JPH03106805A - Acaricide - Google Patents

Abstract

PURPOSE:To obtain an acaricide, containing ylang-ylang oil as an active ingredient, capable of effectively exterminating mites by application thereof to the interior of rooms, beddings, furniture, etc., and having high safety. CONSTITUTION:An acaricide containing 1-40wt.% ylang-ylang oil obtained by steam distillation of flowers collected from Canangium odorata formangenium belonging to the family Annonacea. The aforementioned acaricide is prepared by blending the ylang-ylang oil with a liquid carrier (e.g. water, alcohols, aliphatic and aromatic hydrocarbons) or a solid carrier (e.g. kaolin or wheat flour) in combination and then formulating the obtained blend into a suitable dosage form of an oil, emulsion, wettable powder, aerosol, dust, granule, fumigant, etc. The above-mentioned acaricide is capable of exhibiting excellent effects on mites of the genuses Dermatoohagoides, Tyrophagus, etc., and readily exterminating the mites in rooms in a short time by application thereof to TATAMI mats, carpets, floors, mattresses, FUTON (thick bedquilts), sofas, etc.

Description

[Detailed description of the invention] [Industrial application field] The present invention relates to a novel acaricide.

[Prior Art] With changes in lifestyles in recent years, a large number of mites have been occurring indoors, which has become a major problem. for example,
Dust mites that appear and live on carpets, futons, etc. become allergens for asthma and other conditions, and pose a major health threat. Furthermore, although the mites that live on tatami mats are not directly harmful to health, they cause discomfort and are a factor that induces large outbreaks of mites.

Conventionally, in order to control mites living indoors, phosphate compounds such as fenitrothion, fenthion, DDvP, and diazinon, carbamate compounds such as Proboxer and NAC, birethroid compounds such as resmethrin forte, and other phenyl salicylates have been used. , benzyl benzoate, and DEET (N,N-diethyl-3-methylbenzamide).

[Problems to be Solved by the Invention] However, the above-mentioned mite control agents all have drawbacks such as being highly toxic, expensive, and effective only against a certain range of mites.

In addition, these chemicals are not effective unless they come into contact with mites, so in order for them to be effective, they must be treated intermittently, or when treating the inside of tatami mats, the chemicals must be injected evenly. There was a drawback that it had to be done.

Furthermore, regarding the control of mites on bedding such as futons, there has been concern about the actual use of these bedding products due to the problem of residual drug toxicity.

[Means for Solving the Problems] In order to obtain a new acaricide, the present inventor was searching for the pharmacological action of various compounds against mites, and found that Cananga odorata (Ca.
nangiumodorata foriageniu
The present invention was completed based on the discovery that ylang-ylang oil obtained by steam distilling the flowers of (m) has an excellent acaricidal effect and also overcomes the drawbacks of conventional mite control agents.

That is, the present invention provides an acaricide containing ylang-ylang oil as an active ingredient.

Ylang-ylang oil, which is used as an active ingredient in the acaricide of the present invention, is a well-known compound that is used as a fragrance in high-end cosmetics and soaps.

The acaricide of the present invention can be prepared by combining this ylang-ylang oil with a known liquid or solid carrier, such as an oil solution, an emulsion, a wettable powder,
It is prepared by preparing a suitable dosage form such as a spray, an aerosol, a powder, a granule, a fumigation agent, or a transpiration agent.

Examples of liquid carriers that can be used include water, alcohols such as methanol, ethanol, and isopropyl alcohol; ketones such as acetone, methyl ethyl ketone, and cyclohexanone; tetrahydrofuran, dioxane,
Ethers such as dimethyl ether; aliphatic hydrocarbons such as hexane, kerosene, normal paraffin, and solpent naphtha; aromatic hydrocarbons such as benzene and toluene;
Examples include halogenated hydrocarbons such as dichloromethane and dichloroethane; esters such as ethyl acetate and butyl acetate.

Examples of solid carriers include inorganic powders such as silicic acid, kaolin, activated carbon, bentonite, diatomaceous earth, talc, clay, and calcium carbonate; vegetable powders such as soybean flour, wheat flour, and starch; and clathrate compounds such as cyclodextrin. can be mentioned.

The acaricide of the present invention may further contain emulsifiers, dispersants, spreading agents, stabilizers, propellants, and volatile preparation agents depending on the dosage form and its necessity.

The amount of active ingredient in the acaricide of the present invention obtained as described above can be adjusted depending on the dosage form, method of use, place of use, etc., but in general, 0. It is desirable that the content be about 1 to 80% by weight, particularly about 1 to 40% by weight.

In order to obtain a preferable acaricidal effect with the acaricide of the present invention, for example, when spraying on a carpet or the like, it is sufficient to spray at least about 20 mg of the active ingredient per square meter.

In addition, since ylang-ylang oil, which is the active ingredient of the acaricide of the present invention, has a miticidal effect by itself, the composition should have a surface area commensurate with the size of the room where it is to be sprayed. Continuous dispersion is possible and convenient by action alone. By doing this, it is possible to expect a sufficient effect against, for example, mites in tatami mats, with fewer injection points than before. In addition, by applying the chemical to futons and other bedding, it is possible to effectively control the dust mites in the futon cotton, and since the chemical evaporates quickly, any residual chemical after treatment can be removed in a short time. It is possible.

[Action and Effect of the Invention] Ylang-ylang oil, which is the active ingredient of the acaricide of the present invention, is effective against the mites such as Dermatophagoides nigricans and Dermatophagoides,
It has an excellent effect on mites such as woolly mites and wheat mites, and is a natural ingredient that is highly safe for humans and animals.

Therefore, the acaricide of the present invention can be applied not only to indoor areas such as tatami mats, carpets, floors, and hallways, but also to bedding such as mattresses, futons, pillows, and furniture such as sofas and storage utensils.
Mites can be exterminated safely and effectively.

In particular, acaricides that utilize the self-volatile ability of ylang-ylang oil are extremely advantageous because they can easily exterminate indoor mites in a short period of time.

[Example] Next, the present invention will be explained in more detail by giving Examples and Test Examples.

Conducted fRl acaricidal test: Dermatophagoide
spteronyssius) and the woolly mite (Tyrophgus putrescentiae)
) was used as a test insect, and the effect of the acaricide of the present invention was investigated using the dry film method and medium mixing method shown below.

The test results are shown in Tables 1 and 2.

Test method: (1) Dry film method A fixed amount of a drug diluted with acetone to a predetermined concentration was placed in a glass vial (diameter 1 cm, height 6 tubes). After the chemical was applied uniformly to the inner surface of the container and the acetone was volatilized, a predetermined number of mites were placed in the container, and the mouth was closed with breathable Teflon wrap.

Each plot was set in triplicate and stored under conditions of relative humidity of 90% and temperature of 25°C, and the mortality rate was observed after one day.

(2) Medium mixing method: Reduce the moisture content to around 15%! The test sample was mixed into the powdered sample medium at a concentration of 1%.

5 g of this mixed medium was placed in a vial (diameter 3 am, height 6
cm) and then inoculated with 0.1 g of mite breeding medium and mixed gently. The mouth of the vial was closed with air-permeable wrap and stored under conditions of relative humidity of 90% and temperature of 25°C.

0.1 g of the medium was taken after one week for the woolly mites, and after two weeks for the mites.
The number of live mites was counted using the saline suspension method, the total number was estimated, and the growth inhibition rate was calculated using the following formula to determine efficacy. Each section was divided into two series, and the number of mites was counted twice. ●Proliferation inhibition 11
J! 1! (!) = (1-T/C) X 1 0 0
C: Number of mites per unit weight in control area T: Number of mites per unit weight in treated area Results: Table 1 (margins below) 2nd! Ii Wipe sample Kena is Konada mite
Mite-killing effect of #1l powder: Diameter 5. A 5-cell filter paper was impregnated with the drug, placed in a petri dish of the same diameter, and the mouth was covered with paper used for a garbage bag for a vacuum cleaner. On the other hand, a breeding medium for woolly mites and Dermatophagoides mites was placed in each vial (diameter 3 cI1, height 6 Cl1), and the mouth was closed with breathable plastic wrap.

Each tick vial and drug petri dish were placed in an IKE flask, and the mouth of the flask was sealed with plastic wrap.
After leaving it for one day, the mites were observed to see if they were alive or dead, and the acaricidal activity by volatilization of the chemical was determined. The results are shown in Table 3.

As is clear from the results in Table 3, ylang-ylang oil has strong insecticidal activity even in its volatile components, unlike conventional acaricides.

Example 3 Spray acaricide: 20g ylang-ylang oil, 130g ethanol and 1
A miticide was obtained by filling 50 g of liquefied petroleum gas into an aerosol pressure can according to a conventional method.

Example 4 Sheet type acaricide: Ylang-ylang oil on a filter paper with a diameter of 11 cm Acaricide was obtained by impregnating 0.5 g.

Test example l 1? 0.5 of woolly mite breeding medium in Z flask
g, and the acaricide obtained in Example 3 was sprayed thereon for 3 seconds. After leaving it for one day, a portion of the culture medium was taken and the acaricidal rate was measured, and the acaricidal rate was approximately 100%.

Test Example 2 The acaricidal sheet obtained in Example 4 was placed in a glass container, an 8x8 cm carpet was placed on top of it, and 0.5 g of a breeding medium for woolly mites was added. After leaving the lid on for one day, the number of live mites was measured to determine the mite control rate. As a result, the dust mite control rate was almost 100%, and sufficient efficacy was obtained.

Test Example 3 The acaricidal sheet obtained in Example 4 was placed in a glass container, and 2 g of cotton was placed on top of it. To this, 1 g of a breeding medium for woolly mites was added, and after leaving it for one day with a lid on, the number of living mites was measured to obtain a mite control vehicle. As a result, the mite control rate was almost 100%, indicating sufficient efficacy.

Below Up Out wish Man workman vinegar a transformation studies Co., Ltd.

Claims (1)

[Claims] (1) Acaricide containing ylang-ylang oil as an active ingredient.