JPH0482805A - Acarid control agent and acarid control material - Google Patents

Abstract

PURPOSE:To obtain an acarid control agent containing dl-menthol and/or isomer thereof as an active ingredient, being low in toxicity and having wide acarid control region and acarid control material obtained by retaining the agent in a substrate such as synthetic resin sheet or paper. CONSTITUTION:dl-Menthol and/or isomer thereof is directly used or carried in a liquid support (e.g. methanol, acetone, THF or benzene) or on a solid support (e.g. kaolin, clay or cyclodextrin) and as necessary coating film forming agent, emulsifying agent, humectant, propellant, etc., is added thereto to produce the aimed acarid control agent used in a form of oil, emulsion, hydrate, propellant, aerosol, fumingating agent, coating agent, powder, etc., in a home. A film, sheet, building material, etc., having acarid controlling property can be produced by retaining the acarid control agent in a substrate such as resin sheet, paper or leather by a means of coating, impregnation, kneading, etc.

Description

[Detailed description of the invention] <Industrial application field> The present invention relates to a novel mite control agent and a new mite control material.

<Prior Art> Dust mites are almost always present in the indoor dust of ordinary households, but in recent years, with changes in housing and lifestyles, the number of mites has increased. Conventionally, as mite control materials against indoor dust mites, organic phosphorus compounds such as fenitrothion, fenthion, DDVP, and diazinon, carbamate compounds such as propoxar and NAC, and pyrethroid compounds such as resmethrin have been known. It is being

<Problems to be Solved by the Invention> These known mite control agents are used by keeping them on tatami mats, carpets, and sheets, or by scattering or spraying them as they are, but they have the following disadvantages. There is. In other words, organophosphorus-based mite control agents have the disadvantages of being highly toxic, have a bad odor, and have low effectiveness against Dermatophagoides mites, while carbamate-based mite control agents are highly toxic and have a low effect on Dermatophagoides mites. However, pyrethroid-based mite control agents have the disadvantages of being expensive and having low effectiveness against woolly mites. Furthermore, there are various problems such as difficulty in using these mite control agents together.

Means for Solving the Problems> Therefore, the present inventor has conducted various studies to provide an inexpensive tick control agent that is low in toxicity and has a wide range of tick control areas, and has developed It has been found that the isomer satisfies the requirements described in item 2.

That is, the present invention relates to a mite-controlling agent characterized by containing d9-menthol and/or its isomer as an active ingredient, and a mite-controlling agent characterized by holding the mite-controlling agent on a base material.

The mite control agent of the present invention contains dε-menthol, dL-(±)-menthol, dL-(±)-neomenthol, dL-(±)-isomenthol, dL-(
±)-neoisomenthol, dg-(-)-menthol, dg-(-)-neomenthol, dL-(-)-isomenthol, dg-(-)-neoisomenthol, dg
-(10) menthol, dL-(+)-neomenthol,
By containing at least one selected from dg-(+)isomenthol and dg-(10)-neisomenthol, it exhibits an extremely excellent mite control effect. The target mites can be any type of mites, but in particular, the mites such as Dermatophagoides nigricans and Dermatophagoides nigra, the Dermatophagoides mites such as the woolly spider mite and the wheat mite,
Examples include dust mites such as dust mites and house dust mites, dust mites such as stag mites and foot mites, and animal parasitic mites such as house dust mites and staghorn mites.

For the mite control agent of the present invention, the control agent containing the above-mentioned active ingredient can be used as it is, but usually, the control agent containing the active ingredient is held in a liquid carrier or a solid carrier,
Add film-forming agents, emulsifiers, dispersants, spreading agents, wetting agents, stabilizers, propellants, volatility regulators, etc. as necessary to prepare oils,
It can be used in the form of an emulsion, an aqueous solution, a spray, an aerosol, a smoke, a liniment, a powder, a granule, and the like. Examples of the liquid carrier include water, alcohols such as methyl alcohol, ethyl alcohol, and isopropyl alcohol, ketones such as acetone, methyl ethyl ketone, and cyclohexanone, ethers such as tetrahydrofuran, dioxane, and dimethyl ether, hexane, kerosene, normal paraffin, and solvents. Aliphatic hydrocarbons such as naphtha, aromatic hydrocarbons such as benzene and toluene, halogenated hydrocarbons such as dichloromethane and dichloroethane,
Examples include esters such as ethyl acetate and butyl acetate. Examples of solid carriers include mineral powders such as silicic acid, kaolin, activated carbon, bentonite, diatomaceous powder, talc, clay, calcium carbonate, and ceramic powder, vegetable powders such as wood flour, soy flour, wheat flour, and starch, and cyclodextrin. Examples include clathrate compounds such as.

In addition, examples of coating film forming agents include cellulose derivatives, vinyl resins, alkyd resins, urea resins, epoxy resins, polyester resins, urethane resins, silicone resins, acrylic resins, chlorinated rubber, polyvinyl alcohol, etc. In addition, as emulsifiers, dispersants, and spreading agents, soaps, polyoxyethylene alkyl ethers, polyoxyethylene alkyl phenyl ethers, polyoxyethylene fatty acid esters, fatty acid glycerides, sorbitan fatty acid esters, sulfuric esters of higher alcohols, Surfactants such as alkylaryl sulfonates, and propellants such as liquefied petroleum gas,
Examples include dimethyl ether, CO2, and fluorocarbon. Further, as a volatilization regulator, tricyclodecane, cyclododecane, 2. 4. , 6-triisoprobyl-1
．． 3. The mite control agent can be made into a sublimable solid agent by using a sublimable carrier such as 5-trioxane or trimethylene norbornene or a sublimable insect repellent such as balajichlorobenzene, naphthalene, or camphor. It can also be used as a volatile mite control agent in combination with other volatile insect repellents.

Furthermore, the mite control agent of the present invention may contain various insect repellents, synergists, pest repellents, rat repellents, antioxidants, decomposition inhibitors, bactericides, fungicides, fragrances, colorants, etc. You can also do it. As the insect repellent that can be blended, any of the various chemicals conventionally used for exterminating pests can be used. A typical drug is 3-allyl-2-methylcyclopent-2-
En-4-one-1yl dl-cis/trans-chrysanthemate 3-allyl-2-methylcyclopenta-2
-en-4-one-1-yl d-cis/trans-chrysanthemate d-3-allyl-2-methylcyclopent-2-en-4-one-1-yl d-) lance-chrysanthemate mate, 3-allyl-2-methylcyclopent-2-en-4-one-1-yl dtrans-chrysanthemate, N-(3,4,5,6-titrahydrophthalimido)-methyl dl- cis/trans-chrysanthemate, 5-benzyl 3-furylmethyl d-cis/trans-chrysanthemate, 5-(2-propargyl)-3-furylmethylchrysanthemate 3-phenoxybenzyl 2,2-dimethyl- 3-(2' ・2°-
dichloro)vinylcyclopropane hydroxylate, 3
-phenoxybenzyl d-cis/trans-chrysanthemate, α-cyanophenoxybenzyl isopropyl-4-chlorophenylacetate, (S)-α-cyano-3-phenoxybenzyl (IR・cis)3-(2
・2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate, (R-5)α-cyano-3-
Phenoxybenzyl (IR・l5)-cis/trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate, α-cyano-3-phenoxybenzyl d-cis/trans Santemate 1-ethynyl-2-methyl-2-pentenyl cis/trans-chrysantemate, 1-ethynyl-2-methyl-2-pentenyl 2,2-dimethyl-3-(2methyl-copropenyl)cyclopropane- ] Carboxylate 1-ethynyl-2-methyl-2pentenyl 2
・2,3,3-tetramethylcyclopropanecarboxylate, 1-ethynyl-2methyl-2-pentenyl 2
・2-dimethyl-3(2,2-dichlorovinyl)cyclopropane-1-carboxylate, [(pentafluorophenyl)-methyl]-1R,3R-3-(2,2-
dichlorovinyl)-2,2-dimethyl-cyclopropanecarboxylate, 0-0-dimethyl 0-(2,2-
dichloro)vinyl phosphate, O-isopropoxyphenylmethyl carbamate, o-O-dimethyl C)-(
3-Methyl-4-nitrophenyl)thionophosphate, 0-O-diethyl 0-2-isopropyl-4-methyl-pyrimidyl-(6)-thiophosphate, 0.
0-dimethyl 5-(1,2 dicarboethoxyethyl)
-dithiophosphate etc. can be exemplified.

The amount of active ingredient in the mite control agent of the present invention may be appropriately determined depending on its dosage form, application method, application location, etc. However, when used in the form of a wettable powder or emulsion, the active ingredient composition 0. When used in the form of oil or aerosol, it is preferable that the active ingredient composition be 0.1 to 30% by weight, and the amount to be applied is 0.1 to 30% by weight. Approximately 100mg or more, applicable space 1
It is desirable that the active ingredient composition is present in an amount of about 1.0 mg or more per rri'.

The present invention also provides a mite-controlling material in which the above-mentioned mite-controlling agent is retained in a base material. The tick control material is
Utilizing the characteristics of the base material, it is used as a film with dust mite repellent properties, a sheet construction/construction +2 material, etc. Here, the base material includes, for example, synthetic resin sheets such as polyethylene, polypropylene, nylon, polyvinyl chloride, polyvinylidene chloride, and polyester, animal and vegetable or inorganic fiber sheets (paper, cloth, nonwoven fabric, leather, etc.), and these synthetic resins. Examples include mixed sheets or blended fabrics with inorganic fibers or powder, blended fabrics or nonwoven fabrics with the above synthetic resins and animal and plant fibers, foils or films of metals such as aluminum, stainless steel, and zinc, and laminated sheets of the above various sheets. Further, as the above-mentioned base material, natural wood used as building and construction materials such as awn, pencil fern, oak, etc., and molded products of plastics such as vinyl chloride resin, chlorinated polyethylene, polyethylene, polypropylene, etc. can also be effectively used. The means for retaining the mite control agent of the present invention on these substrates is not particularly limited;
For example, it can be carried out by coating, impregnating, dropping, crossing, etc. The retained amount is also not particularly limited and can be determined as appropriate; however, in the case of impregnating the above-mentioned profiteers, it is preferable to set the amount up to the saturated impregnated amount.

<Operation and Effects of the Invention> As described above, the mite control agent of the present invention can be used on tatami mats, carpets, floors, hallways, pine mattresses, sofa-1 stuffed animals, bedding such as futons, pillows, blankets, and sheets, closets, and storage. Ingredients,
If you directly treat it by placing it in a warehouse, spraying, spraying, painting, fogging, heating evaporation, etc., or if you install a tick control material with the insecticide in the base material in the above place, you can Shows mite control effect.

<Example> Hereinafter, the present invention will be explained in more detail with reference to Examples.

Example 1 Effect test on Dermatophagoides farinae and Dermatophagoides mite Test method A filter paper (2 cm
x 2 cm) and dissolve the active ingredient in acetone to make a drug, and the content of the active ingredient is 1 mg to 1.
Impregnate with the drug so that it becomes 0■. Place 100 to 200 mites of each type in a waist-high petri dish, and seal it using the lid covered with the treated paper. The exposure was stopped after 2 hours had elapsed, and 24 hours after the cessation of the exposure, the viability of each type of mite was determined under a stereomicroscope, and the results are shown in Table 1.

Example 2 250 mesh nylon goose bag (6cm x 1
After putting 2.5 g of mixed cotton together with 0.2 g of mite culture medium into a 2 cm), the sample was placed in positions (1) to (4) shown in FIG. 1 with the mouth closed to prevent mites from escaping.

Then dl-menthol 1.6g on 90x50an paper
and impregnated with 0.4 g of isoparaffin (5
) to (10) using various packaging tools.
Exposure to active ingredient for 4 hours at 5°C. Thereafter, the goose bag was taken out and cultured for one week at a temperature of 25° C. and a humidity of 74%, and then the number of live mites was measured using the saturated saline method to determine the growth inhibition rate. The results are shown in Table 2.

Example 3 To 30 g of dl-menthol, add a small amount of fragrance and 20 d of isoparaffin, and then add ethanol to make the total 27 g.
0rd, and 30 g of dimethyl ether and 6 g of carbon dioxide gas were filled into an aerosol pressure-resistant can (content: 300 Id), attached to an injection device, and sealed to obtain the mite control material of the present invention in the form of an aerosol.

The following tests were conducted using each of the aerosols thus obtained.

(Test method) After putting 2.5 g of blended cotton together with 0.2 g of mite culture medium into a 22 cm Goose bag (6X), close the Goose bag. ~■)
After installing the following aerosol on each side of the futon, apply the following aerosol for 15 seconds on both sides of the futon, and for 20 seconds on one side of the futon.
As shown in Figure 2, the mattress was folded into three and placed under 25°C for 4 hours while covered with the futon. Thereafter, the futon is dried in the shade, and when the drug is completely removed, the goose bag containing the mites is taken out and placed at 25°C and 74% humidity. One week later, only the mites were separated using the saturated saline method, and the live mites were counted to determine the growth inhibition rate relative to the control group.

Table 3 Table 4 Example 4 120 parts of ethylene methyl methacrylate (containing 20% methyl methacrylate) and 20 parts of dl-menthol were added] and extrusion molding was carried out at 60"C. 20X10
1 mm thick sheet (approximately 5 cm thick as di-menthol)
g) was obtained.

Using the sheet thus obtained, the following tests were conducted. As shown in Figure 3, a futon bag (96X62X6
0cm), fold the mattress into three and four, respectively, and store them. After putting 2.5 g of blended cotton together with 0.2 g of mite culture medium into a 250-mesh nylon goose bag (6 cm x 12 cm), place the sample in positions 1 to 3 with the mouth closed to prevent mites from escaping. . Thereafter, the sheet obtained above was placed in positions 4 to 6, the futon bag was closed, and the temperature was kept at 25°C. After one week, the number of live mites was measured using the saturated saline method to determine the growth inhibition rate. and the results are shown in Table 4.
Shown below.

Example 5 Part of dl-menI.-L]O was sufficiently stirred and mixed with 90 parts of silicon oxide and then pulverized to obtain a powder form of the mite control material of the present invention. The powder thus obtained was tested according to the following test method.
The mite control effect was tested. For comparison, powders were prepared in the same manner except that d-menthol and 1-menthol were used.

Test method: Straw cut into approximately 2 cm length was heated to kill insects, and then 5 g of it was heated to 10
Pour 0mM into an Erlenmeyer flask, then add 0.1g of powder.

After adding 0.5 g and mixing, the mixture was sealed with polyvinylidene chloride film and stored for one day at 25° C. and 185 to 90% RH. Approximately 400 woolly mites were placed in this Erlenmeyer flask, and after storing them for 2 days under the same conditions, the surviving mites were expelled using the heat expulsion method, and their number was counted.
The mortality rate was calculated using the following formula.

As a result, in the present invention, almost 100%
It was possible to obtain a mortality rate of 1,000,000,000, and showed sufficient mite control properties, whereas in comparison, all concentrations were about 0 to 30%.

Indicates the condition. In the figure, (]) to (3) indicate the installation positions of the sample, and (4) to (6) indicate the installation positions of the support having the volatile active ingredient.

X: Number of surviving mites in untreated area y; Number of living mites in treated area

[Brief explanation of the drawing]

FIG. 1 is an explanatory diagram showing an example of the processing state of the present invention, in which a four-fold comforter (A) is placed on a three-fold mattress (A).
Shows the state in which B) is placed. In the figure, (1) to (4) indicate the installation positions of the sample, and (5) to (1o) indicate the installation positions of the support having the volatile active ingredient. FIG. 2 is an explanatory view showing another example of the embodiment of the processing state of the present invention, and shows a state in which a trifold mattress (A) is covered with a comforter (B). In the figure, (1) to (3) indicate the installation positions of the samples. FIG. 3 is an explanatory diagram showing still another example of the embodiment of the processing state of the present invention, in which the mattress (A) is folded in three in the futon bag (C).
) A four-folded comforter (B) was placed on top of the (above) Patent applicant: Earth Pharmaceutical Co., Ltd.

Claims (2)

[Claims] (1) A mite control agent containing dl-menthol and/or its isomer as an active ingredient. (2) The mite control material according to claim 1, characterized in that the above-mentioned control agent is held in a carrier.