JPH0312900B2 - - Google Patents

Info

Publication number

JPH0312900B2

JPH0312900B2 JP57162244A JP16224482A JPH0312900B2 JP H0312900 B2 JPH0312900 B2 JP H0312900B2 JP 57162244 A JP57162244 A JP 57162244A JP 16224482 A JP16224482 A JP 16224482A JP H0312900 B2 JPH0312900 B2 JP H0312900B2

Authority

JP

Japan

Prior art keywords

fiber

adsorption capacity

blood

fibers

present

Prior art date

1982-09-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Lifetime

Links

• Espacenet
• Global Dossier
• Discuss

• 210000004369 blood Anatomy 0.000 claims description 13
• 239000008280 blood Substances 0.000 claims description 13
• 125000003118 aryl group Chemical group 0.000 claims description 11
• 125000000524 functional group Chemical group 0.000 claims description 10
• -1 plasma Substances 0.000 claims description 7
• 210000002381 plasma Anatomy 0.000 claims description 6
• 229920002554 vinyl polymer Polymers 0.000 claims description 6
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
• 210000001124 body fluid Anatomy 0.000 claims description 4
• 239000010839 body fluid Substances 0.000 claims description 4
• 125000000217 alkyl group Chemical group 0.000 claims description 3
• VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 2
• 150000001450 anions Chemical class 0.000 claims description 2
• 229910052799 carbon Inorganic materials 0.000 claims description 2
• 239000000835 fiber Substances 0.000 description 34
• 238000001179 sorption measurement Methods 0.000 description 29
• BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 22
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 20
• 239000003463 adsorbent Substances 0.000 description 14
• 239000003795 chemical substances by application Substances 0.000 description 12
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
• 230000000052 comparative effect Effects 0.000 description 10
• 239000000243 solution Substances 0.000 description 10
• 239000000047 product Substances 0.000 description 9
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 8
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
• 238000000354 decomposition reaction Methods 0.000 description 7
• 230000007935 neutral effect Effects 0.000 description 7
• 150000003839 salts Chemical class 0.000 description 7
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
• 229920000669 heparin Polymers 0.000 description 6
• PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 description 6
• 239000012452 mother liquor Substances 0.000 description 6
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 5
• 239000007864 aqueous solution Substances 0.000 description 5
• 229960002897 heparin Drugs 0.000 description 5
• 231100000614 poison Toxicity 0.000 description 5
• 239000003440 toxic substance Substances 0.000 description 5
• 206010023126 Jaundice Diseases 0.000 description 4
• SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 4
• VXIVSQZSERGHQP-UHFFFAOYSA-N chloroacetamide Chemical compound NC(=O)CCl VXIVSQZSERGHQP-UHFFFAOYSA-N 0.000 description 4
• LQNUZADURLCDLV-UHFFFAOYSA-N nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC=C1 LQNUZADURLCDLV-UHFFFAOYSA-N 0.000 description 4
• 239000008363 phosphate buffer Substances 0.000 description 4
• 102000009027 Albumins Human genes 0.000 description 3
• 108010088751 Albumins Proteins 0.000 description 3
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
• ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
• 239000004793 Polystyrene Substances 0.000 description 3
• PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 3
• ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
• 125000004432 carbon atom Chemical group C* 0.000 description 3
• 238000004132 cross linking Methods 0.000 description 3
• 230000007423 decrease Effects 0.000 description 3
• 238000000034 method Methods 0.000 description 3
• 229920002223 polystyrene Polymers 0.000 description 3
• NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
• 210000002966 serum Anatomy 0.000 description 3
• GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 3
• MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 2
• PYSGFFTXMUWEOT-UHFFFAOYSA-N 3-(dimethylamino)propan-1-ol Chemical compound CN(C)CCCO PYSGFFTXMUWEOT-UHFFFAOYSA-N 0.000 description 2
• 241000283690 Bos taurus Species 0.000 description 2
• ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
• 239000004743 Polypropylene Substances 0.000 description 2
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
• 230000006931 brain damage Effects 0.000 description 2
• 231100000874 brain damage Toxicity 0.000 description 2
• 208000029028 brain injury Diseases 0.000 description 2
• 229920001429 chelating resin Polymers 0.000 description 2
• 239000008187 granular material Substances 0.000 description 2
• 230000003908 liver function Effects 0.000 description 2
• BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
• 229920001155 polypropylene Polymers 0.000 description 2
• 239000000126 substance Substances 0.000 description 2
• 239000006228 supernatant Substances 0.000 description 2
• ZMANZCXQSJIPKH-UHFFFAOYSA-O triethylammonium ion Chemical compound CC[NH+](CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-O 0.000 description 2
• NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
• TXNSZCSYBXHETP-UHFFFAOYSA-N 2-chloro-n-(hydroxymethyl)acetamide Chemical compound OCNC(=O)CCl TXNSZCSYBXHETP-UHFFFAOYSA-N 0.000 description 1
• OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
• 206010028980 Neoplasm Diseases 0.000 description 1
• 229930040373 Paraformaldehyde Natural products 0.000 description 1
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
• 238000008050 Total Bilirubin Reagent Methods 0.000 description 1
• 241000700605 Viruses Species 0.000 description 1
• 238000002835 absorbance Methods 0.000 description 1
• 125000003277 amino group Chemical group 0.000 description 1
• 150000001491 aromatic compounds Chemical class 0.000 description 1
• 230000036772 blood pressure Effects 0.000 description 1
• 239000012888 bovine serum Substances 0.000 description 1
• 210000004556 brain Anatomy 0.000 description 1
• 238000011088 calibration curve Methods 0.000 description 1
• 201000011510 cancer Diseases 0.000 description 1
• 238000006243 chemical reaction Methods 0.000 description 1
• 239000003153 chemical reaction reagent Substances 0.000 description 1
• 239000002131 composite material Substances 0.000 description 1
• 229920001577 copolymer Polymers 0.000 description 1
• 229920006037 cross link polymer Polymers 0.000 description 1
• 238000000502 dialysis Methods 0.000 description 1
• HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
• 238000010790 dilution Methods 0.000 description 1
• 239000012895 dilution Substances 0.000 description 1
• WEHWNAOGRSTTBQ-UHFFFAOYSA-N dipropylamine Chemical compound CCCNCCC WEHWNAOGRSTTBQ-UHFFFAOYSA-N 0.000 description 1
• 229940079593 drug Drugs 0.000 description 1
• 239000003814 drug Substances 0.000 description 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
• 235000019253 formic acid Nutrition 0.000 description 1
• ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 1
• 229960001008 heparin sodium Drugs 0.000 description 1
• 206010019692 hepatic necrosis Diseases 0.000 description 1
• 230000007062 hydrolysis Effects 0.000 description 1
• 238000006460 hydrolysis reaction Methods 0.000 description 1
• 239000005457 ice water Substances 0.000 description 1
• 230000001771 impaired effect Effects 0.000 description 1
• 238000005342 ion exchange Methods 0.000 description 1
• 239000003456 ion exchange resin Substances 0.000 description 1
• 229920003303 ion-exchange polymer Polymers 0.000 description 1
• 150000002500 ions Chemical class 0.000 description 1
• 210000004185 liver Anatomy 0.000 description 1
• 231100000149 liver necrosis Toxicity 0.000 description 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
• 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
• 239000011259 mixed solution Substances 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 239000000178 monomer Substances 0.000 description 1
• 229910052757 nitrogen Inorganic materials 0.000 description 1
• 125000004433 nitrogen atom Chemical group N* 0.000 description 1
• 229920002866 paraformaldehyde Polymers 0.000 description 1
• 239000000049 pigment Substances 0.000 description 1
• 229920000642 polymer Polymers 0.000 description 1
• 239000002994 raw material Substances 0.000 description 1
• 238000010992 reflux Methods 0.000 description 1
• 230000003014 reinforcing effect Effects 0.000 description 1
• 230000001568 sexual effect Effects 0.000 description 1
• 206010040560 shock Diseases 0.000 description 1
• 239000011780 sodium chloride Substances 0.000 description 1
• 125000001424 substituent group Chemical group 0.000 description 1
• 125000001174 sulfone group Chemical group 0.000 description 1
• 230000008961 swelling Effects 0.000 description 1
• DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 1
• IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
• IMFACGCPASFAPR-UHFFFAOYSA-O tributylazanium Chemical compound CCCC[NH+](CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-O 0.000 description 1
• YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
• 238000005406 washing Methods 0.000 description 1