JP5393364B2 - Dialysis agent container and dialysate preparation method - Google Patents

Description

  The present invention relates to a bag-like container containing a solid dialysis agent applied to artificial dialysis, and a method for preparing a dialysis solution using the container.

  In recent years, powdered or granular solid-type dialysis agents have been widely used because they are lighter in transportation work and save storage space than liquid-type dialysis agents. In the dialysis treatment, the solid dialysis agent is introduced into, for example, an automatic dissolution apparatus and dissolved in purified water to prepare a dialysis solution. There are mainly bottle-shaped containers and bag-shaped containers for storing the solid dialysis agent. Patent Document 1 shows an example of a bottle-shaped container, and Patent Document 2 shows an example of a bag-shaped container.

  A bottle-shaped container is mainly used for an automatic dissolution apparatus for dialysis agents. If a bottle-shaped container is set in an automatic dissolution apparatus, dialysate can be prepared fully automatically, and a clean dialysate can be obtained more efficiently than when dialysate is prepared manually. The work load is reduced. For example, a bottle-shaped container applied to such an automatic dissolving device has a double seal on its spout, and it is automatically dissolved after removing the outer seal that may be exposed to the outside air during transportation. By attaching to the apparatus, dust and impurities are prevented from adhering. In the automatic dissolution apparatus, the inner seal of the spout is automatically opened, and a circulation circuit for dissolving the dialysis agent is connected to the bottle-shaped container via the adapter. The circulation circuit forms a closed circuit that circulates purified water between the bottle-shaped container and the dissolution tank via a pump, and this allows the inside of the bottle-shaped container to be cleaned under clean conditions without touching the outside air. A dialysis solution can be prepared by dissolving the dialysis agent. The dialysate prepared at this time is usually a stock solution, and when used for dialysis treatment, it is further diluted with purified water at a predetermined magnification (hereinafter referred to as “dialysate” is a stock solution used after such dilution). Is included).

JP 2001-340447 A JP 2007-313089 A

  The bottle-shaped container as described above is formed of a high-rigidity material such as high-density polyethylene, for example, so that even if it becomes empty after use, it is difficult to crush and reduce its capacity, and it is bulky when disposed as garbage There is. On the other hand, since the bag-like container is formed of a flexible sheet-like material, it can be flattened after use, is not bulky, and can be easily disposed of.

  On the other hand, when the solid dialysis agent is contained in a bag-like container, the following problems in use occur. That is, when a medical worker manually opens a bag one by one and puts a dialysis agent into a dissolution tank to prepare a dialysis solution, work carefully so that the dialysis agent to be injected does not scatter around. However, a certain amount of spraying is inevitable. In addition, when the dialysis agent is introduced, the inlet of the dissolution tank is in an open state, so that dust and surrounding dust attached to the opening of the container may enter the dissolution tank. Furthermore, even when the dialysis agent is automatically charged into the dissolution tank using a bag-like container, the dialysis agent in the container scatters around when opening with a cutter consisting of a rotary blade, etc. Need to clean.

  The present applicant has proposed a bag-like container that has solved such problems as shown in Patent Document 2. This is a double-structured bottom of a bag-like container made of a flexible sheet-like material. The inner bottom portion in contact with the dialysis agent is covered with the outer bottom portion before opening, and is not exposed to the outside. When putting the dialysis agent into the dissolution tank, open the outer bottom and then open the inner bottom with a cutter, etc., and pour the dialysis agent into the dissolution tank through a clean inner bottom incision. be able to. At this time, the inner bottom portion is kept clean before opening, and the periphery is covered with the opening portion of the outer bottom portion, so that the dialysis agent is charged, so the dust attached to the outer surface of the container There is no risk that dust and the surrounding dust will enter the melting tank. In addition, when the inside bottom part is cut with a cutter and the dialysis agent is automatically put into the dissolved layer, the opening part of the outside bottom part covers the inside bottom part. Can be prevented.

  The present invention is a further improvement of such a bag-like container for dialysis agent and a method for preparing a dialysate using this container. That is, an object of the present invention is to more reliably prevent the entry of dust and the like when the dialysis agent is introduced from the bag-like container into the dissolution tank and the scattering of the dialysis agent around the dialysis agent. Another object of the present invention is to simplify the structure of the bag-like dialysis agent container.

  Claim 1 is a bag-shaped dialysis agent container made of a flexible sheet-like material and enclosing a solid-type dialysis agent inside, and set at one end of the container from the inside of the container A tapered injection portion that gradually expands toward the opening portion is formed, and this tapered injection portion has an inner peripheral surface thereof on an outer peripheral surface of a tapered receiving portion provided at the charging port of the dissolution tank. A dialysis agent container characterized by being formed so as to be fitted.

  A second aspect of the present invention is characterized in that, in the first aspect, the tapered injection portion is formed to have a dimension corresponding to the tapered receiving portion having a substantially elliptical cross-sectional shape. This is a container for dialysis agent.

  A third aspect of the present invention provides the dialysis agent according to the first or second aspect, wherein the narrow diameter portion of the tapered injection portion is smaller than the inner diameter of the tapered receiving portion. It is a container.

  A fourth aspect of the present invention is characterized in that, in the first to third aspects, a tapered inclined portion is formed which gradually increases in diameter toward the inside of the container rather than the narrow diameter portion of the tapered injection portion. This is a container for dialysis agent.

  A fifth aspect of the present invention is the dialysis agent container according to the fourth aspect of the present invention, wherein a linear passage portion whose inner diameter does not change is formed between the injection portion and the inclined portion.

Claim 6 is a method for preparing a dialysate by introducing a dialysis agent sealed in the bag-like container according to any one of claims 1 to 5 into a dissolution tank,
A step of clamping the space part above the dialysis agent inside the container and below the injection part with clamps from both outer side surfaces of the container in a state where the container is erected so that the injection part faces upward,
After the step of sandwiching with the clamp, the step of opening the injection portion of the container,
After the step of opening the injection portion of the container, the step of coupling the injection portion of the container so that the inner peripheral surface thereof is fitted to the outer peripheral surface of the tapered receiving portion communicating with the dissolution tank,
After the step of coupling the container to the receiving portion of the dissolution tank, holding the container in an inverted state, opening the clamp, and charging the dialysis agent in the container into the dissolution tank,
And a method for preparing a dialysis agent.

  In a seventh aspect of the present invention, in the step of coupling the container to the receiving portion of the dissolution tank according to the sixth aspect, the container is inverted with respect to the receiving portion provided so as to open upward in the dissolving tank. This is a method for preparing a dialysis agent characterized in that

  An eighth aspect of the present invention is the method of the sixth aspect, wherein the receiving portion is configured to be detachable from the dissolution tank, and the receiving portion separated from the dissolution tank is coupled to an upright container. A method for preparing a dialysis agent, wherein the container is inverted and connected to the inlet of the dissolution tank.

  A ninth aspect of the present invention is the method of the sixth aspect, wherein the receiving portion is connected to the dissolving tank so that the direction can be changed in the vertical direction via a flexible hose, and the receiving portion that is turned downward is placed in an upright container. Then, the container is inverted, and the dialysis agent in the container is introduced into the dissolution tank via a flexible hose.

  According to the dialysis agent container and the preparation method according to claim 1 and the following claims, the taper-shaped injection gradually expands from the inner side of the bag-shaped container toward the opening portion set at one end of the container. And the inner peripheral surface of the tapered injection portion is fitted to the outer peripheral surface of the tapered receiving portion provided at the charging port of the dissolution tank, so that the tapered injection portion And the receiving portion are fitted with no gap and the tapered surfaces are fitted with each other, so that the centers of the injection portion and the receiving portion are accurately positioned.

  In a close fitting state between the injection part of the bag-shaped container and the receiving part of the dissolution tank, for example, the container is inverted so that the injection part faces downward, and the dialysis agent in the container is dissolved. It is possible to reliably prevent the dialysis agent from splashing outside the charging port of the dissolution tank and keep the periphery of the dissolution tank clean.

  In addition, since the injection part of the bag-shaped container is opened and the inner peripheral surface to which the dust or the like is not attached is fitted to the outer peripheral surface of the receiving part, the bag-shaped container is transferred to the dissolution tank. Thus, it is possible to reliably prevent the entry of dust and the like when the dialysis agent is introduced, and to prepare a dialysate having a high cleanliness.

  Furthermore, the configuration of the bag-like container according to the present invention basically only forms the injection portion in a tapered shape, and the configuration is simple compared to a double bottom structure, etc. The material cost and the manufacturing cost can be reduced.

  According to the container for a dialysis agent according to claim 2, the tapered injection portion is formed to have a dimension corresponding to the tapered receiving portion having a substantially elliptical cross-sectional shape. The deformation of the injection part when opening the bag-like container can be minimized and can be easily fitted to the receiving part.

  According to the dialysis agent container according to claim 3, since the narrow diameter portion of the tapered injection portion is made smaller than the inner diameter of the receiving portion, the dialysis agent in the container is placed in the dissolution tank. When charged, the dialysis agent flowing from the container to the receiving port passes through an opening region inside the fitting surface between the tapered injection port and the receiving port. Therefore, even if there is a gap in the fitting surface, there is little possibility that the dialysis agent enters the portion and wastes.

  According to the dialysis agent container according to claim 4, the dialysis agent is formed by forming the tapered inclined portion that gradually increases in diameter toward the inside of the container rather than the narrow diameter portion of the tapered injection portion. When this is introduced into the dissolution tank, the inclined portion serves as a funnel, and the dialysis agent inside the container can smoothly flow to the tapered injection portion.

  According to the dialysis agent container according to claim 5, since the linear passage portion whose inner diameter does not change is formed between the injection portion and the inclined portion, the dialysis agent is introduced into the dissolution tank. At this time, the flow of the dialysis agent flowing from the inside of the container to the tapered injection portion can be adjusted to flow along the charging direction through this linear passage portion, and smoothly flowed into the dissolution tank. .

  According to the method for preparing a dialysis agent according to claims 6 and below, after the step of clamping from both outer side surfaces of the container with the clamp, the injection portion is opened and fitted with the receiving portion, and then the clamp is performed. And the dialysis agent in the container was put into the dissolution tank, preventing dust and dialysis agent in the container from adhering to the container injection part, A close fitting state can be formed. As a result, the dialysis agent in the container can be charged into the dissolution tank without waste, and a cleaner dialysis solution can be prepared.

  In addition, from the opening of the bag-shaped container to the fitting with the receiving port, the dialysis agent can be kept sealed by the clamp, while after the coupling with the dissolution tank, the clamp can be opened for dialysis in the container. It becomes possible to put the agent into the dissolution tank. Therefore, the process from the opening of the container to the dissolution of the dialysate can be easily automated even in the bag-shaped container.

  Furthermore, when using a cutter when opening a bag-like container, the blade of the cutter does not touch the dialysis agent directly, so that the advantage of not causing deterioration of the cutter due to contact with the dialysis agent There is also.

  In particular, according to the method for preparing a dialysis agent according to claim 7, the step of coupling the container to the receiving portion of the dissolving tank is performed with respect to the receiving portion provided to open upward in the dissolving tank. Since the container is turned upside down, there is little risk of dust or the like entering from the injection part of the container in the opened state, and the fitting with the receiving part can be performed in a cleaner state. . In addition, since the fitting with the receiving portion is performed in an inverted state, the dialysis agent can be immediately introduced into the dissolution tank by releasing the clamp after the fitting step, and the efficiency is high.

  However, in the present invention, as in the method for preparing a dialysis agent according to claim 8 or claim 9, the bag-like container is opened with its injection part facing up, and the receiving part You may make it take the method of making it fit.

(A) is a front view of one Embodiment of the container of the dialysis agent which concerns on this invention, (b) is a side view similarly. (A) is a top view of one Embodiment of the inlet part of the dissolution tank with which the container of the said dialysis agent fits, (b) is front sectional drawing similarly. It is front sectional drawing of the principal part for demonstrating the relationship of the opening dimension of the injection | pouring part of the said container, and the opening part of a dissolution tank. It is a front half sectional view of the principal part for demonstrating the angular relationship of the injection | pouring part of the said container, and the opening part of a dissolution tank. (A) is a top view of other embodiment of the opening part of the dissolution tank which the container of the said dialysis agent fits, (b) is a front view similarly. It is a 1st process drawing which shows one Embodiment of the preparation method of the dialysis agent which concerns on this invention. It is a 2nd process drawing which shows one Embodiment of the preparation method of the dialysis agent which concerns on this invention. In embodiment of the preparation method of the said dialysis agent, it is side surface sectional drawing which shows the state which has pinched the container from the outer surface with the clamp.

<Embodiment of bag-like container>
Next, embodiments of the present invention will be described with reference to the drawings. (A) of FIG. 1 is a front view of one embodiment of a bag-like container containing a dialysis agent, and (b) is a side view of the same. In addition, (b) of a figure is drawn on the assumption that the container swelled at the time of the dialysis agent accommodation for the structural explanation.

  The bag-like container 11 is formed of a flexible sheet material as a whole, and has a substantially cylindrical body portion 12 made of two rectangular sheet materials, and a lower portion in the body portion 12. And a bottom portion 13 provided in such a manner as to be bent inward. As the flexible sheet material, for example, a flexible synthetic resin sheet material such as a polyester laminate film material or a polyethylene film can be used. More specifically, for example, a laminate film obtained by laminating a polyester film having a thickness of 10 to 50 μm, a silicon oxide-deposited polyester film having a thickness of 10 to 50 μm, and a polyethylene film having a thickness of 50 to 100 μm, or a thickness of 10 to 10 μm. For example, a 100 μm polyethylene film.

  In this embodiment, two sheet materials are overlapped, and a required portion indicated by a thick line in FIG. (A) is welded together (including the case of bonding or fusing, the same applies hereinafter) to form a bag-like container. 11 is formed.

  That is, the sealing portions S1 and S1 on the left and right side edges of both sheet materials are welded to form a substantially cylindrical barrel portion 12 and the sealing portion S2 on the upper edge is welded to form a barrel serving as an opening location. The upper end of the portion 12 is sealed. Moreover, the sheet | seat material of the aspect bent inside toward the inner side of the lower end of the trunk | drum 12 is arrange | positioned as the bottom part 13, and the bottom part 13 has the both lower edge part in the lower edge part of the two sheet | seat materials of the trunk | drum 12. Along with the sealing portion S3, the lower portion of the sheet material of the bottom portion 3 is directed to the inside of the lower portion together with the two sheet materials of the body portion 12 so that the front view of the lower portion thereof is tapered. The sealing portions S4 and S4 are formed by welding diagonally.

  Further, the sealing portions S5 and S5 are welded inward and downward from the vicinity of the left and right ends of the sealing portion S2 at the upper end edge, and the pair of sealing portions S5 and S5 are used to lower the upper end edge of the body portion 12 downward. A tapered injection portion 14 whose diameter gradually decreases toward the end is formed. A pair of sealing portions S6 and S6 parallel to each other are welded downward from the injection portion 14 to form a linear passage portion 15 having a predetermined inner diameter over a predetermined length, and this linear passage A pair of sealing portions S7, S7 facing the lower outer direction is welded so as to follow the portion 15, and an inclined portion 16 whose inner diameter gradually increases downward is formed.

  Outer end portions of the sealing portions S7 and S7 are connected to the left and right side sealing portions S1 and S1 that form the container body portion 12, and thus the inside of the body portion 12 is an upper end serving as an opening end. From the edge downward, the injection portion 14, the linear passage portion 15, and the inclined portion 16 are connected in series.

  Among the sealing portions S1 to S7, the sealing portion S2 at the upper edge is welded after a dialysis agent is accommodated in a bag-like container formed by welding other sealing portions, and is formed into a bag shape. It becomes a product as a dialysis agent contained in a container.

  The maximum inner diameter portion of the inclined portion 16 is indicated by a one-dot chain line L1 in FIG. The inside of the body part 12 below is substantially cylindrical, and the capacity of the bag-like container 11 is determined so that the dialysis agent is accommodated in this cylindrical part. Specific examples of the dialysis agent and the container capacity will be described later.

  What is indicated by a one-dot chain line L2 in (a) of the figure is a separation location for opening, and is set slightly inside the sealing portion S2. It is desirable that the bag-like container 11 can be opened linearly by forming a large number of minute holes along the line L2. In the fully automatic processing, the portions of the injection portion 14 and the sealing portion S2 are sandwiched by an automatic machine and then pulled, separated along the line L2, or opened by cutting with a cutter.

  The basic structure and manufacturing method of the bag-like container 11 as a bag are arbitrary, and are not limited to the structure and manufacturing method using a plurality of sheet materials as described above. For example, you may make it form a bag-shaped container by sealing the both-ends opening part of the sheet | seat material previously processed into the cylinder shape.

  The dialysis agent accommodated in the bag-like container 11 is provided in two types of agent A and agent B in order to prevent chemical reaction during dissolution. Agent A is a drug containing components such as glucose, sodium chloride, and magnesium chloride, and Agent B is a drug mainly composed of sodium bicarbonate. In order to prepare the dialysate, for example, 2682.0 g of agent A and 661.6 g of agent B are used. Therefore, the container 11 is set to a capacity that can accommodate any of the above-mentioned used amounts necessary for preparing the dialysate. For example, the capacity of the container 11 for agent A is set to about 3 liters (width about 23 cm, height about 40 cm), and the capacity of the container 11 for agent B is set to about 1 liter (width about 13 cm, height about 23 cm). . In addition, this makes it possible to easily identify the agent A or the agent B simply by looking at the container 11.

  Next, the structure of the part which couple | bonds the said bag-shaped container 11 with a dissolution tank is demonstrated. An imaginary line (two-dot chain line) shown in FIG. 1B shows a state in which the upper end portion of the bag-like container 11 is opened and the open end of the tapered injection portion 14 is opened outward. Show. In this state, the injection portion 14 has a tapered shape whose planar shape is substantially elliptical. Corresponding to this shape, a receiving portion 21 as shown in FIG. 2 is provided at the inlet of the dialysis agent in the dissolution tank (not shown).

  2A is a plan view of the receiving port 21, and FIG. 2B is a front sectional view of the same. As shown in the figure, the receiving portion 21 has a tapered shape with a narrower diameter as an outer shape and a substantially elliptical shape as a planar shape. In this case, the ratio of the major axis to the minor axis of the elliptical shape is about 2: 1. Inside the small diameter portion of the receiving portion 21 is a passage portion 22 penetrating in the axial direction, and the dialysis agent from the bag-like container 11 flows into the dissolution tank through the passage portion 22. Make it. In addition, as a material of this receiving part 21, it is desirable to use materials with low chargeability, such as ceramics, for example so that a powdery dialysis agent and dust may not adhere easily.

  FIG. 3 shows a state in which the container 11 and the receiving portion 21 are coupled. As described above, the container 11 is opened, the tapered injection portion 14 is opened, and the container 11 is turned upside down so that the outer peripheral surface of the receiving portion 21 is fitted to the inner peripheral surface. Combine. At this time, since the container injection part 14 and the receiving part 21 are fitted with each other at the tapered surfaces, they are fitted firmly while being accurately positioned so that their centers coincide.

  In this embodiment, since the cross-sectional shape of the fitting portion is set to be approximately elliptical, the amount of deformation of the tapered injection portion 14 when the bag-like container 11 formed from a sheet material is opened is set. It is possible to fit the receiving portion 21 without difficulty by minimizing it.

  Moreover, in this embodiment, as shown in FIG. 3, in the said fitting state, the internal diameter d1 of the linear channel | path part 15 (or the narrow diameter part of the injection | pouring part 14) of the bag-shaped container 11 is the receiving part. The respective dimensions are set so as to be smaller than the inner diameter d2 of the 21 passage portions 22. This figure shows a dimensional relationship at the major axis portion of the passage portion 22 in a front view, but of course, the inner diameter of the linear passage portion 15 is smaller than the inner diameter of the passage portion 22 over the entire circumference of each opening region. It is like that. By doing in this way, when putting the dialysis agent in the container 11 into the dissolution tank, the dialysis agent flowing from the container 11 to the receiving port 21 is the tapered injection portion 14 and the receiving port 21. It will pass through the opening area inside the fitting surface between. Therefore, even if there is a gap in the fitting surface, there is less possibility that the dialysis agent will enter the portion and waste.

  FIG. 4 is an example of setting the dimensions of the tapered injection part 14 and the receiving part 21 of the container 11. The container 11 shows a flat state before the injection part 14 is opened. In this state, the sealing unit S2 and the sealing part S5 have an angle θ1 of about 45 degrees. Part S5 is formed. On the other hand, as described above, in the receiving portion 21 having a cross-sectional shape in which the ratio of the major axis to the minor axis is about 2 to 1, the outer peripheral surface is a horizontal line at the end in the major axis direction. By setting the angle θ2 to be set to about 50 degrees or more, an appropriate fitting state can be obtained with the injection portion 14.

  Note that a chamfered portion 23 is formed in the receiving portion 21 along the upper end opening edge of the passage portion 22 as illustrated. When the dialysis agent that has fallen from the bag-like container 11 has fallen near the opening edge of the receiving port 21, the chamfer 23 guides the chamfer 23 toward the inside of the passage 22. There exists an effect | action which prevents that the dialysis agent permeates into the clearance gap between the injection | pouring part 14 and the receiving part 21. FIG.

  FIG. 5 shows another example of the shape of the receiving portion 21. (A) is the top view, (b) is also a front view. The receiving portion 21 is substantially the same as the above-described one in that it is formed in a tapered shape having a substantially elliptical cross-sectional shape. However, as shown in FIG. The difference is that the both ends in the major axis direction of the elliptical shape forming the shape are ridges 24 that are slightly acute. By adopting such a shape, when the tapered injection portion 14 of the bag-like container 11 is opened, a gap that may occur in the vicinity of the sealing portion S5 forming the injection portion 14 is a ridge at the both ends. Since it is compensated by the part 24, the injection part 14 and the receiving part 21 can be fitted more closely.

  The injecting portion 14 of the bag-like container 11 and the receiving portion 21 of the dissolution tank are inverted so that the injecting portion of the bag-like container 11 faces downward, and the close fitting as shown in FIG. By connecting the dialysis agent in the bag-like container 11 to the dissolution tank after being connected to the state, the dialysis agent is surely prevented from scattering outside the charging tank inlet, and the dissolution tank The periphery of the can be kept clean. In addition, since the injection portion 14 of the bag-like container 11 is opened and the inner peripheral surface to which dust or the like is not attached is fitted to the outer peripheral surface of the receiving portion 21, the bag-like container 11 Thus, when the dialysis agent is introduced into the dissolution tank, it is possible to reliably prevent the entry of dust and the like into the dissolution tank and to prepare a dialysate with high cleanliness. Furthermore, the bag-like container 11 basically has a simple configuration compared to a double bottom structure or the like, since the injection portion 14 is basically formed in a tapered shape, so that the material cost as a container is reduced. The manufacturing cost can be reduced.

  On the other hand, in this embodiment, since the tapered portion 16 having a diameter gradually increasing toward the inside of the container rather than the narrow diameter portion of the tapered injection portion 14 and the linear passage portion 15, the dialysis agent is added. When thrown into the dissolution tank, the inclined portion 16 serves as a funnel so that the dialysis agent inside the container can smoothly flow to the tapered injection portion 14. Further, since the linear passage portion 15 whose inner diameter does not change is formed between the injection portion 14 and the inclined portion 16, when the dialysis agent is introduced into the dissolution tank, the container body portion 12 tapers. The flow of the dialysis agent toward the injection portion 14 can be adjusted to a flow along the charging direction via the linear passage portion 15 and smoothly flowed into the dissolution tank.

The dialysis agent charged into the dissolution tank is mixed and stirred in purified water injected into the dissolution tank and dissolved to form a dialysate. A specific method for producing this dialysate is exemplified as follows. First, the above-mentioned A agent is put into a dissolving tank for agent A to prepare 9 liters of A stock solution, and B agent is put into a dissolving tank for agent B to prepare 11.34 liters of B stock solution. Next, 315 liters of dialysate is prepared by mixing at a ratio of A stock solution: B stock solution: water = 1: 1.26: 32.74.
<Embodiment of Preparation Method of Dialysis Agent>
Next, an embodiment of a method for preparing a dialysis agent using the bag-like container 11 and the receiving port 21 will be described. This preparation method has a main process from opening the bag-like container 11 to putting the dialysis agent in the container into the dissolution tank, and is suitable for preparing dialysate fully automatically. It is a preparation method.

  6-1 to 6-2 show the steps of the preparation method. The numerals (P1) to (P6) in the figure indicate the order of the steps. (P1) in FIG. 6A shows a state in which the container 11 containing and enclosing the dialysis agent 31 is held in an upright state, and the broken line in the figure indicates the accommodation level of the dialysis agent 31. Show. As described above, the accommodation level of the dialysis agent is set to be the maximum inner diameter portion of the inclined portion 16 or slightly lower than that, and when the container 11 is in the upright state, the dialysis agent is stored above this level. A region (space portion 18) where the agent 31 does not exist is formed.

  In (P2) of the figure, the space 18 of the bag-like container 11 held in the established state as described above is sandwiched from both sides by the clamps 32. For example, as shown in FIG. 7, the clamp 32 includes a pair of rod-like members 32 a and 32 a that are longer than the width-direction dimension of the container 11. The clamp 32 sandwiches the outside of the bag-like container 11 between the rod-like members 32a and 32a, so that the dialysis agent 31 in the body portion 12 does not move to the side of the injection portion 14 that is an opening. Has the effect of temporarily sealing. In addition, the clamp 32 is good also as a thing of the aspect which makes this to the bag-shaped container 11 after the manufacturing process of the bag-shaped container 11, or enclosure of the dialysis agent. That is, for example, a rod-shaped member made of a synthetic resin material is integrally provided on the surface of the sheet material constituting the bag-like container 11 by adhesion or the like, and is released or removed when the clamp is released.

  (P3) in the figure shows a state in which the injection part 14 of the bag-like container 11 is opened after the clamping process by the clamp 32. As described above, this unsealing operation is performed by cutting a portion of the inner area slightly from the sealing portion S2 at the upper edge of the container in a lateral direction with a cutter or the like. In the figure, the cut end 19 of the bag to be excised is drawn in a state of being completely cut off from the container 11 side, but instead of doing this, the cut end 19 is connected to the bag-like container 11 at its end. In this way, it is advantageous that the piece 19 can be disposed of together with the used container 11.

  (P4) in the figure, after the opening process, the bag-like container 11 is inverted while being sandwiched between the clamps 32, and the injection part 14 is opposed to the receiving part 21 communicating with the inlet of the dissolution tank. The state held at the position is shown. In this inverted state, the dialysis agent 31 inside the container tends to drop downward due to gravity, but as described above, the clamp 32 sandwiches the bag-like container 11 from the left and right sides of the bag. The agent 31 does not flow to the injection part 14 side. FIG. 7 shows a state in which the state is viewed from the side of the bag-like container 11. The step (P3) of opening the bag-shaped container 11 may be performed after the bag-shaped container 11 is inverted.

  (P5) in the figure shows a state in which the bag-like container 11 is lowered from the inverted state toward the receiving part 21 and the injection part 14 is fitted to the receiving part 21. Reference numeral 25 in the drawing indicates a charging passage that communicates the receiving port 21 with the charging port of the dissolution tank. At this time, by holding the bag-like container 11 so that the weight of the bag-like container 11 is applied to some extent, as described above, the gap between the inner peripheral surface of the injection portion 14 and the outer peripheral surface of the inlet portion 21 is maintained. Based on the fitting between the tapered surfaces, the injection part 14 and the receiving part 21 are coupled in a state of being in close contact. In addition, in order to open the injection part 14 to such an extent that the fitting can be performed in the process until the injection part 14 of the bag-like container 11 is fitted to the receiving part 21, for example, injection is performed as necessary. The opening may be promoted by sucking both side surfaces of the portion 14 with vacuum air. Moreover, when the rigidity of the sheet | seat material which comprises the bag-shaped container 11 is insufficient, it may raise | generate deformation | transformation, such as a wrinkle producing in the injection | pouring part 14 with the said fitting operation. In order to ensure the fitting state between the injection part 14 and the receiving part 21 including such a case, the periphery of the injection part 14 fitted to the receiving part 21 is made of an elastic material such as silicon rubber. You may make it tighten with the belt which consists of a body, or a strip | belt-shaped jig | tool.

  (P6) in the figure shows a state in which the clamp 32 is opened from the state in which the bag-like container 11 is connected to the receiving portion 21. By opening the clamp 32, the dialysis agent 31 that has been sealed by the clamp 32 flows out under its own weight, and the inclined portion 16, the linear passage portion 15, the injection portion 14, and the receiving portion of the bag-like container 11 are received. It falls into the dissolution tank through the mouth portion 21 and the charging passage 25. At this time, the bag-like container 11 may be vibrated or pressurized from the outside in order to promote the fall of the dialysis agent 31 inside the container.

  Thus, according to this preparation method, after the step of sandwiching with the clamps 32 from both side surfaces of the bag-like container 11, the injection part 14 is unsealed and fitted with the receiving part 21. Since the dialysis agent 31 in the container is opened and put into the dissolution tank, it is possible to prevent dust and dialysis agent powder in the container from adhering to the container injection part 14, A close fitting state can be formed between the two. As a result, the dialysis agent in the container can be charged into the dissolution tank without waste, and a cleaner dialysis solution can be prepared.

  In addition, the dialysis agent 31 can be kept in an enclosed state by the clamp 32 from the opening of the bag-shaped container 11 to the fitting with the receiving port 21, while the clamp 32 is only opened after the coupling with the dissolution tank. The dialysis agent 31 in the container can be put into the dissolution tank. Therefore, the steps from opening the bag-like container 11 to dissolving the dialysate can be easily automated in the bag-like container 11.

  Further, when a cutter is used when opening the bag-like container 11, the cutter blade does not directly touch the dialysis agent 31, which causes deterioration of the cutter due to contact with the dialysis agent 31. There is also an advantage of not.

  In this embodiment, the step of coupling the bag-shaped container 11 to the receiving portion 21 of the dissolution tank is performed with respect to the receiving portion 21 provided so as to open upward in the dissolution tank. 11 is turned upside down, so that there is little risk of dust or the like entering from the injection portion 14 of the bag-like container 11 in the opened state, and the fitting with the receiving portion 21 is performed in a cleaner state. be able to. Further, since the fitting with the receiving portion 21 is performed in an inverted state, the dialysis agent 31 can be immediately put into the dissolution tank by opening the clamp 32 after this fitting step, and the efficiency is high. .

  On the other hand, it is also possible to adopt a method of fitting the receiving portion 21 with the bag-like container 11 in an upright state, that is, with the injection portion 14 facing upward. For this purpose, for example, the receptacle 21 is configured to be detachable from the dissolution tank, and the receptacle 21 separated from the dissolution tank is joined to the upright bag-like container 11, The container 11 is inverted and connected to the charging port of the dissolution tank. Alternatively, the receiving portion 21 is connected to a dissolution tank so that the direction can be changed in the vertical direction via a flexible hose (not shown), and the receiving portion 21 that is directed downward is a bag-like container 11 in an upright state. Then, the bag-like container 11 is inverted and the dialysis agent in the container is put into the dissolution tank via the flexible hose.

  Each of the above-described embodiments is merely a part of a specific configuration example of the present invention, that is, the contents of the present invention are not limited to the configuration of these embodiments.

DESCRIPTION OF SYMBOLS 11 Bag-shaped container 12 Container body 13 Container bottom part S1-S7 Container sealing part 14 Injection | pouring part 15 Linear passage part 16 Inclination part 18 Space part 19 Cut end 21 Receptacle part 22 Passage part 23 Chamfer part 24 Ridge Part 25 Input passage 31 Dialysis agent 32 Clamp 32a Clamp rod-shaped member

Claims (9)

  A bag-like dialysis agent container made of a flexible sheet-like material and enclosing a solid dialysis agent inside, from the inside of the container toward an opening portion set at one end of the container A tapered injection portion that gradually expands in diameter is formed, and this tapered injection portion is configured so that its inner peripheral surface is fitted to the outer peripheral surface of the tapered receiving portion provided at the charging port of the dissolution tank. A container for a dialysis agent, which is formed.   2. The dialysis agent according to claim 1, wherein the tapered injection portion is formed in a size corresponding to the tapered receiving portion having a substantially elliptical cross-sectional shape. container.   The dialysis agent container according to claim 1, wherein the narrow-diameter portion of the tapered injection portion is smaller than the inner diameter of the tapered receiving portion.   The dialysis according to any one of claims 1 to 3, wherein a tapered inclined portion that gradually increases in diameter toward the inside of the container is formed rather than a narrow diameter portion of the tapered injection portion. Container for preparations.   The dialysis agent container according to claim 4, wherein a linear passage portion whose inner diameter does not change is formed between the injection portion and the inclined portion. A method for preparing a dialysate by introducing a dialysis agent sealed in the bag-like container according to any one of claims 1 to 5 into a dissolution tank,
A step of clamping the space part above the dialysis agent inside the container and below the injection part with clamps from both outer side surfaces of the container in a state where the container is erected so that the injection part faces upward,
After the step of sandwiching with the clamp, the step of opening the injection portion of the container,
After the step of opening the injection portion of the container, the step of coupling the injection portion of the container so that the inner peripheral surface thereof is fitted to the outer peripheral surface of the tapered receiving portion communicating with the dissolution tank,
After the step of coupling the container to the receiving portion of the dissolution tank, holding the container in an inverted state, opening the clamp, and charging the dialysis agent in the container into the dissolution tank,
And a method for preparing a dialysis agent.   The step of coupling the container to the receiving part of the dissolution tank is performed by inverting the container with respect to the receiving part provided to open upward in the dissolution tank. A method for preparing the dialysis agent according to claim 6.   The receiving part is configured to be detachable from the dissolution tank, and after the receiving part detached from the dissolution tank is coupled to an upright container, the container is inverted and connected to the dissolution tank. The method for preparing a dialysis agent according to claim 6.   The receiving part is connected to the dissolution tank so that the direction can be changed in the vertical direction via a flexible hose. After the downwardly receiving part is connected to an upright container, the container is inverted. The method for preparing a dialysis agent according to claim 6, wherein the dialysis agent in the container is put into a dissolution tank through the flexible hose.

Images