JPH03188013A - Testosterone-5alpha-reductase inhibitor - Google Patents

Abstract

PURPOSE:To obtain a testosterone-5alpha-reductase inhibitor having excellently preventing effects on removal of hair, hair growing and restoring effects as a hair tonic or skin external preparation, containing an extract of rosaceous plant. CONSTITUTION:Flower, pericarp, fruit, leaf, root, stem, etc., of rosaceous plant such as peach, Rosa rugasa, Rosa odorata, flower of Rosa odorata, R. coptophyllus, Rosa centifolia, sanguisorba officinalis L. or Pseudocydonia siensis is extracted with an organic solvent (e.g. acetone) or a carbon dioxide gas. At least one of the extracts is contained to prepare the objective substance. The extract of rosaceous plant is blended with an extract of plant such as Swertia japonica, Angellicae acutiloba, Panax ginseng, Zingiber officinale or Rhemannia glutinosa to prepare the objective substance. The objective substance can be processed into a dosage form such as solution, milky lotion, ointment, cream, gel of toilet lotion or aerosol.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention provides a new and safe testosterone-5α-reductase inhibitor useful as a hair-growth cosmetic or external skin preparation, and an excellent hair-growth effect. Regarding head cosmetics.

[Prior Art] It has been known that physiological symptoms such as male pattern baldness, hair loss, and seborrhea are caused by increased stimulation of male hormones caused by excessive accumulation of male hormones in the metabolic system. It is known that there are Recently, it has been discovered that the main body of male hormone activity in several organs including hair roots and sebaceous glands is 5α.
- Dihydrotestosterone (hereinafter abbreviated as 5α-DHT), which is well known to be produced when testosterone is reduced by testosterone-5α-reductase (hereinafter abbreviated as reductase) in target organs. There is.

Therefore, it is thought that symptoms such as male-pattern baldness, coarse hair, seborrhea, and ffl healing caused by increased stimulation of androgens can be reduced or prevented by inhibiting reductase. Several inhibitors have been discovered and synthesized. However, the newly synthesized inhibitors to date have a steroid structure or a steroid-like structure, and have the drawback of having some degree of undesirable hormone-like action.

Furthermore, hair nourishing cosmetics containing various drugs have been known. For example, it contains vitamins such as vitamin B, amino acids such as methionine, vasodilators such as acetylcholine derivatives, anti-inflammatory agents such as purple root extract, female hormones such as estradiol, and skin function-enhancing agents such as cephalanthine. It is used to prevent and treat alopecia. However, although conventional hair-growth cosmetics are said to be effective in preventing and improving dandruff, itching, hair loss, etc., and promoting hair growth and growth, no product has yet achieved satisfactory effects.

[Problems to be Solved by the Invention] In view of the above circumstances, the present inventors have developed a naturally derived substance that has an excellent reductase inhibitory effect, is effective in preventing hair loss, hair growth, and hair growth, and is highly safe. As a result of careful inspection, it was discovered that a special plant extract could solve this problem, leading to the completion of the present invention.

[Means for Solving the Problems] That is, claim 1 of the present invention provides peach, red dogwood, bokeh, kusaboke, onbokku, loquat, wild cherry, heavy strawberry, oranda strawberry, pontilla, tormentine, almond, apricot, tonin, Japanese apricot, Plum, plum,
Japanese radish, bucchikunoki, yellow rose, rowan, western rose, salamander rose, cherry blossom rose, yamabuki, karinsaiko, tsuchigumi, yellow strawberry, Japanese rose, naniwaibara, hamanasu, maikai, bushy rose, bramble, tokuriichigo, shimabaraichigo, long strawberry, waremokou, shimocke , Chinmazakura,
This is a testosterone-5α-reductase inhibitor containing one or more extracts of plants of the Rosaceae family selected from 8Y, which consists of raspberry, kohon, and quince.

Claim 2 of the present invention is characterized in that one or more of the Rosaceae plant extracts according to Claim 1 are combined with the following:
Ginger, chili pepper, yellowtail, aloe, Japanese pepper, goshuyu, wolfberry, mugwort, quince, rice, mankeishi, stonewort, quince, broom, broom, gentian, tanjin, loofah, bellflower, pine, japonica, ginseng, safflower, barberry, betel nut. , perilla, eucalyptus, kagosou, osmanthus, goshi, saiko, tea, silkworm, eleuthero, white, wasabi, jyotishi, oranda senchi, gardenia, melon, garlic, honeysuckle, yokuinin, giraffe, burdock, licorice,
Hops, chrysanthemums, rakkyo, chives, green onions, onions, chives, shishuido, senega, amachazuru, stone mushrooms, fennel, onji, kengoshi, peony, valerian, catalpa, snail, bittern, soybean, chinko, gennoshoko, cuckoo thistle, clove, rhubarb , Senso, Shasenso, Gobaishi, Jasho,
Pouki, boufuu, kouhon, rhinoceros, toshishi, kashu, biyakushi, agi, kozui, chiliflower, monoamnonium glycyrrhizinate, sesame, glycyrrhetinic acid,
Senkyu, Botanpi, Mokka, Ouren, Gokahi, Hange, Augi, Kukosi, Bukuriyo, Rhubarb, Tenma, Byakushaku, Hokoshi, Sojinshi, Chin, Keishitaisou, Keiketsuto, Jikoppi, Meiketsu,
Betel nut, Byakubu, Kankyo, Hakusenpi, Aogiri, Anmaroku, Ubai, Nettle, Ookuriharan,
Japanese staghorn, staghorn a1, gubaku, keihi, gedokushi, gokahi, kosou, gomish, kobushi, konotegashiwa, nebula, teuchigurumi, seikou, dokuyoishika, calamus, sycamore, birch, elm, ryokyo, ryuyou, yochishi, toyo, hyakugo, wren. The present invention is a testosterone-5α-reductase inhibitor characterized in that it contains one or more extracts of , Osmanthus oleracea , Oriental japonica , Oriental japonica , Cordyceps sinensis , Cordyceps sinensis , Osmanthus oleracea , Oriental japonica , Oriental japonica , Oriental japonica , Oriental japonica , Oriental melon

Claim 3 of the present invention provides that the Rosaceae plant according to Claim 1 is combined with acetone, ethyl acetate, butyl methyl ketone, diethyl ether, dichloromethane, xylene, trichloroethylene, carbon tetrachloride, benzene, chloroform, toluene, and carbon dioxide gas. This head cosmetic is characterized by containing an extract extracted with one or more solvents selected from the group consisting of:

Claim 4 of the present invention provides that the Rosaceae plant according to Claim 1 is combined with acetone, ethyl acetate, butyl methyl ketone, diethyl ether, dichloromethane, xylene, trichloroethylene, 12 g carbon chloride, benzene, chloroform, toluene, and carbon dioxide gas. An extract extracted with one or more solvents selected from the group consisting of: Jasmine japonica, Japanese horse chestnut, carrot, ginger, chili pepper, Japanese yolk, aloe, Japanese pepper, goshuyu, wolfberry, mugwort, mustard, rice, mankei, manganese , broom, broom, gentian, tanjin, loofah, bellflower, pine, kujin, ginseng, safflower, barberry, betel nut,
Perilla, eucalyptus, kagosou, osmanthus, goshitsu, saiko, tea, silkworm, eleuthero, white, wasabi, 3-year-old daisy, oranda senichenium, gardenia, usubasaishin,
Garlic, honeysuckle, yokuinin, giraffe, burdock, licorice, hop, chrysanthemum, rakkyo, chive, green onion,
Onions, chives, sardines, senega, amadiazulu, stone mushrooms, fennel, onji, tanjin, peony, valerian, catalpa, snail, bittern, soybean, parrot, staghorn, cuckoo thistle, clove, rhubarb, senso, japonica, japonica, jasmine, japonica , Boufuu, Kouhon, Ziou,
Toshishi, Kashu, Japanese beak, Agi, Kozui, Enmeisou, Monoamnonium glycyrrhizinate, Sesame, Glycyrrhetinic acid, Nemium, Botanpi, Mokka, Oren, Gokahi, Hange, Aspergillus, Lycium japonica, Bukuriyo, Rhubarb, Tenma, Juniper, Hokoshi, Soukinshi , Chinpi, Keishitaisou, Keiketou, Jikoppi,
Meiketou, betel nut, Byakubu, Kankyou, Hakusenpi, Aogiri, Anmaroku, Ubai, Nettle, Ookuriharan, Oogi, Ouro, Cuckon, Gubaku, Keihi, Gedokushi, Gokahi, Kosou, Gomishi, Kobushi, Konotegashiwa, Senkyu, Teuchigurumi, Seikou, Dokuyouishika, Contains one or more extracts of Calamus, Calamus, Birch, Japanese elm, Japanese elm, Japanese daisy, Japanese yam, Japanese daisy, Hyakugo, Japanese wren, Japanese osmanthus, Hanmyo, Japanese cypress, Japanese cypress, Chinese chinese chinensis, Japanese chinensis, Japanese chinensis, Cordyceps sinensis. This head cosmetic is characterized by:

Hereinafter, the configuration of the present invention will be explained in detail.

As the plant of the Parafamily used in claims 1 to 4 of the present invention, Arimonia eup
atoria L.), Agrimon
ia pilosa L,), agrimonia pilosa, L.
edeb, ), Chaenome 1esi
aponica L, ), Chaenoa + eles 5pecios
a N,), mokuka which is a fruit of blur, quince (Cy
donia oblonga M,), quince fruit ombok, and red raspberry (Duchesnea c).
hrysantha M), Yabuhebi Strawberry (Duch
esneaindica F), jabai and chamo (Duc
hesnea sp, ), loquat (Eriobotrya
japonica L, ), Natsuyukisou (
Fflipendula ulmaria M,), Dutch strawberry (Fragaria chiloensi)
s L, ), Geum japonic
Geum japonicum, Thunb
), Geum urbanu
m L), Kotsutsuki (Hagenia abyssin)
ica J, F.), Western apple (Malus d.
omestica Borkh, ), Botentilla (P
otentilla anserina L,), Ketsuma, which is the tuberous root of Botentilla, Karin Sai: L (Po
tentilla chinensis S,), Iryosai which is the root or whole plant of Karinsai, Korasai or Honbakusou, Potentill.
a discolor Bunge), Hombakusou, Botentilla tormenteira (
Potentilla tormentilla 5c
hrank), Tormentilla, which is the rhizome of Botentilla tormentilla, Potentil
la wallichiana D), and the whole plant of Ohebiidgo (P. la wallichiana D).

tentilla Kleiniana), Prinsepia uniflora (Prinsepia uni[1o
ra B), Prunus amygdalu, the drupe of Princepia uniflora, Prunus amygdalu, the drupe of Princepia uniflora, and Almond (Prunus amygdalu).
s B), apricot (Prunus armeniaca)
L,), apricot seeds Kyokokon, and Gyoko (P)
runus persica B,), Prunus persica which is the seed of Prunus persica, Prunus grayana Maxim
), Edohigan (Prunus pendula M
axim, ), wild cherry (Prunus jamas)
akura 5ieb, ), Prunus japonica T.
humb, ), ichrin, the seed of Japanese plum, Prunus mandshurica (Prunus mandshurica)
, ), Prunus mume 5ieb, ),
Ubai, which is the unripe fruit of plum, Ezonouwa Mizuzakura (
Prunus padus L, ), peach (Prunu
s persica B,), plum (Prunus)
5alicina L,), plum leaf,
Prunus 5ibirica L,
), Prunus tomentosa
Thunb,), San'outou, which is the fruit of Yusuraume, Ikurinin, which is the seed of Yusuraume, Someiyoshino (
r'runus yedoensis Matsum,
), Prunus mume S, which is the bark of Yoshino cherry tree, Prunus mume S, ), Prunus mume S.
nus perisica B,), P. perisica (Pr.
unus tomentosa Thunb,), cherry rose (Rosa multiflora T,), Japanese rose (Rosa hirtula N,), climbing rose (Rosa spp.

Climbing Rosa), Yatsupusaume (1'r
unus mume S, ), Keyamazakura (Prun
us donarium S,), Prunus donarium S,), Prunus donarium S,), Prunus 5ieboldi W,), Prunus n1pponica M,
Shinami cherry (Prunus pseudo-cera)
sus L,), Prunus
1 aurocerasusu L), Bakudetsuki (P
runus zippeliana M,), Japanese quince (
Pseudocydon 1asinensis S,
), quince fruit Meisa, pear (Pyr
us communis L, ), Jarimbai (Rh
aphiolepis umbellata M,),
Naniwaibara (R.

Rosa laevigata Michx,), roots, leaves, flowers, and offspring of Rosa laevigata (Rosa laevigata Michx,)
Rosa rugosa (Rosa rugosa, Thu
nb), Maikai (R.

sa rugosa, Thunb), the flower of the maikai, Rubus burge (Rubus burge)
Ru
Bus Ching (Hu), Sangu
isorba officinalis L,), roots and leaves of Sorbus spp., Sorbus
comixta Hedl,), Sorbuscomixta Hedlund,
Sorbus gracilis
K.), Sorbus mat
sumurana K.), Takane Sorana (Sor.
bus sambucifolia M,), Spiraea n1pponica M
), Spiraea nervosa
F,), Hozakinonanakamato page 5orbaria 5
orbilolia A,), Japanese quince (Mes
pilus germanica L,), Rosa hirtula N,), Rubus phoenicolasius M,
), Yamachi 3 which is the whole plant of Ebigaraichigo (Rubus Lambert), Rubus Lambert (Rubus Lambert)
ianus S,), Houbai, which is the fruit of the Shimabara strawberry, and Tokkuri Ijigo (R, coreanus Miq).
, ), R. parvifolius
Rosa Thor
yi T,), shujimai, a root vegetable of the bushy rose, and rubus corchorifo (rubus corchorifo).
lius L,), Rubus (R, coptophyl
lus A,), Nagabamomijijigo (R.

palmatus Thunb, ), bittersweet (R,
m1crophyllus), the roots, leaves, and fruits of the velvety strawberry or bramble or the rubus
corchorifolius), Koushimbara Ros
a chinensis Jacq,), Rosa chinensis (Japanese rose flower)
, Yamabuki (Kerria japonjca DC)
, Titou (Kerria jap)
onica), P. onica (P.

tentilla discolor), Shopi (R
osa sp,), Western rose (Rosa cent.
ifolia), Yachoma (Rubus phoeni)
colasius), etc.

Flowers, skins, fruits, leaves, roots, stems, etc. of these plants can be used in the present invention.

In claims 1 to 4 of the present invention, among the plants of the Rosaceae family, peach, hamanasu, macacia, macacia, bramble, bramble, and quince are particularly preferred in terms of effectiveness.

Among the other plants according to claim 2 or 4 used in the present invention, the following are particularly preferred in terms of effects.

Swertia j., a plant of the Gentianaceae family.
aponica), the whole plant of Toki (Japanese aponica), a plant of the Umbelliferae family,
Roots of Angelicae acutiloba), Panax gin (se.
ng) root, ginger (Zin), a plant of the Zingiberaceae family
giber officinale), the root of Capsicum annuum (Capsicum annuum), a plant of the Solanaceae family.
L,), a plant of the Physcomitraceae family, the fruit of R.
ehmannia glutinosa) root, licorice (G
monoammonium glycyrrhizinate and glycyrrhizic acid obtained from glycyrrhizin, which is a component of Lycyrrhiza glabra), seeds of sesame (Sesamum indicum L,), a plant of the Sesame family;
Cnidium of the Umbelliferae family
ficinale or Ligusticum wal
The roots of Polygonum multi, also known as Polygonum polygonum, a plant of the Polygonaceae family.
The roots or leaves of Z. florum, the leaves of Aloesp (Aloesp), the fruit of Zanthoxylum Fruit, a member of the Rutaceae family, and Evodia, a member of the Rutaceae family.
Rutaecarpa or Evodiaof fi
Lycium chinense, a plant of the nightshade family, stems, leaves, roots,
The skin or fruit of artemisia (Artem), a plant of the Chrysanthemum family.
isia princeps) leaves or fruits of quince (Brassica cernua), a member of the Brassicaceae family.
or 5inapis alba L) leaves or seeds;
va L) seeds and stems of Vitex rotundifolia, a plant of the Verbenaceae family.
), the fruit of Rosma, a plant of the Lamiaceae family.
rinus officinalis), the rhizome of Drynaria Fortunei (also known as Drynaria fortunei), a plant of the Polygonaceae family, and the rhizome of Drynaria fortunei (Drynaria fortunei), a plant of the Polygonaceae family.
Cus H, or Rumex crispus) roots, leaves, or fruits.

The Rosaceae plant extract used in claims 1 to 4 of the present invention is an organic compound such as acetone, ethyl acetate, butyl methyl ketone, diethyl ether, dichloromethane, xylene, trichloroethylene, carbon tetrachloride, benzene, chloroform, toluene, etc. It can be obtained by extraction using solvents, carbon dioxide gas (supercritical extraction), etc. alone or in combination.

Other plant extracts used in claim 2 or 4 of the present invention include lower alcohols such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol, hydrous lower alcohols, propylene glycol, 1-3 butylene glycol, etc. Polyhydric alcohols or hydrous alcohols such as hydrous polyhydric alcohols, or acetone, dioxane, methyl ethyl ketone, acetonitrile, acetic acid ethyl ester, butyl methyl ketone, diethyl ether, dichloromethane, xylene, trichloroethylene, carbon tetrachloride, benzene,
It can be obtained by extraction using organic solvents such as chloroform and toluene, carbon dioxide gas (supercritical extraction), etc. alone or in combination.

Claim 3 or 40 of the present invention provides a head cosmetic that includes, in addition to the above-mentioned essential ingredients, vitamins such as vitamin B6, vitamin E and its derivatives, biotin, pantothenic acid and its derivatives, and glyderretinate acid. and its derivatives, nicotinic acid esters such as benzyl nicotinate, cyclosborins, capronium chloride, cephalanthine, oxendrone, diazoxide, minoxidil, hair growth aids such as edinyl estradiol, hinokidiol, hexachlorophene, fer Antibacterial agents such as alcohol, benzalkonium chloride, cetylpyridinium chloride, untylenic acid, trichlorocarbanilide and bithionol, cooling agents such as menthol, salicylic acid,
Zinc and its derivatives, drugs such as lactic acid and its alkyl esters, organic acids such as citric acid, amine marks such as arginine, squalane, liquid paraffin, isopropyl myristate, oils such as higher fatty acids and higher alcohols, glycerin, propylene Polyhydric alcohols such as glycol, aqueous ingredients, humectants, thickeners, preservatives, antioxidants, fragrances,
It is possible to mix colorants, chemicals, etc. The testosterone-5α-reductase inhibitor or head cosmetic of the present invention may be in any form such as liquid, emulsion, ointment, cream, lotion gel, aerosol, etc. For example, cream, lotion, tonic, hair cream, etc. , mousse, shampoo, conditioner, conditioner, scalp treatment, etc.

[Example] Next, the present invention will be explained in detail with reference to Examples.

The present invention is not limited thereby. The blending amount is in weight%.

Takayasu's method (S, Takayasu, K,
Δdachi, J.

CIin, Endocrinol, Metab, ,
1098-1101 (1'172))
Using human hair roots, the amount of testosterone reduced to 5α-D HT was measured, and the reductase inhibitory effect of each crude drug was examined. The results are shown in Table 1.

Table 1 Amount of 5α-DHT produced when no inhibitor is added Human hair root testosterone-5α-reductase inhibition rate (%) In Table 1 above, in contrast to 5α-reductase inhibition in large hair root sebaceous glands, various plant extracts inhibit reductase. The effect was clearly recognized.

Rokupa (hair growth effect measurement in mice) Using male C3H mice (60 days old), Ogawa et al.'s method (Normal and Abnormal Epid
ermal Dif-ferentiation)
M, 5eiji and 1. A.Bernste
The experiment was conducted in accordance with the in 1m Focusing University Publishing Society. Shave the back of the mouse to a size of about 2 x 4 cm, and shave it from the next day.
Samples were applied once a day, and changes in the area ratio of areas where hair regeneration had started were determined to compare the speed of hair regeneration. Samples were prepared by stirring and dissolving dried plant extracts in 75% ethanol, adding and dissolving a surfactant thereto. 75% ethanol was used as a control in the test. Ten mice were used for each sample, and the average value of the rate of change was determined. The results of hair regeneration area after 20 days are shown in percentage in Table 2.

Comparative example 1 (1) 75% ethanol Comparative example 2 (1) 75% ethanol extract (dry product) of Aspergillus japonica (2) 75% ethanol 00 8 Example 1 (1) Acetone extract (dry product) of peach (2 ) 75% ethanol Example 2 (1) Xylene extract of Tonin (dried product) (2) 75
% Ethanol Example 3 (1) Acetate ethyl ester extract (dry product) of Hamanasu (dry product) (2) 75% ethanol Example 4 (1) Ethyl ether extract of Hamanasu (dry product) (2) 75% ethanol Example 5 (1) Maikai carbonate male extract (dried) (2) 75
% Ethanol Example 6 (1) Hexane extract of Mycai squid (dry product) Residue Residue Residue (2) 75% ethanol Residue Example 7 (1) Acetone extract of Mycai squid (dry product) 2 (
2) 75% ethanol Remaining Example 8 (1) Mica squid benzene extract (dry product) 2 (
2) 75% ethanol Remaining Example 9 (1) Toluene extract (dry product) of Ijigo japonica 2 (
2) 75% ethanol Residual Example 10 (1) Rubus isopropanol extract (dried product) 2 (2) 75% ethanol Residual Example 11 (1) Rose (Rosa centifolia L,)
Acetone mixed solvent extract (dry product) of 2(2)75
% ethanol Residual Example 12 (1) Rose (Rosa centifolia L,)
Benzene and toluene mixed solvent extract (dry product) (2)
75% ethanol Example 13 (1) Loquat carbon tetrachloride extract (dry product) (2) 75%
Ethanol Example 14 (1) Diethyl ether extract of loquat (dry product) (2) 75% ethanol Example 15 (1) Dioxane extract of C. elegans (dry product) (2) 75% ethanol Example 16 (1) Dichloromethane extract of Japanese quince (dry product) (2) 75% ethanol Example 17 (1) Butyl methyl ketone extract of Yamabuki (dry product) Residue Residue Residue Residue (2) 75% ethanol Residue Example 18 (1) Acetone mixed solvent extract (dry product) of Japanese strawberry (dry product) 2 (2) 75% ethanol Remaining Example 19 (1) Benzene extract (dry product) of Japanese quince (2)
) 75% ethanol Remaining Example 20 (1) Acetone extract (dry product) of C. spp. 2 (2
) 75% ethanol Residual Example 21 (1) Dichloromethane extract of Japanese quince (dry product) 2 (2) 75% ethanol Residue Example 22 (1) Acetate ethyl ester extract of Citrus chinensis (dry product) 1 (2) Waremokou Diethyl ether extract (dry product) of 1 (3) 75% ethanol Remaining Example 23 (1) Acetone extract (dry product) of Mica
) Chloroform extract (dry product) of Hermanus 1 (3) 75% ethanol Remaining Example 24 (1) Acetone extract (dry product) I (2
) Carbonated extract (dried product) of Hermanus 1 (3) 7
5% ethanol Residual Example 2
5 (1) Rubus toluene extract (dried) 1 (2
) Mica squid benzene extract (dried) 1 (3) 7
5% ethanol Residual Example 2
6 (1) Loquat carbon dioxide extract (dried product) 1 (2
) Dichloromethane extract of Chinese quince (dry product) 1 (3) 75% ethanol Remaining Example 27 (1) Carbon dioxide extract of Chinese quince (dry product) 0.5 (2
) Acetone extract (dry product) of Amaranthus japonica 0.5 (3) Benzene extract (dry product) of Amaranthus japonica (dry product) 0.1 (4) 75
% ethanol Residue Example 28 (1) Benzene extract (dry product) of Maycai 0.4 (2
) Quince acetate ethyl ester extract (dry product) 0.6 (3) 75% ethanol Remaining Example 29 (1) Mica squid acetone extract (dry product) 0.7
5(2) Hexane extract of loquat (dried product) 0.
25(3) Quince acetone extract (dried product) 1
(4) 75% ethanol residual table -
As is clear from No. 2, the effect on hair regeneration was observed in each Example.

Table-2 Hair regeneration surface f# of each sample (after 20 days) Example 30
Hair tonic Prepare a tonic with the composition shown below and use it to improve hair growth.
The effect on symptoms such as hair loss was investigated.

20 men (age 25~) who exhibited symptoms such as hair growth and hair loss.
59 years old) was applied once or twice a day in doses of 1 to 51R for 4 months, and the results shown in Table 3 were obtained.

The symptoms such as hair growth and hair loss were excellent.

(1) Carbon dioxide extract (dry product) of Hermanus 0.5 (2
) Acetone extract of Mica squid (dry product) 1.0 (3) Hexane extract (dry product) of Mica squid 0.5 (4
) Benzene extract (dry product) of Maikai 1.4 (5) Benzene extract (dry product) of Pisces chinensis 0.5 (6) Propylene glycol 5.0 (
7) Sodium hyaluronate 0.01 (
8) 75% Ethanol Residual In Table 3 above, the effectiveness was evaluated based on the following criteria.

1. Hair growth effect test ``Ineffective'' means that no improvement is seen despite treatment.

"Effective" means that new hair growth is observed in 273 or more areas of hair loss.

``Remarkable effect'' means that hair has grown in the hair removal area.

2. Hair removal effect test ``Ineffective'' means that no improvement is seen despite treatment.

"Effective" means that the progression of hair loss has decreased.

"Remarkable response" means that hair loss has stopped.

Example 31 Hair tonic (1) Chloroform extract of rubus (dry product) (2) 50% ethanol extract of bramble (dry product) (3) Ethanol extract of licorice (dry product) (4) Glycyrrhetinic acid (5 ) Octopus sinensis extract (dry product) (6) Acetone extract (dry product) of C. chinensis 1.5 0.5 0.4 0.05 0.2 0.1 (7) Polyoxyethylene (8 mol) ) Oleyl alcohol ether 0.1 (8) 1.3-butylene glycol 0.
05(9) 60% Ethanol The effect of the remaining cosmetic of Example 31 on hair growth was also effective.

Example 32 Hair tonic (1) 50% ethanol extract of Kujin (dry product) 0.05 (2) Acetone extract of Mica squid (dry product) 1.75 (3) Methanol extract of Hyakugou (dry product) 0 .5 (4) Monoammonium glycyrrhizinate 0.05 (
5) Alcoholic extract of Toshishi (dried product) 0.05
(6) Ethyl acetate extract (dry product) of chinensis 0.5 (7) Polyoxyethylene (8 mol) Oleyl alcohol ether 0.05 (8N, 3-butylene glycol 0.05 (9) 60%
Ethanol The effect of the remaining cosmetic of Example 32 on hair growth was also effective.

Example 33 Hair Tonic (1) Hexane extract of Cinnamon chinensis (dry product) (2) Isopropanol extract of Dangjin chinensis (dry product) (3) Dichloromethane extract of Cinnamon chinensis (dry product) (4) Ethanol extract of Cinnamon chinensis (dry product) (dry product) (5) Benzene extract of Maykai (dry product) (6) Acetone extract of Korean ginseng (dry product) (7) Polyoxyethylene (8 mol) Oleyl alcohol ether (8) 1,3-butylene glycol 0.5 0.2 65 0.5 1.45 0.5 0.05 0.05 (9) 60% ethanol The effect of the remaining cosmetic of Example 33 on hair growth was also effective.

Example 34 Hair tonic (1) Ethanol extract of juniper (dry product) (2) Ethanol extract of chili pepper (dry product) (3) Artemisia acetate ethyl ester extract (dry product) (4) Isopropylene extract Patul extract (dried) (5) Dioxane extract of Kotsusaiho (dried) (6) Butanol extract of Loofah (dry) (7) Propatur extract of Kashu (dried) (8) Chikusetsu Carrot dichloromethane extract (dry) 0.1 0.5 0.1 0.8 0.1 0.5 0.1 0.1 (9) Safflower alcoholic extract (dry) 0.1 (10 ) Diethyl ether extract of Stonefish (dry product) 0.1 (11) Acetone extract of Mica squid (dry product) 0.5 (12) Polyoxyethylene (8 mol) Oleyl alcohol ether 0.4 (13) 1. 3-Butylene glycol 0
．． 5(14) 60% Ethanol The effect of the remaining cosmetic of Example 34 on hair growth was also effective.

Example 35 Hair tonic (1) Saiko butanol extract (dry product) 0.1 (2
) Mica squid acetone extract (dried) 0.9 (3)
Silkie acetonitrile extract (dry product) 0.4 (4) Hakusenpi methanol extract (dry product) 0.1 (5) Silkie carbon dioxide extract (dry product) 0.4 (6)
Fennel carbonate extract (dried) 0.5 (7) Polyoxyethylene (8 mol) Oleyl alcohol ether 0.2 (80,3-
Butylene glycol 0.1 (9) 60%
Ethanol The effect of the remaining cosmetic of Example 35 on hair growth was also effective.

Example 36 Heartonic (1) Hexane extract (dry product) of Cinnamon mushroom 0.
05(2) Chloroform extract of burdock (dried product)
0.05(3) Ethanol extract of garlic (dried)
0.05 (4) Ethanol extract of Japanese cabbage (dry product) 0.05 (5) Acetone extract of rubus (dry product) 0.5 (6) 70% ethanol extract of Japanese horseradish (dry product)
(dry product) 0.05 (7) Isoboropanol extract of Japanese oleracea (dry product) 0.05 (8) Ethanol extract of perilla (dry product) 0.
05(9) Pine carbon dioxide extract (dried product)
0.05 (10) Luffa butanol extract (dry)
(11 Acetone extract (dry material) of A. japonica (12. Methanol extract (dry material) of a. Product (dried product) (16) Ethanol extract of dioxica (dried product) (17)
Ethanol extract of Hokoshi (dried product) (18) Benzene extract of Maikai (dry product) (19) Ethanol extract of Porphyra spp.
Dioxane extract of raspberry (dry product) (22) Diethyl ether extract of raspberry (dry product) (23) Xylene extract of raspberry (dry product) (24)
Carbon tetrachloride extract (dry product) of Karin Saiko 0.1 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.5 0.1 0.1 0.1 0. 2 0.2 0.3 (25) Chloroform extract of Radish radish (dried) 0.2 (26) Polyoxyethylene (8 mol) Oleyl alcohol ether 0.5 (27) 1.3-butylene glycol 0. 05(28) 60% Ethanol The effect of the remaining cosmetic of Example 36 on hair growth was also effective.

Example 37 Hair tonic (1) Ethinyl estradiol (2) Roburonium chloride (3) Diazoxide (4) Cephalanthine (5) Minoxidil (6) Cyclosporin (7) Benzyl nicotinate (8) Oxendrone (9) Biotin (10 ) Hinokitiol 0.001 0.01 0.001 0.001 0.01 0.001 0.01 0.01 0.01 0.001 (11) Menthol 0.
001(12) Salicylic acid 0
．． 001(13) Vitamin E
O, 01 (14) Ethanol extract of loquat (dried product) 2 (15) Acetone extract of Hamanasu (dry product)
2 (16) Chloroform extract of quince (dry product) 0
．． 1 (17) Polyoxyethylene (8 mol) Oleyl alcohol ether 0.05 (18) 1.3-Butylene gellicol 0.05 (19) 60%
Ethanol Residual Example 37
The effect of Mf3+ on hair growth was also effective.

Example 38 Shampoo (1) Cocoyl methyl taurine sodium (2) Lauryldimethylaminoacetic acid betaine (3) Lauric acid jetanolamide (4) Ethylene glycol fatty acid ester (5) Propylene glycol (6) Korean carrot ethanol 6.0 8 .0 4.0 1.5 2.0 Extract (dried) 1.0 (7) Hawthorn ethanol extract (dried) 1.0 (
8) Methanol extract of peony (dry product) 1.0 (9) Mica squid acetate ethyl ester extract (dry product) 1.0 (10) Disodium edetate 0.1 (
11) Appropriate amount of fragrance (12
) Purified water Remainder Example 3
9 Rinse (1) Stearyltrimethylammonium chloride (2) Cetyl alcohol (3) Silicone oil (4) Polyoxyethylene (10 mol) Oleyl alcohol ether (5) Glycerin (6) Ethanol extract of Panax ginseng (dried product) 1.5 2.0 3.0 1.0 5.0 0.5 (7) Ethanol extract (dry product) of Kashu (8) Acetonitrile extract (dry product) of Kashu (9) Xylene extract of Koshu (Dry product) (10)
Purified water (11) Preservative (12) Ultraviolet absorber 0.5 1.0 1.0 84.0 Appropriate ■ Appropriate amount Example 40 Hair cream (1) Beeswax (2) Vaseline (3) Liquid paraffin (4) Polyester Oxyethylene (5 moles) Stearic acid ester (5) Polyoxyethylene (6 moles) Oleyl alcohol ether (6) Acetone extract of mica squid (dry product) (7) Mechnol extract of loquat (dry product) (8) Karin Acetone extract (dried product) (9) Purified water 3.0 15.0 42.0 3.0 1.0 1.0 2.0 0.4 Remaining amount (10) Flavor (11) Preservative in appropriate amount Example 41 Hair tonic (1) Ethanol (2) Hinokitiol (3) Nylacol) (Co-60 (4) Fragrance (5) Mica squid betuzen extract (dried) (6) Hawthorn acetone extract (dried) ( 7) Purified water 55, O O,5 1,0 Appropriate amount 1.5 1.5 Remaining example 42 Hair tonic (1) Ethanol (2) Hinokitiol (3) Niracol HCO-60 (4) Kana (5) Maikai Acetone extract (dry product) (6) Chloroform extract of peach (dry product) (7) Purified water 55.0 0.5 1.0 Appropriate amount 1.5 1.5 Remaining example 43 Hair tonic (1) Ethanol (2) Hinokitiol (3) Niracol t (CO-60) (4) Fragrance (5) Carbonated extract of Hermanus (dry product) (6) Xylene extract of Japanese quince (dry product) (7) Diethyl ether of Buchigumi Extract (dried product) (8) Dichloromethane extract (dry product) of Strawberry chinensis (9) Purified water 55.0 0.5 1.0 Appropriate amount 1.5 1.5 1.5 1.5 Remaining effect of the invention The testostere a-5α-reductase inhibitor according to claim 1 or 2 of the present invention is very useful as a hair nourishing cosmetic 1 or a skin preparation for external use.

The head cosmetic according to claim 3 or 40 of the present invention has an extremely excellent hair-nourishing effect.

Claims (4)

[Claims] (1) Peach, golden dogwood, bokeh, kusaboke, onbotsu, loquat, wild cherry, heavy strawberry, orchid strawberry, pontilla, tormenchilla, almond, apricot, tonin, Japanese apricot, plum, Japanese radish, radish, bucchikunoki, Japanese rose, rowan, Japanese rose, Sansho rose, Sakura rose, Yamabuki, Kawara Saiko,
An extract of a plant belonging to the Rosaceae family selected from the group consisting of Tsuchigumi, Ohebiichigo, Kōshinbara, Naniwaibara, Hermanus, Maikai, Bosatsuibara, Rubus, Tokkuriichigo, Shimabaraichigo, Ebigaraichigo, Waremokou, Meadowsweet, Chishimazakura, Fuyuiichigo, Fukubon, and Karin. Testosterone containing one or more types
5α-reductase inhibitor. (2) One or more of the Rosaceae plant extracts according to claim 1, and Japanese trumpet, Chinese cabbage, carrot, ginger, chili pepper, Japanese cabbage, aloe, Japanese cabbage, goshuyu,
Lycium, mugwort, mustard, rice, mandarin grass, stonewort, blackberry, broom fern, gentian, tanjin, loofah, bellflower, pine, chinese ginseng, ginseng, safflower, barberry, betel nut, perilla, eucalyptus, sagebrush,
Osprey, Goshitsu, Saiko, Cha, Silkie, Eleuthero, Japanese radish, Wasabi, Japanese radish, Dutch senchichi, Gardenia, Usuba saisin, Garlic, Mentha, Yokuinin, Kirinketsu palm, Burdock, Licorice, Hop, Chrysanthemum, Rakkyo, Chive, Green onion, Onion , chives, peonies, senega, amachazuru, stone mushrooms, fennel, onji, kengoshi, peony, valerian, catalpa, snail, bittern, soybean, chinko, gennoshoko, cuckoo thistle, clove, rhubarb, senso, shazenshi, gobaishi, jasho, bouki, Japanese sardines, sardines, sardines, toshishi, cashews, juniper, agi, kozui, chiliflower, monoamnonium glycyrrhizinate, sesame, glycyrrhetinic acid, nematode,
Botanpi, Mokka, Ouren, Gokahi, Hange, Aspergillus, Lycium, Bukryo, Rhubarb, Tenma, Byakushaku, Hokotsushi, Sojinshi, Chinpi, Keishitaiso,
Keiketou, Jikoppi, Meiketou, Betel nut, Byakubu, Kankyo, Hakusenpi, Aogiri, Anmaroku, Ubai, Nettle, Ookuriharan, Oogi, Ouro, Kakkon, Gubaku, Keihi, Gedokushi, Gokahi, Kosou, Gomishi, Kobushi, Konotegashiwa, Sankyu, Teuchigurumi, Seikou, Dokuyoishika, Calamus,
Flowerbirch, birch, elm, sagebrush, sagebrush, yochishi, dwarf thorn, zinnia, wren, osmanthus,
1. A testosterone-5α-reductase inhibitor, characterized in that it contains one or more extracts of Oriental persica, Cordyceps sinensis, Cordyceps sinensis, Cordyceps sinensis. (3) The Rosaceae plant according to claim 1 is selected from the group consisting of acetone, ethyl acetate, butyl methyl ketone, diethyl ether, dichloromethane, xylene, trichloroethylene, carbon tetrachloride, benzene, chloroform, toluene, and carbon dioxide gas. A head cosmetic containing an extract extracted with one or more solvents. (4) Acetone, acetic acid ethyl ester, butyl methyl ketone, diethyl ether, dichloromethane, xylene, trichloroethylene,
An extract extracted with one or more solvents selected from the group consisting of carbon tetrachloride, benzene, chloroform, toluene, and carbon dioxide;
Goshuyu, goji, mugwort, mustard, rice, mankei,
Stonecrop, Japanese scallion, broom, gentian, tanjin, loofah, kikiyo, pine, chinese ginseng, ginseng, safflower, barberry, betel nut, perilla, eucalyptus,
Kagosou, Mokutsuu, Goshitsu, Saiko, Cha, Ukogi,
Eleuthero, Japanese radish, wasabi, japanese sensuality, gardenia, gardenia, garlic, mentha, yokuinin, giraffe, burdock, licorice, hop, chrysanthemum, rakkyo, chive, green onion, onion, chives, shishuido, senega, amachazuru, stone mushroom ,
Fennel, Japanese radish, Japanese radish, peony, valerian, Japanese pea, Japanese snail, Japanese bittern, Japanese staghorn, Japanese chinensis, gennoshoko, cuckoo thistle, clove, rhubarb, senso, shazenshi, gobaishi, jasho, bouki, boufuu, kouhon, japonica, toshishi, kashu, juniper. , Agi, Kozui, Trifolium, Monoamnonium glycyrrhizinate, Sesame, Glycyrrhetinic acid, Senkyu, Botanpi, Mokka, Ouren, Gokahi, Hange, Aspergillus, Lycium japonica, Bukryo, Rhubarb, Tenma,
Juniperina, hokotsushi, soukinshi, chimpi, keishitaiso, keiketsu, jikoppi, meiketou, pinro, byakubu, kankyo, hakusenpi, aogiri, anmaroku, ubai, nettle, oukuriharan, ogi, ouro, kakkon, gubaku, keihi, gedokushi,
Gokahi, Kosou, Gomishi, Kobushi, Konotegashiwa, Sankyu, Teuchigurumi, Seikou, Dokuyoishika,
Calamus, calamus, birch, elm, ryokyo, ryuyou, reed, toyo, hyakugou, wren,
1. A head cosmetic containing one or more extracts of Osmanthus oleracea, Oriental melon, Leopard trumpet, Oriental melon, Cucumber spp.