JPH0350285A - Lipid peroxide decomposing agent composition - Google Patents

Abstract

PURPOSE:To obtain the title composition which can reduce the amount of a lipid peroxide derived from a living organism and prevent the worsening of its odor by compounding at least a porphyrin metal complex and an antioxidant. CONSTITUTION:The title composition contains at least a porphyrin metal complex (e.g. sodium iron chlorophyllin) and an antioxidant (e.g. sodium ascorbate).

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to a lipid peroxide decomposition agent composition, and more specifically, it is useful for cosmetics, pharmaceuticals, foods, etc. containing a porphyrin metal complex and an antioxidant as active ingredients. The present invention relates to a lipid peroxide decomposition agent composition.

[Prior Art] It has been known that free radical reaction products steadily accumulate in the body as we age. It has been thought that these reaction products interfere with the smooth functioning of the physiological functions of living organisms, and are highly likely to be closely linked to at least some aging phenomena.

Recently, attempts have been made to directly apply an electric field to free radical reaction products (hydroperoxides) in living organisms.
In particular, when examining the relationship between the amount of hydroperoxide in the skin of mice, rabbits, and humans and aging, it has been reported that the amount of hydroperoxide increases rapidly after a certain age [e.g. R·
Day Lipman, Experimental Zeront O
G., 1988, Vol. 20, pp. 1-5 (R, D.

L ippman, Experimental Ge
rontoloay vol, 20.

p1-5.1988)].

Vitamin B2, vitamin B2 butyrate, and the like have been reported as substances that decompose lipid peroxide, which is a factor in skin aggravation.

[Problems to be Solved by the Invention] However, the above-mentioned substances have problems with their compatibility with sebum, etc. against the level of lipid peroxide actually present in the skin; At present, no lipid peroxide decomposition effect has been observed.

Therefore, the object of the present invention is to provide a lipid peroxide decomposing agent composition that has a sufficient lipid peroxide decomposition effect, can reduce the accumulation of lipid peroxide of biological origin, and can also prevent deterioration of its own odor. It's about providing things.

[Means for Solving the Problems] In view of the above circumstances, the present inventors have made extensive studies and found that a composition containing a porphyrin metal complex and an antioxidant as active ingredients has a strong lipid peroxide decomposition effect. They discovered this and completed the present invention.

That is, the above object of the present invention is achieved by providing a lipid peroxide decomposer composition containing at least a porphyrin metal complex and an antioxidant.

Specifically, the lipid peroxide decomposition agent composition of the present invention can be obtained by blending (coexisting with) a porphyrin metal complex and an antioxidant in water, an aqueous alcohol solution, or an oily substance.

The amounts of the above-mentioned porphyrin gold R complex and antioxidant are preferably 0 for each of the lipid peroxide decomposer composition of the present invention, such as cosmetics, pharmaceuticals, foods, or raw materials thereof.
．． 001 to 5% by weight, more preferably 0.01 to 2f4
ffi%. In addition, the ratio of the porphyrin metal complex to the antioxidant is preferably 1:9 to 10:1 by weight,
Furthermore, the ratio is preferably 1:5 to 5:1, particularly 1:3 to 1:1.

The porphyrin metal complex in the present invention is a metal complex in which a metal is coordinated to the center of a porphyrin skeleton, such as protoporphyrin, hematoporphyrin, sulfonated tetraporphyrin, chlorophyrin, pheophorbite, pyropheophorbite, sulfonated phthalocyanine. or their alkali metal salts (sodium salt, potassium salt) such as copper, iron, zinc, cobalt, manganese, nickel, magnesium, vanadium complexes, tetraphenylporphyrin, octaethylporphyrin, pheophytin, methylpheophorbite, methylpyropheophor Partite copper, iron, zinc, cobalt, manganese, nickel, magnesium, vanadium complexes, etc. are preferred. These porphyrin metal complexes may be used alone or in combination of two or more.

Examples of the antioxidant used in the present invention include ascorbic acid or its sodium salt or potassium salt, ascorbic acid fatty acid ester, erythorbic acid or its sodium salt or potassium salt, BHTlBHA,
Examples include phytic acid, tocopherol, hydroquinone, and tannin. These antioxidants may be used alone or in combination of two or more.

In addition, the form of the composition in which the porphyrin metal complex and the antioxidant are dissolved or dispersed is not particularly limited, and it is effective in various cosmetics, pharmaceuticals, foods, etc. in which they are blended, regardless of whether they are water-based or oil-based. do.

In addition to the above-mentioned essential components, the lipid peroxide decomposition agent composition according to the present invention generally includes pharmaceuticals, quasi-drugs, cosmetics,
Components that are mixed into foods and the like can be added arbitrarily. These components include polyhydric alcohols such as glycerin and propylene glycol, oils such as liquid paraffin, squalane, higher fatty acids and higher alcohols, organic acids such as citric acid and lactic acid, alkalis such as caustic soda and triethanolamine, and higher alkyls. Anionic surfactants such as sulfate ester salts, higher alkyl ether sulfate ester salts, higher fatty acid amide sulfonates, higher alkyl sulfosuccinates, alkylbenzene sulfonates, acyl glutamates, higher alkyl phosphates, higher alkyl quaternary Cationic surfactants such as ammonium salts, fatty acid amine salts, alkylpyridinium salts, amphoteric surfactants such as carboxybetaine, sulfobetaine, imidacillin derivatives, polyoxyethylene alkyl ethers, polyoxyethylene fatty acid amides, sorbitan fatty acid esters, fatty acids Nonionic surfactants such as alkanolamide and polyglycerin fatty acid ester, various drugs such as vitamin C1, vitamin E, glycyrrhizinic acid, saponin, tannin, hinokitiol, and brassenta extract, maltitol, chondroitin sulfate, hyaluronic acid, sodium lactate, etc. Examples include humectants, powders, pigments, dyes, preservatives, anti-oxidants, ultraviolet absorbers, chelating agents, thickeners, alcohol, water, fragrances, and the like.

[Effects of the Invention] The lipid peroxide decomposition agent composition of the present invention provides the following effects.

(1) Suppress product odor deterioration.

(2) Decreasing lipid peroxide of biological origin at the application site of the composition of the present invention.

[Examples] Hereinafter, the present invention will be explained in more detail with reference to Examples, but the present invention is not limited to these Examples.

Example 1 Iron chlorophyllin sodium (Wako Pure Chemical Industries) 10% in a 50% aqueous solution of triethylene glycol (Hanbashira Kagaku)
111 (l and 110 l of sodium ascorbate
1 is added and dissolved to obtain the lipid peroxide decomposition agent composition of the present invention (
Sample 1) of the present invention (10 g) was prepared.

After storing this in a thermostat at 50° C. for 6 days, the odor was evaluated.

For comparison, triethylene glycol without the addition of sodium iron chlorophyllin and sodium ascorbate (comparative sample 1), and triethylene glycol with only the sodium ascorbate of the present invention and the same 7-scorbic acid added (comparative sample 2). Similarly, the same odor evaluation as Sample 1 of the present invention was conducted using triethylene glycol (Comparative Sample 3) to which only sodium ascorbate of the present invention and mixed tocopherol (comparative sample 3) were added.

Table 1 shows the judgment results by three expert panelists.

Table-1 Example 2 Niracol HCO-60 (manufactured by Nikko Chemical Co., Ltd.) 0.2 g
Copper chlorophyllin sodium 10m0, sodium ascorbate 10II in 50% ethanol aqueous solution containing
g of each were added and dissolved to prepare 10 lipid peroxide decomposition agent composition samples 2 (sample 2 of the present invention). Also,
Sample 3 and Sample 2 in which sodium copper chlorophyllin in Sample 2 was changed to 110ll1 of pyropheophorbite iron complex and the addition of sodium ascorbate was changed to 20mg.
Sample 4 was prepared by changing the amount of sodium ascorbate added to 70 ma, and Sample 5 was prepared by changing the amount of sodium copper chlorophyllin added from sample 2 to 50111 (+).

These samples were used to test the effectiveness of the composition of the invention on human skin.

For comparison, 2% HGO-60 containing 5 without the above additives
Comparative sample 4 consisting of only 0% ethanol aqueous solution was prepared and tested in the same manner. The amounts of each composition sample are summarized in Table 2.

In the test, parts of the backs of three male panelists were covered with aluminum foil and exposed to sunlight (in June) for 30 minutes. From the area covered with aluminum foil (dark control area), the area irradiated with sunlight (control area), and the area 3 minutes after applying the sample exposed to sunlight (sample application area) - fixed amount of acetone. Collect sebum from each
The TBA value (thiobarbylic acid value) of each was measured. (Measurement method is Hanafusa, 22nd Oil Chemistry Symposium 146, 1
983) Here, the TBA value is squalene (SQ) (
It was determined as the absorbance against 1+11 (quantified by GLC).

These results are shown in Table 3.

From Table 3 below, the TBA values of the coated areas of samples 2 to 5 of the present invention are significantly lower than those of the control area and the comparative sample coated areas.
It can be seen that it is highly effective in decomposing lipid peroxide in sebum that increases due to sunlight irradiation.

Next, examples of formulations of cosmetics and pharmaceuticals using the lipid peroxide decomposition agent composition of the present invention are shown (however, all formulations (■) are by weight).
). Naturally, the present invention is not limited to these.

Formulation example 1 (health drink) Fructose glucose solution 119 honey
0.1 Sodium copper chlorophyllin 0.01 Ascorbic acid
0.01 citric acid
0.082DL-malic acid 0
．． 041L-Aspartic acid 002L
- Arginine 0.02 Nicotinic acid amide 0.01 Sothorium glutamate 0.001 Thiamine NDS Riboflavin pyridoxine hydrochloride Formerly -α-tocopherol - Sodium malate Decaglyceryl monooleate Purified water Perfume formulation example 2 (emulsion) Stearic acid Cetyl alcohol Vaseline Liquid paraffin polyoxyethylene (10 moles) Monooleic acid ester polyethylene glycol 1500 Triethanolamine Iron lyroline e4 sodium Ascorbate Sodium citrate 1.7x10-4 2.5X 10→ X1G-4 0,05 0, 05 0,1 Remaining appropriate amount 2.5 1.5 5.0 10, O 2,0 3,0 1,0 5,0 5,0 1 Purified water Residual fragrance
Appropriate preservative
Appropriate amount (manufacturing method) Add polyethylene glycol 1500, triethanolamine, sodium ferroline e4, ascorbic acid, and sodium citrate to purified water, dissolve by heating, and keep at 70°C (aqueous phase). Next, the remaining ingredients are mixed, heated and melted, and kept at 70°C (oil phase). The oil phase is pre-emulsified by adding the oil phase to the water phase, and the mixture is uniformly emulsified using a homomixer. After emulsification, the mixture is cooled to 30°C while stirring well.

Formulation example 3 (ointment) γ-oryzanol 1.0 iron biO pheophorbite 0.1 ascorbic acid i.
Rium 0,1 hydrophilic ointment
Residue (manufacturing method) After thoroughly mixing γ-oryzanol, iron pyropheophorbite, and sodium ascorbate with a small amount of hydrophilic ointment, gradually add the following to make the mixture (100%).

however, It is.

(Hydrophilic soft 'fR base) Cetanol polyoxyethylene (30 mol) Cetyl ether glyceryl monostearate (self-emulsifying type) Liquid paraffin white petrolatum methyl paraben butyl paraben propylene glycol Purified water formulation example 4 (back) Polyvinyl alcohol carboxymethyl cellulose residue The formulation of the hydrophilic ointment base is as follows: Sodium 1.07 Sotrium scorpine 3.0 Glycerin
5,0 alcohol (ethanol)
10. 0 purified water
Residual fragrance: Preservative: Preservative (manufacturing method) Add carboxycellulose and polyvinyl alcohol swollen with some ethanol to purified water containing preservative, and add 7
Warm to 0℃ and leave overnight, stirring occasionally.

The next day, add the steel black O filymptrium, sodium ascorbate, glycerin, the remainder of the alcohol, and fragrance, mix evenly, and cool while stirring.

Claims (1)

[Claims] A lipid peroxide decomposition composition comprising at least a porphyrin metal complex and an antioxidant.