JPH0365989B2 - - Google Patents
Info
- Publication number
- JPH0365989B2 JPH0365989B2 JP59187805A JP18780584A JPH0365989B2 JP H0365989 B2 JPH0365989 B2 JP H0365989B2 JP 59187805 A JP59187805 A JP 59187805A JP 18780584 A JP18780584 A JP 18780584A JP H0365989 B2 JPH0365989 B2 JP H0365989B2
- Authority
- JP
- Japan
- Prior art keywords
- plasma
- alkali metal
- proteins
- separating agent
- tube
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004169 proteins and genes Human genes 0.000 claims description 49
- 108090000623 proteins and genes Proteins 0.000 claims description 49
- 239000003795 chemical substances by application Substances 0.000 claims description 38
- 238000000926 separation method Methods 0.000 claims description 34
- 150000001413 amino acids Chemical class 0.000 claims description 29
- 229910052783 alkali metal Inorganic materials 0.000 claims description 26
- -1 alkali metal salt Chemical class 0.000 claims description 26
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 24
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 18
- 108010088751 Albumins Proteins 0.000 claims description 17
- 102000009027 Albumins Human genes 0.000 claims description 17
- 210000004369 blood Anatomy 0.000 claims description 15
- 239000008280 blood Substances 0.000 claims description 15
- 239000002244 precipitate Substances 0.000 claims description 15
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 12
- 210000000601 blood cell Anatomy 0.000 claims description 12
- 239000011780 sodium chloride Substances 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 11
- 239000004471 Glycine Substances 0.000 claims description 9
- 229910001514 alkali metal chloride Inorganic materials 0.000 claims description 9
- 238000001556 precipitation Methods 0.000 claims description 9
- DZTHIGRZJZPRDV-UHFFFAOYSA-N Nalpha-Acetyltryptophan Natural products C1=CC=C2C(CC(NC(=O)C)C(O)=O)=CNC2=C1 DZTHIGRZJZPRDV-UHFFFAOYSA-N 0.000 claims description 8
- 230000007935 neutral effect Effects 0.000 claims description 8
- DZTHIGRZJZPRDV-LBPRGKRZSA-N N-acetyl-L-tryptophan Chemical compound C1=CC=C2C(C[C@H](NC(=O)C)C(O)=O)=CNC2=C1 DZTHIGRZJZPRDV-LBPRGKRZSA-N 0.000 claims description 7
- 229940116191 n-acetyltryptophan Drugs 0.000 claims description 7
- 230000001376 precipitating effect Effects 0.000 claims description 7
- 235000011164 potassium chloride Nutrition 0.000 claims description 6
- 239000001103 potassium chloride Substances 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 description 76
- 235000018102 proteins Nutrition 0.000 description 40
- 229940024606 amino acid Drugs 0.000 description 22
- 235000001014 amino acid Nutrition 0.000 description 22
- 230000000694 effects Effects 0.000 description 21
- 102000004506 Blood Proteins Human genes 0.000 description 9
- 108010017384 Blood Proteins Proteins 0.000 description 9
- 102000006395 Globulins Human genes 0.000 description 8
- 108010044091 Globulins Proteins 0.000 description 8
- 238000005185 salting out Methods 0.000 description 7
- 102000008946 Fibrinogen Human genes 0.000 description 6
- 108010049003 Fibrinogen Proteins 0.000 description 6
- 108060003951 Immunoglobulin Proteins 0.000 description 6
- 229940012952 fibrinogen Drugs 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 102000018358 immunoglobulin Human genes 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 4
- 238000005260 corrosion Methods 0.000 description 4
- 230000007797 corrosion Effects 0.000 description 4
- 238000000502 dialysis Methods 0.000 description 4
- 229940072221 immunoglobulins Drugs 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 230000037452 priming Effects 0.000 description 4
- 229910052938 sodium sulfate Inorganic materials 0.000 description 4
- 235000011152 sodium sulphate Nutrition 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 239000012510 hollow fiber Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 235000004252 protein component Nutrition 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 238000004062 sedimentation Methods 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N Alanine Chemical compound CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
- 229960003767 alanine Drugs 0.000 description 2
- 235000004279 alanine Nutrition 0.000 description 2
- 150000001805 chlorine compounds Chemical class 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- FGDZQCVHDSGLHJ-UHFFFAOYSA-M rubidium chloride Chemical compound [Cl-].[Rb+] FGDZQCVHDSGLHJ-UHFFFAOYSA-M 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102000014702 Haptoglobin Human genes 0.000 description 1
- 108050005077 Haptoglobin Proteins 0.000 description 1
- 102000013271 Hemopexin Human genes 0.000 description 1
- 108010026027 Hemopexin Proteins 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 102000004338 Transferrin Human genes 0.000 description 1
- 108090000901 Transferrin Proteins 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- ROZPZBUZWPOKFI-UHFFFAOYSA-M [Cl-].[Fr+] Chemical compound [Cl-].[Fr+] ROZPZBUZWPOKFI-UHFFFAOYSA-M 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- AIYUHDOJVYHVIT-UHFFFAOYSA-M caesium chloride Chemical compound [Cl-].[Cs+] AIYUHDOJVYHVIT-UHFFFAOYSA-M 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000007799 cork Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 229950010030 dl-alanine Drugs 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000004023 fresh frozen plasma Substances 0.000 description 1
- 229960002449 glycine Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 229960003136 leucine Drugs 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011403 purification operation Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229940102127 rubidium chloride Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 229960004295 valine Drugs 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59187805A JPS6164259A (ja) | 1984-09-07 | 1984-09-07 | 血漿蛋白質分画分離剤および装置 |
| US06/753,713 US4678566A (en) | 1984-07-20 | 1985-07-10 | Apparatus for separating proteins from blood plasma |
| DE8585108830T DE3586832T2 (de) | 1984-07-20 | 1985-07-15 | Vorrichtung zum abtrennen von blutplasma-eiweiss. |
| DE3587989T DE3587989T2 (de) | 1984-07-20 | 1985-07-15 | Vorrichtung zur Trennung der Proteine vom Blutplasma. |
| DE3587888T DE3587888T2 (de) | 1984-07-20 | 1985-07-15 | Mittel zum Abtrennen von Proteinen aus Blutplasma. |
| EP90113273A EP0399572B1 (de) | 1984-07-20 | 1985-07-15 | Vorrichtung zur Trennung der Proteine vom Blutplasma |
| EP90113272A EP0404202B1 (de) | 1984-07-20 | 1985-07-15 | Mittel zum Abtrennen von Proteinen aus Blutplasma |
| EP85108830A EP0168801B1 (de) | 1984-07-20 | 1985-07-15 | Vorrichtung zum Abtrennen von Blutplasma-Eiweiss |
| US07/026,995 US4774019A (en) | 1984-07-20 | 1987-03-17 | Agent for precipitative separation of proteins from blood plasma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59187805A JPS6164259A (ja) | 1984-09-07 | 1984-09-07 | 血漿蛋白質分画分離剤および装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6164259A JPS6164259A (ja) | 1986-04-02 |
| JPH0365989B2 true JPH0365989B2 (de) | 1991-10-15 |
Family
ID=16212546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59187805A Granted JPS6164259A (ja) | 1984-07-20 | 1984-09-07 | 血漿蛋白質分画分離剤および装置 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6164259A (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62266071A (ja) * | 1986-05-14 | 1987-11-18 | テルモ株式会社 | 血漿蛋白質分離装置 |
| JPH01249062A (ja) * | 1988-03-29 | 1989-10-04 | Sekisui Chem Co Ltd | 体外循環回路 |
| JPH0323866A (ja) * | 1989-06-21 | 1991-01-31 | Sekisui Chem Co Ltd | 体外循環回路 |
| JP6583766B2 (ja) * | 2015-02-02 | 2019-10-02 | 学校法人北里研究所 | タンパク質分離方法、タンパク質分析方法、及びタンパク質分離キット |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5566518A (en) * | 1978-11-09 | 1980-05-20 | Behringwerke Ag | Manufacture of colddinsoluble globulin |
| JPS5772915A (en) * | 1980-10-16 | 1982-05-07 | Ionics | Separation of aqueous protein mixture |
| JPS5772916A (en) * | 1980-10-16 | 1982-05-07 | Ionics | Separation of protein mixture by salt addition |
-
1984
- 1984-09-07 JP JP59187805A patent/JPS6164259A/ja active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5566518A (en) * | 1978-11-09 | 1980-05-20 | Behringwerke Ag | Manufacture of colddinsoluble globulin |
| JPS5772915A (en) * | 1980-10-16 | 1982-05-07 | Ionics | Separation of aqueous protein mixture |
| JPS5772916A (en) * | 1980-10-16 | 1982-05-07 | Ionics | Separation of protein mixture by salt addition |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6164259A (ja) | 1986-04-02 |
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