JP2010253042A - Apparatus and method for dissolving chemical - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an apparatus and method for dissolving a chemical, which are capable of preventing a failure that a large amount of the chemical falls at once to clog an inlet of a discharge pipe and smoothing chemical liquid preparation work. <P>SOLUTION: The chemical dissolving apparatus includes a bag body holding mechanism 3 for holding a chemical storage bag body 2, a dissolving tank, a solvent supply pipe 10 capable of supplying a solvent S into the chemical storage bag body 2, a discharge pipe 11 capable of discharging the chemical M and the solvent S from the inside of the chemical storage bag body 2 to the dissolving tank, a solvent pump, and a controller for controlling the drive of the solvent pump and the bag body holding mechanism 3. With a spout 22 of the chemical storage bag body 2, a downstream end of the solvent supply pipe 10 and an upstream end of the discharge pipe 11 communicate in a liquid-tight state. The bag body holding mechanism 3 includes a bag body holder 33 and a turning drive portion 41 capable of converting the chemical storage bag body 2 to an upward attitude and a downward attitude. The controller controls the drive of the solvent pump to supply the solvent S into the chemical storage bag body 2 in the upward attitude, and controls the drive of the turning drive portion 41 to convert the chemical storage bag body 2 to the downward attitude. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a drug dissolution apparatus for dissolving a drug such as a solid dialysis agent in powder form or granular form, which is mainly used for preparing a dialysis solution used for artificial dialysis to a predetermined concentration.

  Conventionally, the dialysate used for artificial dialysis is prepared by dissolving water in a powdered dialysis drug (or simply called a drug) in water to prepare a plurality of (for example, two types) dialysis stock solutions. It is prepared by further diluting the mixed stock solution with water. There are two types of containers for storing dialysis drugs: bottle type and bag type. However, since bottle type drug storage containers are made of highly rigid materials, they can be crushed to reduce capacity even if they become empty after use. However, there is a problem that it is bulky when disposed as garbage. On the other hand, since the bag-type drug storage container (drug storage bag body) is formed into a bag body with a flexible sheet material in the same manner as the container for infusion, the bulk after use is reduced. There is an advantage that can be.

  In the preparation of dialysate using the drug storage bag body, when the work of opening the drug storage bag body and putting the drug in the drug storage bag body into the dissolution apparatus is performed manually by an operator, a quantity of There is a risk that human errors such as mistakes may occur, foreign substances such as dust and hair may be mixed in the medicine, and there is a disadvantage in terms of efficiency. Therefore, in recent years, a drug that can automatically dissolve a prescribed amount of dialysis drug stored in a drug storage bag body into a dissolution tank and mix with water in the dissolution tank to achieve a specified concentration. A melting device is used. With respect to this drug dissolving apparatus, in Patent Document 1, a plurality of containers are arranged and transferred on a turntable, a solvent circulation pipe is connected to the drug container at a predetermined position, and the drug and the solvent are dissolved through the solvent in the drug container. It has been proposed to supply the tank. Moreover, in patent document 2, after opening the chemical | medical agent storage bag body hold | maintained by the bag holding means in the standing state, the bag holding means is rotated and the opening part of the chemical | medical agent storage bag body is connected to a dissolution tank. There has been proposed a drug dissolution apparatus configured to dispense a drug in a drug storage bag to a dissolution tank.

JP-A-5-146487 JP 2000-217906 A

  By the way, in the conventional drug dissolution apparatus, when only a large amount of drug is discharged at once, the pipe (discharge pipe) for introducing the drug into the dissolution tank is clogged with the drug, which hinders the preparation work of the drug. cause. For this reason, it is desirable to discharge the medicine so as not to clog the discharge pipe.

  The present invention has been made in view of the above-described circumstances, and the purpose thereof is to prevent a problem that a large amount of medicine falls at once and clogs the inlet of the discharge pipe, and the preparation of the chemical solution It is an object of the present invention to provide a drug dissolution apparatus and a drug dissolution method that can smoothly proceed with the above.

The present invention has been proposed in order to achieve the above object. According to the first aspect of the present invention, there is provided a bag body holding mechanism for holding a medicine storage bag body in which a medicine is stored, and the medicine is dissolved by a solvent. A dissolution tank capable of preparing a chemical solution, a solvent supply pipe capable of supplying a solvent into the medicine storage bag, a discharge pipe capable of discharging the medicine and solvent from the medicine storage bag to the dissolution tank, and a solvent in the solvent supply pipe A drug dissolving apparatus comprising: a solvent pump for feeding
Enabling the downstream end of the solvent supply pipe and the upstream end of the discharge pipe to communicate with the spout provided in the bag opening of the medicine storage bag body in a liquid-tight state;
The bag body holding mechanism includes a posture conversion unit that can convert the medicine storage bag body into an upward posture in which the spout is directed upward and a downward posture in which the spout is directed downward.
The control device drives and controls the solvent pump to supply the solvent into the medicine storage bag in the upward posture, and drives and controls the posture conversion unit of the bag body holding mechanism to convert the medicine storage bag into the downward posture. This is a drug dissolution apparatus.

  According to a second aspect of the present invention, the control device drives and controls the solvent pump to supply the solvent into the medicine storage bag in the upward posture, and drives and controls the posture conversion unit of the bag body holding mechanism. 2. The drug dissolution apparatus according to claim 1, wherein the drug storage bag body is converted to a downward posture while continuing to be supplied.

  According to a third aspect of the present invention, the control device converts the medicine storage bag body from an upward posture to a downward posture in a state in which the inside is filled with the medicine and the solvent. 2. The drug dissolving apparatus according to 2.

According to a fourth aspect of the present invention, the solvent is supplied to the medicine storage bag body in which the medicine is stored, the medicine is discharged together with the solvent from the medicine storage bag body to the dissolution tank, and the medicine is dissolved in the dissolution tank by the solvent. A drug dissolution method for preparing a drug solution,
The medicine storage bag is in an upward posture with the bag opening facing upward, and in this posture, the solvent is supplied from the bag opening into the medicine storage bag, and the medicine storage bag is converted into a downward posture with the bag opening facing downward. The drug dissolution method is characterized in that the solvent and the drug are discharged from the drug storage bag.

  According to a fifth aspect of the present invention, the medicine storage bag body is converted to a downward posture with the bag opening facing downward while continuing to supply the solvent, and the solvent and the medicine are discharged from the medicine storage bag body. The drug dissolution method according to claim 4.

  According to a sixth aspect of the present invention, the medicine storage bag body is converted from an upward posture to a downward posture with the inside filled with the medicine and a solvent. It is a drug dissolution method.

According to the present invention, the following excellent effects can be obtained.
According to the first and fourth aspects of the invention, the medicine storage bag body is in an upward posture with the bag opening facing upward, and in this posture, the solvent is supplied from the bag opening into the medicine storage bag, Since the body is converted to a downward posture with the bag opening facing downward, the solvent and the drug are discharged from the medicine storage bag body, so when the medicine storage bag body is converted to the downward posture, A solvent can be interposed between the drug located and the discharge pipe located below the drug, thereby preventing a problem that a large amount of drug falls at once and clogs the inlet of the discharge pipe. . Therefore, the preparation of the chemical solution can be smoothly performed, and the work efficiency can be improved.

  According to the second and fifth aspects of the invention, the medicine storage bag body is converted to a downward posture with the bag opening facing downward while continuing to supply the solvent, and the solvent and the medicine are removed from the medicine storage bag body. Since it discharges | emits, the operation | work which supplies a solvent and the operation | work which converts a chemical | medical agent storage bag body into a downward attitude | position can be advanced simultaneously, and the improvement of the efficiency of a chemical | medical agent melt | dissolution operation | work can be aimed at.

  According to the invention of claim 3 and claim 6, since the medicine storage bag body is converted from the upward posture to the downward posture with the inside filled with the medicine and the solvent, the medicine storage bag in the downward posture The body can be prevented from buckling, and the drug and solvent can be discharged from the drug storage bag without any delay.

It is a schematic diagram of a medicine dissolution device. It is explanatory drawing of the principal part of a chemical | medical agent storage bag body and a bag body holding mechanism. It is explanatory drawing of the bag body holding | maintenance mechanism holding the chemical | medical agent storage bag body, (a) is the schematic which hold | maintained the chemical | medical agent storage bag body in the upward posture, (b) supplied the solvent to the chemical | medical agent storage bag body of the upward posture Schematic diagram of the state, (c) is a schematic diagram of a state in which the medicine storage bag body is converted to a downward posture after supplying the solvent, (d) is a schematic diagram of a state in which the medicine and the solvent are discharged while maintaining the downward posture. is there.

  Hereinafter, embodiments for carrying out the present invention will be described with reference to the drawings. In the embodiments described below, various limitations are made as preferred specific examples of the present invention. However, the scope of the present invention is not limited to the following description unless otherwise specified. However, the present invention is not limited to these embodiments.

  As shown in FIG. 1, the drug dissolution apparatus 1 includes a bag body holding mechanism 3 that holds a drug storage bag body 2 in which a dialysis drug M (solid dialysis agent) is stored, and the bag body holding mechanism 3. And a solvent tank (circulation pump) 6 that circulates the solvent S in the drug dissolution apparatus 1 and a dissolution tank 5 in which the drug M can be prepared by dissolving the drug M with the solvent (water) S. The dissolution tank 5 includes a stirrer 7 that stirs the drug M and the solvent S to promote dissolution. Further, the bag holding mechanism 3 and the discharge port 6 a of the solvent pump 6 are connected by a solvent supply pipe 10, and the solvent S is sent from the solvent pump 6 to the solvent supply pipe 10 and supplied into the medicine storage bag body 2. It is possible. Further, the bag holding mechanism 3 and the charging port 5 a of the dissolution tank 5 are connected by a discharge pipe 11, and the drug M and the solvent S in the drug storage bag 2 are passed through the discharge pipe 11 and discharged to the dissolution tank 5. It is possible. The discharge port 5b of the dissolution tank 5 and the suction port 6b of the solvent pump 6 are connected by a return pipe 12, and the drug M and the solvent S are dissolved in the dissolution tank 5, the return pipe 12, the solvent pump 6, and the solvent supply pipe 10. The medicine storage bag body 2 (bag body holding mechanism 3) and the discharge pipe 11 can be circulated in this order. Further, the inner diameter of the discharge pipe 11 is set larger than the inner diameter of the solvent supply pipe 10. Further, a control device 14 is electrically connected to the bag body holding mechanism 3 and the solvent pump 6, and the bag body holding mechanism 3 and the solvent pump 6 can be driven and controlled based on a signal from the control device 14. The driving of the bag body holding mechanism 3 and the driving of the solvent pump 6 will be described in detail later.

  A halfway portion of the return pipe 12 is branched, and a storage tank 17 is connected to the branch portion via a discharge valve 16 so that the chemical solution can be discharged from the dissolution tank 5 and stored in the storage tank 17. The return pipe 12 is provided with a concentration meter 18 composed of a conductivity meter or the like on the downstream side (the solvent pump 6 side) of the branch portion, and whether the concentration of the chemical flowing in the return pipe 12 has reached a predetermined value or not. Is measured by the densitometer 18 to determine whether or not the drug M is sufficiently dissolved in the solvent S, in other words, whether or not the preparation of the drug solution is completed.

Next, the medicine storage bag body 2 and the bag body holding mechanism 3 that holds the medicine storage bag body 2 will be described.
As shown in FIG. 2, the medicine storage bag body 2 includes a bag main body 21 for storing the medicine M and a spout (mouth) 22 joined to the upper portion of the bag main body 21, and is symmetrical. It has a shape. The bag body 21 is made of a flexible synthetic resin sheet material (film) such as a polyethylene film, for example. The body material and the bottom film material are stacked, and the left and right side edges of the stacked film material and the bottom are stacked. The side edges are welded (or fused), and the upper edge of the bag body 21 is welded (or fused) on both the left and right sides, and a bag opening (non-welded portion) 23 is formed in the middle. is doing.

  The spout 22 is a cylindrical body formed of a rigid material (for example, plastic), and is joined to the bag opening 23 of the bag body 21 in a state of protruding upward (outside). Further, inside the spout 22, a communication port 25 communicating with the inside of the bag body 21 is opened, and the opening size of the communication port 25 is set so that the downstream end of the solvent supply pipe 10 can enter. ing. In other words, the opening diameter of the communication port 25 is set larger than the outer diameter of the solvent supply pipe 10. And the flange part 26 is extended toward the outer periphery of the protrusion edge part of the spout 22, and the bag body holding mechanism 3 is located at a position closer to the bag body 21 than the flange part 26 on the outer periphery of the spout 22. An annular fitting groove 27 that can be partially engaged is formed. Further, the lower part of the spout 22 (the part located on the bag body 21 side) is formed so as to have a boat shape when viewed from above to form a joint part 28, and the superposition part of the sheet material constituting the bag body 21 and the spout 22 are joined. The bag body 21 and the spout 22 are configured to be in close contact with each other without forming a gap with the portion 28. When such a spout 22 is joined to the bag opening 23 of the bag body 21, the position is adjusted so that the lower edge portion of the spout 22 and the upper inner edge portion of the bag body 21 are substantially at the same height (see FIG. 2), in this state, the seal portion of the bag body 21 (the inside of the bag opening 23) is heat-sealed to the side surface of the joint portion 28 in a liquid-tight manner.

  The drug (dialysis agent) M stored in the drug storage bag 2 is a powder or granule of glucose, sodium chloride, magnesium chloride, sodium bicarbonate, etc. A predetermined amount is stored in the. In order to store the medicine M in the bag body 21, the medicine M is put in from the communication port 25 of the spout 22 joined to the bag body 21, and a sealing material (not shown) is stuck on the surface of the flange portion 26. And seal. Therefore, when the medicine M is stored in the medicine storage bag body 2 and sealed, the medicine M in the inside does not change in quality and can be stored and transported easily. Further, the medicine storage bag body 2 stores a predetermined amount of medicine M smaller than the volume in the bag body 21 so that the solvent S can be injected into the bag body 21 in the initial stage of the dissolution operation described later. It is configured.

  The bag body holding mechanism 3 is a mechanism disposed at a position above the dissolution tank 5, and as shown in FIG. 3A, a holder is provided on the upper surface of the mechanism base 31 serving as the base of the bag body holding mechanism 3. A bracket 32 is erected, and a bag holder 33 (a part of the posture changing portion in the present invention) that can hold the medicine storage bag body 2 is turned upside down on the top of the holder bracket 32. The bag body holder 33 is pivotally mounted in a pivotable state in a rotating direction, and the bag body holder 33 is positioned at a substantially central portion in the vertical direction of the bag body holder 33. The bag body holder 33 is provided with a holding space portion 36 in which the bag main body 21 can be stored, and a portion of the holding space portion 36 that is located on the bottom side of the drug storage bag body 2 is opened. The insertion opening 37, which is located on the spout 22 side of the medicine storage bag body 2, penetrates the protruding opening 38 through which the spout 22 can protrude, and the holding space 36 is directed from the bag insertion hole 37 to the protruding opening 38. The width is gradually reduced. Further, a fitting protrusion 39 is provided at the opening edge of the protruding opening 38, and the fitting protrusion 39 is fitted into the fitting groove 27 of the spout 22 to hold the medicine storage bag body 2 held in the holding space portion 36. Is prevented from falling off from the bag holder 33.

  A rotation drive unit 41 such as a step motor or a servo motor (a part of the posture conversion unit in the present invention) is connected to the rotation shaft 34 of the bag holder 33, and the rotation drive unit 41 is connected to the control device 14. It is configured to be able to change the posture of the bag holder 33 by driving based on the drive signal from the. Specifically, when the bag holder 33 holding the medicine storage bag body 2 is rotated and the protruding opening 38 is directed upward, the spout 22 is placed on the top of the medicine storage bag body 2. When the spout 22 and the bag opening 23 are positioned and set in an upward posture (normal posture) (see FIG. 3A) and the protruding opening 38 is directed downward, the spout 22 The spout 22 and the bag opening 23 are positioned in the lower part of the medicine storage bag body 2 and are set in a downward posture (medicine discharge posture) facing downward (see FIG. 3C). Further, at least in the downward posture, the medicine storage bag body 2 is held in a state of being positioned above the dissolution tank 5. In addition, in the upward posture, if a measure (for example, mounting of a check valve) is applied to the discharge pipe 11 so that the storage (solvent or chemical solution) in the dissolution tank 5 does not flow into the medicine storage bag body 2, it is not always necessary. Although it is not necessary for the medicine storage bag body 2 to be positioned above the dissolution tank 5 in the upward posture, in this embodiment, the medicine storage bag body 2 is positioned above the dissolution tank 5 even in the upward posture. It shall be held in

  Further, a pipe joint 44 is provided on the opposite side of the bag holder 33 from the holding space 36 with the protruding opening 38 interposed therebetween. The pipe joint 44 is connected to the spout 22 to communicate the solvent supply pipe 10 and the discharge pipe 11 into the medicine storage bag body 2 (in the bag main body 21) in a liquid-tight state, as shown in FIG. A joint body 45 that is slightly larger than the spout 22, and a discharge connection channel 46 bent at 90 degrees is set inside the joint body 45 so as to have the same inner diameter as the pipe inner diameter of the discharge pipe 11. The upstream opening 46 a of the connection channel 46 is opened to the lower part of the joint body 45 so that it can be connected to the communication port 25 of the spout 22, and the downstream end 46 b of the discharge connection channel 46 projects to the side of the joint body 45. It opens and the upstream part of the discharge pipe 11 can be connected. Further, a seal member 48 such as packing is provided at the opening edge of the upstream opening 46 a of the discharge connection flow path 46, and the seal member is provided between the flange portion 26 of the spout 22 and the opening edge of the upstream opening 46 a of the discharge connection flow path 46. In this state, the joint body 45 is pressed against the spout 22 so that the upstream end of the discharge pipe 11 can communicate with the spout 22 in a liquid-tight state.

  A joint holder 50 is loosely fitted on the joint body 45 on the opposite side of the spout 22 (in other words, on the upper side of the joint body 45 in the normal posture) across the discharge connection flow path 46. The position relative to the fitting protrusion 39 is fixed to the body holder 33 so that the relative position is always constant. Further, a flange-shaped bracket portion 51 protrudes sideways at a position located on the spout 22 side of the joint body 45 (in other words, below the joint body 45 in the normal posture), and the joint holder 50 An urging member 53 such as a coil spring is provided between the bracket portion 51 and the bracket portion 51. Further, the press adjusting screw 52 is loosely fitted into the loose fitting hole 50 a opened in the joint holder 50 in a posture in which the tip is directed to the bracket portion 51 side, and the tip of the press adjusting screw 52 is screwed to the side portion of the bracket portion 51. is doing. Therefore, when the pressure adjusting screw 52 is loosened, the joint body 45 including the bracket portion 51 is moved from the joint holder 50 side to the fitting projection 39 side by the urging force of the urging member 53, and the seal member 48 of the joint body 45 is spouted. The spout 22 and the piping joint 44 can be connected to each other in a liquid-tight state by being pressed against the flange portion 26 of 22. When the pressing adjustment screw 52 is tightened, the joint body 45 including the bracket portion 51 is moved from the fitting projection 39 side to the joint holder 50 side against the urging force of the urging member 53, and the joint body 45 is sealed. The pipe 48 can be removed from the spout 22 by separating the member 48 and the flange portion 26 of the spout 22.

  Further, the downstream portion of the solvent supply pipe 10 is inserted into the joint main body 45 from the bracket portion 51 side (upper side of the joint main body 45), and between the insertion opening of the joint main body 45 and the outer peripheral surface of the solvent supply pipe 10. The liquid supply state is made by filling with a sealant or the like, and the downstream end of the solvent supply pipe 10 faces the central portion of the upstream opening 46 a of the discharge connection channel 46. When the spout 22 is connected to the pipe joint 44, the downstream end of the solvent supply pipe 10 is inserted into the communication port 25 so as to face and communicate with the bag body 21 from the spout 22 side.

  Next, the dissolving operation of the medicine M in the medicine dissolving apparatus 1 will be described. As shown in FIG. 1, the dissolution tank 5 contains a predetermined amount (specifically, water of the medicine M stored in the medicine storage bag 2) of a solvent (water in this embodiment) S for dissolving the medicine M. When the amount is dissolved in the solvent S, an amount set so as to obtain a solution component concentration suitable as a chemical solution is stored in advance, the discharge valve 16 is closed, and the solvent S in the dissolution tank 5 is the solvent. It flows into the suction port 6b of the pump 6. Moreover, the stirrer 7 is driven beforehand and the inside of the dissolution tank 5 is constantly stirred.

  First, the bag body holder 33 is set to a posture in which the protruding opening 38 is positioned on the upper side, and in this state, the medicine storage bag body 2 is held in the holding space portion 36 and set to an upward posture. Further, a pipe joint 44 is connected to the spout 22 protruding from the protruding opening 38, and the downstream end of the solvent supply pipe 10 and the upstream end of the discharge pipe 11 are communicated with the bag body 21. If the pipe joint 44 is connected to the spout 22, the solvent pump 6 is driven and controlled by the control device 14, and the solvent S in the dissolution tank 5 is passed through the solvent supply pipe 10 by the solvent pump 6 and spout 22 (bag opening 23). From above into the medicine storage bag body 2 in an upward posture (see FIG. 3B). At this time, the solvent pump 6 is set so that the solvent S is delivered at a pressure (for example, a pressure of 30 kPa or less) that the bag body 21 of the medicine storage bag body 2 can withstand without rupturing. Further, the amount of the solvent S delivered by the solvent pump 6 is adjusted so that the inflow amount (inflow amount per unit time) of the solvent S supplied from the solvent supply tube 10 into the medicine storage bag body 2 is within the discharge tube 11. Is set to be smaller than the outflow amount (outflow amount per unit time) of the medicine M and the solvent S flowing down. Specifically, the flow rate is set to be smaller than the outflow amount of the medicine M and the solvent S flowing down in the discharge pipe 11 due to a drop (level difference) from the spout 22 to the dissolution tank 5.

  When the solvent S is supplied into the medicine storage bag body 2, as shown in FIG. 3B, the solvent S is stored above the medicine M in the bag main body 21, and the medicine M and the medicine M are stored. It is interposed between the upstream end of the discharge pipe 11 located above (specifically, between the medicine M and the discharge connection flow path 46). If a predetermined time has elapsed since the solvent pump 6 started to be driven, specifically, the time until the medicine storage bag body 2 is filled with the medicine M and the solvent S (for example, 10 seconds) has elapsed, the control device 14 drives and controls the rotation drive unit 41 to invert the bag holder 33, and continues to supply the solvent S into the drug storage bag body 2, while the drug storage bag body 2 is inside the bag body 21. The state is changed from the upward posture to the downward posture while being filled with M and the solvent S. Then, as shown in FIG. 3C, the solvent S is located immediately above the bag body 21 side of the communication port 25 of the spout 22, and the medicine M is located above the solvent S. Therefore, when the medicine dissolving device 1 converts the medicine storage bag body 2 into the downward posture, the medicine M located above the medicine storage bag body 2, the discharge pipe 11 located below the medicine M, and the discharge connection flow Solvent S can be interposed between the channel 46 and a problem that a large amount of the medicine M falls at once and clogs the communication port 25, the discharge connection channel 46 and the inlet of the discharge pipe 11. Can do. Thereby, the chemical | medical solution preparation operation (dissolution operation) can proceed smoothly, and the work efficiency can be improved.

  In addition, since the medicine storage bag body 2 is converted into the downward posture while continuing to supply the solvent S, the operation of supplying the solvent S and the operation of converting the medicine storage bag body 2 into the downward posture can be simultaneously performed. The efficiency of the melting operation can be improved. Furthermore, even if the medicine M located on the spout 22 side (the medicine M located on the upper side in the upward posture) is agglomerated, the solvent S interposed between the medicine M and the discharge pipe 11 and the discharge connection channel 46. The drug M (powdered or granular drug M) can be dispersed therein to release the lump. Therefore, the medicine M can be made to flow easily and can be discharged from the medicine storage bag body 2 without delay.

  Then, when the medicine storage bag body 2 is converted to a downward posture, the solvent S stored immediately above the communication port 25 flows down to the communication port 25 and the discharge connection channel 46 before the medicine M, and the medicine storage bag body. 2 is discharged into the discharge pipe 11. Further, after the solvent S is discharged, the drug M flows down the communication port 25 and the discharge connection channel 46 and is discharged from the drug storage bag body 2 to the discharge pipe 11. Here, since the medicine storage bag body 2 is converted into a downward posture in a state where the inside is filled with the medicine M and the solvent S, the medicine storage bag body 2 in the downward posture is prevented from buckling. The medicine M and the solvent S can be discharged from the medicine storage bag body 2 without any delay.

  In addition, the solvent S and the medicine M are continuously supplied from the solvent supply pipe 10 into the medicine storage bag body 2 while being discharged from the medicine storage bag body 2 to the discharge pipe 11. At this time, the inflow amount of the solvent S supplied into the medicine storage bag body 2 is set to be smaller than the outflow amounts of the medicine M and the solvent S flowing down in the discharge pipe 11 based on the drop from the spout 22 to the dissolution tank 5. As a result, the outflow amount of the medicine M and the solvent S from the medicine storage bag body 2 is reduced by the solvent to the medicine storage bag body 2 due to trying to maintain the balance of entering and exiting the medicine storage bag body 2. It can be regulated that the amount of S increases extremely with respect to the inflow amount. Therefore, it is possible to more reliably prevent a large amount of medicine M from flowing into the discharge pipe 11 at one time, and it is possible to further suppress the inconvenience that the medicine M clogs the discharge pipe 11. Moreover, the medicine M and the solvent S can be discharged while the medicine storage bag body 2 is gradually deflated, and the volume of the medicine storage bag body 2 can be reduced while performing the preparation operation. Therefore, it is possible to save the trouble of reducing the volume by crushing the medicine storage bag body 2 after the preparation work, and avoid the disadvantage that the medicine storage bag body 2 swells and bursts during the preparation work.

  When a predetermined time elapses while the medicine storage bag body 2 is maintained in the downward posture, most of the medicine M is discharged into the discharge pipe 11, but a small amount of the medicine M is caught in the gap of the bag body 21 where the bag body 21 is deflated. May remain. In addition, the solvent S continuously supplied from the solvent supply pipe 10 flows into the medicine storage bag body 2 from the spout 22, but is not stored in the medicine storage bag body 2 and is immediately stored in the communication port 25 and the discharge connection flow. The medicine M that has flowed down to the path 46 and remains in the downward posture cannot flow the medicine M remaining in the medicine storage bag body 2 with the solvent S. Therefore, the drug dissolving device 1 returns the drug storage bag body 2 from the downward posture to the upward posture and stores the solvent S in the drug storage bag body 2.

  More specifically, the control device 14 monitors the time during which the downward posture is continued, and this time is set to a predetermined time (specifically, enough for most medicine M to be discharged from the medicine storage bag 2). If the time is exceeded, the rotation drive unit 41 is driven and controlled by the control device 14 to return the bag holder 33 to the original position, and the drug storage bag body 2 is removed while continuing to supply the solvent S into the drug storage bag body 2. Convert from a downward posture to an upward posture. Then, the solvent S starts to be stored in the medicine storage bag body 2. When the solvent S is sufficiently stored, the bag of the bag body 21 is stretched and the remaining medicine M is dispersed in the solvent S. If the medicine M is dispersed in the solvent S (in other words, if a sufficient time has passed for the medicine M to completely disperse in the solvent S), the controller 14 drives and controls the rotation drive unit 41. The bag body holder 33 is inverted again, and the medicine storage bag body 2 is changed from the upward posture to the downward posture while the solvent S is continuously supplied into the medicine storage bag body 2, and the medicine M and the solvent S are converted into the medicine storage bag body 2. It discharges from the inside to the discharge pipe 11. At this time, the inflow amount of the solvent S supplied into the medicine storage bag body 2 is set to be smaller than the outflow amounts of the medicine M and the solvent S flowing down in the discharge pipe 11 due to a drop from the spout 22 to the dissolution tank 5. Therefore, even if the solvent S is stored and the drug storage bag body 2 is inflated, the drug M and the solvent S can be discharged while being gradually deflated, and the volume of the drug storage bag body 2 is reduced after the preparation work. This saves you time and effort.

  Further, the medicine M and the solvent S discharged from the medicine storage bag 2 flow down into the discharge pipe 11 by a drop from the spout 22 to the dissolution tank 5 (a drop between the medicine storage bag 2 and the dissolution tank 5). , Charged into the dissolution tank 5. Then, the drug dissolving device 1 stirs the drug M and the solvent S with the stirrer 7 in the dissolution tank 5 or continues to drive the solvent pump 6 so that the circulation channel (return pipe 12, solvent supply) in the drug dissolving device 1. The drug M is sufficiently dissolved in the solvent S to circulate through the tube 10, the drug storage bag body 2, the discharge pipe 11, the dissolution tank 5), and the drug solution is prepared. And the density | concentration of the chemical | medical solution which flows in the return piping 12 is measured with the densitometer 18, and when the measurement result reaches the predetermined density | concentration predetermined, the solvent pump 6 will be stopped and the circulation of a chemical | medical solution will be terminated, The chemical solution in the storage bag body 2 is allowed to flow down naturally and extracted into the dissolution tank 5. Moreover, the drive of the stirrer 7 is stopped. Then, the discharge valve 16 is opened, and the chemical solution in the dissolution tank 5, the return pipe 12, the solvent pump 6, and the solvent supply pipe 10 is extracted and stored in the storage tank 17.

  By the way, in the above embodiment, when the bag body holding mechanism 3 is driven to convert the medicine storage bag body 2 from the upward posture to the downward posture, the solvent S is continuously supplied into the medicine storage bag body 2. The invention is not limited to this. For example, when the bag holding mechanism 3 is being driven, the control device 14 stops the solvent pump 6 to temporarily stop the supply of the solvent S to the medicine storage bag 2 and drive the bag holding mechanism 3. After stopping, the solvent pump 6 may be driven again to restart the supply of the solvent S to the medicine storage bag body 2. Furthermore, in the said embodiment, although the bag body holding mechanism 3 was driven based on progress of predetermined time and the attitude | position of the chemical | medical agent storage bag body 2 was converted, this invention is not limited to this. For example, using a detector such as a photosensor, the state in the medicine storage bag body 2 (for example, discharge of medicine or rise in the solvent liquid level) is detected, and the bag body holding mechanism 3 is driven based on the detection result. The posture of the medicine storage bag body 2 may be converted.

  Further, in the above embodiment, in order to cause the drug M remaining in the drug storage bag body 2 to flow with the solvent S, the drug storage bag body 2 is returned from the downward posture to the upward posture, and the solvent S is put into the drug storage bag body 2. Although stored, the present invention is not limited to this. For example, an opening / closing valve is provided in the middle of the discharge pipe 11, the opening / closing valve can be controlled to open / close by the control device, the medicine storage bag body 2 is maintained in a downward posture, and the opening / closing valve is closed in this state to close the medicine storage bag body 2. Alternatively, the solvent S may be stored, and when a preset time has elapsed, the on-off valve may be opened to discharge the drug M and the solvent S from the drug storage bag body 2 to the discharge pipe 11.

  In each of the above embodiments, the drug to be dissolved by the drug dissolving apparatus is a dialysis agent, but the present invention is not limited to this. That is, any solid drug (granule or powder) dissolved in the solvent S can be used.

DESCRIPTION OF SYMBOLS 1 Drug dissolution device 2 Drug storage bag body 3 Bag body holding mechanism 5 Dissolution tank 5a Input port 5b Discharge port 6 Solvent pump 6a Discharge port 6b Intake port 7 Stirrer 10 Solvent supply tube 11 Discharge tube 12 Return pipe 14 Control device 16 Discharge valve 17 Reservoir 18 Conductivity Measuring Device 21 Bag Main Body 22 Spout 23 Bag Opening 25 Communication Port 26 Flange 27 Fitting Groove 28 Joint 31 Mechanical Base 32 Holder Bracket 33 Bag Holder 34 Rotating Shaft 36 Holding Space 37 Bag Insertion port 38 Projection opening 41 Rotation drive part 44 Piping joint 45 Joint body 46 Discharge connection flow path 46a Upstream opening 46b Downstream end 48 Seal member 49 Press plate 50 Joint holder 50a Free fitting hole 51 Bracket part 52 Press adjustment screw

Claims (6)

A bag body holding mechanism for holding a medicine storage bag body in which a medicine is stored, a dissolution tank capable of preparing a medicine liquid by dissolving the medicine with a solvent, a solvent supply pipe capable of supplying a solvent into the medicine storage bag, and a medicine A discharge pipe capable of discharging the medicine and the solvent from the storage bag body to the dissolution tank, a solvent pump for sending the solvent to the solvent supply pipe, and a control device for driving and controlling the solvent pump and the bag body holding mechanism. A drug dissolving device,
Enabling the downstream end of the solvent supply pipe and the upstream end of the discharge pipe to communicate with the spout provided in the bag opening of the medicine storage bag body in a liquid-tight state;
The bag body holding mechanism includes a posture conversion unit that can convert the medicine storage bag body into an upward posture in which the spout is directed upward and a downward posture in which the spout is directed downward.
The control device drives and controls the solvent pump to supply the solvent into the medicine storage bag in the upward posture, and drives and controls the posture conversion unit of the bag body holding mechanism to convert the medicine storage bag into the downward posture. A drug dissolution apparatus characterized by the above.   The control device drives and controls the solvent pump to supply the solvent into the medicine storage bag in the upward posture, and drives and controls the posture conversion unit of the bag body holding mechanism to keep supplying the solvent while keeping the solvent. The drug dissolving device according to claim 1, wherein the medicine is converted into a downward posture.   3. The drug dissolving device according to claim 1, wherein the control device converts the medicine storage bag body from an upward posture to a downward posture in a state in which the inside is filled with the medicine and the solvent. This is a drug dissolution method in which a solvent is supplied to a drug storage bag body containing a drug, the drug is discharged from the drug storage bag body together with the solvent to the dissolution tank, and the drug is dissolved in the dissolution tank with the solvent to prepare a drug solution. And
The medicine storage bag is in an upward posture with the bag opening facing upward, and in this posture, the solvent is supplied from the bag opening into the medicine storage bag, and the medicine storage bag is converted into a downward posture with the bag opening facing downward. And discharging the solvent and the drug from the drug storage bag.   5. The medicine according to claim 4, wherein the medicine storage bag body is converted to a downward posture with the bag opening facing downward while the solvent is continuously supplied, and the solvent and the medicine are discharged from the medicine storage bag body. Dissolution method.   The drug dissolution method according to claim 4 or 5, wherein the drug storage bag is converted from an upward posture to a downward posture in a state where the inside is filled with a drug and a solvent.

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