JPH0331177B2 - - Google Patents

Info

Publication number

JPH0331177B2

JPH0331177B2 JP58147235A JP14723583A JPH0331177B2 JP H0331177 B2 JPH0331177 B2 JP H0331177B2 JP 58147235 A JP58147235 A JP 58147235A JP 14723583 A JP14723583 A JP 14723583A JP H0331177 B2 JPH0331177 B2 JP H0331177B2

Authority

JP

Japan

Prior art keywords

present

protein

antihypertensive agent

protein polysaccharide

administered

Prior art date

1983-08-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Lifetime

Links

• Espacenet
• Global Dossier
• Discuss

• 108090000623 proteins and genes Proteins 0.000 claims description 17
• 102000004169 proteins and genes Human genes 0.000 claims description 17
• 150000004676 glycans Chemical class 0.000 claims description 14
• 229920001282 polysaccharide Polymers 0.000 claims description 14
• 239000005017 polysaccharide Substances 0.000 claims description 14
• 239000002220 antihypertensive agent Substances 0.000 claims description 12
• 229940030600 antihypertensive agent Drugs 0.000 claims description 11
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
• 241000221198 Basidiomycota Species 0.000 claims description 3
• 239000004480 active ingredient Substances 0.000 claims description 3
• 241000019462 Colpodium versicolor Species 0.000 claims description 2
• 238000012258 culturing Methods 0.000 claims description 2
• 238000005199 ultracentrifugation Methods 0.000 claims description 2
• 239000006286 aqueous extract Substances 0.000 claims 1
• 238000000691 measurement method Methods 0.000 claims 1
• 235000018102 proteins Nutrition 0.000 description 14
• 238000011699 spontaneously hypertensive rat Methods 0.000 description 10
• 230000036772 blood pressure Effects 0.000 description 7
• 235000001014 amino acid Nutrition 0.000 description 4
• 150000001413 amino acids Chemical class 0.000 description 4
• 229940079593 drug Drugs 0.000 description 4
• 239000003814 drug Substances 0.000 description 4
• 108010001062 polysaccharide-K Proteins 0.000 description 4
• UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
• 241000282412 Homo Species 0.000 description 3
• 241001465754 Metazoa Species 0.000 description 3
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
• 230000007059 acute toxicity Effects 0.000 description 3
• 231100000403 acute toxicity Toxicity 0.000 description 3
• 239000000654 additive Substances 0.000 description 3
• 239000000203 mixture Substances 0.000 description 3
• VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
• 239000000126 substance Substances 0.000 description 3
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
• 208000007530 Essential hypertension Diseases 0.000 description 2
• 206010020751 Hypersensitivity Diseases 0.000 description 2
• 241000699670 Mus sp. Species 0.000 description 2
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
• 241000700159 Rattus Species 0.000 description 2
• 239000007864 aqueous solution Substances 0.000 description 2
• 230000037396 body weight Effects 0.000 description 2
• 239000002775 capsule Substances 0.000 description 2
• 239000000839 emulsion Substances 0.000 description 2
• 239000007924 injection Substances 0.000 description 2
• 238000002347 injection Methods 0.000 description 2
• 238000001990 intravenous administration Methods 0.000 description 2
• 231100000053 low toxicity Toxicity 0.000 description 2
• 239000000843 powder Substances 0.000 description 2
• 239000003755 preservative agent Substances 0.000 description 2
• 239000000243 solution Substances 0.000 description 2
• 238000007920 subcutaneous administration Methods 0.000 description 2
• 239000000725 suspension Substances 0.000 description 2
• 239000003981 vehicle Substances 0.000 description 2
• YKFCISHFRZHKHY-NGQGLHOPSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;trihydrate Chemical compound O.O.O.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1 YKFCISHFRZHKHY-NGQGLHOPSA-N 0.000 description 1
• FYGDTMLNYKFZSV-WFYNLLPOSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,3s,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-WFYNLLPOSA-N 0.000 description 1
• 239000004475 Arginine Substances 0.000 description 1
• 229920002498 Beta-glucan Polymers 0.000 description 1
• 206010060891 General symptom Diseases 0.000 description 1
• 229920001503 Glucan Polymers 0.000 description 1
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
• 239000004472 Lysine Substances 0.000 description 1
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
• 208000031320 Teratogenesis Diseases 0.000 description 1
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
• 230000002378 acidificating effect Effects 0.000 description 1
• 239000013543 active substance Substances 0.000 description 1
• 229930013930 alkaloid Natural products 0.000 description 1
• 230000003276 anti-hypertensive effect Effects 0.000 description 1
• 230000000259 anti-tumor effect Effects 0.000 description 1
• 239000002246 antineoplastic agent Substances 0.000 description 1
• 239000008135 aqueous vehicle Substances 0.000 description 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
• 235000003704 aspartic acid Nutrition 0.000 description 1
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
• 239000011230 binding agent Substances 0.000 description 1
• 230000004531 blood pressure lowering effect Effects 0.000 description 1
• 238000009530 blood pressure measurement Methods 0.000 description 1
• 239000000872 buffer Substances 0.000 description 1
• 229940083181 centrally acting adntiadrenergic agent methyldopa Drugs 0.000 description 1
• 239000003795 chemical substances by application Substances 0.000 description 1
• 239000007884 disintegrant Substances 0.000 description 1
• 239000012153 distilled water Substances 0.000 description 1
• 239000002552 dosage form Substances 0.000 description 1
• 230000000694 effects Effects 0.000 description 1
• 239000008393 encapsulating agent Substances 0.000 description 1
• 235000013922 glutamic acid Nutrition 0.000 description 1
• 239000004220 glutamic acid Substances 0.000 description 1
• 239000008187 granular material Substances 0.000 description 1
• ACGDKVXYNVEAGU-UHFFFAOYSA-N guanethidine Chemical compound NC(N)=NCCN1CCCCCCC1 ACGDKVXYNVEAGU-UHFFFAOYSA-N 0.000 description 1
• 229960003602 guanethidine Drugs 0.000 description 1
• 239000007902 hard capsule Substances 0.000 description 1
• 238000001802 infusion Methods 0.000 description 1
• 230000000968 intestinal effect Effects 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 238000007912 intraperitoneal administration Methods 0.000 description 1
• 239000007788 liquid Substances 0.000 description 1
• 239000012669 liquid formulation Substances 0.000 description 1
• 239000000314 lubricant Substances 0.000 description 1
• 238000005259 measurement Methods 0.000 description 1
• 230000007886 mutagenicity Effects 0.000 description 1
• 231100000299 mutagenicity Toxicity 0.000 description 1
• 230000007935 neutral effect Effects 0.000 description 1
• 239000002547 new drug Substances 0.000 description 1
• 231100000957 no side effect Toxicity 0.000 description 1
• 239000006186 oral dosage form Substances 0.000 description 1
• 238000007911 parenteral administration Methods 0.000 description 1
• 239000000546 pharmaceutical excipient Substances 0.000 description 1
• 230000000144 pharmacologic effect Effects 0.000 description 1
• 239000002504 physiological saline solution Substances 0.000 description 1
• 238000002360 preparation method Methods 0.000 description 1
• UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
• 239000003381 stabilizer Substances 0.000 description 1
• 239000006188 syrup Substances 0.000 description 1
• 235000020357 syrup Nutrition 0.000 description 1
• 238000010998 test method Methods 0.000 description 1
• 239000003451 thiazide diuretic agent Substances 0.000 description 1
• 239000004474 valine Substances 0.000 description 1
• -1 valine and leucine Chemical class 0.000 description 1
• 238000005303 weighing Methods 0.000 description 1
• 239000000080 wetting agent Substances 0.000 description 1