JP5146991B2 - Storage container, apparatus for transferring contents in storage container to second container, and method for operating same - Google Patents

Description

  The present invention relates to a cylindrical or bag-like container that contains a solid dialysis agent or a liquid dialysis agent that is mainly used in the preparation of a dialysis solution used in, for example, artificial dialysis.

  Since the conventional problem regarding this kind of bag-like container is described in patent document 1, the description is cited. That is, “the bag-type dialysis agent storage container is formed into a bag body with a flexible sheet material in the same manner as the container for the drip solution, so that the bulkiness after use can be reduced. However, since dialysis workers manually open each bag one by one and put it into an automatic dissolution apparatus to prepare dialysate, there is a risk of quantity differences due to human error. There is a high risk that foreign matter such as dust, germs, human hair, etc. adhering to the bag will be mixed when the automatic dissolving device is introduced. There is also a problem that the automatic melting device malfunctions.

Further, when the bag body is cut and opened with a blade, chips of the bag body are generated at the time of cutting, and if the chips fall into the automatic melting apparatus, there is a risk of causing a malfunction of the automatic melting apparatus. Further, when the dialysis agent adheres to the blade, the blade is easily corroded by the components of the dialysis agent, which hinders the opening operation. And the dialysis agent adhering to the blade tends to absorb moisture and deteriorate. If the deteriorated dialysis agent is mixed in the dialysis agent in the automatic dissolution apparatus in the subsequent dissolution operation, the prepared dialysis solution may be contaminated. "
Patent Document 1 relates to this problem: “A bag body made of a flexible sheet material, in which a dialysis agent can be stored, and a dialysis agent discharge passage formed at the lower end of the bag body and communicating with the bag body. A dialysis agent storage container having a cylindrical outlet member to form a compartment, and a bag expanded by enclosing gas is inserted into the outlet member to close the dialysis agent discharge path, A part of the bag is fixed to the inside of the outlet member, the outlet member below the bag is sealed, the gap between the sealing portion and the bag is cut, and the outlet side of the dialysis agent discharge path is opened. The bag is contracted by discharging gas, and the dialysis agent in the bag body is discharged to the outside through the dialysis agent discharge path. With this configuration, in Patent Document 1, the automatic dissolution apparatus is set. In this case, the dialysis agent discharge path, which is the dialysis agent supply port, is sealed until use. Therefore, when the dialysis agent is put into the automatic dissolution apparatus, dust and bacteria adhering to the dialysis agent storage container are mixed into the automatic dissolution apparatus. In addition, the bag can be contracted in a state where it is set in the automatic dissolution apparatus, and the dialysis agent can be gradually dropped, and dust generation due to discharge of the dialysis agent can be suppressed. In addition, the empty used dialysis agent storage container can be easily reduced in volume, facilitating disposal, and the dialysis agent discharge passage is opened to discharge the dialysis agent. In addition, there is no need to open it with a blade, etc. Therefore, chips of the bag body are not generated, and malfunction of the automatic melting apparatus due to mixing of chips does not occur. The blade is corroded and the efficiency of the opening operation In addition, the dialysis agent that has deteriorated due to adhesion to the blade is not mixed into the dialysis agent in the automatic dissolution apparatus, and the risk of contaminating the prepared dialysate can be eliminated. " Have been described.

  However, in the dialysis agent storage container 1 of Patent Document 1, the bag 7 expanded by enclosing gas is inserted into the outlet member 4 to close the dialysis agent discharge passage 3, and Since the outlet part 4 is fixed to the inside of the outlet member 4 and the outlet member 4 below the bag 7 is sealed, the structure of the container for inserting the bag 7 is complicated, and the manufacturing cost of the container is high. There is.

Furthermore, the container of Patent Document 1 needs to have a conical structure for the discharge part in order to improve the powder discharge. However, if the discharge part has a conical structure, the powder storage space in the container is reduced. In addition, a large container is required to fill a predetermined amount of medicine. In addition, when a plurality of containers having such a large shape are put in a case, the space ratio in the transport case increases and the transport cost also increases.
JP2006-158824, claims, drawings

  The present invention has been made in view of the above circumstances. The drug storage unit and the drug discharge unit are separated via a seal layer, and when stored, the drug is reliably stored in the drug storage unit by the seal layer, and predetermined when discharged A container with a simple structure in which the seal layer is opened by applying the pressure of the drug and the drug is discharged from the drug discharge part, the drug does not leak to the outside, and there is no problem of environmental degradation during transfer. It is to provide. Moreover, the container which can exhibit the effect that a foreign material may not mix carelessly from the outside is provided. Moreover, since the shape of the container is arbitrary and the discharge part does not need to have a conical structure, it is designed in a rectangular shape so that the storage capacity is high and the space ratio in the transport case can be kept low. Provided is a storage container that can be used.

  In order to solve the above problems, the present invention has the following configuration. Here, for easy understanding, reference numerals corresponding to the drawings are attached, but the present invention is not meant to be specified by the configuration of the drawings.

(1) A medicine container that forms a closed internal space,
The internal space separates and forms two chambers of the medicine storage part 60 and the medicine discharge part 70 through the seal layer 50,
The seal layer 50 is sufficient to support the mass of the medicine stored in the medicine storage section, and opens when a pressure is applied to the medicine storage section 60 or the medicine discharge section 70 storing the medicine. A drug storage container having a sealing force sufficient to communicate with a drug discharge unit, and when the seal layer is opened, the drug is discharged from the drug storage unit 60 through the drug discharge unit 70 to the outside.

(2) The seal layer is sufficient to support the mass of the medicine stored in the medicine storage section, and opens when a pressure of 0.1 to 25 kPa is applied in the medicine storage section or medicine discharge section storing the medicine. The drug container according to (1), which has a sealing force of

(3) The drug container according to (1) or (2), wherein the seal layer is located at a boundary between the drug container and the drug discharge part.

(4) The seal layer has an inner bag shape and also serves as a medicine discharge portion, and the drug discharge portion further has a skirt portion formed on the outer side of the inner bag shape seal layer (1) or ( 2) The medicine container according to the above.

(5) The medicine container according to any one of (1) to (4), wherein the seal layer is formed of a plastic material or a laminate made of a plastic material.

(6) The seal layer is made of a laminate of an engineering plastic material and / or a polyolefin material and a polyolefin elastomer material, and the polyolefin elastomer material is disposed on the inner side and is weakly bonded ( The medicine container according to 1) to (5).

(7) The seal layer has a content contact surface and a content non-contact surface, and part or all of the content non-contact surface (excluding the sealing portion) is a low melting point polyolefin material, an easily peelable material, The storage container according to any one of (1) to (6), wherein the storage container is formed by one or more means selected from the group consisting of resealable materials.

(8) a step of preparing the medicine container described in any one of (1) to (7);
Opening the drug discharge side end of the drug container;
After this opening step, a physical / or mechanical pressure is applied in the medicine container or medicine discharge section to open the seal layer, and the medicine is discharged from the medicine discharge section side;
A method of discharging a medicine from a medicine container characterized by comprising:

(9) The method according to (8), wherein the seal layer is opened by applying a pressure in the range of 0.1 to 25 kPa in the drug storage part or the drug discharge part.

(10) The method further includes a step of pulling the drug discharger side in a direction to open the seal layer at a timing before or after or simultaneously with the step of applying physical / mechanical pressure to the drug container. 9) The method described.

(11) A storage container for transferring the contents to the second container, and the length of the medicine discharge part is sufficient to cover the contents filling inlet part of the second container to which the contents are transferred The storage container according to any one of (1) to (10), wherein a skirt portion having a length is formed.

(12) A method of transferring the contents in the storage container to the second container using the storage container according to any one of (1) to (11),
Opening the lower end of the medicine discharge part of the storage container containing the liquid or powdered contents;
Disposing the lower end of the opened medicine discharge part on the content filling inlet part provided in the second container;
Applying physical and / or mechanical pressure to the contents in the medicine container to open the seal layer,
The method for transferring the contents in the storage container to the second container, wherein the contents are transferred to the second container through the medicine discharge section by the pressure and gravity.

(13) The means for applying physical and / or mechanical pressure to the contents in the medicine container blows air into the medicine container, presses the contents through the medicine container, and blows liquid into the medicine container. The method according to (12), wherein the method is one or more means.

(14) The medicine storage part is provided with a gas or liquid introduction hole forming part on the peripheral side part, and a hole is formed in the formation part, and the medicine or the liquid is blown from the introduction pipe through the introduction pipe. The method according to (12) or (13), wherein physical and / or mechanical pressure is applied to the contents in the storage section.

(15) The contents in the medicine container are mixed with gas, and physical and / or mechanical pressure is applied to the contents in the medicine container by pushing the medicine container from the outside ( The method according to 12) or (13).

(16) In the medicine storage part, only the contents are stored without mixing gas, and the pressure applied to the contents causes the medicine storage part to communicate with the outside air and sends the outside air into the medicine storage part. The method according to (12) or (13), wherein physical and / or mechanical pressure is applied to the contents in the medicine container by artificially pressing.

(17) By physically ejecting the liquid in the second container or separately supplied liquid from the nozzle inserted into the medicine container through the medicine discharge part and the seal layer, the contents in the medicine container are physically and The method according to (12) or (13), wherein mechanical pressure is applied.

(18) The method according to any one of (12) to (17), wherein the storage container for the contents is a dialysis agent storage container, and the second container is an automatic dissolution apparatus.

(Definition)
In the claims and description,
“Drug” has a broad meaning and includes not only a narrowly defined drug but also a health food.

The “storage container” is a flexible bag-like container for replacing contents with another container. For example, a container having a fixed shape such as glass or metal is included in the “storage container” of the present invention. Not included.

“Plastic material” refers to engineering plastic material, polyolefin material, polyolefin elastomer material, and the like.

“Engineering plastic material” refers to a material having relatively high strength, such as polyamide, polyester such as polyethylene terephthalate, and polycarbonate.

The “polyolefin material” refers to a material such as PE (polyethylene), PP (polypropylene), ethylene-α-olefin copolymer, propylene-α-olefin copolymer.

“Polyolefin elastomer material” means EVA (ethylene vinyl acetate copolymer), SEBS (styrene-ethylene-butadiene-styrene), EPR (ethylene-propylene rubber), EBR (ethylene-butadiene rubber), HEBS (hydrogenated) (Ethylene-butadiene-styrene) or a mixture of these materials and polyolefin materials.

"Low-melting polyolefin material" means a material that has low adhesive strength at room temperature and can be re-adhered, such as ethylene-α-olefin copolymer or a mixture of polyethylene and ethylene vinyl acetate copolymer. Say.

“Easily peelable material” means a material made of polypropylene, polyethylene, polystyrene, ethylene vinyl acetate, etc. that can be easily peeled off. The easily peelable material is applied to the film. Also included. Examples of the peeling mode include cohesive peeling, delamination, and interface peeling.

The “resealable material” refers to a structure in which convex protrusions and concave grooves are joined and joined, represented by a chuck seal, and can be easily attached and detached.

“Physical and / or mechanical pressure” means that a liquid or gas is injected into a cylindrical member filled with a drug or into a drug discharge part, or an external force is applied to the cylindrical member, or a combination thereof. This includes the pressure applied to the drug.

The “unscheduled opening portion” means a portion that is first opened when the medicine replacement operation is started using the storage container. The “scheduled opening portion” of the present invention includes a structure in which a notch, a cut line, and a cut tape are formed on the scheduled opening portion for easy opening. In addition, the “scheduled opening portion” of the present invention includes not only a structure intended to be opened manually but also a structure intended to be mechanically opened.

  In the present invention, the two chambers of the medicine storage part and the medicine discharge part are separately formed via the seal layer, and the medicine discharge part is not in contact with the medicine. For this reason, there is no fear that the opening cutter or the like may inadvertently touch the medicine when the planned opening portion of the medicine discharge section is opened, and hygienic discharge becomes possible. Further, simply opening the planned opening portion of the medicine discharge section does not cause the medicine in the medicine storage section to come out or come into contact with the outside air, so that physical and mechanical pressure is applied to the medicine storage section and / or the medicine discharge section. For the first time, the medicine falls into the medicine discharge section. For this reason, the discharge timing of the medicine can be appropriately performed, and the medicine can be discharged after the container is moved to a predetermined discharge position. As a result, the drug does not leak to the outside, dust generation can be reduced, and there is no problem of environmental degradation during discharge. Moreover, there is no possibility that foreign matter is inadvertently mixed from the outside. In particular, when the sealing layer is composed of two overlapping films, the entire inner surfaces of the overlapping films are made of a low-melting-point polyolefin material, and the inner surfaces are bonded to each other in a peelable manner, or the sealing layer If the edges are made of low melting point polyolefin material, easily peelable material, resealable material, etc., the drug will not leak from the seal layer when stored in the container, and the seal layer will be sealed when the planned opening portion is opened. Therefore, it is possible to prevent the medicine from going out more reliably and to prevent contact with the outside air.

  Furthermore, if the sealing layer is an inner bag shape and an inverted trapezoidal shape, particularly when the drug is liquid, the tilt angle is 10 to 90 degrees, and if the drug is powdery, if it is about 25 to 90 degrees, a funnel shape Therefore, the medicine is discharged smoothly and does not remain in the container.

  Further, even if the inner bag shape is not used, the cylindrical member is sealed obliquely from both peripheral side portions toward the drug discharge portion, and the tip is set as a planned opening portion with a seal layer, and then a funnel-like shape is formed after opening. As a result, it is discharged smoothly and does not remain in the container.

  Furthermore, by forming a skirt having a sufficient length below the seal layer, it is possible to more reliably prevent foreign matters from being mixed from outside during transfer, and to reduce dust generation.

  The present invention has a very simple structure in which the medicine storage part and the medicine discharge part are separated and formed through a seal layer, and an opening made of another material is attached to the opening of the medicine discharge part. Since it is not necessary, a bag-like container can be manufactured at low cost.

  Moreover, since the shape of the container is not limited, by designing it into a rectangular shape, the storage volume is high and the space ratio in the transport case can be kept low.

  Furthermore, the present invention can be naturally dropped by the weight of the contents, but is physically and / or mechanically, preferably in the range of 0.1 to 25 kPa in the medicine storage part and / or in the medicine discharge part. By applying the pressure, the liquid or powdered medicine can be vigorously discharged to a specific position in a short time, and the discharge efficiency can be improved.

  The present invention will be described below with reference to the illustrated embodiments.

(First embodiment)
FIG. 1 is a front view showing an example of a storage container in which a liquid or powdered drug (for example, a dialysis drug) is stored. FIG. 4 is a side view showing a state in which the medicine is accommodated. This storage container is constituted by a cylindrical member 10.

  The cylindrical member 10 has a rectangular shape and seals the inside by sealing both sides 11 and 11, the lower end portion 12 (first end portion), and the upper end portion 13 (second end portion) constituting the peripheral side portion. A closed internal space is formed. In the internal space of the cylindrical member 10, two chambers of the drug storage unit 60 and the drug discharge unit 70 are separately formed via the seal layer 50. One or two or more holes 14 for container transportation or container suspension are provided in the upper end sealing part (drug storage part side) of the cylindrical member 10.

  Moreover, a hole, a convex part, etc. can also be provided in the vicinity of the opening scheduled part 16 as a means for assisting opening. Opening is facilitated by hooking or pulling the holes, protrusions, and the like by mechanical means provided in the melting apparatus.

  In the sealing locations on both sides, notches 15 and 15 are formed at slightly higher positions than the lower end sealing location (drug discharge portion side) of the tubular member 10 to create an opening start trigger, A line (shown by a broken line) connecting the notches 15 and 15 on both sides is a scheduled opening portion 16 of the cylindrical member 10. The planned opening portion 16 can be easily opened in a straight line by giving the film a straight cut or attaching a cut line or a cut tape. Further, the opening portion 16 may be formed by a chuck seal, and the opening portion 16 and the first end portion 21 of the bag-like sealing layer 50 formed by a cut line or a cutting tape are used as the chuck seal. You may arrange | position between. In this case, even if the scheduled opening portion 16 is opened, the container is kept airtight by the chuck seal.

  Further, the chuck seal is directional, and has a characteristic that it is easy to open from one side (for example, the outside) and is difficult to open from the opposite side (for example, the inside). Therefore, when the chuck seal is used in a mechanism for opening from the first end 12 side of the cylindrical member using an artificial or mechanical opening means, it is easy to open from the outside (first end 12 side), and the bag It is preferable to install in a direction that is difficult to open from the inside. On the other hand, when the chuck seal is not opened from the first end 12 side of the cylindrical member, that is, by introducing gas or liquid to the inside of the bag, pressing from the outside of the bag, and a mechanism for opening them by the pressure of these and the medicine Can be installed with a direction that is easy to open from the inside and difficult to open from the outside.

  The tubular member 10 is formed of polyester, polyethylene material, or the like, and a gas or liquid introduction hole forming portion 17 with a piece of rubber material, plastic material, or the like is formed on the circumferential surface of the tubular member. Even if a hole is drilled, the material is not torn to other places. The gas or liquid introduction hole forming portion 17 is not limited to a rubber material or a plastic material, and may be formed so that the container material is not torn and leaked when the gas or liquid is introduced.

  Thus, the seal layer 50 has a sealing force enough to open when a pressure is applied to the drug storage part storing the drug. When the seal layer is opened, the drug passes from the drug storage part through the drug discharge part to the outside. Are discharged.

  In order to have such a sealing force, the seal layer 50 is formed of a polyolefin material such as polyethylene or polypropylene, an engineering plastic material such as polyamide or polyester, or a laminate made of polyethylene / polyester. The seal layer 50 is made of a laminate of polyethylene and ethylene vinyl acetate copolymer and a laminate of polyethylene, and the mixture of polyethylene and ethylene vinyl acetate copolymer is arranged on the inner side to seal the seal layer 50. Since the non-contact surface of the contents of the layer 50 is weakly bonded so that it can be reattached, it is preferable.

  The material is not limited to the above, and other materials may be used as long as the object that the non-contact surface of the contents can be weakly joined can be achieved. In particular, the material is preferably formed by one or more means selected from the group of low melting point polyolefin materials, easily peelable materials, and resealable materials. Furthermore, it is desirable that the sealing layer of the resealable material is formed so as to be more easily opened than the side on which the opening is scheduled on the medicine storage part side and the medicine discharge part side.

  Further, in the present storage container filled with the medicine, although the medicine is present in the medicine storage portion, nothing is contained in the medicine discharge portion. In such a form, there is a concern about waste of space when a plurality of items are stored in a transport case and inconvenience of handling when taking out from the case. In this case, the medicine discharge part side where nothing is contained is folded back (see FIG. 8), and the outsides of the cylindrical members are weakly bonded to each other so that they can be easily peeled, and can be expanded and used during use. Is preferred.

  Next, with reference to FIG. 1, FIG. 2, FIG. 4, the usage method of the container comprised in this way is demonstrated.

  The unscheduled opening portion 16 of the storage container containing the liquid or powdered medicine is artificially and / or mechanically opened, and the lower end portion 12 of the closed cylindrical member 10 (the medicine discharge portion 70) is removed. Open. In this state, the drug does not fall from the lower end portion 12 due to the sealing force of the seal layer 50.

  In this state, the lower end side of the cylindrical member 10 (drug discharge part 70) is disposed on the opening (drug filling inlet part 31) formed in the second container 30. The medicine discharge part functions as the skirt part 18 and covers the medicine filling inlet part 31 of the second container 30. As a result, the medicine does not scatter to the outside at the time of transfer, and foreign matter does not enter from the outside. At this time, the effect can be increased by using another mechanism (for example, a dissolution apparatus) that closely contacts the inner surface of the skirt portion 18 and the outer surface of the medicine filling inlet portion 31.

  Next, physical and / or mechanical pressure is applied to the medicine container to open the seal layer 50, and the medicine is moved downward by the pressure applied to the medicine and the gravity of the medicine. A suitable pressure applied in the medicine storage part or medicine discharge part in order to open the seal layer is 0.1 to 25 kPa. By opening the seal layer in this manner, the drug in the container is discharged into the second container through the drug discharge unit. Here, the opening end portion of the medicine discharge portion should be communicated with the medicine filling inlet portion 31, but in some cases, the medicine may leak from the filling inlet portion 31. In order to avoid this danger, it is desirable to install another mechanism (for example, a melting device) that closely contacts the inner surface of the skirt portion 18 and the outer surface of the content filling inlet portion 31 described above.

  As a means for applying pressure to the medicine in the tubular member, any means such as blowing air into the tubular member, blowing liquid into the tubular member, or pressing the contents through the tubular member may be taken. it can.

  For example, a hole is formed in the gas or liquid introduction hole forming portion 17 provided on the peripheral side portion of the cylindrical member, and air is blown through the introduction tube 40 through the introduction tube 40, thereby applying air pressure into the cylindrical member, The drug can be moved downward. If a large amount of gas is mixed at the time of filling the medicine, the medicine can be dropped into the second container by simply pressing the cylindrical member 10 from the outside.

  Further, when only the medicine is stored in the cylindrical member without mixing air (so-called vacuum packing), the cylindrical member is communicated with the outside air and the outside air is put into the cylindrical member, and / or Alternatively, the drug can be dropped into the second container by artificially pressing.

  Further, when the second container 30 for transfer is an automatic dissolving apparatus, as shown in FIG. 3, a nozzle 32 is inserted into the container from the automatic dissolving apparatus, and a liquid is blown from the nozzle, whereby a medicine is obtained. It is also possible to transfer to an automatic dissolution apparatus while dissolving.

  When air or liquid is blown in, it is easier to discharge with a certain level of pressure (speed), specifically 0.1 to 25 kPa. If the pressure is too strong, the container may rupture, and if it is too weak, it takes time to open and discharge, and further causes a problem of defective discharge.

  Further, the drug filling inlet 31 and the skirt 18 are brought into close contact with each other, air is introduced into the dissolution apparatus 30 and the pressure on the drug discharge part side is set to 0.1 to 25 kPa to open the seal layer and discharge the drug. You can also.

(Second Embodiment)
FIG. 5 is a front view showing another example of a storage container in which a liquid or powdered drug (for example, a dialysis drug) is stored. FIG. 6 is a view in which the storage container is positioned on the upper part of the first container for transfer. FIG. 7 is a side view of the medicine stored. The storage container includes a cylindrical member 10 and a bag-like seal layer 50.

  The second embodiment differs from the first embodiment in the shape and structure of the seal layer. Therefore, the same components as those in the first embodiment are denoted by the same reference numerals and the description thereof is omitted, and different configurations will be described here. The seal layer 50 in FIG. 5 has an inverted trapezoidal bag shape and is inherent in the medicine discharge portion 70. That is, the upper end portion 21 (first end portion), the lower end portion 22 (second end portion) shorter than the upper end portion, and the inclined both sides 23, 23 (circumferential side) connecting the upper end portion 21 and the lower end portion 22. Part). The outer peripheral surface of the upper end portion 21 and the inner peripheral surface of the cylindrical member have the same length, and the outer peripheral surface of the upper end portion 21 is sealed with the inner peripheral surface of the cylindrical member 10. The sealed upper end portion 21 is located above the scheduled opening portion 16 of the tubular member. The length between the upper end portion 21 and the opening scheduled portion 16 of the cylindrical member (hereinafter, this portion is referred to as the skirt portion 18) is the drug in the second container 30 for transfer (for example, an automatic dissolution apparatus). It has a length sufficient to cover the filling port (opening). In other words, the lower end portion 22 is in the skirt portion 18 or in the medicine filling port of the second container 30. Both sides of the bag-like sealing layer 50 are sealed. The sealing layer 50 configured as described above has a sealing force enough to open when a pressure is applied to the medicine storage portion storing the medicine, as in the first embodiment, and when the sealing layer is opened, the medicine is stored. Is discharged from the medicine storage part to the outside through the medicine discharge part. Since the sealing layer 50 has such a sealing force, the material is formed by one or more means selected from the group of low melting point polyolefin material, easily peelable material, and resealable material. Is preferred. In particular, it is desirable that the seal layer of the resealable material is formed so that the medicine storage part side is more easily opened than the medicine discharge part side.

  Specifically, the bag-like seal layer is formed of polyethylene alone or a laminate material made of polyethylene / polyester. In particular, it is preferable that the bag-like sealing layer 50 has a film of a mixture of polyethylene / ethylene vinyl acetate copolymer disposed inside.

  The inclination angle with respect to the bottoms on both sides of the bag-shaped seal layer is 10 to 90 degrees when the drug is liquid, and 25 to 90 degrees when the drug is in a powder form.

  Note that the thickness of the bag-like seal layer is preferably 150 μm or less, and more preferably 100 μm or less. However, if it is too thin, there is a problem in strength, so 10 μm or more is preferable.

  Moreover, in said example, although the outer peripheral surface of the upper end part 21 of the bag-shaped sealing layer 50 and the cylindrical member inner peripheral surface were made into the same length, this invention is not limited to this. When the outer peripheral surface of the bag-shaped seal layer upper end portion 21 is shorter than the inner peripheral surface of the cylindrical member, the outer peripheral surface of the bag-shaped seal layer upper end portion 21 is sealed at a predetermined location on the inner peripheral surface of the cylindrical member, and the remaining portion is It can be made to seal with cylindrical member inner peripheral surfaces mutually. In short, it is sufficient that the medicine can be stored.

  Next, with reference to FIG. 6 and FIG. 7, the usage method of the container comprised in this way is demonstrated.

  Since the usage method of the second embodiment is basically the same as that of the first embodiment, the description thereof is omitted to avoid duplication. The difference from the first embodiment is that since the sealing layer 50 has an inverted trapezoidal shape, the drug can be accurately discharged into the second container while being guided by the sealing layer.

  As mentioned above, although the storage container of this invention and its usage method were demonstrated based on drawing, this invention is not limited to what was described in drawing. For example, the cylindrical member is not limited to a rectangle and is not particularly limited as long as it accommodates a medicine. Further, the bag-like sealing layer is not limited to a trapezoidal shape, and may be any one that can drop the drug when transferred. The material of the cylindrical member and the seal layer is not particularly limited as long as the medicine can be accommodated flexibly and the medicine does not leak to the outside. The drug is also in liquid or powder form, but is not limited to the above as long as it has fluidity that can be discharged from the discharge section, such as slurry, granules, and blocks.

Example 1
A container shown in FIG. 9 was prepared using the seal layer 50 of FIG. 1 as a chuck seal.

  A polyester / silica-deposited polyester / polyethylene laminate bag was used as the outer cylinder member, and a polyethylene chuck seal was used to prepare a container of the following size.

L (length): 400mm
W (horizontal): 150mm
l (length of medicine discharge part): 100mm
Chuck seal length: 150mm
Chuck seal width: 5mm
The outer cylinder member lower end portion 12 is sealed by heat sealing, and a powder dialysis agent 1000 g is formed in a space formed by the inner cylinder member lower end portion 50, the peripheral side portion 11, and the outer cylinder member upper end portion 13 (hereinafter referred to as a drug filling portion). The outer cylinder member upper end portion 13 was heat-sealed.

  The hole 14 of the drug container was hooked and the drug container was suspended, and was placed on the content filling inlet 31. The planned opening portion 16 was opened, and the skirt portion 18 from which the medicine was discharged was positioned outside the content filling inlet portion 31. Moreover, in order to measure the internal pressure of the medicine filling portion, a tube connected to a pressure gauge was inserted into the medicine container, and preparation for discharge was completed.

  Next, an air nozzle was inserted into the gas introduction hole forming part 17 and air adjusted to an original pressure of 50 kPa was introduced at a flow rate of about 15 L / min for about 10 seconds. The drug filling portion swelled, the internal pressure increased, the chuck seal was released, and the contents completely moved to the melting hopper 30 in about 5 seconds. At this time, the maximum pressure in the drug filling portion was about 18 kPa. The container of Example 1 is extremely easy to manufacture. Moreover, since clean air can be introduced in a completely sealed system, it was confirmed that the contents can be discharged smoothly and smoothly in a short time.

The figure which shows an example of the storage container of this invention. Explanatory drawing which shows the usage method of the storage container. Explanatory drawing which shows the other usage method. It is the figure which looked at the storage container of FIG. 1 from the side, and shows the state discharged | emitted from the state with which the chemical | medical agent was filled. The figure which shows the other example of the storage container of this invention. Explanatory drawing which shows the usage method of the storage container. It is the figure which looked at the storage container of FIG. 5 from the side surface, and shows the state discharged | emitted from the state with which the chemical | medical agent was filled. The figure which shows the state which folded the skirt part at the time of transporting the storage container of FIG. The figure which shows the specific example which used the seal layer 50 of the storage container of FIG. 1 as the chuck seal.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 ... Cylindrical member 11 ... Both sides of cylindrical member 12 ... Cylindrical member lower end part 13 ... Cylindrical member upper end part 14 ... Hole for container transportation or container suspension 15 ... Notch 16 ... Planned opening part 17 ... Gas or Liquid introduction hole forming part 18 ... Skirt part 21 ... Upper end part (of bag-like seal layer) 22 ... Lower end part (of bag-like seal layer) 23 ... Peripheral side part (of bag-like seal layer) 30 ... 2 container 31 ... medicine filling inlet 32 ... introduction pipe 40 ... introduction pipe 50 ... seal layer (lower end of inner cylinder member)
60 ... Drug storage unit 70 ... Drug discharge unit C ... Drug L ... Vertical length of container W ... Length in horizontal width direction of container l ... Length of drug discharge unit of container

Claims (13)

A medicine container that forms a closed internal space,
The internal space separates and forms two chambers, a drug storage part and a drug discharge part, through a seal layer,
The seal layer is sufficient to support the mass of the medicine stored in the medicine storage section, and opens when a pressure is applied in the medicine storage section or medicine discharge section storing the medicine, and the medicine storage section and the drug discharge section A medicine storage container characterized in that the medicine is discharged to the outside through the medicine discharge section from the medicine storage section when the seal layer is opened,
The seal layer is located at the boundary between the medicine storage part and the medicine discharge part,
As a result, the seal layer has a content contact surface that contacts the content when the content is stored and a content non-contact surface that does not contact the content when the content is stored, and part or all of the content non-contact surface. (Excluding the sealing portion) is formed by one or more means selected from the group consisting of low melting point polyolefin material, easily peelable material, resealable material,
The seal layer is sufficient to support the mass of the drug stored in the drug storage unit, and is a seal that opens when a pressure of 0.1 to 25 kPa is applied in the drug storage unit or drug discharge unit storing the drug. It has a force,
The medicine container is characterized in that the medicine discharge section has a skirt portion long enough to cover the contents filling inlet of the second container to which the contents are transferred . The sealing layer is made of a laminate of an engineering plastic material and / or a polyolefin material and a polyolefin elastomer material. The storage container according to claim 1, wherein: The sealing layer also serves as a medicine discharge portion in the shape of an inner bag. The medicine discharge portion further forms a skirt portion on the outer side of the inner bag shape sealing layer , and the skirt portion is longer than the inner bag shape sealing layer. The medicine container according to claim 1 or 2, wherein the container has a length sufficient to cover the content filling inlet of the second container to which the content is transferred . The storage container according to any one of claims 1 to 3, means for applying physical and / or mechanical pressure to the contents in the outer cylindrical member of the storage container, and the contents in the storage container are transferred. A device for transferring the contents in the storage container to the second container. 5. The apparatus according to claim 4 , wherein the content storage container is a dialysis agent storage container, and the second container is an automatic dissolution apparatus . The means for applying physical and / or mechanical pressure to the contents in the medicine container is one of blowing air into the medicine container, pressing the contents through the medicine container, or blowing liquid into the medicine container. The apparatus according to claim 4 or 5 , wherein the apparatus is two or more means. An operation method of an apparatus for transferring the contents in the storage container according to any one of claims 4 to 6 to a second container ,
Opening the lower end of the medicine discharge part of the storage container containing the liquid or powdered contents;
Disposing the lower end of the opened medicine discharge part on the content filling inlet part provided in the second container;
Applying physical and / or mechanical pressure to the contents in the medicine container to open the seal layer;
Transferring the contents through the medicine discharge section into the second container by the pressure and gravity;
A method for operating an apparatus comprising : The operating method of the apparatus of Claim 7 which applies the pressure of the range of 0.1-25 kPa in a chemical | medical agent storage part or a chemical | medical agent discharge part, and opens a sealing layer. Any timing before, after or simultaneous step of applying physical / or mechanical pressure to the medicine storing section, according to claim 7 or 8 further comprising the step of pulling the medicine discharge section side in the direction of opening the sealing layer How the device works . The medicine storage part is provided with a gas or liquid introduction hole forming part on the peripheral side part, and a hole is formed in the formation part, the gas or liquid is blown from the introduction pipe through the introduction pipe, and the inside of the medicine storage part The method for operating an apparatus according to any one of claims 7 to 9 , wherein physical and / or mechanical pressure is applied to the contents. The contents of the medicine container portion is gas mixed, claim, characterized in adding physical and / or mechanical pressure to the contents of the medicine container portion by pressing the medicine container unit from the outside 7 A method for operating the apparatus according to any one of claims 10 to 10 . In the medicine container, only the contents are stored without mixing gas, and the pressure applied to the contents causes the medicine container to communicate with the outside air to send the outside air into the medicine container, and / or method of operating apparatus according to any one of claims 7 to 11, characterized in that the addition of physical and / or mechanical pressure to the contents of the medicine container portion by the pressure pressing. The liquid in the second container or the liquid supplied separately is ejected from the nozzle inserted into the medicine container through the medicine discharge part and the seal layer, and the contents in the medicine container are physically and / or machined. A method of operating a device according to any one of claims 7 to 12, characterized in that a static pressure is applied.

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