JPH0325438B2 - - Google Patents
Info
- Publication number
- JPH0325438B2 JPH0325438B2 JP62149892A JP14989287A JPH0325438B2 JP H0325438 B2 JPH0325438 B2 JP H0325438B2 JP 62149892 A JP62149892 A JP 62149892A JP 14989287 A JP14989287 A JP 14989287A JP H0325438 B2 JPH0325438 B2 JP H0325438B2
- Authority
- JP
- Japan
- Prior art keywords
- apm
- crystals
- cooling
- crystallization
- methyl ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000013078 crystal Substances 0.000 claims description 82
- 238000001816 cooling Methods 0.000 claims description 44
- 238000002425 crystallisation Methods 0.000 claims description 33
- 230000008025 crystallization Effects 0.000 claims description 28
- 239000007790 solid phase Substances 0.000 claims description 12
- YZQCXOFQZKCETR-UWVGGRQHSA-N Asp-Phe Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 YZQCXOFQZKCETR-UWVGGRQHSA-N 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- 238000001704 evaporation Methods 0.000 claims description 5
- 230000003068 static effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 description 32
- 239000000243 solution Substances 0.000 description 26
- 239000002002 slurry Substances 0.000 description 25
- 238000004519 manufacturing process Methods 0.000 description 24
- 238000007796 conventional method Methods 0.000 description 16
- 239000002994 raw material Substances 0.000 description 14
- 238000000926 separation method Methods 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 238000012546 transfer Methods 0.000 description 11
- 239000007788 liquid Substances 0.000 description 8
- 239000003507 refrigerant Substances 0.000 description 8
- 239000002904 solvent Substances 0.000 description 8
- 239000000843 powder Substances 0.000 description 7
- 238000001914 filtration Methods 0.000 description 6
- 239000012452 mother liquor Substances 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 230000018044 dehydration Effects 0.000 description 4
- 238000006297 dehydration reaction Methods 0.000 description 4
- BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical compound O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229910000831 Steel Inorganic materials 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 230000008030 elimination Effects 0.000 description 3
- 238000003379 elimination reaction Methods 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- VSDUZFOSJDMAFZ-VIFPVBQESA-N methyl L-phenylalaninate Chemical class COC(=O)[C@@H](N)CC1=CC=CC=C1 VSDUZFOSJDMAFZ-VIFPVBQESA-N 0.000 description 3
- 238000001000 micrograph Methods 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 238000007790 scraping Methods 0.000 description 3
- 239000010959 steel Substances 0.000 description 3
- GWKOSRIHVSBBIA-REOHCLBHSA-N (3s)-3-aminooxolane-2,5-dione Chemical class N[C@H]1CC(=O)OC1=O GWKOSRIHVSBBIA-REOHCLBHSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000000498 cooling water Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000010907 mechanical stirring Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 150000001509 aspartic acid derivatives Chemical class 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000011437 continuous method Methods 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 210000001787 dendrite Anatomy 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000000635 electron micrograph Methods 0.000 description 1
- 230000003631 expected effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000013615 non-nutritive sweetener Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000000634 powder X-ray diffraction Methods 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000007712 rapid solidification Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
Landscapes
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14989287A JPS63183554A (ja) | 1987-06-16 | 1987-06-16 | Ｌ−α−アスパルチル−Ｌ−フェニルアラニンメチルエステル束状集合晶 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14989287A JPS63183554A (ja) | 1987-06-16 | 1987-06-16 | Ｌ−α−アスパルチル−Ｌ−フェニルアラニンメチルエステル束状集合晶 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57060671A Division JPS58177952A (ja) | 1982-04-12 | 1982-04-12 | Ｌ−α−アスパルチル−Ｌ−フエニルアラニンメチルエステルの晶析法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63183554A JPS63183554A (ja) | 1988-07-28 |
| JPH0325438B2 true JPH0325438B2 (es) | 1991-04-05 |
Family
ID=15484907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14989287A Granted JPS63183554A (ja) | 1987-06-16 | 1987-06-16 | Ｌ−α−アスパルチル−Ｌ−フェニルアラニンメチルエステル束状集合晶 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS63183554A (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001081100A (ja) * | 1999-08-18 | 2001-03-27 | Daesang Corp | アルファ−ｌ−アスパルチル−ｌ−フェニルアラニンメチルエステルの結晶化 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5535059A (en) * | 1978-09-05 | 1980-03-11 | Ajinomoto Co Inc | Preparation of lower alkyl ester of alpha-l-aspartyl-l- phenylalanine |
-
1987
- 1987-06-16 JP JP14989287A patent/JPS63183554A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5535059A (en) * | 1978-09-05 | 1980-03-11 | Ajinomoto Co Inc | Preparation of lower alkyl ester of alpha-l-aspartyl-l- phenylalanine |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS63183554A (ja) | 1988-07-28 |
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