficiently adjusted to the predetermined concentration by the solvent, in other words, whether or not the preparation of the drug solution has been completed. It may be configured. The position of the branch portion by the branch pipe 38 may be any part in the middle of the circulation pipe 34, and is not particularly limited. The installation position of the densitometer 42 may be any part in the middle of the circulation pipe 34, and is not particularly limited, but may be the chemical solution preparation tank 20.

Next, a method for preparing a drug solution in the drug solution preparation device 1 using the drug storage container 10 will be described.

First, as shown in FIG. 2, in the chemical solution preparation tank 20, a predetermined amount (specifically, for example) of a solvent (for example, water) 30 for adjusting the chemical 32 to a predetermined concentration is passed through, for example, a solvent supply pipe 46. When the amount of the drug 32 stored in the drug storage unit 12 is mixed with the solvent 30, an amount set so as to obtain a solution component concentration suitable for the drug solution) is supplied, stored in advance, and discharged. The valve 40 is closed so that the solvent 30 in the chemical solution preparation tank 20 flows into the suction port of the circulation pump 22. The solvent 30 may not be stored in the drug solution preparation tank 20 in advance before the drug 32 is charged into the drug solution preparation tank 20, but dust generation or the like when the drug 32 is charged into the drug solution preparation tank 20 may be generated. In order to suppress this, it is better to store the solvent 30 in the chemical solution preparation tank 20 in advance. Further, depending on the means for supplying the solvent (for example, when a solvent supply amount measuring device 48 such as a flow meter is used), it is not necessary to supply the entire amount of the solvent 30 to the chemical solution preparation tank 20 in advance, and the drug in the form of powder or the like may be used. In this case, even if the solvent 30 is supplied to the chemical solution preparation tank 20 to the extent that dust generation is suppressed, and the solvent 30 is supplied to the chemical solution preparation tank 20 while the circulation pump 22 is operated to circulate the solvent or the mixed solution. good.

As shown in FIG. 3, for example, the container support portions 14 (for example, “holes”) formed at both ends of the sheet-shaped drug storage container 10 in the lateral direction are provided with the container transport mechanism 16 (for example, “for transport”). Power is transmitted by hooking on a support member such as a pin connected to the "chain"), the drug storage container 10 is moved, and the drug storage section 12 is above (for example, directly above) the tank opening 36 of the drug solution preparation tank 20. Will be transported automatically or manually.

Next, as shown in FIG. 4, for example, a substantially U-shaped cut as shown in FIG. 3 is cut in the drug storage section 12 above (for example, directly above) the tank opening 36 of the drug solution preparation tank 20. When the mechanism 18 is pressed from above, it is cut from the sheet leaving a part from the front end portion and a part from the rear end portion of the drug storage section 12, that is, the rear end of the drug storage section 12. As shown in FIG. 5, the thick end face of the portion was cut above the tank opening 36 of the chemical solution preparation tank 20, for example, by cutting so as to leave a part of the thin end face of the tip portion. The drug storage section 12 is supported by a thick end face portion that is a part of the remaining rear end portion of the drug storage section 12 and hangs down to the lower drug solution preparation tank 20 side, and an open opening on the tip end side. The drug 32 in the drug storage unit 12 is discharged from the drug 44 into the drug solution preparation tank 20 so as to flow down.

In this way, for example, by cutting from the sheet leaving a part from the front end portion and a part from the rear end portion of the drug storage portion 12, that is, a thick end face of the rear end portion of the medicine storage portion 12. The opening 44 is formed to be narrow by cutting without cutting, for example, leaving a part of the end face of the tip, and the drug 32 flows down from the opening 44 of the narrow end face of the tip to prepare a drug solution. Since it is put into the tank 20, it has excellent applicability to an automatic chemical preparation device. Further, it is difficult for gas such as air to be entrained from the opening 44 of the drug storage unit 12, and the drug 32 is charged in a mass without disturbing the air flow, so that dust generation at the time of charging is suppressed and the periphery of the drug solution preparation device 1 is suppressed. Problems such as contamination of the part and contamination of the environment where the chemical preparation device is installed are suppressed.

Since the plurality of drug storage units 12 are connected in the form of one sheet, the drug storage unit 12 can be opened and the drug 32 in the drug storage unit 12 can be liquidated even if the bag is made of a flexible sheet material. Positioning to be transferred to the preparation tank 20 is easy, and the chemical solution preparation device can be automated. Further, since the plurality of drug storage portions 12 are connected in the form of one sheet, it is possible to prevent the risk of erroneous injection of the drug, and it is possible to set a large amount of the drug in the drug solution preparing device at one time.

The drug storage container 10 is moved by the container support portion 14 and the container transport mechanism 16, and the drug storage section 12 is accurately transported to above (for example, directly above) the tank opening 36 of the drug solution preparation tank 20. It is easy to open the drug storage unit 12 and position the drug 32 in the drug storage unit 12 to be transferred to the drug solution preparation tank 20, and if the drug storage container 10 is automatically transported by the container transfer mechanism 16, the drug solution preparation device can be automated. Can be done. In the case of a bag-shaped container for each bag, it is difficult to position the transfer.

Then, in the chemical solution preparation device 1, for example, the circulation pump 22 is driven by the control unit, and the chemical solution preparation tank 20 and the piping are provided by the circulation pipe 34, which is the circulation flow path in the chemical solution preparation device 1, in which the mixed solution of the drug 32 and the solvent 30 is driven. 24, the circulation pump 22, the pipe 26, and the chemical solution preparation tank 20 are circulated in this order, and the chemical agent 32 is sufficiently mixed with the solvent 30 to prepare a chemical solution having a predetermined concentration. The circulation pump 22 may be driven before charging the drug 32 into the drug solution preparation tank 20.

After it is confirmed by the densitometer 42 such as the electric conductivity meter that the concentration adjustment work is properly completed when the chemical solution reaches a predetermined concentration, the circulation pump 22 is stopped by, for example, a control device. The discharge valve 40 of the chemical solution in the chemical solution preparation tank 20 is opened, and the chemical solution is supplied to a dialysate supply device such as a dialysate supply device for a large number of people through a branch pipe 38.

The drug solution preparation device 1 and the drug solution preparation method according to the present embodiment are mainly used for preparing a dialysate used for artificial dialysis, and for adjusting a drug such as a powdery or granular solid dialysis agent to a predetermined concentration. belongs to. In each of the above embodiments, the dialysis agent has been described as an example of the agent whose concentration is adjusted by the chemical solution preparation device 1, but the present invention is not limited thereto. That is, any solid drug (granule or powder) dissolved in a solvent, a liquid drug in a colloidal state, a concentrated liquid state, or the like can be used.

The chemical solution preparation tank 20 can accommodate a predetermined amount of the solvent 30, or a mixed solution of the drug 32 and the solvent 30, and can prepare the drug solution by adjusting the drug 32 to a predetermined concentration with the solvent 30. Well, there are no particular restrictions. The chemical solution preparation tank 20 may be provided with a stirring device having a solvent 30 in the chemical solution preparation tank 20 or a stirring blade for stirring the mixed solution of the chemical solution 32 and the solvent 30.

The drug solution preparation tank 20 has an opening 44 of the drug solution preparation tank 20 so that the drug 32 in the drug solution storage section 12 does not scatter as much as possible when the cut drug storage unit 12 hangs down toward the lower drug solution preparation tank 20. A guide portion 28 protruding from the opening 44 toward the drug storage container 10 at a predetermined angle may be provided in at least a part of the periphery. The guide portion 28 can guide the drug 32 that has fallen when the cut drug storage section 12 hangs down toward the lower drug solution preparation tank 20 into the drug solution preparation tank 20.

The solvent supply amount measuring device 48 may be a float switch, a weight scale, or the like installed in the chemical solution preparation tank 20 in addition to the flow meter installed in the solvent supply pipe 46.

The circulation pipe 34 may be any as long as it can flow the solvent 30, or a mixed solution of the drug 32 and the solvent 30, and is not particularly limited. Plumbing is used.

The concentration meter 42, which is a means for measuring the concentration of the chemical solution, may be any as long as it can measure the concentration of the drug 32 in the mixed solution of the drug 32 and the solvent 30, and is not particularly limited. , Ultrasonic densitometer, refractometer, spectrophotometer and the like.

The drug storage container 10 is made of a flexible sheet material, for example, a synthetic resin such as polyethylene. The drug storage container 10 has, for example, two or more sheets so that a plurality of tapered cavities (bags) that taper from the rear end to the tip are arranged side by side along the longitudinal direction of the sheet. It is formed by laminating resin sheets. The portion of the drug storage section 12 that comes into contact with the drug is preferably made of a material having chemical resistance, for example, a synthetic resin such as polyethylene, polypropylene, or polyvinyl chloride. The surface side of the drug storage container 10 may be reinforced with polyethylene terephthalate or the like in order to have a certain degree of rigidity. Since the drug storage container 10 is made of a flexible sheet material, the bulkiness during storage and after use can be easily reduced as in the case of the bag type.

The drug storage unit 12 may be configured in a bag shape and may have a size capable of storing a predetermined amount of drug. The number of the drug storage portions 12 in the sheet of one drug storage container 10 is not particularly limited, but is, for example, about 2 to 100, and usually about 10 to 50.

The shape of the drug storage unit 12 may be any as long as it is configured in a bag shape, and is not particularly limited. The shape of the drug storage portion 12 is, for example, a tapered bag shape that becomes thinner from the rear end portion toward the tip portion, as shown in FIGS. 1, 3 and 6 (a) and FIG. 6 (b). It is composed. Further, as shown in FIGS. 6 (c), (d), (e), and (f), it is configured in a bag shape that narrows from the middle of the rear end toward the tip to the tip. You may. The shape of the drug storage portion 12 may be a bag shape such as a rectangular parallelepiped, but a tapered bag shape that becomes thinner from the rear end portion toward the tip portion. Is preferable.

The tapered angle of the tip of the drug storage unit 12 is preferably set to an angle larger than the collapse angle of the drug stored in the drug storage unit 12, and is preferably equal to or greater than the angle of repose of the drug. More preferred.

In order to store the drug in the drug storage section 12, for example, the two sheets are heat-welded so as to form a tapered cavity that becomes thinner from the rear end portion toward the tip portion. Next, after filling the cavity with the drug, the drug may be stored in the drug storage 12 by heat welding the end of the opened cavity.

The cutting mechanism 18 can cut from the sheet leaving a part from the front end portion and a part from the rear end portion of the drug storage portion 12, that is, cuts a thick end face of the rear end portion of the medicine storage portion 12. It is not particularly limited as long as it can be cut so as to leave a part of the end face of the tip portion. For example, as shown in FIG. 3, the thick end face of the rear end portion of the drug storage portion 12 having a tapered bag shape that becomes thinner from the rear end portion toward the tip portion is not cut, and the tip portion is thin. Examples thereof include, but are not limited to, a substantially U-shaped cutter that can cut so as to leave a part of the end face. Here, "cutting" means "cutting" into a predetermined shape by a cutting tool such as a cutter (cutting tool), as well as perforations or notches formed in advance in the sheet portion of the drug storage container 10 in a predetermined shape. It also includes "pushing" by applying force to a fragile part such as with a pressing device.

In the cutting by the cutting mechanism 18, an opening 44 is formed on the side of the tip end portion of the drug storage portion 12, the drug is prevented from leaking from other than the opening portion 44, and the drug storage section 12 is provided on the thick end face portion of the rear end portion. It suffices to cut so that it is supported and hangs downward, and the cutting shape is not particularly limited. For example, as shown in FIG. 3, the thick end face of the rear end portion of the drug storage portion 12, which is configured in a tapered bag shape that becomes thinner from the rear end portion toward the tip portion, is not cut, and the tip portion is thin. It may be cut in a substantially U-shape so as to leave a part of the end face. Further, as shown in FIG. 7A, the thick end face of the rear end portion of the drug storage portion 12 having a bag shape such as a rectangular parallelepiped is not cut, and one corner portion of the tip portion is left. As shown in FIG. 7 (b), the thick end face of the rear end portion of the drug storage portion 12 having a bag shape such as a rectangular parallelepiped may not be cut, and the tip portion may be cut. It may be cut in a shape that leaves a part so as to be cut out, and as shown in FIG. 7 (c), the rear end portion of the drug storage portion 12 having a bag shape such as a rectangular parallelepiped is thick. It may be cut in a shape that leaves both corners of the tip without cutting the end face. In the case of cutting in FIG. 7 (c), both sides may hang down with the central portion of the bag of the drug storage section 12 (indicated by the dotted line in FIG. 7 (c)) as a boundary, and the drug may be dropped.

In cutting by the cutting mechanism 18, it is preferable to reduce the amount of the drug 32 at the tip of the drug storage section 12 as much as possible to improve the cutting accuracy at the time of opening. In this case, it is preferable to cut in an inclined state or a horizontal state in which the tip portion is slightly higher, for example, so that the amount of the drug 32 at the tip portion of the drug storage portion 12 is as small as possible.

The size of the opening 44 formed by the cutting mechanism 18 is not particularly limited as long as the medicine 32 in the medicine storage portion 12 can flow down without being scattered as much as possible. It may be determined to be as small as possible in consideration of the particle size, viscosity, volume and the like of the drug 32.

The container transport mechanism 16 is connected to the container support portion 14 of the drug storage container 10, and the drug storage section 12 is automatically or manually placed above (for example, directly above) the tank opening 36 of the drug solution preparation tank 20 of the drug solution preparation device 1. However, there is no particular limitation as long as it can be transported automatically. The container transport mechanism 16 has, for example, a transport member having a support member such as a pin for connecting the container support portions 14 (for example, “holes”) formed at both ends of the sheet-shaped drug storage container 10 in the lateral direction. It is a chain for, and power is transmitted by hooking a container support portion 14 (for example, a “hole”) on a connected pin to move the drug storage container 10, and the drug storage section 12 opens the tank of the drug solution preparation tank 20. It can be transported above (for example, directly above) the portion 36. In addition, the container transport mechanism 16 is provided with a non-slip rail at a position where both ends of the drug storage container in the lateral direction are placed, and a method of moving the rail or a method of transporting the drug by sandwiching the end of the drug storage container. There may be.

The container support portion 14 may be in a form that can be connected to the container transport mechanism 16, and is not particularly limited. The container support portion 14 is, for example, a hole, and one or more holes are formed side by side along both ends of the sheet of the drug storage container 10 in the lateral direction. The container support portion 14 may also be, for example, a protrusion, in which one or more protrusions may be formed side by side along both ends of the sheet of the drug storage container 10 in the lateral direction.

Positioning of the drug storage unit 12 by the container transport mechanism 16 may be performed by, for example, image processing (for example, by detecting an anchor such as a color or a line), a thickness sensor, or the like.

The control device includes a control element such as a CPU, and has a function of controlling the circulation pump 22, the cutting mechanism 18, the container transport mechanism 16, and the like.

The chemical solution preparing device 1 may further include at least one of a storage unit, a user interface, an input unit, and the like. The storage unit is configured to include, for example, a storage device such as a semiconductor memory, a hard disk, or an optical disk device, and can store and hold electronic information such as programs and data processed by the control device. The user interface is configured to include a monitor, a touch panel, and the like, and is used for receiving instructions from the user to the control device and presenting information to the user. The input unit includes a keyboard, a mouse, a touch panel, and the like, and is used to acquire various information used for processing from the user. When the user interface includes an input unit such as a touch panel, the input unit may not be provided.

The drug 32 is, for example, a solid drug, for example, in the form of powder or granules. The agent 32 may be a colloidal agent such as a gel state or a liquid agent such as a concentrated liquid state, in addition to the solid type. The agent 32 is, for example, a dialysis agent containing at least one of an electrolyte component, a pH adjuster, a sugar component, and an alkalizing component.

Examples of the electrolyte component include sodium chloride, potassium chloride, magnesium chloride, calcium chloride, sodium acetate, sodium citrate and the like.

Examples of the pH adjuster include organic solid acids such as citrate anhydride, malic acid, lactic acid, fumaric acid, succinic acid and malonic acid, citrates such as sodium citrate, and acetates such as sodium acetate and sodium diacetate. , Lactate such as sodium lactate, malate such as sodium malate, fumarate such as sodium fumarate, succinate such as sodium succinate, organic acid salt such as malonate such as sodium malonate, etc. Can be mentioned. Of these, preferred pH adjusters include citric acid monohydrate, sodium citrate anhydride, sodium citrate dihydrate, acetic acid, sodium diacetate, and sodium acetate anhydride, in addition to citric acid anhydride. Is.

Examples of the sugar component include glucose such as anhydrous crystalline glucose.

Examples of the alkalizing component include sodium hydrogen carbonate (sodium bicarbonate) and the like.

The solvent 30 is, for example, water.

The amount of the solvent 30 to be used, that is, the amount of the solvent 30 stored in advance in the drug solution preparation tank 20, is suitable as a drug solution when, for example, the amount of the drug 32 stored in the drug storage unit 12 is mixed with the solvent 30. The amount may be set so that the concentration of the solution component can be obtained.

The temperature of the solvent may be, for example, in the range of 10 ° C to 50 ° C.

The flow rate during operation of the chemical solution preparation device 1 may be any flow rate as long as the mixed solution of the chemical solution 32 and the solvent 30 in the chemical solution preparation tank 20 can move through the circulation pipe 34, and is not particularly limited, but is, for example, 5 liters. The range may be from 1 minute to 40 liters per minute.

1 Chemical solution preparation device, 10 Drug storage container, 12 Drug storage section, 14 Container support section, 16 Container transfer mechanism, 18 Cutting mechanism, 20 Chemical solution preparation tank, 22 Circulation pump, 24, 26 piping, 28 Guide section, 30 Solvent, 32 chemicals, 34 circulation pipes, 36 tank openings, 38 branch pipes, 40 discharge valves, 42 densitometers, 44 openings, 46 solvent supply pipes, 48 solvent supply amount measuring devices.

Claims (6)

A drug storage container in which multiple drug storage units are connected in the form of a single sheet.
The drug storage unit is configured in a bag shape and has a bag shape.
It has a container support portion for supporting the drug storage container, and has a container support portion.
The container support portion is a drug storage container characterized in that it is formed side by side along both ends of the sheet of the drug storage container in the lateral direction. The drug storage container according to claim 1.
The drug storage container is characterized in that it is configured in a bag shape that becomes thinner from the rear end portion toward the tip portion. The drug storage container according to claim 1 or 2.
The container support is a hole or protrusion, characterized in that one or more of the holes or protrusions are formed side by side along both ends of the sheet of the drug storage container in the lateral direction. Drug storage container. It is a drug solution preparation method for preparing a drug solution by adjusting the drug to a predetermined concentration with a solvent.
It includes a circulation step of circulating and supplying a mixed solution of the drug and the solvent discharged from the drug solution preparation tank to the drug solution preparation tank through a circulation pipe.
A container for supporting the drug storage container in a drug storage container in which a plurality of drug storage units in which drugs are stored are connected in a single sheet shape and the drug storage unit is configured in a bag shape. A method for preparing a drug solution, which comprises transporting each drug storage section of the drug storage container to the top of the drug solution preparation tank by supporting the support portion and transmitting power. The method for preparing a drug solution according to claim 4 , wherein the drug solution is prepared.
A method for preparing a drug solution, wherein the drug storage section is configured in a bag shape that becomes thinner from the rear end portion toward the tip portion. The method for preparing a drug solution according to claim 4 or 5 .
The container support is a hole or protrusion, characterized in that one or more of the holes or protrusions are formed side by side along both ends of the sheet of the drug storage container in the lateral direction. Chemical solution preparation method.

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